@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MRGX1_HUMAN: (2016-01-11 )
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ
Atome Classification :
(20 SA)
---------......---------...10........20.......-.30.-.......40........50....-...--.-.60........70...------....-----.-80....---...----.--90--.----.-.......100.......110.......120......-.-130.---......140.......150---------.---......----..160.....--..-----.170-----..--------...--------------....180.......190......-----------.200---....----------------...-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.210.........220.----------.....----------.230..-...-----..240--------..--...-------.-------.-..250.......260.......270.....-..280..-.....-290.......300.......310--.........320-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MDPTIS---------TLDTELTPINGTEE
T
L
C
Y
K
Q
T
L
-
S
L
T
V
-
L
T
C
I
V
S
L
VGLTG
N
A
V
V
L
W
-
L
L
GC-RMR--R-
N
A
F
S
I
Y
I
L
NLAA
A
D
F
L
------
F
L
S
G
-----
R
-
L
I
Y
S
L
L
---
S
F
I----S--I---
P
----
H
-
T
I
S
K
I
L
Y
P
V
M
M
F
S
Y
F
A
G
L
S
F
L
S
A
V
S
T
E
R
C
L
S
V
L
W
P
I
-
W
-
Y
R
CH---RP
T
H
L
S
A
V
V
C
V
L
L
W
A
L
S
-----------
L
---
L
R
S
I
L
E
----
W
M
L
-
C
G
F
L
FS--GA-----DS-------AW--------CQT--------------S
D
F
I
T
V
A
W
L
I
F
L
C
V
V
L
C
G
S
S
L
V
L
-----------
L
I
-----
R
I
L
C----------------GSR-------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------------------------------------------------------------------------------------------------------------------I
P
--
L
T
R
L
Y
V
T
I
L
L
T
V
L
----------
V
F
L
LC----------GL
P
F
G
I
-
Q
F
F
-----
L
F
L
----------
W
I
--
H
VD-------R-------E-
V
L
F
C
H
V
H
L
V
S
I
F
L
S
A
L
NSSAN
P
I
I
Y
F
FV
G
S
-
F
R
Q
RQN
R
-
Q
N
L
K
L
-
V
L
Q
R
A
L
Q
D
A
S
E
VDEGGGQL
P
E
----
E
I
L
E
LSGSRLEQ-
2
PsiBlast_PDB
85.54
25%
-161
- C2 -
4XT3
2
US28_HCMVA
A:
[26-309]
---------------------------
E
D
A
T
P
C
V
F
T
D
---
V
L
N
Q
S
K
-
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
T
W
-
R
R
R
I-
Q
-
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
------
F
V
C
T
L
P
L
W
M
Q
-
Y
L
L
D
H
------
A
----
S
--
V
---
P
----
C
-
T
L
L
T
A
C
F
Y
V
A
M
---
F
A
S
L
C
F
I
T
E
I
A
L
D
R
----
Y
Y
A
I
-
V
-
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
-----------
V
---
I
I
A
I
P
H
----
F
M
V
-
V
----
T
--
K
K
-----
D
N
-------
Q
C
--------
M
T
D
--------------
Y
D
Y
L
E
V
S
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
-----
R
I
V
A
----------------
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
--
K
G
R
I
V
R
V
L
I
A
V
V
L
----------
V
F
I
I
F
----------
W
L
P
Y
H
L
-
T
L
F
V
D
T
L
K
L
L
K
----------
W
I
S
S
S
C
E
-------
F
-------
E
-
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
-
L
L
A
E
----------------------------------------
19
PsiBlast_PDB
85.48
21%
-148
- C2 -
3PWH
1
?
A:
[16-305]
--------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
W
L
-
N
S
N
L-
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
------
V
G
V
L
-----
A
-
I
P
F
A
I
T
I
ST
G
F
C
----
A
--
A
---
C
----
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
-
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
M
L
G
----
W
N
N
-
C
G
Q
P
----------------------GCGEGQVA
C
L
F
--------------
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
I
F
A
----------------
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
L
K
Q
M
E
S
QP----------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
----------
W
L
P
L
H
I
I
N
C
F
-----
T
F
F
----------
C
P
--
D
C
S
-------
H
-------
A
-
P
L
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
-
Y
R
I
R
E
F
R
-
Q
T
F
R
K
-
I
I
R
S
----------------------------------
20
PsiBlast_PDB
84.28
21%
-152
- C2 -
3REY
1
AA2AR_HUMAN
A:
[16-305]
--------------------------------------------------------
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
W
L
-
N
S
N
L-
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
------
V
G
V
L
-----
A
-
I
P
F
A
I
T
I
S
T
G
F
C
----
A
--
A
---
C
----
H
-
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
-
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
-
R
-
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----------
F
A
I
G
L
T
P
M
L
G
----
W
N
N
-
C
G
Q
P
----------------------GCGEGQVA
C
L
F
--------------
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
-----------
L
M
L
G
V
Y
L
R
I
F
A
----------------
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
L
K
Q
M
E
S
QP----------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
----------
W
L
P
L
H
I
I
N
C
F
-----
T
F
F
----------
C
P
--
D
C
S
-------
H
-------
A
-
P
L
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
-
Y
R
I
R
E
F
R
-
Q
T
F
R
K
-
I
I
R
S
----------------------------------
1
PsiBlast_PDB
83.71
25%
-167
- C2 -
4XT1
15
US28_HCMVA
A:
[25-309]
--------------------------
D
E
D
A
T
P
C
V
F
T
D
---
V
L
N
Q
S
K
-
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
-
T
I
T
W
-
R
R
R
I-
Q
-
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
------
F
V
C
T
L
P
L
W
M
Q
-
Y
L
L
D
------------
S
--
V
---
P
----
C
-
T
L
L
T
A
C
F
Y
V
A
M
---
F
A
S
L
C
F
I
T
E
I
A
L
D
R
----
Y
Y
A
I
-
V
-
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
-----------
V
---
I
I
A
I
P
H
----
F
M
V
-
V
----
T
--
K
K
-----
D
N
-------
Q
C
--------
M
T
D
--------------
Y
D
Y
L
E
V
S
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
-----
R
I
V
A
----------------
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
--
K
G
R
I
V
R
V
L
I
A
V
V
L
----------
V
F
I
I
F
----------
W
L
P
Y
H
L
-
T
L
F
V
D
T
L
K
L
L
K
----------
W
I
S
S
S
C
E
-------
F
-------
E
-
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
-
L
L
A
E
F
-
R
-------------------------------------
6
PsiBlast_PDB
83.58
24%
-163
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[122-404]
--------------------------------------------
A
I
-
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
-
T
K
M
--
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
F
Q
S
A
-----
K
-
Y
L
M
E
T
W
---
P
F
G
----
E
--
L
-----------
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
---
T
R
P
R
D
G
----
A
V
V
-
C
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
W
--------------------------
D
T
V
T
K
-----
I
C
V
F
L
F
A
F
V
V
P
I
-----------
L
I
-----
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
RLLS-
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
----------
W
A
P
--
I
-
H
I
F
-----
V
I
V
----------
W
T
--
L
V
D
IDR----
R
-------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
-----------------------------------------
8
PsiBlast_PDB
82.60
24%
-160
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[125-407]
--------------------------------------------
A
I
-
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
-
T
K
M
--
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
F
Q
S
A
-----
K
-
Y
L
M
E
T
W
---
P
F
G
----
E
--
L
-----------
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
---
T
R
P
R
D
G
----
A
V
V
-
C
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
W
--------------------------
D
T
V
T
K
-----
I
C
V
F
L
F
A
F
V
V
P
I
-----------
L
I
-----
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
RLLS-
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
----------
W
A
P
--
I
-
H
I
F
-----
V
I
V
----------
W
T
--
L
V
D
IDR----
R
-------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
R
K
-
P
C
G
