@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O4C45_HUMAN: (2016-01-12 )
MNNVIEFILLGLTHNPELQKFLFVMFLITYLITLAGNLFISVIIFISPALGSPMYSFPSYLFIIDIFCSSSIAPKMNFDLISEKNTISFNGCMTQLFTEHFFYYYYYYTLTEIILLSVMAYDHYVAIRKPLHYATIMSQPMCGFLMVVAGILGFVHGGIQTLFIAQLPFCGPNVINHFMCDLVPLLELACTDTHTLGPLIAANSGSLCFLIFSMLVASYVIILCFLRTHSSEGRRKALSSCASHIFIVILFFVPFSYLYLRPTSFPTDKAVTVFCTLFTPMLNPLIYTLKNKEVKNVIKKLWKQIMTTDDK
Atome Classification :
(20 SA)
----------------------------------------------------------....-.....10........20........30----.--........40--------.........50..----------......60.....--------------------...70.-.......80-....-....90.....---..------.100.......110.......120.....--..130-----....---...--------------140.......150.....-..160....------...170.------------------......180.......190--.......200.......210.......220...-----------....230-------------------------------------------------------------------------------------------------------------------------------------------------------------------...-..---------...240.......250.......260.--.-----.--------------.--------...270......---.280----------------.....--....290...---....300.......-310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------MN
N
V
-
I
E
F
I
L
LGLTH
N
P
E
L
Q
K
F
L
F
V
M
F
L
I
T
Y
-----
L
--
I
T
L
A
G
N
L
F
I
---------
S
V
I
I
F
ISPALGSP----------MYSFP
S
Y
L
F
I
I
D
I
--------------------FCSSSI-APKM
N
F
D
L
I-SEK
N
-
T
I
SF
N
G
C
M
T
Q
L
---
F
T
------
E
H
F
F
Y
Y
Y
Y
Y
Y
T
L
T
E
I
I
L
L
S
V
M
A
YD
H
Y
V
A
I
--RKP
L
H
-----
Y
A
T
I
---MSQ--------------P
M
C
G
F
L
M
V
V
A
G
I
L
G
F
V
HG-G
I
Q
T
L
F
I
AQ------LPFC
G
P
N
------------------
V
I
N
H
F
M
C
D
L
V
P
L
L
E
L
ACTD--THTLG
P
L
I
AANSG
S
L
C
F
L
I
F
S
M
L
V
A
S
Y
V
I
I
L
C
F
-----------
L
RTHSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
R
-
R
K
---------
A
L
S
S
C
A
S
H
I
F
I
V
I
L
F
F
V
P
F
S
Y
L
Y
LRPT--S-----F--------------P--------TD
K
A
V
T
V
F
C
T
L
F
---
T
P
------------------
M
L
N
P
L
--
I
Y
TLK
N
K
E
V
K
---
N
V
I
K
K
L
W
K
Q
I
MTTD-DK
30
HHSearch
88.65
18%
-146
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
-----
L
--
A
I
V
F
G
N
G
L
V
---------
C
M
A
V
L
K
E
R
A
L
Q
T
T
----------
T
N
Y
L
V
V
S
L
A
V
A
D
L
--------------------
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
C
C
D
V
F
V
---
T
L
------
D
V
M
------
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
--
V
M
P
V
H
-----
Y
Q
H
G
T
G
Q
S
S
C
--------------
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
G
F
N
T
------
T
-------------------------
G
D
P
T
V
C
S
I
S
N
P
--------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
-----------
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
-
K
K
---------
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
-
C
QTCHV
S
--------------
P
--------
E
L
Y
S
A
T
T
W
L
G
Y
V
---
N
S
------------------
A
L
N
P
V
--
I
Y
T
T
F
N
I
E
F
R
---
K
A
F
L
K
I
L
S
C
--------
24
HHSearch
85.44
16%
-147
- C2 -
3EML
13
ENLYS_BPT4
A:
[20-471]
----------------------------------------------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
-----
V
--
L
A
I
L
G
N
V
L
V
---------
C
W
A
V
W
L
N
S
N
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
--------------------
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
G
C
L
F
I
A
---
C
F
------
V
L
V
------
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
--
R
I
P
L
R
-----
Y
N
G
L
---
V
T
G
--------------
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
G
W
N
N
------
C
G
Q
-------------------------
S
Q
G
C
G
E
G
Q
V
A
---
C
L
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
-----------
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
-
V
H
---------
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F-
C
-----
P
DCSHAP--------
L
--------
W
L
M
Y
L
A
I
V
L
S
H
T
---
N
S
------------------
V
V
N
P
F
--
I
Y
A
Y
R
I
R
E
F
R
---
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---
20
HHSearch
84.63
17%
-140
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
------------------------------------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
-----
L
--
V
T
V
G
L
N
L
L
V
---------
L
Y
A
V
R
S
E
R
K
L
H
T
V
----------
G
N
L
Y
I
V
S
L
S
V
A
D
L
--------------------
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
-
S
L
G
R
P
L
C
L
F
W
L
---
S
M
------
D
Y
V
------
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
--
Q
Q
P
L
R
-----
Y
L
K
Y
---
R
T
K
--------------
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
G
W
N
H
---------------------------------
R
R
E
D
K
C
E
T
D
F
Y
D
V
-----------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
-----------
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
-
R
K
---------
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F-
C
KNCC-
N
--------------
E
--------
H
L
H
M
F
T
I
W
L
G
Y
I
---
N
S
------------------
T
L
N
P
L
--
I
Y
P
L
C
N
E
N
F
K
---
K
T
F
K
R
I
L
H
I
--------
22
HHSearch
84.31
15%
-140
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
-----
L
--
A
I
V
F
G
N
V
L
V
---------
I
T
A
I
A
K
F
E
R
L
Q
T
V
----------
T
N
Y
F
I
T
S
L
A
C
A
D
L
--------------------
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
---
S
I
------
D
V
L
------
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
--
T
S
P
F
K
-----
Y
Q
S
L
---
L
T
K
--------------
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
------
R
A
T
----------------------
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
-----------
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
-
H
K
---------
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
-
Q
-----
D
NLIR----------
K
--------
E
V
Y
I
L
L
N
W
I
G
Y
V
---
N
S
------------------
G
F
N
P
L
--
I
Y
C
-
R
S
P
D
F
R
---
I
A
F
Q
E
L
L
C
L
--------
29
HHSearch
80.96
15%
-141
- C2 -
2Z73
5
OPSD_TODPA
A:
[31-333]
--------------------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
-----
I
--
I
G
C
G
G
N
G
I
V
---------
I
Y
L
F
T
K
T
K
S
L
Q
T
P
----------
A
N
M
F
I
I
N
L
A
F
S
D
F
--------------------
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
---
F
I
------
G
G
I
------
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
--
G
R
P
M
A
-----
A
S
K
K
---
M
S
H
--------------
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
------
Y
T
L
----------------------
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
-----------
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
-
M
R
---------
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F-
G
-----
P
LEWVT---------
P
--------
Y
A
A
Q
L
P
V
M
F
A
K
A
---
S
A
------------------
I
H
N
P
M
--
I
Y
S
V
S
H
P
K
F
R
---
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
-
Q
F
19
HHSearch
79.96
15%
-134
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-499]
------------------------------------------------------------------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
-----
L
--
T
G
I
V
G
N
G
L
V
---------
I
L
V
M
G
Y
Q
K
K
L
R
S
M
----------
T
D
K
Y
R
L
H
L
S
V
A
D
L
--------------------
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
-
Y
F
G
N
F
L
C
K
A
V
H
---
V
I
------
Y
T
V
------
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
--
V
H
A
T
N
-----
S
Q
R
P
---
R
K
L
--------------
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
D
F
I
F
A
N
V
------
S
E
-----------------------
A
D
D
R
Y
I
C
D
R
F
Y
P
N
D
--------
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
-----------
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
-
R
K
---------
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
-
I
-----
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
--------
K
W
I
S
I
T
E
A
L
A
F
F
---
H
C
------------------
C
L
N
P
I
--
L
Y
A
F
L
G
A
K
F
K
---
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
-
V
L
42
Fugue
79.02
18%
-160
- C2 -
4L9P
11
?
B:
[68-519]
VHPGIP
A
L
F
R
E
PPLIHDLLST
E
T
T
E
L
Q
S
E
T
V
N
K
C
L
P
L
L
K
GIHNSQKGPFNKYGIPALQ
R
K
D
H
-
L
E
Y
L
Y
D
S
L
E
D
Y
P
A
S
F
V
A
L
D
A
S
R
P
W
M
V
-----
Y
--
W
A
L
A
G
L
C
L
L
GEDVTRF
R
E
R
V
I
S
T
F
T
A
A
Q
N
S
T
G
G
I
G
GGHGQM
S
H
V
A
S
S
Y
A
A
V
L
S
I
--------------------
A
M
V
G
G
----
E
E
A
F
K
L
I
-
D
R
K
A
-
M
W
K
W
L
G
K
L
K
Q
P
DGG
F
T
VCEG
G
E
E
D
V
R
G
A
Y
C
A
M
V
V
H
A
L
L
D
L
P
L
A
L
P
P
E
A
E
A
R
--
Q
N
G
L
E
TFTDG
L
P
E
Y
---
L
S
R
C
QTYEGGISGSPGS
E
A
H
G
A
Y
A
F
C
A
L
A
C
L
C
L
L
G
-
R
P
E
V
V
V
P
R
Y
M
N
I
A
T
L
L
P
W
L
S
A
R
QYAPEGGFSGRTN
K
L
V
D
G
C
Y
S
H
W
V
G
N
C
W
P
L
V
Q
A
A
L
D
G
--
T
Q
---
P
L
A
G
P
K
R
S
S
V
G
N
L
Y
S
R
E
G
L
T
R
Y
I
L
S
C
C
Q
-----------
C
K
L
G
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
P
G
K
---------
H
P
D
S
Y
H
T
C
Y
A
L
T
G
L
S
T
V
Q
Y
Y
H
Y
C
T
D
S
S
--
V
-----
S
--------------
S
--------
K
D
D
F
S
S
A
F
S
W
K
H
---
D
P
NFASDGQGSDIGVFTEND
R
L
V
P
F
HP
I
F
V
I
P
H
K
S
A
E
---
D
I
R
V
W
F
E
N
Q
S
F
D
L
----
18
HHSearch
76.87
16%
-147
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-----------------------------------------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
-----
L
--
V
T
I
I
G
N
I
L
V
---------
M
V
S
I
K
V
N
R
H
L
Q
T
V
----------
N
N
Y
F
L
F
S
L
A
C
A
D
L
--------------------
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
---
A
L
------
D
Y
V
------
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
--
T
K
P
L
T
-----
Y
P
V
K
---
R
T
T
--------------
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
W
Q
F
------
I
V
G
V
--
R
------------------
T
V
E
D
G
E
C
Y
I
Q
F
F
S
-----------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
-----------
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
E
-
K
K
---------
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
-
C
-----
A
PCIP----------
N
--------
T
V
W
T
I
G
Y
W
L
C
Y
I
---
N
S
------------------
T
I
N
P
A
--
C
Y
A
L
C
N
A
T
F
K
---
K
T
F
K
H
L
L
M
---------
44
Fugue
76.06
21%
-153
- C1 -
1DMU
5
T2B1_BACIU
A:
[1-299]
----------------------------------------------------------
M
Y
N
L
H
R
E
K
I
F
M
S
Y
N
Q
N
---
K
Q
Y
L
E
D
N
P
E
I
Q
E
-----
K
--
I
E
L
Y
G
L
N
L
L
---------
N
E
V
I
S
D
N
E
E
E
I
R
A
----------
D
Y
N
E
A
N
F
L
H
P
F
W
M
NYPPLDRGKMPKGDQIPW
I
E
V
G
E
K
A
V
-
G
S
K
L
T
R
L
V
S
-
Q
R
E
D
I
T
V
R
E
I
G
L
P
T
G
P
---
D
E
------
R
Y
L
L
T
S
P
T
I
Y
S
L
T
N
G
F
T
D
S
I
M
M
F
V
D
I
K
S
V
G
P
R
D
S
D
Y
-----
D
L
V
L
---
S
P
N
--------------
Q
V
S
G
-----
N
G
D
W
A
Q
L
E
G
-
G
I
Q
N
---
N
Q
------
Q
T
I
Q
G
P
R
------------------
S
S
Q
I
F
L
----------------
P
T
I
P
P
L
Y
I
L
S
D
G
T
I
A
P
V
V
H
L
F
I
K
P
I
Y
A
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
S
L
---------
T
K
G
D
T
G
Q
S
L
Y
K
I
K
L
A
S
V
P
N
G
L
G
L
F
C
N
P
--
G
-----
Y
--------------
A
--------
F
D
S
A
Y
K
---
F
L
F
---
R
P
------------------
G
K
D
D
R
--
T
K
S
L
L
Q
K
R
V
R
V
D
L
R
V
L
D
K
I
G
P
R
V
M
T
I
D
M
D
K
26
HHSearch
75.85
15%
-135
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
-------------------------------------------------------------------------
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
-----
C
--
F
I
I
L
E
N
I
F
V
---------
L
L
T
I
W
K
T
K
K
F
H
R
P
----------
M
Y
Y
F
I
G
N
