@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADA2B_HUMAN: (2016-01-08 )
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
Atome Classification :
(20 SA)
-------------------------.........10........20........30........40........50........60....-....70....-....80........90........100.......110....---...120-.........130.......140.......---150.......160.------.---....--------.------.-170-........180.......190-.......200.-------.--------.....210--------.......---..220......------...230-----...-.....240.--......250.......260---........------270..--------.....280---------........290.......300-----.........310.......320.....-..330.......340.......350.......360.......370.......380.......390....-...400.......410.......420.......430..-.....440.....------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MDHQDPY
S
V
Q
A
T
A
A
I
A
A
A
I
T
F
L
I
L
F
T
I
FG
N
A
L
V
I
L
A
V
L
T
SRSLRAPQ
N
L
F
L
V
S
L
A
A
A
D
I
L
V
A
T
L
I
-
I
P
F
S
L
A
N
E
L
L
-
G
Y
W
Y
F
R
R
T
W
C
E
V
Y
L
A
L
D
V
L
F
C
T
S
S
I
V
H
L
C
A
I
S
L
D
R
Y
W
A
V
S
R
---
A
L
EY---NSKRTP
R
R
I
K
C
I
I
L
T
V
W
L
I
A
A
V
I
SLP
P
L
I
---YKGDQGPQPRG-RP------Q---
C
K
LN--------
Q
------
E
-
A
W
--
Y
I
L
A
S
S
I
G
S
F
F
A
P
C
L
I
M
I
L
V
Y
-
L
R
I
Y
L
I
A
KRSN-------R--------RGPRAK----------GGPGQGE---SKQ--PRPDHG------GALAS------AK
L
-
P
A
L
A
S
V
A
S
A
--REVNGHSKSTGEKEEGET----PEDTGTRA------LPP
S
W
--------AALPNS-G---------QGQKEGVCGASPEDEA
E
E
E
-------
E
E
E
E
EECEPQAVPVSPASACSPPLQQP-QG
S
R
V
L
A
T
LRG
Q
V
L
L
GRGVGAI
G
G
Q
W
W
R
R
R
A
Q
L
T
R
E
K
R
F
T
F
V
L
A
V
V
I
G
V
F
V
L
C
W
F
P
F
F
F
SY
S
L
GAI
C
P
K
-HCKV
P
H
G
L
F
Q
F
F
F
W
I
G
Y
CNSSLN
P
V
I
Y
T
I
F
N
Q
D
F
R
R
A
F
-
R
R
I
LCRPWTQTAW------------
8
PsiBlast_PDB
87.89
28%
-164
- C3 -
3P0G
1
ENLYS_BPT4
A:
[42-477]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ET
C
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
R
R
-----------------
2
PsiBlast_PDB
85.02
32%
-95
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[48-470]
----------------------------------------------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
---
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
--------
G
F
N
T
T
G
-
D
P
------
T
---
V
C
S
I
--------
S
------
N
-
P
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
-------
R
--------
K
N
I
F
E
M
----------
L
R
I
D
E
G
L
---
R
L
K
--
I
Y
K
D
T
E
------
G
Y
Y
T
I
G
IGHLL
T
K
S
-
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
-
V
F
--------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
G
V
P
L
-
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
-
Q
-
T
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
-
L
K
I
L
S
C
-------------------
21
PsiBlast_CBE
84.52
32%
-97
- C3 -
3PBL
2
DRD3_HUMAN (first)
B:
[48-470]
----------------------------------------------
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
---
P
---------
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
--------
G
F
N
T
T
G
-
D
P
------
T
---
V
C
S
I
--------
S
------
N
-
P
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
-
A
R
I
Y
V
V
L
K
Q
R
R
-------
R
--------
K
N
I
F
E
M
----------
L
R
I
D
E
G
L
---
R
L
K
--
I
Y
K
D
T
E
------
G
Y
Y
T
I
GIGHLL
T
K
S
-
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
-
V
F
--------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
G
V
P
L
-
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
-
Q
-
T
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
-
L
K
I
L
S
C
-------------------
5
PsiBlast_PDB
83.09
28%
-92
- C3 -
3NY8
7
ENLYS_BPT4
A:
[41-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
9
PsiBlast_PDB
82.79
28%
-91
- C3 -
3PDS
8
ADRB2_HUMAN (first)
A:
[9-445]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
--------
I
F
E
M
L
R
----------
I
D
E
G
L
-
R
---
L
K
I
--
Y
K
D
T
E
G
YYTIGI
G
H
L
L
T
-------
K
S
-
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
-
V
F
--------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
3
PsiBlast_PDB
82.22
28%
-93
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-476]
-------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYT
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
-
V
F
--------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
6
PsiBlast_PDB
82.03
28%
-93
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[41-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYT
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
4
PsiBlast_PDB
81.13
28%
-94
- C3 -
3D4S
6
ENLYS_BPT4
A:
[41-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYT
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
7
PsiBlast_PDB
80.93
28%
-91
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[41-477]
------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
MHW
Y
R
A
T
H
Q
E
A
I
N
C
-
Y
A
------
E
ETC
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
1
PsiBlast_PDB
80.74
28%
-95
- C3 -
4IAR
2
C562_ECOLX
A:
[11-395]
---------------------------
Y
Q
D
S
I
S
L
P
W
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
T
-
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
---
A
V
E
Y
---
S
A
K
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
F
---
W
R
--
Q
A
-------
S
------
E
---
C
V
V
N
--------
T
------
D
H
I
L
--
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
-
G
R
I
Y
V
E
A
R
--
S
-------
R
--------
I
A
D
L
E
D
----------
N
W
E
T
L
N
D
---
N
L
K
V
I
E
K
A
D
N
A
------
A
Q
V
K
D
------
A
L
T
-
K
M
R
A
A
A
L
D
A
--
Q
------
K
A
T
P
P
K
L
E
D
K
S
----
P
D
S
P
E
M
K
D
------
F
R
H
G
F
--------
D
I
L
V
--------------
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
-------
Q
A
A
A
E
Q
---------------------------
L
K
T
T
R
N
A
Y
I
--------------
Q
K
Y
L
A
A
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
-
H
K
L
I
R
F
K
------------------
15
PsiBlast_PDB
79.07
25%
-103
- C3 -
4U15
6
ACM3_RAT
A:
[8-398]
--------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
---
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
-
E
C
------
F
---
I
Q
F
L
--------
S
------
E
-
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
--
R
--------
I
D
E
G
G
G
----------
S
G
G
D
E
A
E
K
L
F
N
Q
D
--
V
D
A
A
V
R
------
G
I
L
R
N
------
A
K
L
K
P
V
Y
D
S
L
D
A
V
--
R
R
-----------------------------------------------
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
---
D
A
Y
L
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
-
D
-
S
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
L
----------------------
45
Fugue
77.85
24%
-78
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
---
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
---
M
H
W
Y
R
A
T
H
Q
E
A
-
I
N
C
Y
A
EET
C
---
C
D
F
F
--------
T
------
N
-
Q
A
--
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-
S
R
V
F
Q
E
A
K
R
Q
L
-------
N
--------
I
F
E
M
L
R
----------
I
D
E
G
L
-
R
---
L
K
I
--
Y
K
D
T
E
G
------
Y
Y
T
I
G
------
I
G
H
-
L
L
T
K
S
P
S
L
N
--
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
----
T
K
D
E
A
E
K
L
------
F
N
Q
D
V
--------
D
A
A
V
R
G
-
I
---------
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
-
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-
L
--
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
-
S
P
D
F
R
I
A
F
-
Q
E
L
L
C
L
-------------------
14
PsiBlast_PDB
77.81
25%
-94
- C3 -
4U14
1
ENLYS_BPT4
A:
[8-442]
--------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
---
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
FWQ
Y
F
V
G
K
R
T
V
P
P
G
-
E
C
------
F
---
I
Q
F
L
--------
S
------
E
-
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
C
F
E
M
L
R
I
D
--------
E
G
L
R
L
K
I
Y
K
D
CEG
Y
Y
T
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
--------
D
S
L
D
A
V
-
R
R
C
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
C
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
---
D
A
Y
L
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
-
D
-
S
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
L
L
L
--------------------
16
PsiBlast_PDB
77.42
25%
-106
- C3 -
4U16
2
?
