@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51S1_HUMAN: (2016-01-12 )
MSTLPTQIAPNSSTSMAPTFLLVGMPGLSGAPSWWTLPLIAVYLLSALGNGTILWIIALQPALHRPMHFFLFLLSVSDIGLVTALMPTLLGIALAGAHTVPASACLLQMVFIHVFSVMESSVLLAMSIDRALAICRPLHYPALLTNGVISKISLAISFRCLGLHLPLPFLLAYMPYCLPQVLTHSYCLHPDVARLACPEAWGAAYSLFVVLSAMGLDPLLIFFSYGLIGKVLQGVESREDRWKAGQTCAAHLSAVLLFYIPMILLALINHPELPITQHTHTLLSYVHFLLPPLINPILYSVKMKEIRKRILNRLQPRKVGGAQ
Atome Classification :
(20 SA)
---......---...10........20........30......--..40..--......---50........60........70........80....-....90...-....-.100.......110.......120.......130.....-----------..140.---...----...150.......160..----------.....170....-----...180....--------...190..-.---....200--...---------.....210..-------------.....220..-----...-----..230--------...----..------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.240..---.....250....-----...260....--...---------270.--.--.----....280.......--290--.-..-------.....300...--------....310..--------.....320.-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MSTLPT---QIAPNSSTSMA
P
T
F
L
L
V
GMPGLSGAPS
W
W
T
L
--
P
L
I
A
V
Y
--
L
L
S
A
LG---N
G
T
I
L
W
I
I
AL
Q
P
A
LH
R
P
M
H
F
F
L
F
L
L
S
VS
D
I
G
L
V
T
A
L
-
M
P
T
L
L
G
I
A
L-AGAH-TV
P
A
S
A
C
L
L
Q
M
V
F
I
H
V
F
S
V
M
E
S
S
V
L
L
A
M
S
I
D
R
A
L
A
I
CRP-----------LH
Y
P
A
L
---
L
T
N----
G
V
I
S
K
I
S
L
A
I
S
F
R
C
L
GLH----------L
P
L
P
F
L
L
A
Y
M
P
Y
-----
C
L
P
Q
V
L
T
HSY--------CLHP
D
V
A
R
-L---AC
P
E
A
W
---
G
A
A
---------
Y
S
L
F
V
V
L
S
A
M-------------GL
D
P
L
L
I
F
F
S
-----
Y
G
L
-----
I
G
K
V
L
--------
Q
G
V
----
E
S------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
R
WKA---G
Q
T
C
A
A
H
L
S
A
V
L
-----
L
F
Y
I
P
M
I
L
L
A
--LIN---------HPEL--P--
I
----
T
Q
H
T
H
T
L
L
S
Y
V
H
F
L
--
L
P
---
P
-
L
I
-------
N
P
I
L
Y
S
V
K
M
K
E
--------
I
R
K
R
I
L
N
RL--------QPRKVGGAQ-----------------
7
PsiBlast_PDB
90.02
24%
-150
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[6-319]
------------------------------------
S
S
V
Y
I
T
V
--
E
L
-
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
P
K
E
G
K
-
A
---
G
C
G
E
G
Q
---
V
A
C
LFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
-
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
--------
E
P
F
K
A
A
A
A
------------------
5
PsiBlast_PDB
89.12
24%
-150
- C4 -
2YDV
6
?
A:
[5-320]
-----------------------------------
G
S
S
V
Y
I
T
V
--
E
L
-
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
P
K
E
G
K
-
A
H
S
Q
G
C
G
E
G
Q
---
V
A
C
LFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
F
C
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
--------
E
P
F
K
A
A
A
A
E
-----------------
29
HHSearch
88.33
19%
-160
- C4 -
3EML
13
ENLYS_BPT4
A:
[21-471]
-------------------------------------
S
S
V
Y
I
T
--
V
E
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
----
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
L
G
W
N
N
C
G
Q
------------
S
Q
G
--------
C
G
E
G
Q
V
-------
A
C
L
F
E
D
VVP
M
N
Y
---------
M
V
Y
F
N
F
F
A
C
V
-------------
L
V
P
L
L
L
M
L
G
V
-----
Y
L
R
-----
I
F
L
A
A
--------
R
R
Q
----
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
---
A
K
S
L
A
I
I
V
G
L
F
A
-----
L
C
W
L
P
L
H
I
I
N
--
C
F
T
---------
F
F
C
P
--
D
CS
H
----
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
--
T
N
---
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
--------
F
R
Q
T
F
R
K
I
I
--------
R
S
H
V
L
R
Q
-------------------
21
HHSearch
87.92
20%
-162
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------
V
F
I
V
L
--
V
A
G
S
L
S
--
L
V
T
I
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
-----------
L
T
Y
P
V
K
---
R
T
T
----
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
----------
A
P
A
I
L
F
W
Q
F
I
V
G
-----
V
R
--
T
V
E
D
G
E
--------
C
Y
I
Q
F
F
S
---------------
N
A
A
---------
V
T
F
G
T
A
I
A
A
F
-------------
Y
L
P
V
I
I
M
T
V
L
-----
Y
W
H
-----
I
S
R
A
S
--------
K
S
R
----
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
---
T
R
T
I
L
A
I
L
L
A
F
I
-----
I
T
W
A
P
Y
N
V
M
V
--
L
I
N
---------
T
F
C
A
--
P
--
C
----
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
--
I
N
---
S
-
T
I
-------
N
P
A
C
Y
A
L
C
N
A
T
--------
F
K
K
T
F
K
H
L
L
--------
M
-------------------------
13
PsiBlast_PDB
86.63
24%
-158
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
-
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
P
----------------GCGEGQVA
C
L
F
E
D
V
V
--------
P
M
N
Y
---
M
V
Y
---------
F
N
F
F
----
A
C
-------------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
-----
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
10
PsiBlast_PDB
86.21
24%
-156
- C4 -
3PWH
1
?
A:
[14-305]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
-
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
P
----------------GCGEGQVA
C
L
F
E
D
V
V
--------
P
M
N
Y
---
M
V
Y
---------
F
N
F
F
----
A
C
-------------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
-----
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
4
PsiBlast_PDB
86.05
24%
-150
- C4 -
2YDO
3
?
A:
[6-320]
------------------------------------
S
S
V
Y
I
T
V
--
E
L
-
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
P
K
E
G
K
-
A
H
S
Q
G
C
G
E
G
Q
---
V
A
C
LFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------
K
Q
M
----
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
F
C
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
--------
E
P
F
K
A
A
A
A
E
-----------------
20
PsiBlast_PDB
85.34
18%
-147
- C4 -
3C9M
1
OPSD_BOVIN
A:
[35-321]
----------------------------------------
W
Q
F
--
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
N
F
R
F
---
G
E
N
----
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
----------
C
A
A
P
P
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
S
C
--------
G
I
D
Y
Y
T
P
H
-------
E
E
T
N
---
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
-------------
I
I
P
L
I
V
I
F
F
C
-----
Y
G
Q
-----
L
V
F
T
V
--------
K
E
A
----
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
---
T
Q
K
A
E
K
E
V
T
R
M
V
-----
I
I
M
V
I
A
F
L
I
C
--
W
L
P
---------
Y
A
G
V
--
A
F
Y
I
----
F
T
H
Q
G
S
C
F
G
P
I
F
M
T
--
I
P
---
A
-
F
F
AKTSAVY
N
P
V
I
Y
I
M
M
N
K
Q
--------
F
R
N
C
M
V
T
T
L
--------
C
C
G
K
N
P
--------------------
14
PsiBlast_PDB
85.08
24%
-159
