@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GALR2_HUMAN: (2016-01-09 )
MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80......-..90........100.......110.......120.......130....---...140.......150......-.160---..-.....---.-170-..-....---.------180.----..---....---190.......200.......210......------------------------------.220---.-----------------------------------------------------------------------------------------------------------------------------------------------------------.....-.230-------.........-----------240.......250.......260----...--------..-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNVSGCPGAGNASQAGGGGGWH
P
E
A
V
I
V
P
L
L
F
A
L
I
F
L
V
G
TV
G
N
T
L
V
L
A
V
L
L
RGG
Q
A
V
S
T
T
N
L
F
I
L
NL
G
V
A
D
L
C
F
I
L
C
CVPFQ
A
T
I
Y
T
-L
D
G
W
V
F
G
S
L
L
C
K
A
V
H
F
L
I
F
L
T
MHASS
F
T
L
A
A
V
SL
D
R
Y
L
A
I
RYPLHSREL---RT
P
R
N
A
L
A
A
I
G
L
I
W
G
L
S
L
LFSG-
P
Y
L
----
S
Y
-
Y
R
Q
SQ---L-A
N
L
-
T
V
-CHPA---W------S
A
P
R
----
R
R
---
A
M
D
I
---
C
T
F
V
F
S
Y
L
L
P
V
L
V
L
G
L
T
Y
A
R
T
L
R
Y
L
W
R
AV------------------------------DPVA---A-----------------------------------------------------------------------------------------------------------------------------------------------------------GS
G
A
R
-
R
A
---------
K
R
K
V
T
R
M
I
L
-----------
I
V
A
A
L
F
C
L
C
WMPHH
A
L
I
L
C
V
WF-----GQF--------P
L
-
T
R
A
T
Y
A
L
R
I
L
S
H
L
V
S
Y
A
N
S
C
V
N
P
I
V
Y
A
L
V
S
K
H
F
R
K
G
F
R
T
I
C
A
G
L
LGRAPGRASG
R
V
C
A
A
ARGTHSGSVLERESSD
L
L
H
M
S
E
AAGALRPCPGASQ
P
C
I
LEPCPGPSWQGPKAGD
S
I
L
T
V
DVA
60
HHSearch
88.38
27%
-155
- C6 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
----
F
G
-
F
N
T
T
------
G
D
P
-
T
V
-
C
S
I
S
---
N
------
P
------------
D
F
V
I
---
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
------------------------------
R
K
N
I
---
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
V
P
-
L
R
---------
E
K
K
A
T
Q
M
V
A
-----------
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
--
L
N
-----
T
H
C
--------
Q
T
-
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------------------------------------------------
51
HHSearch
87.34
22%
-147
- C6 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-
P
A
I
----
L
F
-
W
Q
F
I
V
GVR
T
-
V
E
D
-
G
E
-
C
Y
I
Q
---
F
------
F
S
------
N
A
---
A
V
T
F
---
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
------------------------------
N
I
F
E
---
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
P
P
P
-
S
R
---------
E
K
K
V
T
R
T
I
L
-----------
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
--
N
-----
T
F
C
--------
A
P
--
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------------------------------------------------
59
HHSearch
86.93
25%
-143
- C6 -
3EML
13
ENLYS_BPT4
A:
[21-472]
------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-
T
P
M
----
L
G
-
W
N
N
C
G
---
Q
---
S
-
Q
G
-
C
G
E
G
---
Q
VACLFE
D
V
V
P
----
M
N
---
Y
M
V
Y
---
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
------------------------------
N
I
F
E
---
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
-
Y
R
S
T
L
-
Q
K
---------
E
V
H
A
A
K
S
L
A
-----------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
--
F
T
-----
F
F
C
--------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------------------------------------------------
53
HHSearch
86.05
25%
-141
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
----
Q
M
H
W
Y
R
A
T
---
H
-
Q
E
A
-
I
N
-
C
Y
A
E
---
E
TCC---
D
F
F
T
----
N
Q
---
A
Y
A
I
---
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
------------------------------
N
I
F
E
---
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
K
F
C
-
L
K
---------
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
--
H
-----
V
I
Q
--------
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------
2
PsiBlast_PDB
85.12
32%
-163
- C6 -
5C1M
7
?