A:
[8-388]
--------------------------------
T
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
---
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
-
E
C
------
F
---
I
Q
F
L
--------
S
------
E
-
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
--
R
--------
I
D
E
G
G
G
----------
S
G
G
D
E
A
E
K
L
F
N
Q
D
--
V
D
A
A
V
R
------
G
I
L
R
N
------
A
K
L
K
P
V
Y
D
S
L
D
A
V
--
R
R
-----------------------------------------------
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
---
D
A
Y
L
I
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
-
D
-
S
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
---------------------------------
13
PsiBlast_PDB
77.09
25%
-90
- C3 -
4DAJ
5
ACM3_RAT (first)
A:
[9-440]
---------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
-
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
---
P
L
T
Y
---
R
A
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
A
P
A
I
L
F
W
Q
Y
F
V
G
K
R
T
V
P
P
G
-
E
C
------
F
---
I
Q
F
L
--------
S
------
E
-
P
T
--
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
-
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
--------
E
G
L
R
L
K
I
Y
K
D
TEGYYT
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
------------
T
G
T
W
---
D
A
Y
L
I
K
E
---
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
T
F
C
D
S
--
C
-
I
P
K
T
Y
W
N
L
G
Y
W
L
C
Y
I
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
-
K
T
-----------------------
11
PsiBlast_PDB
76.48
29%
-105
- C3 -
4NC3
12
C562_ECOLX
A:
[33-414]
----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
PIQ
A
N
Q
Y
---
N
S
R
A
T
A
-
F
I
K
--
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
---
K
G
I
E
T
-
V
D
N
P
N
-
N
I
------
T
---
C
V
L
T
--------
K
------
E
-
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
-------
D
--------
L
E
D
N
W
E
----------
T
L
N
D
N
L
K
---
V
I
E
---
K
A
D
N
A
------
A
Q
V
K
D
------
A
L
T
-
K
M
R
A
-----------------------------------
K
D
------
F
R
H
G
F
--------
D
I
L
V
--------------
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
------------------------
A
Q
A
A
A
E
Q
L
K
T
T
-
R
N
A
Y
I
Q
K
Y
L
Q
---------------------
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
-----------------
10
PsiBlast_PDB
76.09
29%
-99
- C3 -
4IB4
10
5HT2B_HUMAN (first)
A:
[33-414]
----------------------------------------
A
L
L
I
L
M
V
I
I
P
T
I
G
G
N
T
L
V
I
L
A
V
S
L
E
K
K
L
Q
Y
A
T
N
Y
F
L
M
S
L
A
V
A
D
L
L
V
G
L
F
V
-
M
P
I
A
L
L
T
I
M
F
E
A
M
W
P
L
P
L
V
L
C
P
A
W
L
F
L
D
V
L
F
S
T
A
S
I
W
H
L
C
A
I
S
V
D
R
Y
I
A
I
K
K
PIQ
A
N
Q
Y
---
N
S
R
A
T
A
-
F
I
K
--
I
T
V
V
W
L
I
S
I
G
I
A
I
P
V
P
I
---
K
G
I
E
T
---
N
P
N
-
N
I
------
T
---
C
V
L
T
--------
K
------
E
-
R
F
G
D
F
M
L
F
G
S
L
A
A
F
F
T
P
L
A
I
M
I
V
T
Y
F
L
T
I
H
A
L
Q
K
K
A
A
-------
D
--------
L
E
D
N
W
E
----------
T
L
N
D
N
L
K
---
V
I
E
---
K
A
D
N
A
------
A
Q
V
K
D
------
A
L
T
-
K
M
R
A
A
A
L
D
A
--
Q
------
K
--------------------
K
D
------
F
R
H
G
F
--------
D
I
L
V
--------------
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
------------------------
A
Q
A
A
A
E
Q
L
K
T
T
-
R
N
A
Y
I
Q
K
Y
L
Q
---------------------
T
I
S
N
E
Q
R
A
S
K
V
L
G
I
V
F
F
L
F
L
L
M
W
C
P
F
F
I
T
N
I
T
L
V
L
C
D
S
C
N
Q
T
T
L
Q
M
L
L
E
I
F
V
W
I
G
Y
V
S
S
G
V
N
P
L
V
Y
T
L
F
N
K
T
F
R
D
A
F
G
R
Y
I
T
C
N
Y
R
-----------------
12
PsiBlast_PDB
75.47
26%
-94
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-441]
---------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
---
P
L
R
Y
---
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
---
W
N
H
------
R
R
-
E
D
------
K
---
C
E
T
D
FY------
D
------
V
-
T
W
--
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
-
A
K
I
Y
K
A
V
R
Q
H
C
-------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
---
T
K
S
--
P
------------
S
L
N
A
------
A
K
---
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
----
D
V
D
A
A
V
R
G
I
L
R
NAK
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
---------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-------
K
R
W
D
E
A
----
A
V
N
L
A
K
S
R
W
Y
N
---
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
-------------
W
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
-
K
-
N
C
C
N
E
H
-
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
-
K
R
I
L
H
I
-------------------
52
Fugue
68.49
19%
-120
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSPFE
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
S
----
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---
G
W
S
R
Y
I
P
E
--
G
M
Q
C
------
S
---
C
G
I
D
YYTPHEET
N
------
N
-
E
S
--
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
-
G
Q
L
V
F
T
V
K
E
A
A
-------
A
--------
S
A
T
T
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
-
G
V
A
F
Y
I
F
T
H
Q
-
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
-
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A
65
HHSearch
68.36
23%
-120
- C3 -
2Z73
5
OPSD_TODPA
A:
[30-333]
--------------------------------
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
---
P
M
A
A
---
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
---
G
W
G
A
Y
T
L
E
-
G
V
-
L
C
------
N
---
C
S
F
D
--------
Y
ISRD
S
T
T
-
R
S
--
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
-
F
N
I
V
M
S
V
S
N
H
E
-------
K
--------
E
M
A
A
M
A
----------
K
R
L
-----------------------------------------------------------
N
A
K
---------------------------------------------------------------------------------------
E
---------------------------------------------
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
-
E
-
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
-
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------