@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2T11_HUMAN: (2016-01-11 )
MTNTSSSDFTLLGLLVNSEAAGIVFTVILAVFLGAVTANLVMIFLIQVDSRLHTPMYFLLSQLSIMDTLFICTTVPKLLADMVSKEKIISFVACGIQIFLYLTMIGSEFFLLGLMAYDCYVAVCNPLRYPVLMNRKKCLLLAAGAWFGGSLDGFLLTPITMNVPYCGSRSINHFFCEIPAVLKLACADTSLYETLMYICCVLMLLIPISIISTSYSLILLTIHRMPSAEGRKKAFTTCSSHLTVVSIFYGAAFYTYVLPQSFHTPEQDKVVSAFYTIVTPMLNPLIYSLRNKDVIGAFKKVFACCSSAQKVATSDA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80--...-......90........100.......110.......120.......130---.......140.......150.......160.......170....-...180..----..--...190.........200.......210----.......220..---------...------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.230--.---------.......240.......-------.250-----........260.----......270...--..--..280.......290.......300.......310....----------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTNTSSS
D
F
T
L
L
G
L
L
VNSEA
A
G
I
V
F
T
V
I
L
A
V
F
L
G
A
V
T
A
N
L
V
M
I
F
L
I
QVDSRL
H
T
P
M
Y
F
L
L
S
Q
L
S
I
M
D
T
L
F
I
C
T
T
V
P
K
L
L
A
---
D
M
V
-
S
K
E
K
I
I
S
F
V
A
C
G
I
Q
I
F
L
Y
L
T
M
IG
S
E
F
F
L
L
G
L
M
A
Y
D
C
Y
V
A
VCNPLRY
P
V
L---MNRK
K
C
L
L
L
A
AGAWFGGSLD
G
F
L
L
T
P
I
T
MNVPYCGSRS
I
N
H
F
FC-E
I
P
A
V
L
K
L
----AC--AD
T
S
--
L
Y
E
T
L
M
Y
I
C
C
V
L
M
L
L
I
P
I
S
I
IS----TS
Y
S
L
I
L
L
T
I
HR---------MPS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------EGR---
K
---------
K
A
F
TTCSSH-
L
T
V
V
S
I
F
-------YG
A
------
A
F
Y
T
YVLPQSFH----TP
E
Q
D
K
V
V
S
A
F
Y
--
T
I
--
V
T
P
M
L
N
P
L
I
Y
S
LRN
K
D
V
I
G
A
F
K
K
V
F
A
C
C
S
S
A
Q
K
VATSDA----------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
93.46
20%
-145
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[6-302]
--------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
-----
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
----
G
C
G
E
G
Q
V
----
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
---------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------
N
C
F
T
F
F
C
P
D
C
-
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.95
20%
-149
- C3 -
2YDV
6
?
A:
[5-302]
-------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
-----
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
-
Q
G
C
G
E
G
Q
V
----
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
T
L
Q
---------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.31
20%
-147
- C3 -
4UG2
3
?
A:
[6-302]
--------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
-----
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
-
Q
G
C
G
E
G
Q
V
----
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
---------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
90.35
20%
-166
- C3 -
3VG9
8
?
A:
[6-302]
--------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
--
F
A
---
I
T
I
-
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
-------
S
-
Q
G
C
G
E
G
Q
V
----
A
C
L
F
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
---------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.15
20%
-146
- C3 -
2YDO
3
?
A:
[6-302]
--------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
A
I
S
T
G
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
-----
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
--
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
-
Q
G
C
G
E
G
Q
V
----
A
C
LF
E
D
V
V
--
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
L
-
Q
---------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
89.54
19%
-151
* C3 *
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
---
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
---
T
H
Q
E
A
I
N
C
-
Y
A
E
----
E
----
T
C
--
C
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
----
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
---
H
---------
K
A
L
K
T
L
G
I
I
-
M
G
T
F
T
L
C
-------
W
L
P
------
F
F
I
V
N
I
V
H
V
I
Q
D
NL--
I
R
K
E
V
Y
I
L
L
N
W
I
--
G
Y
--
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
88.61
19%
-153
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
---
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
-------
T
G
D
P
T
V
C
-
S
I
S
N
------------------
P
-
D
F
-
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
----
L
V
Y
A
R
I
Y
V
V
L
K
Q
---------
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
---
K
---------
K
A
T
Q
M
V
A
I
V
-
L
G
A
F
I
V
C
-------
W
L
P
------
F
F
L
T
H
V
L
N
T
H
C
Q
TCH-
V
S
P
E
L
Y
S
A
T
T
W
L
--
G
Y
--
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.54
22%
-157
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.37
22%
-160
- C3 -
2Y00
13
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
87.23
18%
-160
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-472]
--------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
---
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
-
G
E
G
Q
V
-------
A
C
--
L
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
----
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
---
V
---------
H
A
A
K
S
L
A
I
I
-
V
G
L
F
A
L
C
-------
W
L
P
------
L
H
I
I
N
C
F
T
F
F
C
P
DCSH
A
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.12
22%
-160
- C3 -
2Y01
12
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.95
22%
-161
- C3 -
2Y02
13
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
86.94
22%
-158
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
86.80
22%
-159
- C3 -
2Y04
13
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.48
22%
-159
- C3 -
2Y03
9
ADRB1_MELGA
A:
[5-300]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
85.99
22%
-158
- C3 -
2YCW
7
ADRB1_MELGA
A:
[5-299]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
---
K
---------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-------
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RDL-
V
P
D
W
L
F
V
A
F
N
W
L
--
G
Y
--
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
85.17
22%
-160
- C3 -
3ZPR
11
ADRB1_MELGA
A:
[5-299]
-------------
L
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
L
M
R
E
H
---
K
A
L
K
T
L
G
I
I
-
M
G
V
F
T
L
C
-------
W
L
P
------
F
F
L
V
N
I
V
N
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
--
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.87
22%
-157
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
-----------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
---
K
---------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-------
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RDL-
V
P
D
W
L
F
V
A
F
N
W
L
--
G
Y
--
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.89
22%
-159
- C3 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
---
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
--
P
I
M
M
-----------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
--
C
D
F
V
--
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
---
K
---------
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
-------
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
RDL-
V
P
D
W
L
F
V
A
F
N
W
L
--
G
Y
--
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
82.75
16%
-131
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
---
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
--
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
-
E
-----
E
T
----
C
C
---
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
----
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
---
L
---------
R
I
D
E
G
L
R
L
K
-
I
Y
K
D
T
E
G
-------
Y
Y
T
------
I
G
I
G
H
L
L
T
K
S
P
S
----
L
N
A
A
K
S
E
L
D
K
A
I
GR
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL