@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52N2_HUMAN: (2016-01-12 )
MSGDNSSSLTPGFFILNGVPGLEATHIWISLPFCFMYIIAVVGNCGLICLISHEEALHRPMYYFLALLSFTDVTLCTTMVPNMLCIFWFNLKEIDFNACLAQMFFVHMLTGMESGVLMLMALDRYVAICYPLRYATILTNPVIAKAGLATFLRNVMLIIPFTLLTKRLPYCRGNFIPHTYCDHMSVAKVSCGNFKVNAIYGLMVALLIGVFDICCISVSYTMILQAVMSLSSADARHKAFSTCTSHMCSIVITYVAAFFTFFTHRFVGHNIPNHIHIIVANLYLLLPPTMNPIVYGVKTKQIQEGVIKFLLGDKVSFTYDK
Atome Classification :
(20 SA)
-------------------.........10----------.........20........---30.....--------------.-..40.....----...50........-60........70.--------------------------.......-80.--------------.--..---------.....----90...----..--...100..----.---....110.......120---------........-.-130--.......140--------....----....150..-----...--..160----...--.-.....---170..------.....180..------.-....190---------.-------..-.----------------....200..---....-.210...--....220...--------------....230...-----------------------------------------------------------------------------------------------------------------------------------------------------------------.--------..-------...240---.........250-........260---------.......-------..270.------.--.--------.----.....280..-..-----..---.290.....-..300.........310.......320----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------MSGDNSSSLT-----------
P
G
F
F
I
L
NGVPGL
E
A
T
H
I
W
I
---S
L
P
F
C
F
M
--------------
Y
-
I
I
A
V
VGNC
G
----
L
I
C
L
IS
H
E
E
A
L
H
R
-
P
M
Y
Y
F
L
A
L
L
S
FT
D
--------------------------
V
T
L
C
T
T
M-V-P--------------N--
M
L
---------
C
I
F
W
F----NLKEI----
D
F
--
N
A
C
L
A
Q
M
F
----
F
---
V
H
M
L
T
G
MES
G
V
L
M
L
M
-----------
A
L
D
R
Y
V
A
I
-
C
-YP
L
--
R
Y
A
TILTN
P
---------
V
I
A
K
----
A
G
L
A
T
F
L
R
N
-----
V
M
L
--
I
I
P
------
F
T
L
--
L
-
T
KRLP---YCRGN------FIPHTYCDHM------
S
-
V
A
K
VSC----------G-------
N
F
-
K
----------------
V
N
A
I
Y
G
L
M
V
---
A
L
L
I
-
G
V
F
D
I
C
C
--
I
S
V
S
Y
T
M
I
L
Q
--------------
A
V
M
S
L--SSA-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------
A
R
-------
H
K
A
F
-----
S
T
C
T
S
H
M
C
S
I
V
--
I
T
Y
V
A
A
F
F
T
-----------
F
F
T
H
R
F
V-------GHN--I------P--
N
--------
H
----
I
H
I
I
V
A
N
L
Y
L
-LL-----PP---TM
N
P
I
V
YGV-
K
T
K
--
Q
I
Q
E
G
V
I
K
F
L
LGD
K
V
S
F
TYDK-----------------------------------
24
HHSearch
83.35
15%
-153
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
--------------------------------------------------------
M
P
L
---
V
V
V
L
S
T
I
--------------
C
-
L
V
T
V
G
L
N
L
L
----
V
L
Y
A
V
R
S
E
R
K
L
H
T
-
V
G
N
L
Y
I
V
S
L
S
V
A
D
--------------------------
L
I
V
G
A
V
V
-
M
-
P
--------------
M
--
N
I
---------
L
Y
L
L
M
----
S
K
W
S
L
----
G
R
--
P
L
C
L
F
W
L
S
----
M
---
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
-----------
C
I
D
R
Y
R
S
V
-
Q
-
Q
P
L
--
R
Y
L
K
Y
R
T
K
T
---------
R
A
S
A
----
T
I
L
G
A
W
F
L
S
-----
F
L
W
--
V
I
P
------
I
L
G
----
W
N
H
-----------------
R
R
E
D
K
C
E
T
D
------
F
-
Y
D
-------------------------------------------
V
T
W
F
K
V
M
T
---
A
I
I
N
-
F
Y