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
-
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
P
----------------GCGEGQVA
C
L
F
E
D
V
V
--------
P
M
N
Y
---
M
V
Y
---------
F
N
F
F
----
A
C
-------------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
-----
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
12
PsiBlast_PDB
84.68
24%
-161
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
-
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
P
----------------GCGEGQVA
C
L
F
E
D
V
V
--------
P
M
N
Y
---
M
V
Y
---------
F
N
F
F
----
A
C
-------------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
-----
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
11
PsiBlast_PDB
84.65
24%
-160
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
-----------
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
-
I
C
W
V
L
S
F
A
-
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
P
----------------GCGEGQVA
C
L
F
E
D
V
V
--------
P
M
N
Y
---
M
V
Y
---------
F
N
F
F
----
A
C
-------------
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
-----
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
---
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
FC
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
A
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------
32
HHSearch
84.51
20%
-155
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------
Y
A
L
--
S
Y
C
A
L
I
--
L
A
I
V
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
-----------
V
H
Y
Q
H
G
T
G
Q
S
S
C
----
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
----------
C
P
L
L
F
G
F
N
T
T
G
------------
D
P
T
V
--------
C
S
I
S
N
------------------
P
D
---------
F
V
I
Y
S
S
V
V
S
F
-------------
Y
L
P
F
G
V
T
V
L
V
-----
Y
A
R
-----
I
Y
V
V
L
--------
K
Q
R
----
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
---
T
Q
M
V
A
I
V
L
G
A
F
I
-----
V
C
W
L
P
F
F
L
T
H
--
V
L
N
---------
T
H
C
Q
--
T
C-
H
----
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
--
V
N
---
S
-
A
L
-------
N
P
V
I
Y
T
T
F
N
I
E
--------
F
R
K
A
F
L
K
I
L
--------
S
C
------------------------
41
Fugue
83.61
17%
-141
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
PNF
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
N
F
R
F
---
G
E
N
----
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
----------
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
I
D
Y
Y
T
P
H
------------------------
E
E
T
N
---
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
-------------
I
I
P
L
I
V
I
F
F
C
-----
Y
G
Q
-----
L
V
F
T
V
--------
K
E
A
AASA
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
---
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
Y
A
G
V
A
--
F
Y
I
---------
F
T
H
Q
--
G
--
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
--
K
T
---
S
A
V
Y
-------
N
P
V
I
Y
I
M
M
N
K
Q
--------
F
R
N
C
M
V
T
T
L
C
CGKNPST
T
V
S
K
T
E
T
S
Q
V
A
P
A-------------
9
PsiBlast_PDB
82.86
23%
-149
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-308]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
-----S
Q
---
G
C
G
E
G
Q
---
V
A
C
L
F
EDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
F
C
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------
28
HHSearch
82.24
16%
-153
* C4 *
2Z73
5
OPSD_TODPA
A:
[30-333]
---------------------------------
P
D
A
V
Y
Y
S
L
G
I
--
F
I
G
I
C
G
--
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
-----------
M
A
A
S
K
K
---
M
S
H
----
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
----------
I
G
P
I
F
G
W
G
A
Y
T
L
---------
E
G
V
L
C
N
--------
C
S
F
D
Y
I
S
R
--------
D
S
T
---
T
R
S
---------
N
I
L
C
M
F
I
L
G
F
-------------
F
G
P
I
L
I
I
F
F
C
-----
Y
F
N
-----
I
V
M
S
V
--------
S
N
H
----
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
---
A
K
I
S
I
V
I
V
S
Q
F
L
-----
L
S
W
S
P
Y
A
V
V
A
--
L
L
A
---------
Q
F
G
P
--
L
E-
W
----
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
--
A
S
---
A
-
I
H
