@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52N5_HUMAN: (2016-01-12 )
MPLFNSLCWFPTIHVTPPSFILNGIPGLERVHVWISLPLCTMYIIFLVGNLGLVYLIYYEESLHHPMYFFFGHALSLIDLLTCTTTLPNALCIFWFSLKEINFNACLAQMFFVHGFTGVESGVLMLMALDRYVAICYPLRYATTLTNPIIAKAELATFLRGVLLMIPFPFLVKRLPFCQSNIISHTYCDHMSVVKLSCASIKVNVIYGLMVALLIGVFDICCISLSYTLILKAAISLSSSDARQKAFSTCTAHISAIIITYVPAFFTFFAHRFGGHTIPPSLHIIVANLYLLLPPTLNPIVYGVKTKQIRKSVIKFFQGDKGAG
Atome Classification :
(20 SA)
--------------------------------------------------------------.........10----...-......---------------20...-...---------..30......----..40.......-------.50----.......-..60........70-------.-...-----------....----.80..--------------..----------.-..--------------.90---------..---..-....100--.-..---.-...------.110...----..---------------------.---.120..-.....130--.....-----------------------------..--------------------..140..---.---...-.150...------.------...160......-----.170..----------------...-----.------------..180....----...190------.......200.........210.......220....---------..---.230.......-------------------------------------------------------------------------------------------------------------------------------------------------------------------240-----------------------------------------------------------------------------------------------------------------------------------------------------------------........----.250..-----....----.260-------........270.--.-..---------.---------.---.280...-----..----------..290..-....---.300......-.310.......320--...----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------MPLFNSLCWF-----
P
T
I-HVT
P
P
S
---------------
F
I
L
NG-IPG---------
L
E
R
V
H
V
W
I
SL----
P
L
C
T
M
Y
I
I
F
L
V-------GN-----L
G
L
V
Y
L
I
-
Y
YEESLHH
P
M
Y
F
F
--------
F
-
G
H
A
-----------
L
S
L
I
----
D
L
L
T
C--------------TT----------T-LP--------------NA
L
---------
C
I
---
F
W
-
F
S
L
K
EI---
N
-
F
N
---
A
-
C
L
A
------
Q
M
F
F
V
HG----FT---------------------
G
---
V
E
S
G
V
L
-
M
L
M
A
L
D
----
R
Y
V
A
I
-----------------------------
C
Y--------------------P
L
R
Y
A
T
T---L---TN
P
-
I
I
A
K
A
E
L
------
A
------
T
F
L
R
G
V
L
L
MI
P
F
-----
P
F
L
-
V
K
----------------RLP-----F------------
C
Q
S
N
II
S
H
T----YCDHM
S
------
V
V
K
L
S
C
A
S
--
I
K
V
N
V
I
Y
G
L
M
V
A
L
L
I
G
V
F
D
I
C
C
I
S
L
S
---------
Y
T
---
L
I
L
K
A
A
ISLSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
R
Q
K
A
F
S
----
T
C
T
A
H
I
-----
S
A
I
I
----
I
T
Y
--------
V
P
A
F
F
T
F
F
A
H
R
F--G-GH---------T---------I---PP
S
L
H
I
I
-----
V
A
----------
N
L
Y
L
LLP-PTL
N
---
P
I
VYGV
K
T
K
Q
-
I
R
K
S
V
I
K
F
FQGDK---GAG----------------------
29
HHSearch
88.67
17%
-143
* C7 *
2Z73
5
OPSD_TODPA
A:
[29-333]
--------------------------------------------------------------------------------------------------------------
V
---------
P
D
A
V
Y
Y
S
L
G
I
----
F
I
G
I
C
G
I
I
G
C
G
-------
G
N
-----
G
I
V
I
Y
L
F
-
T
K
T
K
S
L
Q
T
P
A
N
M
F
--------
I
-
I
-
N
-----------
L
A
F
S
----
D
F
T
F
S
--------------
L
V
----------
N
G
F
P
--------------
L
M
T
---------
I
S
---
C
F
-
L
K
K