L
P
T
L
L
--
M
L
W
F
Y
A
K
I
Y
K
--------------
A
V
R
Q
H
--
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM
N
--------
R
E
-------
R
K
A
A
-----
K
Q
L
G
F
I
M
A
A
F
I
--
L
C
W
I
P
Y
F
I
F
-----------
F
M
V
I
A
F
--------
C
K
N
--
C
------
C
--
N
--------
E
----
H
L
H
M
F
T
I
W
L
G
-
Y
I
-----
N
S
---
T
L
N
P
L
I
Y
P
L
-
C
N
E
--
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------
23
HHSearch
82.32
16%
-151
* C3 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------
V
F
I
---
V
L
V
A
G
S
L
--------------
S
-
L
V
T
I
I
G
N
I
L
----
V
M
V
S
I
K
V
N
R
H
L
Q
T
-
V
N
N
Y
F
L
F
S
L
A
C
A
D
--------------------------
L
I
I
G
V
F
S
-
M
-
N
--------------
L
--
Y
T
---------
L
Y
T
V
I
----
G
Y
W
P
L
----
G
P
--
V
V
C
D
L
W
L
A
----
L
---
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
-----------
S
F
D
R
Y
F
C
V
-
T
-
K
P
L
--
T
Y
P
V
K
R
T
T
K
---------
M
A
G
M
----
M
I
A
A
A
W
V
L
S
-----
F
I
L
--
W
A
P
------
A
I
L
--
F
-
W
Q
F
I
V
---
G
V
--
R
------
T
V
E
D
G
E
C
Y
I
Q
------
F
-
F
-------------------------------------------
S
N
A
A
V
T
F
G
T
---
A
I
A
A
-
F
Y
L
P
V
I
I
--
M
T
V
L
Y
W
H
I
S
R
--------------
A
S
K
S
R
--
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP
S
--------
R
E
-------
K
K
V
T
-----
R
T
I
L
A
I
L
L
A
F
I
--
I
T
W
A
P
Y
N
V
M
-----------
V
L
I
N
T
F
--------
C
A
P
--
C
------
I
--
P
--------
N
----
T
V
W
T
I
G
Y
W
L
C
-
Y
I
-----
N
S
---
T
I
N
P
A
C
Y
A
L
-
C
N
A
--
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------
30
HHSearch
79.85
16%
-141
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
---------------------------------------------------------
L
W
---
A
A
A
Y
T
V
I
--------------
V
-
V
T
S
V
V
G
N
V
V
----
V
M
W
I
I
L
A
H
K
R
M
R
T
-
V
T
N
Y
F
L
V
N
L
A
F
A
E
--------------------------
A
S
M
A
A
F
N
-
T
-
V
--------------
V
--
N
F
---------
T
Y
A
V
H
----
N
E
W
Y
Y
----
G
L
--
F
Y
C
K
F
H
N
F
----
F
---
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
-----------
A
F
D
R
Y
M
A
I
-
I
-
H
P
L
--
Q
P
R
L
--
S
A
T
---------
A
T
K
V
----
V
I
C
V
I
W
V
L
A
-----
L
L
L
--
A
F
P
------
Q
G
Y
--
Y
-
S
T
T
E
T
--------------
M
P
S
R
V
V
C
M
I
E
------
W
-
P
E
H
P
--------------------
N
K
-
I
----------------
Y
E
K
V
Y
H
I
C
V
---
T
V
L
I
-
Y
F
L
P
L
L
V
--
I
G
Y
A
Y
T
V
V
G
I
--------------
T
L
W
A
S
--
E
I
P
GDSSDRYH
E
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------
A
K
-------
R
K
V
V
-----
K
M
M
I
V
V
V
C
T
F
A
--
I
C
W
L
P
F
H
I
F
-----------
F
L
L
P
Y
I
--------
N
P
D
--
L
YL----
K
KF
I
--------
Q
----
Q
V
Y
L
A
I
M
W
L
A
-
M
S
-----
S
T
---
M
Y
N
P
I
I
Y
C
C
-
L
N
D
--
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
-----------------------------------
41
Fugue
79.08
15%
-127
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVR
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
---
A
A
Y
M
F
L
L
--------------
I
-
M
L
G
F
P
I
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------------------
L
F
M
V
F
G
G
-
F
-
T
--------------
T
--
T
L
---------
Y
T
S
L
H
----
