@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPSR1_HUMAN: (2016-01-11 )
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
Atome Classification :
(20 SA)
.........10........20........30..-......40........50........-60....-....70..-.....-.80....-.....90........100.......110.-.......120.......130.......140.......150....--..-----.160.......170.......-180.......190.......200--..---....--.210......------.220.......230.......240.......----250---------------------------.------------------------.----------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------.----------------------------------------------------------.---------------..------------------.260-------------.---------------....---...------------------------.270.......280.......290.......300...-------.-..--------...310-.-......320.......330------........340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPANFTEGSFDSSGTGQTLDSSPV
A
C
T
E
T
V
T
F
T
-
E
VVEGKEW
G
S
F
Y
Y
S
FKT
E
Q
L
I
T
L
W
V
L
-
F
V
F
T
I
V-GN
S
V
V
L
F
S
-
T
W
R
R
K-KK-S
R
M
T
-
F
F
V
T
Q
L
A
IT
D
S
F
T
G
L
V
N
I
L
TD
I
N
W
R
F
T-G-DFT
A
P
D
L
V
C
R
V
V
R
Y
L
Q
V
V
L
L
YAS
T
Y
V
L
V
S
L
SID
R
Y
H
A
I
V
Y
P
M
K
F
--LQ-----GEKQ
A
R
V
L
I
V
I
A
W
S
L
S
F
L
F
SI-
P
T
L
I
I
F
GKRTLSNG
E
V
Q
C
W
A
L
WP--DD---SYW
T
--
P
Y
M
T
I
V
A
F
L
V
------
Y
F
I
P
L
T
I
I
S
I
M
Y
G
I
V
I
R
T
I
W
I
KS
K
T
Y
E
T
V
I
S----NC----------------------------S------------------------D----------------------------------------------------------------------------------------G------------------------------------------------------------------------------------------------
K
----------------------------------------------------------
L
---------------
C
S
------------------
S
Y---------------N---------------RGLI---SKA------------------------
K
I
K
A
I
K
Y
S
I
I
I
I
L
A
F
I
C
CW
S
P
Y
F
L
F
D
I
L
DNFN--LLP-------D-
T
Q
--------
E
R
F
Y
A
S
-
V
-
I
I
Q
NL
P
A
L
N
S
A
I
N
P
L
I
Y
C
-------
V
FSSSISFP
C
R
E
QRSQDS
R
M
T
F
R
E
R
T
E
R
H
E
M
Q
ILSKPEFI
25
HHSearch
90.92
23%
-113
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[45-477]
------------------------------------------------------
I
V
M
S
L
I
-
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
-
I
A
K
F
E
R
L
Q
-
T
V
T
N
-
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
--
Q
S
LL---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
CC
D
F
---
F
T
N
Q
--
A
Y
A
I
A
S
S
I
V
S
------
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
----
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTK----
S
PS
L
N
A
A
K
S
E
L
D
K
A
I
GRNT------
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
----------
A
------------------------------------------------------------------------------------------------
K
S
R
W
-------------------------------------------------------
Y
---------------
N
Q
------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
---------------
A
Y
K
F
---
C
L
K
------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
--
D
N
L
-------
I
--
R
----------
K
E
V
Y
-
I
-
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
--------
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------
2
PsiBlast_PDB
88.19
25%
-126
- C1 -
4XNW
2
RUBR_CLOPA
A:
[37-382]
-------------------------------
S
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
F
V
F
H
M
K
-
P
W
-
S
G
I
S
-
V
Y
M
F
N
L
A
L
A
D
-
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
--
L
G
RL---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
S
--
D
E
Y
L
R
S
Y
F
I
---
Y
S
M
C
T
T
V
A
M
------
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
P
----------------------------
E
------------------------
D
----------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
P
---------------
D
N
------------------
G
V
---------------
N
---------------
P
G
T
D
---
F
K
D
IPDDWVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
L
R
--
A
R
L
-------
D
-
F
Q
TPAM
C
A
F
N
D
R
V
Y
A
T
-
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
---------
F
L
A
G
D
T
F
-----
R
R
R
------------------------
1
PsiBlast_PDB
87.45
25%
-127
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
F
V
F
H
M
K
-
P
W
-
S
G
I
S
-
V
Y
M
F
N
L
A
L
A
D
-
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
--
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
-
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
S
--
D
E
Y
L
R
S
Y
F
I
---
Y
S
M
C
T
T
V
A
M
------
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
P
----------------------------
E
------------------------
D
----------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
P
---------------
D
N
------------------
G
V
---------------
N
---------------
P
G
T
D
---
F
K
D
IVCPLCGVGKDQ
F
E
E
V
EE
P
L
----
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
-
N
L
R
--
A
R
L
-------
D
-
F
Q
TPAM
C
A
F
N
D
R
V
Y
A
T
-