W
I
F
---
G
-
F
A
---
A
-
C
K
V
------
Y
G
F
I
G
G
I
----
F
G
---------------------
F
---
M
S
I
M
T
M
-
A
M
I
S
I
D
----
R
Y
N
V
I
-----------------------------
G
R
--------------------
P
M
A
A
S
K
K
---
M
---
S
H
R
-
R
A
F
I
M
I
I
------
F
------
V
W
L
W
S
V
L
W
A
I
G
P
-----
I
F
G
-
W
G
----------------
A
Y
T
-----
L
----------------
E
G
V
L
C
----
N
C
S
F
D
Y
------
I
S
-----
R
--
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
---------
Y
F
---
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
----
I
S
I
V
I
V
-----
S
Q
F
L
----
L
S
W
--------
S
P
Y
A
V
V
A
L
L
A
Q
F
--
G
-
P
L
---------
E
---------
W
---
V
T
P
Y
A
A
Q
-----
L
P
----------
V
M
F
A
K
A
S
-
A
I
H
N
---
P
M
I
Y
S
V
S
H
P
K
-
F
R
E
A
I
S
Q
T
F
P
W
V
L
---
T
C
C
----------------------
26
HHSearch
88.29
18%
-143
- C7 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-----------------------------------------------------------------------------------------------------------------------------
M
P
L
V
V
----
V
L
S
T
I
C
L
V
T
V
G
-------
L
N
-----
L
L
V
L
Y
A
V
-
R
S
E
R
K
L
H
T
V
G
N
L
Y
--------
I
-
V
-
S
-----------
L
S
V
A
----
D
L
I
V
G
--------------
A
V
----------
V
-
M
P
--------------
M
N
I
---------
L
Y
---
L
L
-
M
S
K
W
S
L
---
G
-
R
P
---
L
-
C
L
F
------
W
L
S
M
D
Y
V
----
A
S
---------------------
T
---
A
S
I
F
S
V
-
F
I
L
C
I
D
----
R
Y
R
S
V
-----------------------------
Q
Q
--------------------
P
L
R
Y
L
K
Y
---
R
---
T
K
T
-
R
A
S
A
T
I
L
------
G
------
A
W
F
L
S
F
L
W
V
I
P
I
-----
L
G
--
W
N
----------------
H
-------------------------
R
R
E
D
----
K
C
E
T
D
F
------
Y
D
-----------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
---------
Y
A
---
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
----
Q
L
G
F
I
M
-----
A
A
F
I
----
L
C
W
--------
I
P
Y
F
I
F
F
M
V
I
A
F
--
C
-
K
N
-------------------
C
---
C
N
E
H
L
H
M
-----
F
T
----------
I
W
L
G
Y
I
N
-
S
T
L
N
---
P
L
I
Y
P
L
C
N
E
N
-
F
K
K
T
F
K
R
I
L
H
I
------------------------------
33
HHSearch
83.12
16%
-145
- C7 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------------------------------------------------------------------------------------
Y
A
L
----
S
Y
C
A
L
I
L
A
I
V
F
-------
G
N
-----
G
L
V
C
M
A
V
-
L
K
E
R
A
L
Q
T
T
T
N
Y
L
--------
V
-
V
-
S
-----------
L
A
V
A
----
D
L
L
V
A
--------------
T
L
----------
V
-
M
P
--------------
W
V
V
---------
Y
L
---
E
V
T
G
G
V
W
N
F
---
S
-
R
I
---
C
-
C
D
V
------
F
V
T
L
D
V
M
----
M
C
---------------------
T
---
A
S
I
W
N
L
-
C
A
I
S
I
D
----
R
Y
T
A
V
-----------------------------
V
M
--------------------
P
V
H
Y
Q
H
G
T
G
Q
S
---
S
C
R
-
R
V
A
L
M
I
T
------
A
------
V
W
V
L
A
F
A
V
S
C
P
L
-----
L
F
G
-
F
N
----------------
T
T
------------------------
G
D
P
T
----
V
C
S
I
S
N
--------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
---------
Y
A
---
R
I
Y
V
V
L
K
Q
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
----
M
V
A
I
V
L
-----
G
A
F
I
----
V
C
W
--------
L
P
F
F
L
T
H
V
L
N
T
H
--
C
-
Q
T
---------
C
---------
H
---
V
S
P
E
L
Y
S
-----
A
T
----------
T
W
L
G
Y
V
N
