@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NTR2_HUMAN: (2016-01-11 )
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60....--....70---.........80........90........100.......110.......120.......130.......140....---...150.......160.....-..170.-......180.......190......--------.200--.--.......210.-......220.......230.......240.......250------------------.----.----..--------------------.---------...-------260----------------------------------------------....------------------------------.---------------------..----------------.270.....---------...280.......290.......300.......310.......320----.......330.......340-.........350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
METSSPRPPRPSSNPGL
S
L
D
A
RLGV
D
T
R
L
W
A
K
V
L
F
T
A
L
Y
A
L
I
W
A
LGAAGN
A
L
S
A
H
V
V
L
K
ARAGRA--
G
R
L
R
H
----
H
V
L
S
L
A
L
A
G
L
L
L
L
L
VGV
P
V
E
L
Y
S
F
V
W
FHY
P
W
V
F
GDLGC
R
G
Y
Y
F
V
H
E
L
C
A
Y
A
T
V
L
S
V
AGL
S
A
E
R
C
L
A
V
C
Q
P
L
R
A
R
SL---LTPRR
T
R
W
L
V
A
L
S
W
A
A
SL
G
L
A
-
L
P
M
A
V
I
-MGQKHELETADGEP
E
P
A
S
R
V
C
T
V
L
V
--------
S
R
T
---
A
--
L
Q
V
F
I
Q
V
N
V
L
V
-
S
F
V
L
P
L
A
L
T
A
F
LNG
V
T
V
S
H
L
L
A
L
C
S
QVPSTSTPGSS
T
P
-------------------
S
----
R
----
L
E
--------------------
L
---------
L
S
E-------E
G
-----------------------------------------------
L
L
S
F
------------------------------
I
---------------------
V
W
----------------
K
K
T
-FIQGG---------
Q
V
S
L
V
R
H
K
D
V
R
R
I
R
S
L
Q
R
S
V
Q
V
L
R
A
I
V
V
M
Y
V
I
C
WL
P
Y
H
A
R
R
L
M
Y
C
Y----VPDDAWT
D
P
L
Y
N
F
Y
H
Y
F
Y
---
M
V
T
N
T
L
F
Y
V
S
S
A
V
T
P
L
L
Y
N
A
V
S
S
S
F
R
K
L
F
L
E
A
V
S
S
L
C
GEHH
P
M
KRLPPKPQSP
T
L
MDTASGFGDPPETRT
1
PsiBlast_PDB
97.80
39%
-152
- C1 -
3ZEV
6
NTR1_RAT
A:
[6-325]
------------------
P
N
S
D
L
D
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
V
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
H
Q
-----------------------------------------------------------------------------------
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
----
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
---
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
-----------------------------------
2
PsiBlast_PDB
97.74
39%
-152
- C1 -
4BUO
10
NTR1_RAT
A:
[6-320]
-------------------
N
S
D
L
D
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
K
---
S
L
Q
S
T
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
V
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
H
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
--------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
----
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
---
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
-------------------------------------
22
PsiBlast_CBE
97.64
39%
-152
- C1 -
4BUO
5
NTR1_RAT
B:
[3-322]
----------------
S
G
P
N
S
D
L
D
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
------LQ
S
T
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
V
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
H
Q
A
A
F
N
M
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
P
G
--------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
----
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
---
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
-----------------------------------
21
PsiBlast_CBE
97.02
39%
-159
- C1 -
3ZEV
2
NTR1_RAT
B:
[6-325]
------------------
P
N
S
D
L
D
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
------
S
L
Q
S
T
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
V
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V
----------------------------------------------------------------------------
T
E
-------
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
----
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
---
M
L
T
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
-----------------------------------
4
PsiBlast_PDB
96.67
37%
-159
- C1 -
4BV0
1
NTR1_RAT
A:
[7-326]
---------------
N
S
D
L
D
----
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
-------
S
R
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
-----
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
V
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
L
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V
H
------------------------------------------------------------------------------------
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
----
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
---
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
----------------------------------
3
PsiBlast_PDB
96.11
38%
-157
- C1 -
4BWB
1
NTR1_RAT
A:
[7-327]
---------------
N
S
D
L
D
----
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-----
Q
S
L
Q
S
R
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
R
V
V
I
Q
L
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V
-----------------------------------------------------------------------------
E
-------
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
----
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
---
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
---------------------------------
24
PsiBlast_CBE
95.58
37%
-157
- C1 -
4BV0
1
NTR1_RAT
B:
[6-327]
--------------
P
N
S
D
L
D
----
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
------L
Q
S
R
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
V
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
R
H
P
F
K
H
K
T
----
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
V
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
K
V
V
I
Q
L
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
R
R
L
T
V
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
M
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
----
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
---
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
A
C
L
C
P
--------------------------------
23
PsiBlast_CBE
93.89
38%
-150
- C1 -
4BWB
1
NTR1_RAT
B:
[8-323]
----------------
S
D
L
D
----
V
N
T
D
I
Y
S
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
R
K
K
------
S
R
V
D
Y
----
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
P
V
D
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
--
A
K
T
L
---
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
P
M
L
F
T
-
M
G
L
Q
N
--
L
S
G
D
G
T
-
H
P
G
G
L
V
C
T
P
I
V
--------
D
T
A
---
T
--
L
R
V
V
I
Q
L
N
T
F
M
-
S
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
L
T
V
M
V
H
Q
A
A
---------------------------------------------------------------------------------
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
Q
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
----
I
S
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
---
M
L
S
N
A
L
V
Y
V
S
A
A
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
F
L
S
T
L
-------------------------------------
37
HHSearch
78.15
19%
-122
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
-
A
L
Q
--
T
T
T
N
Y
----
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
-
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
G
-
F
N
T
T
-----------
G
D
P
T
V
C
S
I
S
N
--------
P
D
----------
F
V
I
Y
S
S
V
V
-
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
RL
K
I
Y
K
D
------------
T
EG
Y
-
Y
T
I
G
I
G
H
LLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
G
R
---------
N
T
N
GVI----
T
K
-----------------------------------------------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
-
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
----
C
Q
T
C
H
V
-------
S
P
E
L
Y
---
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------
30
HHSearch
77.90
19%
-109
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[37-477]
----------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
-
R
L
Q
--
T
V
T
N
Y
----
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
--
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
--
N
-
C
Y
A
E
E
T
C
C
D
F
F
--------
T
--------
N
Q
A
Y
A
I
A
S
S
I
V
-
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLT
K
SPS
L
N
----
A
A
--------------------
K
S
E
L
D
K
A
I
GR
N
T
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
------------------------------
N
---------------------
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
-
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----
Q
D
N
L
I
--------
R
K
E
V
Y
---
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------
51
Fugue
77.81
20%
-121
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------
S
F
K
C
A
L
T
K
T
G
-------------
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
-
H
M
K
P
W
--
S
G
I
S
V
----
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
--
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
-
S
P
I
L
F
Y
-
S
G
--------
T
G
V
R
K
N
K
T
I
T
C
Y
D
T
T
--------
S
D
E
Y
L
R
S
--
Y
F
I
Y
S
M
C
T
T
V
A
-
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
P
-------------------
E
----
D
----
G
D
-------------------------------
P
D
-------
N
G
-----------------------------------------------
V
N
P
G
------------------------------
T
---------------------
D
F
----------------
K
D
I
-
V
C
P
L
C
---------
G
V
G
K
D
Q
F
E
E
V
E
E
-
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
----
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
------------------------------------------
8
PsiBlast_PDB
76.82
21%
-143
- C1 -
4RWA
2
C562_ECOLX (first)
A:
[123-406]
--------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
--
A
T
-
N
I
----
Y
I
F
N
L
A
L
A
D
A
L
---
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
----------
A
V
T
R
P
R
D
G
A
V
V
C
M
L
Q
F
PSP
S
W
Y
W
D
T
V
T
---
K
--
I
C
V
F
-----
L
F
-
A
F
V
V
P
I
L
I
------
I
T
V
C
Y
G
L
M
L
L
---------
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
----
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
D
I
D
R
-
R
D
P
L
V
V
A
A
L
H
L
C
---
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------
20
PsiBlast_PDB
75.61
23%
-131
- C1 -
3ZPR
11
ADRB1_MELGA
A:
[17-295]
-------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
-----
V
L
V
I
A
A
I
G
S
T
--
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
--
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
--------
T
N
R
---
A
--
Y
A
I
---
A
S
S
I
I
-
S
F
Y
I
P
L
L
I
M
I
F
---
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------
M
--------------------
L
---------
M
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
NRDL
V
P
D
------------
W
L
F
---
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-------------------------------------
7
PsiBlast_PDB
75.11
21%
-133
- C1 -
4N6H
23
C562_ECOLX (first)
A:
[126-414]
--------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
--
A
T
-
N
I
----
Y
I
F
N
L
A
L
A
D
A
L
---
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
----------
A
V
T
R
P
R
D
G
A
V
V
C
M
L
Q
F
P
SP
S
W
Y
W
D
T
V
T
---
K
--
I
C
V
F
-----
L
F
-
A
F
V
V
P
I
L
I
------
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
----
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
D
I
D
R
-
R
D
P
L
V
V
A
A
L
H
L
C
---
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
--------------------------------
10
PsiBlast_PDB
74.70
19%
-136
- C1 -
5C1M
7
?