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
---------
F
L
A
G
D
T
F
-----
R
R
R
------------------------
31
HHSearch
85.67
20%
-125
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------
Y
A
L
S
Y
C
A
L
-
I
L
A
I
V
F
-
G
N
G
L
V
C
M
A
-
V
L
K
E
R
A
L
Q
-
T
T
T
N
-
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
-
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
--
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-
P
L
L
F
G
F
N
T
T
---
G
D
P
T
V
C
S
I
S
N
-----------
P
--
D
F
V
I
Y
S
S
V
V
S
------
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
----
R
I
----------------------------
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLT
K
SPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
------------------------------------------------------------------------------------------------
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-------------------------------------------
Q
---------------
T
P
N
-----------------
R
A
K
R
V
I
T
T
F
R
T
GTW---
D
---------------
A
Y
G
V
---
P
L
R
------------------------
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
--
Q
T
C
-------
H
-
V
S
----------
P
E
L
Y
-
S
-
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
-------
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------
42
Fugue
85.14
25%
-123
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
A
L
T
K
T
----------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
-
F
V
F
H
M
-
K
P
W
S
G
I
S
-
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
K
-
T
-
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
--
G
R
-----
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
S
--
D
E
Y
L
-
R
S
Y
F
--
I
Y
S
M
C
T
T
V
A
M
------
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
P
----------------------------
E
------------------------
D
----------------------------------------------------------------------------------------
G
------------------------------------------------------------------------------------------------
D
PDNGVNPGTDFKDIVCP-----------------------------------------
L
---------------
C
G
------------------
V
G
---------------
K
---------------
D
Q
F
E
E
V
E
E
P
L
------------------------
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
--
R
L
D
FQTPAM
C
A
-
F
N
--------
D
R
V
Y
A
T
Y
Q
-
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
-------
L
A
G
D
----------------
T
F
R
R
R
---------------
6
PsiBlast_PDB
85.12
26%
-117
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
---------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
---------
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
----
Q
I
----------------------------
R
------------------------
K
----------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
R
---------------
A
S
------------------
K
R
---------------
K
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------
26
HHSearch
84.92
21%
-107
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[49-494]
--------------------------------------------------
I
F
L
P
T
I
Y
S
I
I
-
F
L
T
G
I
V
-
G
N
G
L
V
I
L
V
-
M
G
Y
Q
K
K
L
R
-
S
M
T
D
-
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
--
A
-
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
--
Q
R
P
R
---
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
-
P
D
F
I
F
A
N
V
S
E
-
A
D
D
R
Y
I
C
D
R
F
Y
P
--
N
D
---
L
W
V
V
--
V
F
Q
F
Q
H
I
M
V
G
------
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
----
I
D
----------------------------
E
------------------------
G
----------------------------------------------------------------------------------------
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
-----------------------------
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
------------------
W
D
---------------
A
---------------
Y
G
S
K
---
G
H
Q
------------------------
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
--
L
L
E
I
I
K
Q
G
C
-
E
F
E
N
--------
T
V
H
K
W
I
-
S
-
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
-------
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
---------------
24
HHSearch
84.75
23%
-115
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
-----------------------------------------------------
V
V
V
L
S
T
I
-
C
L
V
T
V
G
-
L
N
L
L
V
L
Y
A
-
V
R
S
E
R
K
L
H
-
T
V
G
N
-
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
--
L
K
YR---
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-
P
I
L
G
W
N
H
-----
R
R
E
D
K
C
E
T
D
F
Y
--
D
V
------
T
--
W
F
K
V
M
T
A
I
I
N
------
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
----
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
------------------------
A
A
K
S
E
L
D
K
A
I
G------------------------------------------------------------------------------
R
NTNGVIT
K
D
---------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
---------------