-
S
A
L
N
---
P
V
I
Y
T
T
F
N
I
E
-
F
R
K
A
F
L
K
I
L
S
C
------------------------------
32
HHSearch
82.25
15%
-150
- C7 -
3EML
13
ENLYS_BPT4
A:
[21-470]
----------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
----
V
E
L
A
I
A
V
L
A
I
L
-------
G
N
-----
V
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
N
Y
F
--------
V
-
V
-
S
-----------
L
A
A
A
----
D
I
A
V
G
--------------
V
L
----------
A
-
I
P
--------------
F
A
I
---------
T
I
---
S
T
---
G
F
C
A
---
A
-
C
H
---
G
-
C
L
F
------
I
A
C
F
V
L
V
----
L
T
---------------------
Q
---
S
S
I
F
S
L
-
L
A
I
A
I
D
----
R
Y
I
A
I
-----------------------------
R
I
--------------------
P
L
R
Y
N
G
L
---
V
---
T
G
T
-
R
A
K
G
I
I
A
------
I
------
C
W
V
L
S
F
A
I
G
L
T
P
-----
M
L
G
-
W
N
----------------
N
C
G
-----
Q
-------------------
S
Q
----
G
C
G
E
G
Q
------
V
---
A
C
L
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
---------
Y
L
---
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
----
S
L
A
I
I
V
-----
G
L
F
A
----
L
C
W
--------
L
P
L
H
I
I
N
C
F
T
F
F
--
C
-
P
D
---------
C
S--------
H
---
A
P
L
W
L
M
Y
-----
L
A
----------
I
V
L
S
H
T
N
-
S
V
V
N
---
P
F
I
Y
A
Y
R
I
R
E
-
F
R
Q
T
F
R
K
I
I
R
S
H
V
---
L
R
Q
----------------------
35
HHSearch
81.70
16%
-151
- C7 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-------------------------------------------------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
----
V
F
I
L
I
C
C
F
I
I
L
-------
E
N
-----
I
F
V
L
L
T
I
-
W
K
T
K
K
F
H
R
P
M
Y
Y
F
--------
I
-
G
-
N
-----------
L
A
L
S
----
D
L
L
A
G
--------------
V
A
----------
Y
-
T
A
--------------
N
L
L
---------
L
S
---
G
A
--
T
T
Y
K
L
---
T
-
P
A
---
Q
-
W
F
L
------
R
E
G
S
M
F
V
----
A
L
---------------------
S
---
A
S
V
F
S
L
-
L
A
I
A
I
E
----
R
Y
I
T
M
-----------------------------
L
K
----------------------------------
N
N
F
-
R
L
F
L
L
I
S
------
A
------
C
W
V
I
S
L
I
L
G
G
L
P
-----
I
M
G
-
W
N
----------------
C
I
------------------------
S
A
L
S
----
S
C
S
T
V
L
------
P
L
----------
Y
H
K
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
---------
Y
C
---
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
--
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
----
T
V
I
I
V
L
-----
S
V
F
I
----
A
C
W
--------
A
P
L
F
I
L
L
L
L
D
V
G
--
C
-
K
V
---------
K
T--------
C
---
D
I
L
F
R
A
E
-----
Y
F
----------
L
V
L
A
V
L
N
-
S
G
T
N
---
P
I
I
Y
T
L
T
N
K
E
-
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------
42
Fugue
81.63
14%
-128
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------------------------------------------------
M
N
G
T
E
G
P
N
F
Y
VPFSN
K
T
G
-
V
V
R
S
P
F
---------------
E
A
P
Q
Y
-
Y
L
A
---------
E
P
W
Q
F
S
M
L
A
A
----
Y
M
F
L
L
I
M
L
G
F
P
-------
I
N
-----
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
--------
L
--
L
N
-----------
L
A
V
A
----
D
L
F
M
V
--------------
F
G
----------
G
-
F
T
--------------
T
T
L
---------
Y
T
---
S
L
-
H
G
Y
F
V
F
---
G
-
P
T
---
G
-
C
N
L
------
E
G
F
F
A
T
L
----
G
G
---------------------
E
---
I
A
L
W
S
L
-
V
V
L
A
I
E
----
R
Y
V
V
V
-----------------------------
C
K
--------------------
P
M
S
N
F
R
F
---
G
---
E
N
H
-
A
I
M
G
V
A
F
------
T
------
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
G
W
-
S
R
----------------
Y
I
P
E
GMQC
S
------------
C
G
I
D
Y
Y
T
P
H
EETN
N
E
S
F
V
I
------
Y
M
F
V
V
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
-------------------------
V
K
E
A
A
A
S
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
----
M
V
I
I
M
V
-----
I
A
F
L
----
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
--
H
-
Q
G
---------
S
---------
D
---
F
G
P
I
F
M
T
-----
I
P
----------
A
F
F
A
K
T
S
-
A
V
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
P
S
TTVSKTETS
Q
V
A
P
A--------
24
HHSearch
81.20
16%
-143
- C7 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
----
V
A
G
S
L
S
L
V
T
I
I
-------
G
N
-----
I
L
V
M
V
S
I
-
K
V
N
R
H
L
Q
T
V
N
N
Y
F
--------
L
-
F
-
S
-----------
L
A
C
A
----
D
L
I
I
G
--------------
V
F
----------
S
-
M
N
--------------
L
Y
T
---------
L
Y
---
T
V
-
I
G
Y
W
P
L
---
G
-
P
V
---
V
-
C
D
L
------
W
L
A
L
D
Y
V
----
V
S
---------------------
N
---
A
S
V
M
N
L
-
L
I
I
S
F
D
----
R
Y
F
C
V
-----------------------------
T
K
--------------------
P
L
T
Y
P
V
K
---
R
---
T
T
K
-
M
A
G
M
M
I
A
------
A
------
A
W
V
L
S
F
I
L
W
A
P
A
-----
I
L
F
-
W
Q
----------------
F
I
V
-----
G
------------
V
R
--
T
V
E
D
G
----
E
C
Y
I
Q
F
------
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
---------
Y
W
---
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
----
T
I
L
A
I
L
-----
L
A
F
I
----
I
T
W
--------
A
P
Y
N
V
M
V
L
I
N
T
F
--
C
-
A
P
-------------------
C
---
I
P
N
T
V
W
T
-----
I
G
----------
Y
W
L
C
Y
I
N
-
S
T
I
N
---
P
A
C
Y
A
L
C
N
A
T
-
F
K
K
T
F
K
H
L
L
M
-------------------------------
25
HHSearch
79.10
17%
-141
- C7 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-497]
-------------------------------------------------------------------------------------------------------------------------
N
F
N
K
I
F
L
P
T
----
I
Y
S
I
I
F
L
T
G
I
V
-------
G
N
-----
G
L
V
I
L
V
M
-
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
--------
R
-
L
-
H
-----------
L
S
V
A
----
D
L
L
F
V
---------------
I
----------
T
-
L
P
--------------
F
W
A
---------
V
D
---
A
V
--
A
N
W
Y
F
---
G
-
N
F
---
L
-
C
K
A
------
V
H
V
I
Y
T
V
----
N
L
---------------------
Y
---
S
S
V
W
I
L
-
A
F
I
S
L
D
----
R
Y
L
A
I
-----------------------------
V
H
--------------------
A
T
N
S
Q
R
P
---
R
---
K
L
L
-
A
E
K
V
V
Y
V
------
G
------
V
W
I
P
A
L
L
L
T
I
P
D
-----
F
I
F
-
A
N
----------------
V
S
E
----------------------
A
D
D
R
Y
----
I
C
D
R
F
Y
------
P
N
--------
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
---------
Y
C
---
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
K
R
K
A
L
K
----
T
T
V
I
L
I
-----
L
A
F
F
----
A
C
W
--------
L
P
Y
Y
I
G
I
S
I
D
S
F
--
I
-
L
L
EI
I
K
Q
G
C
E
F
E
---------
N
---
T
V
H
K
W
I
S
-----
I
T
----------
E
A
L
A
F
F
H
-
C
C
L
N
---
P
I
L
Y
A
F
L
G
A
K
-
F
K
T
S
A
Q
H
A
L
T
S
G
R
---
P
L
E
----------------------
46
Fugue