G
Y
F
V
F
----
G
P
--
T
G
C
N
L
E
G
F
----
F
---
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
-----------
A
I
E
R
Y
V
V
V
-
C
-
K
P
M
--
S
N
F
R
F
G
E
N
H
---------
A
I
M
G
----
V
A
F
T
W
V
M
A
L
-----
A
C
A
--
A
P
P
------
L
--------------
V
G
W
S
R
------
Y
I
P
E
G
M
--------------
Q
C
S
C
----------
G
I
DYYTPH
E
E
-
T
----------------
N
N
E
S
F
V
I
Y
M
---
F
V
V
H
-
F
I
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
F
--------------
T
V
K
E
A
--
A
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
T
T
-------
Q
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
--
I
A
F
L
I
C
W
L
P
-----------
Y
A
G
V
A
F
Y
-------
I
F
T
--
H
------
Q
--
G
--------
S
DFGP
I
F
M
T
I
P
A
F
F
A
-
K
T
-----
S
A
---
V
Y
N
P
V
I
Y
I
M
-
M
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A-------------------------
5
PsiBlast_PDB
79.02
21%
-163
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[20-270]
----------------------------------------------------------------------------------------
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
T
KTWTFG
N
--
F
W
---------
C
E
F
W
T
----
S
I
D
V
L
----
C
V
--
T
A
S
I
E
---------------------
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
------------
K
----
A
R
V
I
----------
I
L
M
--
V
W
I
------
V
S
G
--
L
-
T
S
F
L
P
----
I
Q
M
H
------
W
Y
R
A
T
H
Q
E
A
I
------
N
C
Y
A
E
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
-------------
A
K
R
Q
L
--
Q
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
KFC
L
----
K
E
-------
H
K
A
L
-----
K
T
L
G
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
-----------
N
I
V
H
V
I
Q
-------
D
N
L
--
I
------
R
--
K
--------
E
----
V
Y
I
L
L
-
N
W
I
G
-
Y
V
-----
N
S
---
G
F
N
P
L
I
Y
C
R
-
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------
45
Fugue
78.89
17%
-138
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------
S
F
K
C
A
L
T
-----------
K
T
G
F
----------
Q
F
Y
Y
L
---
P
A
V
Y
I
L
V
--------------
F
-
I
I
G
F
L
G
N
S
V
----
A
I
W
M
F
V
F
H
M
K
P
W
S
-
G
I
S
V
Y
M
F
N
L
A
L
A
D
--------------------------
F
L
Y
V
L
T
L
-
P
-------------------
A
L
---------
I
F
Y
Y
F
----
N
K
T
D
W
----
I
F
G
D
A
M
C
K
L
Q
R
F
----
I
---
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
-----------
S
A
H
R
Y
S
G
V
-
V
-
Y
P
K
--
S
L
G
R
L
K
K
K
N
---------
A
I
C
I
----
S
V
L
V
W
L
I
V
V
-----
V
A
I
S
P
I
L
F
------
Y
S
G
--
T
-
G
V
R
K
N
KTI
T
C
Y
D
T
TSDEY
L
R
S
Y
F
I
Y
S
M
C
T
------
T
-
V
A
M
F
C
V
----------
P
-------
L
V
-
L
----------------
I
L
G
C
Y
G
L
I
V
---
R
A
L
I
Y
K
M
K
K
Y
T
C
--
T
V
C
G
Y
I
Y
N
P
E
DGDPDNGVNPGTDF
K
D
I
V
C
--
P
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------
V
G
-------
K
D
Q
F
-----
E
E
V
E
E
P
L
R
R
K
S
--
I
Y
L
V
I
I
V
L
T
-----------
V
F
A
V
S
Y
I
-------
P
F
H
--
V
------
M
--
K
--------
T
----
M
N
L
R
A
R
L
D
F
Q
--------
T
P
---
A
M
C
A
F
N
D
R
V
Y
A
T
Y
--
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
GDTFRRR----------------------------
50
Fugue
78.70
19%
-153
- C2 -
4QT9
2
?
A:
[19-432]
LS
D
D
A
L
M
D
T
V
Q
R
R
T
F
L
Y
F
W
E
G
A
E
P
N
S
G
L
A
-----------
P
E
R
Y
H
V
D
G
V
Y
P
Q
N
D
A
N
V
V
T
---
S
G
G
S
G
F
G
--------------
I
M
A
I
L
A
G
I
D
R
G
----
Y
V
---
T
R
E
E
G
L
A
R
M
E
--
R
I
V
S
F
L
E
K
A
D
RFHGAYPHWWYGDTGKVKPFGQKDNG
G
D
L
V
E
T
A
F
L
M
Q
--------------
G
--
L
L
---------
A
V
H
Q
Y
Y
A
NG
N
D
K
E
K
----
A
I
--
A
Q
R
I
D
R
L
W
----
R
E
VD
W
D
W
Y
R
K
G
G
Q
N
V
L
Y
W
H
WSPTYGWEMD
F
P
I
H
G
Y
N
E
C
M
I
M
Y
I
L
--
A
A
A
S
-
P
T
H
G
---------
V
P
A
A
----
V
Y
H
D
G
W
A
Q
N
-----
G
A
I
--
V
S
P
------
H
K
V
EG
I
-
E
L
H
L
R
---
Y
Q
G
T
E
------
A
G
P
L
F
W
A
-
Q
Y
------
S
-
F
L
G
L
D
P
----------
V
-------
G
L
-
K
DEYCPS
Y
F
H
E
M
R
N
L
T
L
V
N
R
A
Y
C
I
R
N
---
P
K
H
Y
-
K
G
F
G
P
D
C
W
G
L
T
A
S
Y
S
V
D
G
Y
--------------
A
A
H
S
P
--
N
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------
D
---------
K
G
V
-----
I
S
P
T
A
A
L
S
S
I
V
--
Y
T
P
E
Y
S
L
Q
V
M
R
H
L
Y
N
M
GDKV
F
G
P
F
G
F
Y
DAFSETD
N
W
Y
--
P
------
Q
--
R
--------
Y
----
L
A
I
D
Q
G
P
I
A
V
M
I
E
-----
N
Y
---
R
T
G
L
L
W
K
L
F
M
S
H
P
--
D
V
Q
A
G
L
T
K
L
------
G
F
N
T
N
------------------------------------
4
PsiBlast_PDB
78.43
20%
-172
- C3 -
4QKX
2
ADRB2_HUMAN
A:
[177-447]
-----------------------------------------------------
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
--------------
V
-
L
A
I
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
C
I
L
T
KTWTFG
N
--
F
W
---------
C
E
F
W
T
----
S
I
D
V
L
----
C
V
--
T
A
S
I
E
---------------------
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
------------
K
----
A
R
V
I
----------
I
L
M
--
V
W
I
------
V
S
G
--
L
-
T
S
F
L
P
----
I
Q
M
H
------
W
Y
R
A
T
H
Q
E
A
I
------
N
C
Y
A
E
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
-------------
A
K
R
Q
L
--
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------KFAL----
K
E
-------
H
K
A
L
-----
K
T
L
G
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
-----------
N
I
V
H
V
I
Q
-------
D
N
L
--
I
------
R
--
K
--------
E
----
V
Y
I
L
L
-
N
W
I
G
-
Y
V
-----
N
S
---
G
F
N
P
L
I
Y
C
R
-
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------
1
PsiBlast_PDB
77.43
20%
-174
- C3 -
4LDE
3
A:
[177-447]
-----------------------------------------------------
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
--------------
V
-
L
A
I
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
T
KTWTFG
N
--
F
W
---------
C
E
F
W
T
----
S
I
D
V
L
----
C
V
--
T
A
S
I
E
---------------------
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
------------
K
----
A
R
V
I
----------
I
L
M
--
V
W
I
------
V
S
G
--
L
-
T
S
F
L
P
----
I
Q
M
H
------
W
Y
R
A
T
H
Q
E
A
I
------
N
C
Y
A
E
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
-------------
A
K
R
Q
L
--
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------KFAL----
K
E
-------
H
K
A
L
-----
K
T
L
G
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
-----------
N
I
V
H
V
I
Q
-------
D
N
L
--
I
------
R
--
K
--------
E
----
V
Y
I
L
L
-
N
W
I
G
-
Y
V
-----
N
S
---
G
F
N
P
L
I
Y
C
R
-
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------
2
PsiBlast_PDB
77.04
20%
-173
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[177-447]
-----------------------------------------------------
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
--------------
V
-
L
A
I
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
T
KTWTFG
N
--
F
W
---------
C
E
F
W
T
----
S
I
D
V
L
----
C
V
--
T
A
S
I
E
---------------------
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
------------
K
----
A
R
V
I
----------
I
L
M
--
V
W
I
------
V
S
G
--
L
-
T
S
F
L
P
----
I
Q
M
H
------
W
Y
R
A
T
H
Q
E
A
I
------
N
C
Y
A
E
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
-------------
A
K
R
Q
L
--
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------KFA
L
----
K
E
-------
H
K
A
L
-----
K
T
L
G
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
-----------
N
I
V
H
V
I
Q
-------
D
N
L
--
I
------
R
--
K
--------
E
----
V
Y
I
L
L
-
N
W
I
G
-
Y
V
-----
N
S
---
G
F
N
P
L
I
Y
C
R
-
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------
42
Fugue
76.91
15%
-129
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
-----------
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
---
A
A
Y
M
F
L
L
--------------
I
-
M
L
G
F
P
I
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------------------
L
F
M
V
F
G
G
-
F
-
T
--------------
T
--
T
L
---------
Y
T
S
L
H
----
G
Y
F
V
F
----
G
P
--
T
G
C
N
L
E
G
F
----
F
---
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
-----------
A
I
E
R
Y
V
V
V
-
C
-
K
P
M
--
S
N
F
R
F
G
E
N
H
---------
A
I
M
G
----
V
A
F
T
W
V
M
A
L
-----
A
C
A
--
A
P
P
------
L
--------------
V
G
W
S
R
------
Y
I
P
E
G
M
--------------
Q
C
S
C
----------
G
I
DYYTPH
E
E
-
T
----------------
N
N
E
S
F
V
I
Y
M
---
F
V
V
H
-
F
I
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
F
--------------
T
V
K
E
A
--
A
A
Q
QQES-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
T
T
-------
Q
K
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
--
I
A
F
L
I
C
W
L
P
-----------
Y
A
G
V
A
F
Y
-------
I
F
T
--
H
------
Q
--
G
--------
S
DFGP
I
F
M
T
I
P
A
F
F
A
-
K
T
-----
S
A
---
V
Y
N
P
V
I
Y
I
M
-
M
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA-------------------
3
PsiBlast_PDB
76.82
20%
-171
- C3 -
4LDO
3
A:
[177-447]
-----------------------------------------------------
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
--------------
V
-
L
A
I
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
T
KTWTFG
N
--
F
W
---------
C
E
F
W
T
----
S
I
D
V
L
----
C
V
--
T
A
S
I
E
---------------------
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
------------
K
----
A
R
V
I
----------
I
L
M
--
V
W
I
------
V
S
G
--
L
-
T
S
F
L
P
----
I
Q
M
H
------
W
Y
R
A
T
H
Q
E
A
I
------
N
C
Y
A
E
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
E
-------------
A
K
R
Q
L
--
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------KFAL----
K
E
-------
H
K
A
L
-----
K
T
L
G
I
I
M
G
T
F
T
--
L
C
W
L
P
F
F
I
V
-----------
N
I
V
H
V
I
Q
-------
D
N
L
--
I
------
R
--
K
--------
E
----
V
Y
I
L
L
-
N
W
I
G
-
Y
V
-----
N
S
---
G
F
N
P
L
I
Y
C
R
-
S
P
D
--
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------
35
HHSearch
75.95
16%
-148
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-334]
-----------------------------------------------------
A
V
Y
Y
S
L
---
G
I
F
I
G
I
C
--------------
G
-
I
I
G
C
G
G
N
G
I
----
V
I
Y
L
F
T
K
T
K
S
L
Q
T
-
P
A
N
M
F
I
I
N
L
A
F
S
D
--------------------------
F
T
F
S
L
V
N
G
F
-
P
--------------
L
--
M
T
---------
I
S
C
F
L
----
K
K
W
I
F
----
G
F
--
A
A
C
K
V
Y
G
F
----
I
---
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
-----------
S
I
D
R
Y
N
V
I
-
G
-
R
P
M
--
A
A
S
K
K
M
S
H
R
---------
R
A
F
I
----
M
I
I
F
V
W
L
W
S
-----
V
L
W
--
A
I
G
------
P
I
F
--
G
-
W
G
A
Y
T
---
L
----------
E
G
V
L
C
N
C
S
F
D
------
Y
-
I
S
R
----------------------
D
-
S
----------------
T
T
R
S
N
I
L
C
M
---
F
I
L
G
-
F
F
G
P
I
L
I
--
I
F
F
C
Y
F
N
I
V
M
--------------
S
V
S
N
H
--
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
---------------------------------------------------------------------------------------------------------------------------------------------
N
--------
A
E
-------
M
R
L
A
-----
K
I
S
I
V
I
V
S
Q
F
L
--
L
S
W
S
P
Y
A
V
V
-----------
A
L
L
A
Q
F
--------
G
P
L
E-
W
------
V
--
T
--------
P
----
Y
A
A
Q
L
P
V
M
F
A
-
K
A
-----
S
A
---
I
H
N
P
M
I
Y
S
V
-
S
H
P
--
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
-----------------------------------
34
HHSearch
70.10
14%
-141
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------------------------
N
S
I
K
L
T
---
S
V
V
F
I
L
I
--------------
C
-
C
F
I
I
L
E
N
I
F
----
V
L
L
T
I
W
K
T
K
K
F
H
R
-
P
M
Y
Y
F
I
G
N
L
A
L
S
D
--------------------------
L
L
A
G
V
A
Y
-
T
-
A
--------------
N
--
L
L
---------
L
S
G
A
-----
T
T
Y
K
L
----
T
P
--
A
Q
W
F
L
R
E
G
----
S
---
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
-----------
A
I
E
R
Y
I
T
M
-
L
-
K
----------
N
N
F
---------
R
L
F
L
----
L
I
S
A
C
W
V
I
S
-----
L
I
L
--
G
G
L
------
P
I
M
--
G
-
W
N
C
I
----------------
S
A
L
S
S
C
S
T
V
------
L
-
P
L
------------------------------------------
Y
H
K
H
Y
I
L
-
F
---
C
T
T
V
-
F
T
L
L
L
L
S
--
I
V
I
L
Y
C
R
I
Y
S
--------------
L
V
R
T
R
--
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
S
--------
E
N
-------
V
A
L
L
-----
K
T
V
I
I
V
L
S
V
F
I
--
A
C
W
A
P
L
F
I
L
-----------
L
L
L
D
V
G
--------
C
K
V
--
K
------
T
--
C
D
I
------
L
----
F
R
A
E
Y
F
L
V
L
A
-
V
L
-----
N
S
---
G
T
N
P
I
I
Y
T
L
-
T
N
K
--
E
M
R
R
A
F
I
R
I
M
G
R
P
L
------------------------------------------
33
HHSearch
65.15
13%
-137
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-330]
--------------------------------------------------------
S
M
L
---
A
A
Y
M
F
L
L
--------------
I
-
M
L
G
F
P
I
N
F
L
----
T
L
Y
V
T
V
Q
H
K
K
L
R
T
-
P
L
N
Y
I
L
L
N
L
A
V
A
D
--------------------------
L
F
M
V
F
G
G
-
F
-
T
--------------
T
--
T
L
---------
Y
T
S
L
H
----
G
Y
F
V
F
----
G
P
--
T
G
C
N
L
E
G
F
----
F
---
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
-----------
A
I
E
R
Y
V
V
V
-
C
-
K
P
M
--
S
N
F
R
-
F
G
E
N
---------
H
A
I
M
----
G
V
A
F
T
W
V
M
A
-----
L
A
C
--
A
A
P
------
P
L
V
--
G
-
W
S
R
Y
I
---
P
----------
E
G
M
Q
C
S
C
G
I
D
------
Y
-
Y
T
P
-------------
H
-------
E
E
-
T
----------------
N
N
E
S
F
V
I
Y
M
---
F
V
V
H
-
F
I
I
P
L
I
V
--
I
F
F
C
Y
G
Q
L
V
F
--------------
T
V
K
E
A
--
A
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QESA
T
T
Q
K
A
E
-------
K
E
V
T
-----
R
M
V
I
I
M
V
I
A
F
L
--
I
C
W
L
P
Y
A
G
V
-----------
A
F
Y
I
F
T
--------
H
Q
G
S-
D
------
F
--
G
--------
P
----
I
F
M
T
I
P
A
F
F
A
-
K
T
-----
S
A
---
V
Y
N
P
V
I
Y
I
M
-
M
N
K
--
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
-----------------------------------
32
HHSearch
65.13
14%
-141
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[35-323]
---------------------------------------------------
E
T
L
N
K
Y
V
V
---
I
I
A
Y
A
L
V
--------------
F
-
L
L
S
L
L
G
N
S
L
----
V
M
L
V
I
L
Y
S
R
V
G
R
S
-
V
T
D
V
Y
L
L
N
L
A
L
A
D
--------------------------
L
L
F
A
L
-
T
-
L
-
P
--------------
I
--
W
A
---------
A
S
K
-
V
----
N
G
W
I
F
----
G
T
--
F
L
C
K
V
V
S
L
----
L
---
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
-----------
S
V
D
R
Y
L
A
I
-
V
-
H
A
T
--
R
T
L
T
-
Q
K
R
H
---------
L
V
K
F
----
V
C
L
G
C
W
G
L
S
-----
M
N
L
--
S
L
P
------
F
F
L
--
F
-
R
Q
A
Y
H
-----
P
--------
N
N
S
S
P
V
C
Y
E
V
------
L
-
G
N
D
---------------------
T
A
-
K
----------------
W
R
M
V
L
R
I
L
P
---
H
T
F
G
-
F
I
V
P
L
F
V
--
M
L
F
C
Y
G
F
T
L
R
--------------
T
L
F
K
A
--
H
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------
Q
K
-------
H
R
A
M
-----
R
V
I
F
A
V
V
L
I
F
L
--
L
C
W
L
P
Y
N
L
V
-----------
L
L
A
D
T
L
--------
M
R
T
QV
I
QE
S
C
E
R
R
--
N
N
I
------
G
----
R
A
L
D
A
T
E
I
L
G
-
F
L
-----
H
S
---
C
L
N
P
I
I
Y
A
F
-
I
G
Q
--
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------
48
Fugue
63.06
14%
-171
* C2 *
2CE7
1
FTSH_THEMA
A:
[5-457]
-------------------
Y
K
P
S
G
N
K
R
V
T
----------------
F
K
D
V
G
G
A
E
E
A
I
E
E
L
---
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
GARMP
K
-
G
I
L
L
V
G
P
P
G
TG
K
T
L
L
A
R
A
V
A
G
E
A
--
N
-
V
P
F
F
H
I
S
G
S
D
F
V
E
LF------------------------
V
G
V
G
A
A
R
-
V
-
R
--------------
D
--
L
F
A
Q
A
K
A
H
AP
C
I
V
F
I
D
----
E
I
D
A
V
GRHD
E
R
--
E
Q
T
L
N
Q
L
L
----
V
---
E
M
D
G
F
D
S
K
E
G
I
I
V
M
A
-----------
A
T
N
R
P
D
I
L
-
D
-
P
A
L
--
L
R
P
G
R
F
D
K
K
---------
I
V
V
D
PPD
M
L
G
R
K
K
I
L
E
I
-----
H
T
R
--
N
K
P
L
A
EDVN
L
E
I
--
I
-
A
K
R
T
P
---
G
F
V
G
A
------
D
L
E
N
L
V
N
E
A
A
------
L
-
L
A
A
R
E
G
----------
R
-------
D
K
-
I
----------------
T
M
K
D
F
E
E
A
I
---
D
R
V
I
-
L
I
S
P
A
E
K
--
R
I
I
A
Y
H
E
A
G
H
--------------
A
V
V
S
T
V
V
P
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------
P
V
-------
H
R
I
S
IIKYL
V
S
R
N
E
L
L
D
K
L
T
--
A
L
L
G
G
R
A
A
E
-----------
E
V
V
F
G
D
V
-------
T
S
G
--
A
------
A
--
N
--------
D
----
I
E
R
A
T
E
I
A
R
N
-
M
V
CQLGM
S
E
---
E
L
G
P
L
A
W
G
K
-
L
R
N
YS
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
KETIE
G
D
E
L
R
R
I
L
S
25
HHSearch
60.60
17%
-151
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
-------------------------------------------------------
V
V
G
M
---
G
I
V
M
S
L
I
--------------
V
-
L
A
I
V
F
G
N
V
L
----
V
I
T
A
I
A
K
F
E
R
L
Q
T
-
V
T
N
Y
F
I
T
S
L
A
C
A
D
--------------------------
L
V
M
G
L
A
V
-
V
-
P
--------------
F
--
G
A
---------
A
H
I
L
M
----
K
M
W
T
F
----
G
N
--
F
W
C
E
F
W
T
S
----