L
A
L
S
D
L
--------------------
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
-
K
L
T
P
A
Q
W
F
L
R
E
---
G
S
------
M
F
V
------
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
--
L
K
----------------
N
N
--------------
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
-
G
L
P
I
M
G
W
N
C
------
I
-------------------------
S
A
L
S
S
C
S
T
V
L
P
L
Y
----------
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
-----------
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
N
-
V
A
---------
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
-
C
-----
K
VKTC
D
I
--------
L
--------
F
R
A
E
Y
F
L
V
L
A
V
L
---
N
S
------------------
G
T
N
P
I
--
I
Y
T
L
T
N
K
E
M
R
---
R
A
F
I
R
I
M
G
R
P
L
------
25
HHSearch
69.39
14%
-142
- C2 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
-----------------------------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
-----
V
--
T
S
V
V
G
N
V
V
V
---------
M
W
I
I
L
A
H
K
R
M
R
T
V
----------
T
N
Y
F
L
V
N
L
A
F
A
E
A
--------------------
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
---
F
F
------
P
I
A
------
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
--
I
H
P
L
Q
-----
P
R
L
-----
S
A
--------------
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
Y
S
T
T
------
E
T
-----------------------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
-----------
L
W
A
S
E
I
PGDSSDRYH
E
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
-
R
K
---------
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
-
N
-----
P
--------------
D
LYLKKFI
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
---
S
T
------------------
M
Y
N
P
I
--
I
Y
C
C
L
N
D
R
F
R
---
L
G
F
K
H
A
F
R
C
C
P
F
I
S
-
A
G
17
PsiBlast_PDB
69.05
23%
-159
- C2 -
4EA3
2
C562_ECOLX (first)
A:
[205-405]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
--
C
H
P
---------------
T
S
--------------
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
G
S
A
Q
------
V
E
------------------------
D
E
E
I
E
C
----
L
V
E
I
P
-
T
P
--
Q
D
Y
W
G
P
V
F
A
-----
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
RGVR
L
L
S
G
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
-
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
S
--
S
--------------------
E
--------
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
------------------
C
L
N
P
I
--
L
Y
A
F
L
D
E
N
F
K
---
A
C
F
R
-------------
28
HHSearch
69.00
11%
-114
- C2 -
1U19
14
OPSD_BOVIN
A:
[36-328]
-------------------------------------------------------------------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-----
M
--
L
G
F
P
I
N
F
L
T
---------
L
Y
V
T
V
Q
H
K
K
L
R
T
P
----------
L
N
Y
I
L
L
N
L
A
V
A
D
L
--------------------
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
---
F
F
------
A
T
L
------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
--
C
K
P
M
S
-----
N
F
R
F
----
G
E
--------------
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
------
Y
I
P
----------------------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
---
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
-----------
V
K
E
A
A
A
QQQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
-
K
E
---------
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