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
---------------
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
Y
L
H
---
M
N
R
------------------------
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
--
K
N
C
-------
C
-
N
---------
E
--
H
L
H
-
M
-
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
-------
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------
4
PsiBlast_PDB
84.06
26%
-114
- C1 -
2YCW
7
ADRB1_MELGA
A:
[3-299]
---------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
QS
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
---------
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
----
Q
I
----------------------------
R
------------------------
K
----------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
R
---------------
A
S
------------------
K
R
---------------
K
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------
15
PsiBlast_PDB
84.00
26%
-129
- C1 -
3ZPQ
11
ADRB1_MELGA
A:
[2-300]
--------------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
9
PsiBlast_PDB
83.97
26%
-131
- C1 -
2Y00
13
ADRB1_MELGA
A:
[3-300]
---------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
11
PsiBlast_PDB
83.86
26%
-130
- C1 -
2Y02
13
ADRB1_MELGA
A:
[3-300]
---------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
10
PsiBlast_PDB
83.59
26%
-129
- C1 -
2Y01
12
ADRB1_MELGA
A:
[3-300]
---------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
5
PsiBlast_PDB
83.34
26%
-117
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
---------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
---------
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
----
Q
I
----------------------------
R
------------------------
K
----------------------------------------------------------------------------------------
I
------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
R
---------------
A
S
------------------
K
R
---------------
K
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
-------------------------------------
14
PsiBlast_PDB
83.26
26%
-126
- C1 -
4AMJ
12
ADRB1_MELGA
A:
[2-300]
--------------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
3
PsiBlast_PDB
83.10
26%
-120
- C1 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
----------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
---------
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
----
Q
I
----------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
17
PsiBlast_PDB
82.80
26%
-119
- C1 -
4GBR
1
ADRB2_HUMAN
A:
[14-282]
-----------------------------------------------------------
L
-
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
-
I
A
K
F
E
-
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
T
-
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
QS
L
L
-----
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
--
C
C
---
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
------
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
----
E
A
K
R
Q
L
Q
K
I
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------------------------------------------------------
F
---------------
C
L
------------------
K
E
---------------
H
---------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
---
H
--
V
I
Q
-------
D
-
N
L
--------
I
R
K
E
V
Y
-
I
-
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
--------------------
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------
16
PsiBlast_PDB
82.78
26%
-130
- C1 -
3ZPR
11
ADRB1_MELGA
A:
[2-299]
--------------------------------------
G
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
----------------------------------
13
PsiBlast_PDB
82.60
26%
-131
- C1 -
2Y04
13
ADRB1_MELGA
A:
[3-300]
---------------------------------------
A
E
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
---
I
M
I
F
V
A
L
R
-
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------
7
PsiBlast_PDB
82.16
26%
-120
- C1 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
----------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
-
L
I
--
V
A
-
G
N
V
L
V
I
A
A
-
I
G
S
T
Q
-
R
L
-
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
R
-
G
-
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
-----
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
------
Q
D
---
P
G
C
C
--
D
F
V
T
N
R
A
---------
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
----
Q
I
----------------------------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----------------------------------------------------------
R
---------------
A
S
------------------
K
R
---------------
K
---------------
R
V
M
L
---
M
R
E
------------------------
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RD
L
V
P
-------
D
--------------
W
L
F
-
V
-
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
RS
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------