I
---
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
-----------
A
V
D
R
Y
F
A
I
-
T
-
S
P
F
--
K
Y
Q
S
L
L
T
K
N
---------
K
A
R
V
----
I
I
L
M
V
W
I
V
S
-----
G
L
T
--
S
F
L
------
P
I
Q
--
M
H
W
Y
R
A
T
---
H
-----------
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
----------
C
-------
D
F
-
F
----------------
T
N
Q
A
Y
A
I
A
S
---
S
I
V
S
-
F
Y
V
P
L
V
I
--
M
V
F
V
Y
S
R
V
F
Q
--------------
E
A
K
R
Q
--
L
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------
E
M
-------
L
R
I
D
-----
E
G
L
R
L
K
I
Y
K
D
T
--
E
G
Y
Y
T
I
G
I
G
-----------
H
L
L
T
K
S
P
-------
S
L
N
--
A
------
A
--
K
--------
S
----
E
L
D
K
A
I
G
R
N
T
-
N
G
-----
V
I
---
T
K
D
E
A
E
K
L
F
-
N
Q
D
--
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
-----------------------------------
26
HHSearch
58.90
18%
-158
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-222]
--------------------------------------------------------
S
V
Y
---
I
T
V
E
L
A
I
--------------
A
-
V
L
A
I
L
G
N
V
L
----
V
C
W
A
V
W
L
N
S
N
L
Q
N
-
V
T
N
Y
F
V
V
S
L
A
A
A
D
--------------------------
I
A
V
G
V
L
A
-
I
-
P
--------------
F
--
A
I
---------
T
I
S
T
------
G
F
C
A
----
A
C
--
H
G
C
L
F
I
A
C
----
F
---
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
-----------
A
I
D
R
Y
I
A
I
-
R
-
I
P
L
--
R
Y
N
G
L
V
T
G
T
---------
R
A
K
G
----
I
I
A
I
C
W
V
L
S
-----
F
A
I
--
G
L
T
------
P
M
L
--
G
-
W
N
N
C
G
---
Q
-------------
S
Q
G
C
G
E
G
------
Q
----
V
A
C
----------
L
-------
F
E
D
V
V---------------
P
M
N
Y
M
V
Y
F
N
---
F
F
A
C
-
V
L
V
P
L
L
L
--
M
L
G
V
Y
L
R
I
F
L
--------------
A
A
R
R
Q
--
L
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--------
E
M
-------
L
R
I
D
-----
E
G
L
R
L
K
I
Y
K
D
T
--
E
G
Y
Y
T
I
G
I
G
-----------
H
L
L
T
K
S
P
-------
S
L
N
--
A
------
A
--
K
--------
S
----
E
L
D
K
A
I
G
R
N
T
-
N
G
-----
V
I
---
T
K
D
E
A
E
K
L
F
-
N
Q
D
--
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
-----------------------------------
46
Fugue
58.36
12%
-159
- C2 -
4EI7
1
REPX_BACC1
A:
[3-384]
-----------------GN
F
S
E
I
E
S
Q
G
N
I
-----------
S
L
K
F
G
F
L
G
L
-
G
M
G
G
C
A
I
A
A
---
E
C
A
N
K
E
T
--------------
Q
-
I
K
N
N
K
Y
P
Y
R
----
A
I
L
V
N
T
N
S
Q
D
F
N
K
-
I
E
I
K
N
T
G
N
V
R
K
I
Q
--------------------------
L
E
G
Y
E
Q
G
-
A
-
A
--------------
R
N
P
Q
V
---------
G
E
E
A
F
----
V
K
H
E
T
----
K
I
--
F
E
A
V
K
Q
E
F
E
DRD
F
---
I
W
I
T
C
G
L
G
G
G
-
T
G
T
G
-----------
A
L
L
K
A
I
E
M
-
L
-
Y
E
H
DY
N
F
G
L
L
L
T
L
P
R
DAEAL
K
V
L
E
N
A
T
----
S
R
I
R
S
I
A
M
N
QEAFG
S
I
V
--
L
I
D
------
N
A
K
--
L
-
Y
R
K
F
E
---
E
E
N
P
S
------
A
L
A
N
E
Y
T
S
Y
S
N
K
Y
I
A
D
A
-
L
H
E
I
N
L
V
T
SSFTPFSD
T
-------
H
F
-
D
----------------
A
S
E
F
A
Q
V
I
N
TP
G
V
L
S
L
-
A
K
L
E
L
K
S
--
N
Q
L
D
T
E
N
P
L
G
--------------
Y
L
T
Q
L
--
G
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--------
E
K
GVL
Y
D
T
E
R
E
E
L
-----
E
S
A
K
K
S
A
L
S
I
V
T
S
P
L
R
A
G
R
L
Y
N
-----------
F
S
F
L
N
Q
M
-------
E
N
F
--
L
------
K
--
E
R
TPYVDER
P
----
I
A
P
Y
V
N
K
H
T
T
-
K
K
-----
E
E
D
I
V
K
F
Y
S
V
V
A
G
L
-
P
L
P
--
K
R
V
S
D
I
I
D
E
I
T
R
I
K
E
E
R
E
Q
A
N
-----------------------------------