-----------------------------------
5
PsiBlast_PDB
81.17
24%
-161
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[122-404]
--------------------------------------------
A
I
-
A
I
T
A
-
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
-
T
K
M
--
K
-
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
F
Q
S
A
-----
K
-
Y
L
M
E
T
W
---
P
F
G
----
E
--
L
-----------
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
-
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
---
T
R
P
R
D
G
----
A
V
V
-
C
M
L
Q
F
P
--
S
P
-----
S
W
-------
Y
W
--------------------------
D
T
V
T
K
-----
I
C
V
F
L
F
A
F
V
V
P
I
-----------
L
I
-----
I
T
V
C
Y
G
L
M
LL----------
G
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
----------
A
F
V
V
C
----------
W
A
P
--
I
-
H
I
F
-----
V
I
V
----------
W
T
--
L
V
D
IDR----
R
-------
D
-
P
L
V
V
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
-
N
F
K
R
C
F
R
-
Q
L
C
-----------------------------------------
24
HHSearch
80.09
19%
-142
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-495]
---------------------------------------
N
A
N
F
N
K
I
-
F
L
P
T
-
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
-
V
M
G
Y
Q
K
K
L
--
R
-
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
------
F
V
I
T
-----
L
-
P
F
W
A
V
D
---
A
V
A
----
N
--
W
Y--
F
----
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
-
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
-----------
L
---
L
L
T
I
P
D
----
F
I
F
-
A
N
V
S
E
A
--
D
------
D
R
-------
Y
I
--------
C
D
R
F
Y
PN
D
L
W
V
V
V
F
---
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
-----------
I
S
-----
K
L
S
H
----------------
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
--
K
R
K
A
L
K
T
T
V
I
L
I
L
----------
A
F
F
A
C
----------
W
L
P
Y
Y
I
-
G
I
S
-----
I
D
S
----------
F
I
--
L
L
E
I
I
K
Q
G
C
E
F
-------
E
-
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
-
K
F
--
K
---
T
S
A
Q
H
-
A
L
T
S
G
R
P
L
E
V
L
F
Q
-------------------------
41
Fugue
79.71
21%
-129
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------
S
F
K
C
A
L
T
K
T
G
--------
F
Q
F
Y
-
Y
L
P
A
-
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
-
M
F
V
F
-
H
M
K
--
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
------
Y
V
L
T
-----
L
-
P
A
L
I
F
Y
---
Y
F
N
----
K
--
T
---
D
WIFG
D
-
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
-
G
R
L
K
---
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
-----------
A
---
I
S
P
I
L
F
----
Y
S
G
-
T
G
V
R
K
N
--
K
T
-----
I
T
-------
C
Y
--------
D
T
T
--------------
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
-----------
L
V
-----
L
I
L
G
----------------
C
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
--
R
A
L
I
Y
K
M
K
K
Y
T
C
T
----------
V
C
G
Y
I
Y
N
PEDGDPDN
G
V
N
P
G
T
-
D
F
K
-----
D
I
V
CPLCGVGKDQ
F
E
--
E
V
E
-------
E
-------
P
-
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
-
L
R
A
R
L
D
F
-
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
28
HHSearch
78.73
18%
-146
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-----------------------------------------------
P
L
V
V
-
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
-
A
V
R
S
E
R
K
L
--
H
-
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
------
V
G
A
V
-----
V
-
M
P
M
N
I
L
---
Y
L
L
----
M
SK
W
S--
L
----
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
-
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
-----------
F
---
L
W
V
I
P
I
----
L
G
W
-
N
H
-------
R
-----
R
E
-------
D
K
--------
C
E
T
DFYDV
T
W
F
------
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-----------
Y
K
-----
A
V
R
Q
----------------
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
--
E
R
K
A
A
K
Q
L
G
F
I
M
A
----------
A
F
I
L
C
----------
W
I
P
Y
F
I
-
F
F
M
-----
V
I
A
----------
F
C
--
K
N
------------------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
-
N
F
--
K
---
K
T
F
K
R
-
I
L
H
I
----------------------------------
34
HHSearch
78.67
18%
-150
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-323]
---------------------------------------------
V
-
L
W
A
A
-
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-
I
I
L
A
H
K
R
M
--
R
-
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
------
M
A
A
F
-----
N
-
T
V
V
N
F
T
---
Y
A
V
----
H
--
N
EWY
Y
----
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
-
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
-----------
L
---
L
L
A
F
P
Q
----
G
Y
Y
-
S
T
T
E
T
M
--
P
------
S
R
-------
V
V
--------
C
M
I