78.41
19%
-164
* C6 *
4KQ7
6
?
A:
[2-374]
----------------------------------------------------QSNMTN
E
M
F
D
L
A
K
L
K
S
G
V
K
N
-----
K
R
I
-
S
S
T
D
P
T
GGNRDHLEPFKPGEK
R
I
I
A
D
-
I
K
G
M
--------
G
V
I
N
H
I
W
V
T
I
A
PPP
P
T
L
S
R
N
D
I
I
I
R
M
------
Y
W
-----
D
G
N
D
Y
------
P
S
V
E
S
P
I
G
P
F
--------
F
-
G
Q
G
WD
E
R
Y
N
Y
A
S
LP
L
S
A
G
P
ENG
T
G
L
S
C
Y
F
A
M
P
F
E
K
G
A
R
I
E
I
E
N
----------
Q
-
S
D
--------------
R
N
I
---------
D
A
---
F
Y
-
F
Y
V
D
Y
L
---
E
M
A
K
LPK
D
M
G
R
F
------
H
A
W
Y
N
H
N
----
L
T
EALPEGETEWGVT
G
A
Q
K
P
N
TT
G
---
E
R
N
Y
V
F
M
E
T
Q
G
K
G
----
H
F
V
G
I
-----------------------------
N
Y
--------------------
Y
V
H
C
P
T
P
M--
W
YGE
G
D
D
M
W
F
I
D
G
E
K
------
V
------
P
S
L
I
G
T
G
T
E
D
F
F
-----
N
T
----------------------
A
-----
W
------------
C
P
K
E
A
F
S
H
P
----
Y
F
G
-
Y
P
------
R
V
N
N
D
I
G
W
--
L
G
R
T
H
V
Y
R
F
F
I
E
D
----------
P
I
F
---------
F
E
---
K
S
L
K
G
T
I
E
H
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------
N
L
T
L
D
L
-----
S
T
V
A
----
Y
W
Y
--------
Q
D
S
A
V
A
L
P
E
A
P
T
--
K
-
A
Q
---------
R
---------
A
---
P
K
-------------------------------------
P
F
I
N
H
V
D
I
H
R
-
W
R
D
A
W
R
K
S
K
G
N
K
A
TLW
G
N
E
----------------------
43
Fugue
75.87
14%
-118
- C7 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------------------------MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
-----
K
T
G
-
V
V
R
S
P
F
---------------
E
A
P
Q
Y
-
Y
L
A
---------
E
P
W
Q
F
S
M
L
A
A
----
Y
M
F
L
L
I
M
L
G
F
P
-------
I
N
-----
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
--------
L
--
L
N
-----------
L
A
V
A
----
D
L
F
M
V
--------------
F
G
----------
G
-
F
T
--------------
T
T
L
---------
Y
T
---
S
L
-
H
G
Y
F
V
F
---
G
-
P
T
---
G
-
C
N
L
------
E
G
F
F
A
T
L
----
G
G
---------------------
E
---
I
A
L
W
S
L
-
V
V
L
A
I
E
----
R
Y
V
V
V
-----------------------------
C
K
--------------------
P
M
S
N
F
R
F
---
G
---
E
N
H
-
A
I
M
G
V
A
F
------
T
------
W
V
M
A
L
A
C
A
A
P
P
L
-----
V
G
W
-
S
R
----------------
Y
I
P
E
GMQC
S
------------
C
G
I
D
Y
--------
Y
T
P
H
E
E
------
T
N
N
E
S
F
V
I
--
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
---------
E
A
---
A
A
Q
Q
Q
E
-
S
A
T
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
----
M
V
I
I
M
V
-----
I
A
F
L
----
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
--
H
-
Q
G
---------
S
---------
D
---
F
G
P
I
F
M
T
-----
I
P
----------
A
F
F
A
K
T
S
-
A
V
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
P
L
GDDEA
S
T
T
V
S
K
TETSQVAPA--
51
Fugue
75.60
18%
-167
- C2 -
4XR7
-
PAN3_YEAST
B:
[1-456]
---------MH
S
L
L
Q
YRSADQLFIPNN
I
R
E
D
L
T
K
K
N
L
S
I
L
QVFPSSGKVIPSIVQDYFNLVP
L
N
F
N
N
K
T
T
L
F
-----
K
V
F
S
N
Y
D
G
K
A
---------------
Y
V
L
K
R
-
L
P
N
IDKSMNP
N
K
I
S
K
I
Y
Q
I
W
S
K
----
I
N
C
T
N
L
I
K
F
R
D
I
F
Q
T
TKF
G
D
-----
L
S
I
C
L
V
F
D
Y
Y
P
N
S
L
S
L
Y
D
Y
H
F
--------
V
-
N
F
P
KFP--------
I
T
N
N
----
Y
L
W
I
Y
--------------
L
V
----------
Q
-
L
T
--------------
N
V
I
---------
N
S
---
I
H
-
S
Q
N
L
S
I
---
G
-
N
T
---
L
-
N
W
R
------
K
V
L
I
T
G
---------------------------------
D
P
G
R
I
-
K
L
S
H
C
N
-----
F
M
D
L
-----------------------------
L
F
--------------------
N
D
D
T
D
T
V
---
V
---
S
S
T
-
I
E
G
Q
Q
Q
L
------
D
------
Y
K
Y
L
G
E
L
L
F
N
L
S
-----
I
N
I
-
E
N
S
NNN
T
A
P
K
E
Y
R
LEEIT
P
Q
S
-----
I
------------
D
D
M
R
Q
I
D
D
K
----
F
K
D
V
L
K
------
Y
L
I
S
D
N
G
D
--
S
K
K
S
-
I
H
D
L
T
S
H
F
Y
D
K
M
F
M
V
L
E
S
S
Q
T
---------
Y
T
---
E
Y
M
E
S
V
L
S
R
E
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
G
R
L
F
R
L
V
----
N
K
L
N
C
I
FGRIE
S
R
I
D
----
I
N
W
SESGTK
F
P
I
I
L
F
Y
D
Y
V
F
H
Q
V
D
S
N
-
G
K
---------
P
---------
I
---
M
D
L
T
H
V
L
-----
R
C
L
N
K
L
D
A
GIQ
E
K
L
M
L
V
T
P
-
D
E
L
N
---
C
I
I
I
S
--
Y
K
E
-
L
K
D
L
I
E
S
T
F
R
S
I
T
---
Q
H
-----------------------
28
HHSearch
75.06
16%
-144
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
---------------------------------------------------------------------------------------------------------------------------
W
V
V
G
M
G
I
----
V
M
S
L
I
V
L
A
I
V
F
-------
G
N
-----
V
L
V
I
T
A
I
-
A
K
F
E
R
L
Q
T
V
T
N
Y
F
--------
I
-
T
-
S
-----------
L
A
C
A
----
D
L
V
M
G
--------------
L
A
----------
V
-
V
P
--------------
F
G
A
---------
A
H
---
I
L
-
M
K
M
W
T
F
---
G
-
N
F
---
W
-
C
E
F
------
W
T
S
I
D
V
L
----
C
V
---------------------
T
---
A
S
I
E
T
L
-
C
V
I
A
V
D
----
R
Y
F
A
I
-----------------------------
T
S
--------------------
P
F
K
Y
Q
S
L
---
L
---
T
K
N
-
K
A
R
V
I
I
L
------
M
------
V
W
I
V
S
G
L
T
S
F
L
P
-----
I
Q
M
H
W
Y
----------------
R
A
T
-----
H
-----------------
Q
E
A
I
----
N
C
Y
A
E
E
----------
T
C
C
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
---------
Y
S
---
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
----
T
L
G
I
I
M
-----
G
T
F
T
----
L
C
W
--------
L
P
F
F
I
V
N
I
V
H
V
I
--
Q
-
D
----------
N
---------
L
---
I
R
K
E
V
Y
I
-----
L
L
----------
N
W
I
G
Y
V
N
-
S
G
F
N
---
P
L
I
Y
C
-
R
S
P
D
-
F
R
I
A
F
Q
E
L
L
C
L
------------------------------
31
HHSearch
73.06
15%
-137
- C7 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
----------------------------------------------------------------------------------------------------------------------------
I
V
L
W
A
A
----
A
Y
T
V
I
V
V
T
S
V
V
-------
G
N
-----
V
V
V
M
W
I
I
-
L
A
H
K
R
M
R
T
V
T
N
Y
F
--------
L
-
V
-
N
-----------
L
A
F
A
----
E
A
S
M
A
--------------
A
F
----------
N
-
T
V
--------------
V
N
F
---------
T
Y
---
A
V
-
H
N
E
W
Y
Y
---
G
-
L
F
---
Y
-
C
K
F
------
H
N
F
F
P
I
A
----
A
V
---------------------
F
---
A
S
I
Y
S
M
-
T
A
V
A
F
D
----
R
Y
M
A
I
-----------------------------
I
H
--------------------
P
L
Q
P
R
L
--------
S
A
T
-
A
T
K
V
V
I
C
------
V
------
I
W
V
L
A
L
L
L
A
F
P
Q
-----
G
Y
Y
-
S
T
----------------
T
E
T
----------------------
M
P
S
R
V
----
V
C
M
I
E
W
------
P
E
H
---
P
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
---------
Y
T
---
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
----
M
M
I
V
V
V
-----
C
T
F
A
----
I
C
W
--------
L
P
F
H
I
F
F
L
L
P
Y
I
--
N
-
P
D
---------
L
---------
Y
LKK
F
I
Q
Q
V
Y
L
-----
A
I
----------
M
W
L
A
M
S
S
-
T
M
Y
N
---
P
I
I
Y
C
C
L
N
D
R
-
F
R
L
G
F
K
H
A
F
R
C
C
P
---
F
I
S
----------------------
36
HHSearch
71.45
15%
-140
- C7 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------------------------------------------------------------------------------
L
N
K
Y
V
V
I
I
----
A
Y
A
L
V
F
L
L
S
L
L
-------
G
N
-----
S
L
V
M
L
V
I
-
L
Y
S
R
V
G
R
S
V
T
D
V
Y
--------
L
-
L
-
N
-----------
L
A
L
A
----
D
L
L
F
A
--------------
L
T
------------
L
P
--------------
I
W
A
---------
A
S
---
K
--
V
N
G
W
I
F
---
G
-
T
F
---
L
-
C
K
V
------
V
S
L
L
K
E
V
----
N
F
---------------------
Y
---
S
G
I
L
L
L
-
A
C
I
S
V
D
----
R
Y
L
A
I
-----------------------------
V
H
--------------------
A
T
R
T
L
T
Q
-------
K
R
H
-
L
V
K
F
V
C
L
------
G
------
C
W
G
L
S
M
N
L
S
L
P
F
-----
F
L
F
-
R
Q
----------------
A
Y
H
-----
P
----------------
N
N
S
S
P
----
V
C
Y
E
V
L
------
G
N
D
----
T
--
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
---------
Y
G
---
F
T
L
R
T
L
F
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
----
V
I
F
A
V
V
-----
L
I
F
L
----
L
C
W
--------
L
P
Y
N
L
V
L
L
A
D
T
L
--
M
-
R
T
---------
Q
VIQE
S
C
E
R
R
N
---
N
I
G
R
A
L
D
-----
A
T
----------
E
I
L
G
F
L
H
-
S
C
L
N
---
P
I
I
Y
A
F
I
G
Q
N
-
F
R
H
G
F
L
K
I
L
A
M
H
G
----------------------------
34
HHSearch
69.44
13%
-127
- C7 -
1U19
14
OPSD_BOVIN
A:
[37-327]
-------------------------------------------------------------------------------------------------------------------------
P
W
Q
F
S
M
L
A
A
----
Y
M
F
L
L
I
M
L
G
F
P
-------
I
N
-----
F
L
T
L
Y
V
T
-
V
Q
H
K
K
L
R
T
P
L
N
Y
I
--------
L
-
L
-
N
-----------
L
A
V
A
----
D
L
F
M
V
--------------
F
G
----------
G
-
F
T
--------------
T
T
L
---------
Y
T
---
S
L
-
H
G
Y
F
V
F
---
G
-
P
T
---
G
-
C
N
L
------
E
G
F
F
A
T
L
----
G
G
---------------------
E
---
I
A
L
W
S
L
-
V
V
L
A
I
E
----
R
Y
V
V
V
-----------------------------
C
K
--------------------
P
M
S
N
F
R
F
-------
G
E
N
-
H
A
I
M
G
V
A
------
F
------
T
W
V
M
A
L
A
C
A
A
P
P
-----
L
V
G
-
W
S
----------------
R
Y
I
-----
P
----------------
E
G
M
Q
C
----
S
C
G
I
D
Y
------
Y
T
P
---
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
---------
Y
G
---
Q
L
V
F
T
V
K
E
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
----
M
V
I
I
M
V
-----
I
A
F
L
----
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
--
H
-
Q
G
---------
S
---------
D
---
F
G
P
I
F
M
T
-----
I
P
----------
A
F
F
A
K
T
S
-
A
V
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
-
F
R
N
C
M
V
T
T
L
C
C
G
K
---
N
P
L
----------------------
47
Fugue
69.27
16%
-151
- C5 -
3WI3
17
SLD3_YEAST
A:
[8-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
S
D
P
K
E
Y
---
I
-
E
S
---
K
-
Y
Y
D
------
A
L
F
S
I
H
T
PLAY
F
V
---------------------
K
---
S
N
L
V
R
L
-
K
N
T
C
R
T
----
K
Y
G
S
D
-----------------------------
S
Y
--------------------
K
I
A
Y
Q
A
M
---
L
---
Q
K
F
-
L
L
S
I
V
Q
F
------
K
------
D
R
H
D
N
R
L
L
L
E
P
F
SS---
P
I
A
-
D
E
----------------
K
R
K
-----
N
------------
C
L
T
K
F
V
I
Q
D