A:
[17-296]
------------------------
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
-
P
V
M
F
M
A
T
T
K
-
Y
R
Q
G
S
---
I
D
C
T
L
-
T
F
-
S
H
P
T
---
W
------
Y
W
------
E
N
---
L
L
K
I
---
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
-
K
S
V
------------------------------
R
M
L
S
---
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
E
K
D
-
R
N
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
-----
I
T
I
--------
P
E
-
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.73
31%
-164
- C6 -
4RWA
2
C562_ECOLX (first)
A:
[122-406]
------------------------
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
M
----
V
M
-
A
V
T
R
P
---
R
-
D
G
A
-
V
V
-
C
M
L
Q
---
F
------
P
S
P
S
W
Y
W
-
D
T
---
V
T
K
I
---
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-
V
W
T
LVDID
R
R
D
--------
P
L
-
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------
23
PsiBlast_CBE
84.27
31%
-163
- C6 -
4RWA
1
C562_ECOLX (first)
B:
[122-403]
------------------------
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
M
----
V
M
-
A
V
T
R
P
---
R
-
D
G
A
-
V
V
-
C
M
L
Q
---
F
------
P
S
P
S
W
Y
W
-
D
T
---
V
T
K
I
---
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-
V
W
T
LVDID
R
R
D
--------
P
L
-
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-----------------------------------------------------------------------------------
9
PsiBlast_PDB
84.21
29%
-140
- C6 -
2YCW
7
ADRB1_MELGA
A:
[3-299]
--------
A
E
L
L
S
Q
Q
W
E
A
G
--------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
-
W
W
R
D
E
---
D
-
P
Q
A
-
L
K
-
C
Y
Q
D
P
GC
C
------
D
F
V
T
----
N
R
---
A
Y
A
I
---
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
------------------------------
R
K
I
D
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
-
R
V
M
L
M
R
-----
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
--------
N
V
F
--------
N
R
-
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
22
PsiBlast_CBE
84.19
31%
-159
- C6 -
4RWD
6
C562_ECOLX (first)
B:
[122-405]
------------------------
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
M
----
V
M
-
A
V
T
R
P
---
R
-
D
G
A
-
V
V
-
C
M
L
Q
---
F
------
P
S
P
S
WYW-
D
T
---
V
T
K
I
---
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
--------------------------------
L
L
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-
V
W
T
LVDID
R
R
D
--------
P
L
-
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
---------------------------------------------------------------------------------
42
Fugue
83.97
23%
-146
- C6 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--
S
F
K
C
A
L
T
K
T
----------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-
P
I
L
----
F
Y
-
S
G
T
G
V
---
R
-
K
N
K
T
I
T
-
C
Y
D
T
---
T
------
S
D
E
Y
----
L
R
---
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFK
D
I
V
C
---
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
G
V
G
-
K
D
Q
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
-----------
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
-----
A
R
L
DFQTPAM
C
A
F
-
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-------------------------------------------------------------------------------------
55
HHSearch
83.84
24%
-153
* C6 *
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-
P
I
L
----
G
W
-
N
H
--------
R
R
E
-
D
K
-
C
E
T
D
---
F
------
Y
D
V
------
T
---
W
F
K
V
---
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
------------------------------
N
I
F
E
---
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
H
M
-
N
R
---------
E
R
K
A
A
K
Q
L
G
-----------
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
-------
A
F
C
--------
K
N
--
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------------------------------------------------
3
PsiBlast_PDB
83.81
31%
-152
- C6 -
4N6H
23
C562_ECOLX (first)
A:
[112-409]
----
G
S
P
G
A
R
S
A
S
S
L
A
-------
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
M
----
V
M
-
A
V
T
R
P
---
R
-
D
G
A
-
V
V
-
C
M
L
Q
---
F
------
P
S
P
S
W
Y
W
-
D
T
---
V
T
K
I
---
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
--------------------------------
L
L
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-
V
W
T
LVDID
R
R
D
--------
P
L
-
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
---------------------------------------------------------------------------
5
PsiBlast_PDB
83.74
31%
-159
- C6 -
4RWD
7
C562_ECOLX (first)
A:
[122-406]
------------------------
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
-
P
I
M
----
V
M
-
A
V
T
R
P
---
R
-
D
G
A
-
V
V
-
C
M
L
Q
---
F
------
P
S
P
S
W
Y
W
-
D
T
---
V
T
K
I
---