-------
N
P
M
I
Y
S
V
S
H
P
K
--------
F
R
E
A
I
S
Q
T
F
--------
P
W
V
L
T
C
C
Q
F
-----------------
44
Fugue
82.14
19%
-144
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------
S
---
F
K
C
A
L
T
K
T
G
F
--------------
Q
F
Y
Y
L
P
A
--
V
Y
I
L
V
F
--
I
I
G
F
L
G
---
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
--
P
A
L
I
F
Y
Y
F
-
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
KSL
G
R
L
K
K
K
N
A
I
C
I
S
V
L
---
V
W
L
----
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
KNKTITCYDT
T
S
D
E
Y
L
R
S
Y
F
I
Y
-----
S
M
C
T
T
V
A
M
-
F
--------
C
V
P
L
V
L
I
L
-
G
---
C
Y
G
L
I
V
---
R
A
L
I
Y
K
M
K
K
---
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNP
G
T
D
F
K
D
I
V
C
P
-----
L
C
G
-----
V
G
K
D
Q
--------
F
E
E
----
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
R
K
S
---
I
Y
L
V
I
I
V
L
T
V
F
A
-----
V
S
Y
I
P
F
H
V
M
K
--
T
M
N
L
R
A
R
L
DFQT
P
A
M
C
--
A
--
F
----
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
---
S
-
C
V
-------
N
P
I
L
Y
F
L
A
G
D
T
--------
F
R
R
R
---------------------------------------
27
HHSearch
81.39
15%
-150
- C4 -
2KS9
1
NK1R_HUMAN
A:
[31-325]
------------------------------------
Q
I
V
L
W
A
A
--
A
Y
T
V
I
V
--
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
-----------
L
Q
P
R
L
-----
S
A
----
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
----------
F
P
Q
G
Y
Y
S
T
T
E
T
----------
M
P
S
R
V
V
--------
C
M
I
E
W
P
E
H
-
P
-----
N
K
I
Y
---
E
K
V
---------
Y
H
I
C
V
T
V
L
I
Y
-------------
F
L
P
L
L
V
I
G
Y
A
-----
Y
T
V
-----
V
G
I
T
L
--------
W
A
S
----
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
---
V
K
M
M
I
V
V
V
C
T
F
A
-----
I
C
W
L
P
F
H
I
F
F
--
L
L
P
---------
Y
I
N
P
--
D
--
L
YLKK
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
--
S
S
---
T
-
M
Y
-------
N
P
I
I
Y
C
C
L
N
D
R
--------
F
R
L
G
F
K
H
A
F
--------
R
C
C
P
F
I
S
A
G
-----------------
8
PsiBlast_PDB
80.99
23%
-150
- C4 -
3VG9
8
?
A:
[14-309]
-----------------------------------------------
L
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
-----S
Q
---
G
C
G
E
G
Q
---
V
A
C
L
F
EDVVPMN
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------
K
Q
M
----
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
F
C
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------
40
Fugue
80.66
16%
-130
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
P
N
F
---
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
--
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-----------
M
S
N
F
R
F
---
G
E
N
----
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
----------
P
P
L
V
G
W
S
R
Y
I
P
E
-----
G
M
-----
Q
C
S
--------
C
G
-
I
D
Y
Y
--
T
---
P
H
E
E
T
N
---
N
E
S
---------
F
V
I
Y
M
F
V
V
H
F
-------------
I
I
P
L
I
V
I
F
F
C
-----
Y
G
Q
-----
L
V
F
T
V
KEAAAQQQ
E
S
A
----
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
---
T
R
M
V
I
I
M
V
I
A
F
L
-----
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
---------
H
Q
G
S
--
D
--
F
----
G
P
I
F
M
T
I
P
A
F
F
A
K
T
--
S
A
-----
V
Y
-------
N
P
V
I
Y
I
M
M
N
K
Q
--------
F
R
N
C
M
V
T
T
L
C
-------
C
G
K
N
P
L
G
D
D
EA
S
T
T
V
S
K
TETSQVAPA
6
PsiBlast_PDB
80.27
24%
-156
- C4 -
4UG2
3
?
A:
[6-309]
------------------------------------
S
S
V
Y
I
T
V
--
E
L
-
A
I
A
--
V
L
A
I
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
-
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-----------
L
R
Y
N
G
L
---
V
T
-----
G
T
R
A
K
G
I
I
A
I
C
W
-----------------
V
L
S
F
A
I
G
L
T
P
----------
M
L
G
W
N
N
--------
C
G
Q
P
K
E
G
K
-
A
H
S
Q
G
C
G
E
G
Q
---
V
A
C
LFEDVVP
M
N
Y
M
V
Y
F
N
F
F
A
C
-------------
V
L
V
P
L
L
L
M
L
G
-----
V
Y
L
R
I
F
L
A
A
R
R
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
---
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
--
I
I
N
---------
C
F
T
F
F
C
P
--
D
----
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
-
V
V
-------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------