@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HCAR3_HUMAN: (2016-01-10 )
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
Atome Classification :
(20 SA)
.........10........20---------.........30...---.....40...---.....50........60........70......-.-.--80........90........100.......110.......120.......130--------......---.140........150...--....160.---------.--.-....170-....------...-.-----.----180---..---.-.....190--.----.----.......200.......210....-------.-------------------------------------------------..----------------------------------------220---.-----------------------------------------------------------------------------------------------------------------------------------------------------------------..---------------------------------------------...-----...230........240....-...250....---....260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MN
R
H
H
L
Q
D
H
F
L
E
IDKKN
C
C
V
----------
F
R
D
D
F
I
A
K
V
L
P
P
V
L
---
G
L
E
F
I
F
G
L
LG---N
G
L
A
L
W
I
F
C
F
H
L
K
SWKSS
R
I
F
L
F
N
L
A
V
A
D
F
L
L
I
-
I
-
C
--
L
P
F
V
M
D
Y
Y
V
RRSDWKFGD
I
P
C
R
L
V
L
F
M
F
A
MNRQG
S
I
I
F
L
T
V
V
A
V
D
R
Y
F
R
VVH
P
--------
H
H
A
L
N
K
---IS-
N
W
T
A
A
I
I
S
C
L
L
W
G
I
T
--
V
G
L
T
V
H
L
L
---------
K
--
K
-
K
L
LIQ---NGT
A
------
N
V
C
-
I
-----
S
----
F
S
----
I
C
---
H
-
T
F
R
W
H
E
----
A
----
M
----
F
L
L
E
F
F
L
P
L
G
I
I
L
F
C
S
A
R
I
I
W
S
L
R
-------
Q
-------------------------------------------------
R
Q
----------------------------------------
M
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
---------------------------------------------
A
K
I
-----
K
R
A
I
T
-
F
I
M
V
V
A
I
V
F
V
I
C
F
L
P
-
S
V
V
V
R
-
I
H
I
F
---
W
L
L
HTSGTQN
C
E
V
Y
R
S
V
D
L
A
F
F
I
T
L
S
F
T
Y
M
N
S
M
L
D
P
V
V
Y
YFSSPSF
P
N
F
F
S
T
L
I
N
R
C
L
Q
R
KITGEPDNNRS
T
S
V
E
LTGDPNKTRGA
P
E
A
L
IANSGEPWSPSYLGPTSNNHSKKGHCHQ
E
P
A
S
L
E
K
Q
LGCCIE
41
Fugue
95.62
31%
-166
* C1 *
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------
S
F
K
C
A
L
----------
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
---
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
--------
K
-
S
L
G
R
---
L
K
-
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
--
V
V
A
I
S
P
I
L
---------
F
Y
S
G
-
T
G
V
R
K
---
N
K
T
-------
I
T
C
-
Y
-----
D
----
T
T
SDEY
L
R
---
S
-
Y
F
I
Y
S
M
----
C
----
T
----
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-------
Y
-------------------------------------------------
K
M
----------------------------------------
K
-----
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
-----
R
K
S
I
Y
-
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
-
F
H
V
M
K
T
M
N
L
R
---
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
-----------------------------------
G
D
T
F
R
R
R
------------------------------------------------
32
HHSearch
90.91
23%
-160
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
---
C
A
L
I
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
-
V
--
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
--------
V
H
Y
Q
H
G
T
G
Q
S
S
-
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
--
F
A
V
S
C
P
L
L
---------
F
--
G
-
F
N
T
T
-----
G
D
P
------
T
V
C
-
S
-----
I
----
S
N
----
P
--------
D
F
V
I
----
Y
----
S
----
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
-------
Q
-------------------------------------------------
R
R
----------------------------------------
R
-----
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
---------------------------------------------
L
R
E
-----
K
K
A
T
Q
-
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
-
F
F
L
T
H
-
V
L
N
T
---
H
C
Q
T
---------
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------
2
PsiBlast_PDB
90.28
25%
-161
- C1 -
4XNW
2
RUBR_CLOPA
A:
[40-382]
----------------
K
C
A
L
----------
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
---
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
--------
L
K
S
L
G
R
---
L
K
-
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
--
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
--
K
-
T
I
T
C
Y
---
D
T
T
S
------
D
E
Y
-
L
-----
R
S
Y
F
I
Y
S
----
M
C
---
T
-
T
V
--------
A
----
M
----
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
-------
K
-------------------------------------------------
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVG
K
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
---------------------------------------------
E
E
V
EE
P
L
R
R
K
S
I
Y
-
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
-
F
H
V
M
K
T
M
N
L
R
---
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------
1
PsiBlast_PDB
90.20
25%
-167
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[40-382]
----------------
K
C
A
L
----------
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
---
I
L
V
F
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---------
K
S
L
G
R
---
L
K
-
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
--
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
--
K
-
T
I
T
C
Y
---
D
T
T
S
------
D
E
Y
-
L
-----
R
S
Y
F
I
Y
S
----
M
C
---
T
-
T
V
--------
A
----
M
----
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
-------
K
-------------------------------------------------