EWPEHPNKIY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-----------
G
I
-----
T
L
W
A
----------------
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
--
K
R
K
V
V
K
M
M
I
V
V
V
C
----------
T
F
A
I
C
----------
W
L
P
F
H
I
-
F
F
L
-----
L
P
Y
----------
I
N
--
P
D
L
-------
Y
-------
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
F
--
R
---
L
G
F
K
H
-
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
----
R
Y
L
Q
T
Q
G
S
V
Y
K
V
-
44
Fugue
78.33
16%
-124
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNF
Y
V
P
F
S
N
---------
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
-
H
K
K
L-
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
------
M
V
F
G
-----
G
-
F
T
T
T
L
Y
---
T
S
L
H
GYF
V
--
F
---
G
----
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-----------
C
---
A
A
P
P
L
V
GW
S
R
Y
I
P
-
E
G
M
Q
C
S
--
C
G
-----
I
D
-------
Y
Y
--------
T
P
H
--------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----------
I
F
-----
F
C
Y
G
Q
L
VFTVKEAAAQQQES
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
----------
A
F
L
I
C
----------
W
L
P
Y
-
A
-
G
V
A
-----
F
Y
I
----------
F
T
--
H
Q
G
-------
S
-------
D
-
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
-
N
C
M
V
T
-
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
----
E
T
S
Q
V
A
P
A
-----
42
Fugue
77.80
15%
-147
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------
M
N
G
T
E
G
PNFYVPFSN
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
-
S
M
L
A
-
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
-
Y
V
T
V
-
Q
H
K
KL
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
------
M
V
F
G
-----
G
-
F
T
T
T
L
Y
---
T
S
L
H
GYF
V
--
F
---
G
----
P
-
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-----------
C
---
A
A
P
P
L
V
GW
S
R
Y
I
P
-
E
G
M
Q
C
S
--
C
G
-----
I
D
-------
Y
Y
--------
T
P
H
--------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----------
I
F
-----
F
C
Y
G
Q
L
VFTVKEAAAS----
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
----------
A
F
L
I
C
----------
W
L
P
Y
-
A
-
G
V
A
-----
F
Y
I
----------
F
T
--
H
Q
G
-------
S
-------
D
-
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
-
N
C
M
V
T
-
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
----
P
A
-----------
26
HHSearch
77.44
15%
-140
- C2 -
2Z73
5
OPSD_TODPA
A:
[29-333]
---------------------------------------
V
P
D
A
V
Y
Y
-
S
L
G
I
-
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-
L
F
T
K
T
K
S
L
--
Q
-
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
------
F
S
L
V
-----
N
G
F
P
L
M
T
I
---
S
C
F
----
L
--
K
KWI
F
----
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
-
A
-
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
-----------
V
---
L
W
A
I
G
P
----
I
F
G
-
W
G
A
Y
T
L
--
E
G
-----
V
L
-------
C
N
--------
C
S
F
DYISRD
S
T
T
R
S
N
--
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-----------
V
M
-----
S
V
S
N
----------------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
--
E
M
R
L
A
K
I
S
I
V
I
V
S
----------
Q
F
L
L
S
----------
W
S
P
Y
A
V
-
V
A
L
-----
L
A
Q
----------
F
G
--
P
L
E
-----------------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
F
R
E
-
A
I
S
Q
T
F
P
W
-
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
----
I
P
A
G
E
--------
36
HHSearch
76.07
22%
-149
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
------------------------------------------
L
N
K
Y
-
V
V
I
I
-
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-
V
I
L
Y
S
R
V
G
--
R
-
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
------
F
A
L
T
-----
L
-
P
I
W
A
A
S
---
K
V
N
----
G
--
W
I--
F
----
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
-
R
-
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
-----------
M
---
N
L
S
L
P
F
----
F
L
F
-
R
Q
A
Y
H
P
--
N
N
-----
S
S
-------
P
V
--------
C
Y
E
VLGNDTAKWRMVL-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-----------
L
R
-----
T
L
F
K
----------------
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
--
K
H
R
A
M
R
V
I
F
A
V
V
L
----------
I
F
L
L
C
----------
W
L
P
Y
N
L
-
V
L
L
-----
A
D
T
----------
L
M
--
R
T
Q
-------
V
IQE
S
C
E
R
R
-
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
-
N
F
--
R
---
H
G
F
L
K
-
I
L
A
M
H
G
--------------------------------
25
HHSearch
75.58
16%
-149
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------
V
-
F
I
V
L
-
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-
S
I
K
V
N
R
H
L
--
Q
-
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
------
I
G
V
F
-----
S
-
M
N
L
Y
T
L
---
Y
T
V
----
I
--
G
YWP
L
----
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
-
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
-----------
F
---
I
L
W
A
P
A
----
I
L
F
-
W
Q
F
I
V
G
VR
T
V
-----
E
D
-------
G
E
--------
C
Y
I
QFFSN
A
A
V
------
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------
S
R
-----
A
S
K
S
----------------
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
--
E
K
K
V
T
R
T
I
L
A
I
L
L
----------
A
F
I
I
T
----------
W
A
P
Y
N
V
-
M
V
L
-----
I
N
T
----------
F
C
--
A
P
------------------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
-
T
F
--
K
---
K
T
F
K
H
-
L
L
M
-----------------------------------
33
HHSearch
74.22
16%
-144
- C2 -
1U19
14
OPSD_BOVIN
A:
[39-327]
-------------------------------------------
Q
F
S
-
M
L
A
A
-
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-
V
T
V
Q
H
K
K
L
--
R
-
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
------
M
V
F
G
-----
G
-
F
T
T
T
L
Y
---
T
S
L
----
H
--
G
YFV
F
----
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
-
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-----------
L
---
A
C
A
A
P
P
----
L
V
G
-
W
S
R
Y
I
P
--
E
G
-----
M
Q
-------
C
S
--------
C
G
I
DYYTPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----------
V
F
-----
T
V
K
E
----------------
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
E
K
E
V
T
R
M
V
I
I
M
V
I
----------
A
F
L
I
C
----------
W
L
P
Y
A
G
-
V
A
F
-----
Y
I
F
----------
T
H
--
Q
G
S
-----------------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
F
--
R
---
N
C
M
V
T
-
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
----
E
T
S
Q
V
A
P
A
-----
29
HHSearch
73.93
15%
-154
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[41-477]
---------------------------------------------
V
-
G
M
G
I
-
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-
A
I
A
K
F
E
R
L
--
Q
-
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
------
M
G
L
A
-----
V
-
V
P
F
G
A
A
---
H
I
L
----
M
--
K
MWT
F
----
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
-
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
-----------
G
---
L
T
S
F
L
P
----
I
Q
M
H
W
Y
R
A
T
H
--
Q
E
A
I
N
C
Y
A
E
-------
E
T
--------
C
C
D
FFTN
Q
A
Y
-------
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-----------
F
Q
-----
E
A
K
R
----------------
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
--
E
H
K
A
L
K
T
L
G
I
I
M
G
----------
T
F
T
L
C
----------
W
L
P
F
F
I
-
V
N
I
-----
V
H
V
----------
I
Q
--
D
N
------------------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
-
D
F
--
R
---
I
A
F
Q
E
-
L
L
C
L
----------------------------------
31
HHSearch
73.88
15%
-143
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-470]
--------------------------------------------
S
S
-
V
Y
I
T
-
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-
A
V
W
L
N
S
N
L
--
Q
-
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
------
V
G
V
L
-----
A
-
I
P
F
A
I
T
---
I
S
T
----
G
--
F
C--
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
-
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
-----------
F
---
A
I
G
L
T
P
----
M
L
G
-
W
N
N
C
G
Q
----------
S
QGCGEGQ
V
A
--------
C
L
F
EDVVP
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----------
F
L
-----
A
A
R
R
----------------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
E
V
H
A
A
K
S
L
A
I
I
V
G
----------
L
F
A
L
C
----------
W
L
P
L
H
I
-
I
N
C
-----
F
T
F
----------
F
C
--
P
D
C
-------
S
---------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
F
--
R
---
Q
T
F
R
K
-
I
I
R
S
H
V
L
R
Q
-----------------------------
35
HHSearch
72.48
17%
-152
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------
Y
A
L
-
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
-
A
V
L
K
E
R
A
L
--
Q
-
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
------
V
A
T
L
-----
V
-
M
P
W
V
V
Y
---
L
E
V
T
---
G
GV
W
N--
F
----
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
-
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
-----------
F
---
A
V
S
C
P
L
----
L
F
G
-
F
N
T
T
G
----------
D
P
-------
T
V
--------
C
S
I
SN
P
D
F
---------
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
-----------
Y
V
-----
V
L
K
Q
----------------
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
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--
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-----------------
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---
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----------------------------------