A:
[22-296]
------------------------------------
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
--
A
T
-
N
I
----
Y
I
F
N
L
A
L
A
D
A
L
---
A
T
S
T
L
P
F
Q
S
V
N
Y
L
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
-
L
P
V
M
F
M
-
A
T
T
K
Y
R
Q
G
S
I
D
---------
C
T
L
T
F
--------
S
H
P
---
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
-------------------------------------
K
----
S
----
V
R
--------------------
M
---------
L
S
G
-------
S
-------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
----
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
----
I
-----
T
I
P
E
T
T
F
Q
T
V
S
W
---
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
-----------------------------------------
13
PsiBlast_PDB
74.37
23%
-134
- C1 -
2Y00
13
ADRB1_MELGA
A:
[17-295]
-------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
-----
V
L
V
I
A
A
I
G
S
T
--
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
--
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
--------
T
N
R
---
A
--
Y
A
I
---
A
S
S
I
I
-
S
F
Y
I
P
L
L
I
M
I
F
---
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------
S
----
R
----
V
M
--------------------
L
---------
M
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
NRDL
V
P
D
------------
W
L
F
---
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------
14
PsiBlast_PDB
74.22
23%
-133
- C1 -
2Y01
12
ADRB1_MELGA
A:
[17-295]
-------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
-----
V
L
V
I
A
A
I
G
S
T
--
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
--
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
--------
T
N
R
---
A
--
Y
A
I
---
A
S
S
I
I
-
S
F
Y
I
P
L
L
I
M
I
F
---
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------
S
----
R
----
V
M
--------------------
L
---------
M
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
NRDL
V
P
D
------------
W
L
F
---
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------
9
PsiBlast_PDB
74.21
21%
-136
- C1 -
4RWD
7
C562_ECOLX (first)
A:
[123-406]
--------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
--
A
T
-
N
I
----
Y
I
F
N
L
A
L
A
D
A
L
---
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
----------
A
V
T
R
P
R
D
G
A
V
V
C
M
L
Q
F
P
S
P
S
W
Y
W
D
T
V
T
---
K
--
I
C
V
F
-----
L
F
-
A
F
V
V
P
I
L
I
------
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
----
R
S
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
----
V
D
I
D
R
-
R
D
P
L
V
V
A
A
L
H
L
C
---
I
---
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
-------------------------------------
18
PsiBlast_PDB
74.14
23%
-129
- C1 -
4AMJ
12
ADRB1_MELGA
A:
[17-295]
-------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
-----
V
L
V
I
A
A
I
G
S
T
--
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
--
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
--------
T
N
R
---
A
--
Y
A
I
---
A
S
S
I
I
-
S
F
Y
I
P
L
L
I
M
I
F
---
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------
S
----
R
----
V
M
--------------------
L
---------
M
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
NRDL
V
P
D
------------
W
L
F
---
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------
17
PsiBlast_PDB
73.86
23%
-134
- C1 -
2Y04
13
ADRB1_MELGA
A:
[17-295]
-------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
-----
V
L
V
I
A
A
I
G
S
T
--
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
--
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
---
C
C
D
F
V
--------
T
N
R
---
A
--
Y
A
I
---
A
S
S
I
I
-
S
F
Y
I
P
L
L
I
M
I
F
---
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------
S
----
R
----
V
M
--------------------
L
---------
M
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
NRDL
V
P
D
------------
W
L
F
---
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------