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG----
K
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
---------------------------------------------
E
E
V
EE
P
L
R
R
K
S
I
Y
-
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
-
F
H
V
M
K
T
M
N
L
R
---
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------
26
HHSearch
85.59
20%
-159
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------------------
M
P
L
V
V
V
L
---
S
T
I
C
L
V
T
V
G
L
---
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
-
V
--
M
P
M
N
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
--------
L
R
Y
L
K
Y
---
R
T
-
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
--
F
L
W
V
I
P
I
L
---------
G
--
W
-
N
H
-------
R
R
E
------
D
K
C
-
E
-----
T
----
D
F
----
Y
D
-----
V
T
W
F
K
V
----
M
----
T
----
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-------
Q
-------------------------------------------------
H
C
----------------------------------------
N
-----
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
M
---------------------------------------------
N
R
E
-----
R
K
A
A
K
-
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
-
Y
F
I
F
F
-
M
V
I
A
---
F
C
K
N
----------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------
21
HHSearch
85.43
22%
-158
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-498]
-------------------------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
---
S
I
I
F
L
T
G
I
V
G
---
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
-
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
--------
T
N
S
Q
R
P
---
R
K
-
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
--
L
L
L
T
I
P
D
F
---------
I
--
F
-
A
N
V
S
E
---
A
D
D
R
------
Y
I
C
-
D
-----
R
----
F
Y
----
P
N
D
L
-
W
-
V
V
V
F
Q
F
----
Q
----
H
----
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
-------
H
-------------------------------------------------
S
G
----------------------------------------
S
-----
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
G
---------------------------------------------
H
Q
K
-----
R
K
A
L
K
-
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
-
Y
Y
I
G
I
-
S
I
D
S
---
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------------------------------------------------
5
PsiBlast_PDB
85.09
29%
-156
- C1 -
4RWA
2
C562_ECOLX (first)
A:
[136-406]
-----------------------------------------------------
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
--------
V
K
A
L
D
F
---
R
T
-
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
--
S
G
V
G
V
P
I
M
---------
V
--
M
-
A
V
T
R
P
---
R
D
G
A
------
V
V
C
-
M
-----
L
----
Q
F
----
P
S
---
P
-
S
W
Y
W
D
T
----
V
T
K
I
C
V
----
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
---G------
S
-------------------------------------------------
K
E
----------------------------------------
K
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----------------------------------------------
L
-----
R
R
I
T
R
-
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
-------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
A
----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------------------------------------------
6
PsiBlast_PDB
84.43
29%
-158
- C1 -
4RWD
6
C562_ECOLX (first)
A:
[136-406]
-----------------------------------------------------
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
--------
V
K
A
L
D
F
---
R
T
-
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
--
S
G
V
G
V
P
I
M
---------
V
--
M
-
A
V
T
R
P
---
R
D
G
A
------
V
V
C
-
M
-----
L
----
Q
F
----
P
S
---
P
-
S
W
Y
W
D
T
----
V
T
K
I
C
V
----
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
RLLSG
S
-------------------------------------------------
K
E
----------------------------------------
K
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----------------------------------------------
L
-----
R
R
I
T
R
-
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
-------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
A
----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
------------------------------------------------------------------------------
13
PsiBlast_PDB
83.24
20%
-158
- C1 -
4MBS
8
CCR5_HUMAN (first)
A:
[32-366]
------------------------------------
A
R
L
L
P
P
L
Y
---
S
L
V
F
I
F
G
F
V
G
---
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
-
L
-
T
--
V
P
F
W
A
H
Y
--
A
A
A
Q
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
--------
V
F
A
L
K
A
---
R
T
-
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
--
V
F
A
S
L
P
N
I
---------
I
--
F
-
T
R
S
Q
K
---
E
G
L
H
------
Y
T
C
-
S
-----
S
H
---
F
P
----
Y
S
---
Q
-
Y
Q
F
W
K
N
F
Q
T
L
K
----
I
----
V
I
L
G
L
V
L
P
L
L
V
M
V
I
C
Y
S
G
I
L
K
T
L
L
-------
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQ
F
E
E
----------------------------------------
V
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
---------------------------------------------
K
K
R
-----
H
R
D
V
R
-
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
L
L
-
L
N
T
F
---
Q
E
F
F
--
G
L
N
N
C
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
-----------------------------------------------------------------------------
43
Fugue
83.23
19%
-140
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
---
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
--------
M
S
N
F
R
F
---
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
---------
G
--
W
-
S
R
Y
I
P
---
E
G
M
Q
------
C
S
C
-
G
I
DYYT
P
----
H
E
----
E
T
---
N
-
N
E
S
F
V
I
----
Y
----
M
----
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
AA-----------------------------------------------
A
S
----------------------------------------
A
-----
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
---------------------------------------------
K
A
E
-----
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
----
Y
A
-
G
V
A
F
---
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
--------
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
-----
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------
24
HHSearch
82.91
23%
-155
- C1 -
2Z73
5
OPSD_TODPA
A:
[30-337]
--------------------------------
P
D
A
V
Y
Y
S
L
G
I
F
I
---
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
-
L
-
V
N
G
F
P
L
M
T
I
S
C
-
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
--------
M
A
A
S
K
K
---
M
S
-
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
--
V
L
W
A
I
G
P
I
---------
F
--
G
-
W
G
A
Y
T
L
--
E
G
V
L
------
C
N
C
-
S
-----
F
----
D
Y
----
I
S
RD
S
T
-
T
R
S
N
I
L
----
C
----
M
----
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
-------
N
-------------------------------------------------
H
E
----------------------------------------
K
-----
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------
G
A
---------------------------------------------
N
A
E
-----
M
R
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
-
Y
A
V
V
A
-
L
L
A
Q
---
F
G
P
L
---------
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
--------------------------------------------------
3
PsiBlast_PDB
82.85
30%
-165
- C1 -
5C1M
7
?
A:
[29-296]
---------------------------------------------------
V
V
G
L
F
G
---
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
--
L
P
F
Q
S
V
N
Y
L
M
-
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
--------
V
K
A
L
D
F
---
R
T
-
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
---------
A
--
T
-
T
K
Y
R
Q
----
G
S
I
------
D
C
T
-
L
-----
T
----
F
S
---------
H
P
T
W
Y
W
E
N
----
L
----
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
K
-------
S
-------------------------------------------------
V
R
----------------------------------------
M
LSGS
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
---------------------------------------------
R
N
L
-----
R
R
I
T
R
-
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
-------
I
H
I
Y
---
V
I
I
K
A
L
I
T
I
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
--
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
----------------------------------------------------------------------------------
4
PsiBlast_PDB
82.79
29%
-161
- C1 -
4N6H
21
OPRD_HUMAN
A:
[139-411]
-----------------------------------------------------
G
L
L
G
---
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
-
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
--------
V
K
A
L
D
F
---
R
T
-
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
--
S
G
V
G
V
P
I
M
---------
V
--
M
-
A
V
T
R
P
---
R
D
G
A
------
V
V
C
-
M
-----
L
----
Q
F
----
P
S
---
P
-
S
W
Y
W
D
T
----
V
T
K
I
C
V
----
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
RLLSG
S
-------------------------------------------------
K
E
----------------------------------------
K
-----
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
-----------------------------------------------
L
-----
R
R
I
T
R
-
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
-------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
A
----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-------------------------------------------------------------------------
25
HHSearch
82.68
21%
-155
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
-----------------------------------
W
V
V
G
M
G
I
V
M
---
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
--
V
P
F
G
A
A
H
I
-
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
--------
F
K
Y
Q
S
L
---
L
T
-
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
--
G
L
T
S
F
L
P
I
---------
Q
--
M
H
W
Y
R
A
T
---
H
Q
E
A
I
N
C
Y
A
E
E
T
C
-
C
-----
D
----
F
F
---------
T
-
N
Q
A
Y
A
I
----
A
----
S
----
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
-------
R
-------------------------------------------------
Q
L
----------------------------------------
N
-----
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
C
---------------------------------------------
L
K
E
-----
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
-
F
F
I
V
N
-
I
V
H
V
---
I
Q
D
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------
20
PsiBlast_PDB
81.01
24%
-155
- C1 -
3DQB
6
GNAT1_BOVIN (first)
A:
[45-326]
--------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSNFRFG
E
N
H
A
I
M
G
---
V
A
F
T
W
V
M
A
-
L
A
C
----------
A
A
P
P
L
V
---------
G
--
W
-
S
R
Y
I
P
---
E
G
M
Q
------
C
S
C
G
I
-----
D
----
Y
Y
----
T
P
---
H
-
E
E
T
N
N
E
----
S
F
V
I
Y
M
----
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
--
Q
-------------------------------------------------
Q
E
----------------------------------------
S
-----
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
---------------------------------------------
Q
K
A
-----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
-
F
Y
I
F
------
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
-
A
F
F
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
-----------------------------------------------------------------------
10
PsiBlast_PDB
80.93
25%
-170
- C1 -
4XT1
15
US28_HCMVA
A:
[31-318]
------------------
C
V
----------
F
T
D
-
V
L
N
Q
S
K
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
---
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
-
C
-
T
--
L
P
L
W
M
Q
Y
L
L
D
-------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
--------
R
Y
R
P
V
K
--------
Q
A
C
L
F
S
I
F
W
W
I
F
A
--
V
I
I
A
I
---------------
P
-
H
F
M
V
V
---
T
K
K
D
------
N
Q
C
-
M
-----
T
DYDY
L
E
----
V
S
---
Y
-
P
I
I
L
N
V
----
E
----
L
----
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
-------
V
-------------------------------------------------
S
Q
----------------------------------------
S
-----
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
---------------------------------------------
G
R
I
-----
V
R
V
----
L
I
A
V
V
L
V
F
I
I
F
W
L
P
-
Y
H
L
T
L
-
F
V
D
T
---
L
K
L
L
K
W
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
--------------------------------------------------------------------------
19
PsiBlast_PDB
80.24
24%
-91
- C- -
3C9L
13
OPSD_BOVIN
A:
[45-332]
--------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MSNFRFG
E
N
H
A
I
M
G
---
V
A
F
T
W
V
M
A
-
L
A
C
----------
A
A
P
P
L
V
---------
G
--
W
-
S
R
Y
I
P
---
E
G
M
Q
------
C
S
C
G
I
-----
D
----
Y
Y
----
T
P
---
H
-
E
E
T
N
N
E
----
S
F
V
I
Y
M
----
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
EAAAQ--
Q
-------------------------------------------------
Q
E
----------------------------------------
S
-----
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
---------------------------------------------
Q
K
A
-----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
-
F
Y
I
F
------
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
-
A
F
F
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
-----
D
D
E
---------------------------------------------------------------
18
PsiBlast_PDB
79.83
24%
-162
- C1 -
3CAP
5
OPSD_BOVIN
A:
[45-326]
--------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
MS
N
F
R
F
G
E
N
H
A
I
M
G
---
V
A
F
T
W
V
M
A
-
L
A
C
----------
A
A
P
P
L
V
---------
G
--
W
-
S
R
Y
I
P
---
E
G
M
Q
------
C
S
C
G
I
-----
D
----
Y
Y
----
T
P
---
H
-
E
E
T
N
N
E
----
S
F
V
I
Y
M
----
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
--
Q
-------------------------------------------------
Q
E
----------------------------------------
S
-----
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
---------------------------------------------
Q
K
A
-----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
-
F
Y
I
F
------
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
-
A
F
F
A
K
T
S
A
V
Y
-----
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
-----------------------------------------------------------------------
11
PsiBlast_PDB
79.22
25%
-162
- C1 -
4XT3
2
US28_HCMVA
A:
[31-316]
------------------
C
V
----------
F
T
D
-
V
L
N
Q
S
K
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
---
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
-
C
-
T
--
L
P
L
W
M
Q
Y
L
L
D
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
--------
R
Y
R
P
V
K
--------
Q
A
C
L
F
S
I
F
W
W
I
F
A
--
V
I
I
A
I
---------------
P
-
H
F
M
V
V
---
T
K
K
D
------
N
Q
C
-
M
-----
T
DYDY
L
E
----
V
S
---
Y
-
P
I
I
L
N
V
----
E
----
L
----
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
-------
V
-------------------------------------------------
S
Q
----------------------------------------
S
-----
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
---------------------------------------------
G
R
I
-----
V
R
V
----
L
I
A
V
V
L
V
F
I
I
F
W
L
P
-
Y
H
L
T
L
-
F
V
D
T
---
L
K
L
L
K
W
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
----------------------------------------------------------------------------
23
HHSearch
78.76
19%
-150
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
------------------------------------
V
V
F
I
V
L
V
A
---
G
S
L
S
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
-
S
--
M
N
L
Y
T
L
Y
T
-
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
--------
L
T
Y
P
V
K
---
R
T
-
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
--
F
I
L
W
A
P
A
I
---------
L
--
F
-
W
Q
F
I
V
GVR
T
V
E
D
------
G
E
C
-
Y
-----
I
----
Q
F
----
F
----
S
-
N
A
A
V
T
F
----
G
----
T
----
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
-------
S
-------------------------------------------------
R
I
----------------------------------------
N
-----
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
P
---------------------------------------------
S
R
E
-----
K
K
V
T
R
-
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
-
Y
N
V
M
V
-
L
I
N
T
---
F
C
A
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------