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
--------------------------------
L
L
---
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
---------
L
R
R
I
T
R
M
V
L
-----------
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
-
V
W
T
LVDID
R
R
D
--------
P
L
-
V
V
A
A
L
H
L
C
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
--------------------------------------------------------------------------------
21
PsiBlast_CBE
83.31
35%
-149
- C6 -
4EA3
3
OPRX_HUMAN
B:
[139-407]
--------------------------------------
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
T
L
V
L
L
T
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
I
R
A
L
D
V
---
R
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
-
P
-
V
----
A
I
-
M
G
S
A
----------
E
I
E
C
L
V
E
---
I
------
P
T
P
Q
----
D
Y
W
G
P
V
F
A
I
---
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
-
R
N
---------
L
R
R
I
T
R
L
V
L
-----------
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
-----
G
V
Q
--------
P
S
-
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
K
F
---------------------------------------------------------------------------------
12
PsiBlast_PDB
82.73
29%
-141
- C6 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
---------------
W
E
A
G
--------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
-
W
W
R
D
E
---
D
-
P
Q
A
-
L
K
-
C
Y
Q
D
PGC
C
------
D
F
V
T
----
N
R
---
A
Y
A
I
---
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
------------------------------
R
--
D
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
-
R
V
M
L
M
R
-----
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
--------
N
V
F
--------
N
R
-
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
14
PsiBlast_PDB
82.59
29%
-148
- C6 -
2Y01
12
ADRB1_MELGA
A:
[3-300]
--------
A
E
L
L
S
Q
Q
W
E
A
G
--------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
-
W
W
R
D
E
---
D
-
P
Q
A
-
L
K
-
C
Y
Q
D
PGC
C
------
D
F
V
T
----
N
R
---
A
Y
A
I
---
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
--------
N
V
F
--------
N
R
-
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
1
PsiBlast_PDB
82.42
35%
-151
- C6 -
4EA3
3
C562_ECOLX (first)
A:
[139-405]
--------------------------------------
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
T
L
V
L
L
T
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
-
P
-
V
----
A
I
-
M
G
S
A
Q
---
V
-
E
D
E
-
E
I
E
C
L
V
E
---
I
------
P
T
P
Q
----
D
Y
W
G
P
V
F
A
I
---
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-
R
G
V
------------------------------
R
L
L
S
---
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
D
-
R
N
---------
L
R
R
I
T
R
L
V
L
-----------
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
-----
G
V
Q
--------
P
S
-
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-----------------------------------------------------------------------------------
18
PsiBlast_PDB
82.26
29%
-144
- C6 -
4AMJ
12
ADRB1_MELGA
A:
[2-300]
-------
G
A
E
L
L
S
Q
Q
W
E
A
G
--------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
-
W
W
R
D
E
---
D
-
P
Q
A
-
L
K
-
C
Y
Q
D
PGC
C
------
D
F
V
T
----
N
R
---
A
Y
A
I
---
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
--------
N
V
F
--------
N
R
-
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------------------------------------------
11
PsiBlast_PDB
82.11
29%
-144
- C6 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
--------------
Q
W
E
A
G
--------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----
M
H
-
W
W
R
D
E
---
D
-
P
Q
A
-
L
K
-
C
Y
Q
D
PGC
C
------
D
F
V
T
----
N
R
---
A
Y
A
I
---
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
------------------------------
R
K
I
D
---
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
-
R
V
M
L
M
R
-----
E
H
K
A
L
K
T
L
G
-----------
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
--------
N
V
F
--------
N
R
-
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
-
S
P
D
F
R
K
A
F
K
R
L
L
A
F
------------------------------------------------------------------------------
56
HHSearch
82.03
27%
-152
- C6 -
2KS9
1
NK1R_HUMAN
A:
[32-325]
------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-
P
Q
G
----
Y
Y
-
S
T
T
E
T
---
M
-
P
S
R
-
V
V
-
C
M
I
E
---
W
------
P
E
H
P
NKIY
E
K
---
V
Y
H
I
---
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
------------------------------
I
P
G
D
SSD
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Y
H
E
Q
V
-
S
A
---------
K
R
K
V
V
K
M
M
I
-----------
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-----
N
P
D
--------
L
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
------------------------------------