-----
G
SDFG----------
P
--------
I
F
M
T
I
P
A
F
F
A
K
T
---
S
A
------------------
V
Y
N
P
V
--
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
L
-
G
D
27
HHSearch
68.97
15%
-116
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[35-323]
-------------------------------------------------------------------------
E
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
-----
L
--
L
S
L
L
G
N
S
L
V
---------
M
L
V
I
L
Y
S
R
V
G
R
S
V
----------
T
D
V
Y
L
L
N
L
A
L
A
D
L
--------------------
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
---
L
L
------
K
E
V
------
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
--
V
H
A
T
R
-----
T
L
T
----
Q
K
R
--------------
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
-
L
P
F
F
L
F
R
Q
A
------
Y
H
----
P
------------------
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----
T
--
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
-----------
L
F
K
A
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
-
H
R
---------
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
-
M
-----
R
TQVIQE
S
C
E
R
R
N
N
I
G
--------
R
A
L
D
A
T
E
I
L
G
F
L
---
H
S
------------------
C
L
N
P
I
--
I
Y
A
F
I
G
Q
N
F
R
---
H
G
F
L
K
I
L
A
M
H
G
------
6
PsiBlast_PDB
60.64
20%
-136
- C2 -
4DAJ
2
ACM3_RAT (first)
A:
[9-183]
----------------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
-----
L
A
L
V
T
I
I
G
N
I
L
V
---------
I
V
A
F
K
V
N
K
Q
L
K
T
V
---------------
N
N
Y
F
L
L
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
I
S
M
N
L
F
-
T
T
Y
--
I
I
M
N
R
W
A
L
G
N
L
---
A
C
------
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
--
T
R
P
L
T
-----
Y
R
A
K
---
R
T
T
--------------
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
--------
F
V
G
K
R
------------------
T
V
P
P
G
E
C
----
F
I
Q
F
L
S
E
P
--
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
-----------
I
F
E
M
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
-
G
L
---------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
--
A
-----
A
--------------
K
--------
S
E
L
D
K
A
I
G
R
N
T
N
---
G
V
------------------
I
T
K
D
E
--
A
E
K
L
F
N
Q
D
V
D
---
A
A
V
R
G
I
L
R
N
A
K
L
K
P
-
V
Y
3
PsiBlast_PDB
59.48
20%
-136
- C2 -
4U15
1
ACM3_RAT
A:
[9-183]
----------------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
-----
L
A
L
V
T
I
I
G
N
I
L
V
---------
I
V
A
F
K
V
N
K
Q
L
K
T
V
---------------
N
N
Y
F
L
L
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
I
S
M
N
L
F
-
T
T
Y
--
I
I
M
N
R
W
A
L
G
N
L
---
A
C
------
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
--
T
R
P
L
T
-----
Y
R
A
K
---
R
T
T
--------------
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
--------
F
V
G
K
R
------------------
T
V
P
P
G
E
C
----
F
I
Q
F
L
S
E
P
--
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
-----------
I
F
E
M
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
-
G
G
---------
G
S
G
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
--
L
-----
K
--------------
P
--------
V
Y
D
S
L
D
A
V
R
R
A
A
---
L
I
------------------
N
M
V
F
Q
--
M
G
E
T
G
V
A
G
F
T
---
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
-
A
V
4
PsiBlast_PDB
58.84
20%
-135
- C2 -
4U16
1
?
A:
[9-183]
----------------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
-----
L
A
L
V
T
I
I
G
N
I
L
V
---------
I
V
A
F
K
V
N
K
Q
L
K
T
V
---------------
N
N
Y
F
L
L
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
I
S
M
N
L
F
-
T
T
Y
--
I
I
M
N
R
W
A
L
G
N
L
---
A
C
------
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
--
T
R
P
L
T
-----
Y
R
A
K
---
R
T
T
--------------
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
--------
F
V
G
K
R
------------------
T
V
P
P
G
E
C
----
F
I
Q
F
L
S
E
P
--
T
I
T
F
G
T
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
-----------
I
F
E
M
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
-
G
G
---------
G
S
G
G
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
--
L
-----
K
--------------
P
--------
V
Y
D
S
L
D
A
V
R
R
A
A
---
L
I
------------------
N
M
V
F
Q
--
M
G
E
T
G
V
A
G
F
T
---
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
-
A
V
2
PsiBlast_PDB
54.43
22%
-146
- C2 -
4MQT
2
ACM2_HUMAN
A:
[36-178]
------------------------------------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
--
V
T
I
I
G
N
I
L
V
---------
M
V
S
I
K
V
N
R
H
L
Q
T
V
---------------
N
N
Y
F
L
F
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
F
S
M
N
L
Y
-
T
L
Y
T
-
V
I
G
Y
-
W
P
L
G
P
V
---
V
C
------
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
--
T
K
P
L
T
-----
Y
P
V
K
---
R
T
T
--------------
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
W
Q
F
------
I
V
G
V
R
T
V
------------------
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
G
T
--
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
P
S
R
E
K
K
V
T
R
-----------
T
I
L
A
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
F
-
I
I
---------
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
T
I
G
--
Y
-----
W
--------------
L
--------
C
Y
I
N
S
T
I
N
P
A
C
Y
---
A
L
------------------
C
N
A
T
F
--
K
K
T
F
K
H
L
L
M
C
--------------------
5
PsiBlast_PDB
54.27
20%
-149
- C2 -
4U14
1
ENLYS_BPT4
A:
[9-142]
----------------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
F
-----
L
A
L
V
T
I
I
G
N
I
L
V
---------
I
V
A
F
K
V
N
K
Q
L
K
T
V
---------------
N
N
Y
F
L
L
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
I
S
M
N
L
F
-
T
T
Y
--
I
I
M
N
R
W
A
L
G
N
L
---
A
C
------
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
--
T
R
P
L
T
-----
Y
R
A
K
---
R
T
T
--------------
K
R
A
G
V
M
I
G
L
A
W
V
I
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
------
F
V
G
K
R
T
V
------------------
P
P
G
E
C
F
I
Q
F
L
S
E
P
T
I
T
F
G
T
--
A
I
A
A
F
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
C
F
E
M
L
R
-----------
I
D
E
G
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
-
Y
K
---------
D
C
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
--
D
-----
K
--------------
A
--------
I
G
R
N
T
N
G
V
I
T
K
D
---
E
A
------------------
E
K
L
F
N
--
Q
D
V
D
A
A
V
R
G
I
---
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
-
A
V
1
PsiBlast_PDB
54.06
22%
-144
- C2 -
4MQS
1
?
A:
[36-178]
------------------------------------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
--
V
T
I
I
G
N
I
L
V
---------
M
V
S
I
K
V
N
R
H
L
Q
T
V
---------------
N
N
Y
F
L
F
S
L
--------------------
A
C
A
D
L
I
-
I
G
V
F
S
M
N
L
Y
-
T
L
Y
T
-
V
I
G
Y
-
W
P
L
G
P
V
---
V
C
------
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
--
T
K
P
L
T
-----
Y
P
V
K
---
R
T
T
--------------
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
W
Q
F
------
I
V
G
V
R
T
V
------------------
E
D
G
E
C
Y
I
Q
F
F
S
N
A
A
V
T
F
G
T
--
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
P
P
P
S
R
E
K
K
-----------
V
T
R
T
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
L
-
L
A
---------
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
V
W
--
T
-----
I
--------------
G
--------
Y
W
L
C
Y
I
N
S
T
I
N
P
---
A
C
------------------
Y
A
L
C
N
--
A
T
F
K
K
T
F
K
H
L
---
L
M
---------------