----
E
N
K
N
S
S
------
T
I
A
D
L
C
V
V
--
L
K
S
R
E
I
K
-
L
Q
I
L
L
L
L
E
I
I
G
L
N
D
L
D
W
N
---------
F
R
DFD
Y
C
E
Q
L
D
L
Y
L
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
I
L
D
I
L
L
S
S
ETG
T
I
Q
E
H
K
-----
K
N
I
L
DKSK
E
A
S
--------
L
V
G
F
I
N
Y
V
L
I
P
Y
--
F
-
N
K
---------
K
---------
V
---
P
H
A
V
E
F
I
-----
I
Q
----------
K
L
K
---
G
-
P
S
---------------------------------------------------------
48
Fugue
58.66
14%
-190
- C6 -
1WCD
-
POLS_IBDVC
J:
[11-431]
-------------------------------------------------------------I
V
P
F
I
R
S
L
L
M
P
-----
T
T
G
-
P
A
S
I
P
D
---------------
D
T
L
E
K
H
T
L
R
---------
S
E
T
S
T
Y
N
L
T
V
----
G
D
T
G
S
G
L
I
V
F
F
-------
P
G
FPGSI
V
G
A
H
Y
T
L
-
Q
G
N
G
N
Y
K
F
D
Q
M
L
L
TAQNLPAS
Y
-
N
Y
C
-----------
R
L
V
S
----
R
S
L
T
V
--------------
R
S
S---------
T
-
L
P
--------------
G
G
V
YALNGTINA
V
T
---
F
Q
-
G
S
L
S
E
L
TDV
S
-
Y
N
---
G
-
L
M
S
------
A
T
A
N
I
N
D
----
K
I
---------------------
G
NVL
V
G
E
G
V
T
-
V
L
S
L
P
T
SYDL
G
Y
V
R
L
-----------------------------
G
D
PIPAIGLDPKMVATCDSSDR
P
R
V
Y
T
I
T
---
A
---
A
D
D
-
Y
Q
F
S
S
Q
Y
------
Q
PGGVTI
T
L
F
S
A
N
I
D
A
I
T
S
-----
L
S
V
-
G
G
----------------
E
L
V
-----
F
RTSVHGLVLGAT
I
Y
L
I
G
F
D
G
T
----
T
V
I
T
R
A
------
V
A
A
N
N
G
L
T
--
T
G
T
D
N
L
M
P
F
N
L
V
I
P
T
N
E
I
T
Q
P
I
T
S
I
K
---------
L
E
---
I
V
T
S
K
S
G
G
Q
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
S
W
S
A
R
G
----
S
L
A
V
T
I
-----
H
G
G
N
----
Y
P
G
--------
A
L
R
P
V
T
L
V
A
Y
E
-----
R
V
---------
A
---------
T
---
G
S
V
V
T
V
A
-----
G
V
----------
S
N
F
E
L
I
P
N
P
E
L
A
KNL
V
T
E
Y
G
R
F
D
P
G
-
A
M
N
Y
T
K
L
I
L
S
E
R
D
---
R
L
G
IKTVWPTREYTDFREYFMEVAD
50
Fugue
56.05
14%
-114
- C4 -
3MKT
-
?
A:
[2-461]
ENS
V
H
R
Y
K
K
E
A
S
N
L
I
K
L
A
T
P
V
L
I
A
S
V
A
Q
T
G
MGFVDTIMAGGVSAID
M
A
A
V
S
I
A
A
SIW
L
P
S
I
L
F
G
V
G
L
L
M
A
L
V
-----
P
V
V
-
A
Q
L
N
G
A
---------------
G
R
Q
H
K
-
I
P
F
---------
E
V
H
Q
G
L
I
L
A
L
----
L
V
S
V
P
I
I
A
V
L
F
-------
Q
T
-----
Q
F
I
I
R
F
M
-
D
V
E
E
A
M
A
T
K
T
V
G
Y
--------
M
H
A
V
I
-----------
F
A
V
P
----
A
Y
L
L
F
--------------
Q
A
L
RSFTDGMSL
T
-
K
P
--------------
A
M
V
---------
I
G
---
F
I
-
G
L
L
L
N
I
---
P
-
L
N
---
W
-
I
F
V
YGKFG
A
P
E
L
G
G
V
G
----
C
G
---------------------
V
---
A
T
A
I
V
Y
-
W
I
M
L
L
L
----
L
L
F
Y
I
VTSKRLAHVK
V
F
E
T
F
H
K
P
Q
P
K
EL
I
R
L
F
R
L
G
F
--------------------
P
V
A
A
A
L
F
---
F
---
E
V
T
-
L
F
A
V
V
A
L
LVAPLG
S
------
T
V
V
A
A
H
Q
V
A
L
N
F
-----
S
S
L
-
V
F
----------------
M
F
P
-----
M
------------
S
I
G
A
A
V
S
I
R
----
V
G
H
K
L
G
E
QDTKG
A
A
I
A
A
N
V
G
--
L
M
T
G
L
A
T
A
C
I
T
A
L
L
T
V
L
F
R
E
Q
I
A
L
L
Y
TENQVV
V
A
L
A
M
---
Q
L
L
L
F
A
A
I
Y
Q
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
V
Q
V
V
A
A
----
G
S
L
R
G
Y
-----
K
D
M
T
----
A
I
F
--------
H
R
T
F
I
S
Y
W
V
L
G
L
--
P
T
G
Y
---------
I
---------
L
---
G
M
T
N
W
L
T
EQPL
G
A
K
----------
G
F
W
L
G
F
I
-
I
G
L
S
---
A
A
A
L
M
L
G
Q
R
L
Y
W
L
Q
K
Q
S
D
D
V
Q
L
H
L
---
A
A
K
----------------------
1
PsiBlast_PDB
56.02
22%
-150
- C7 -
3RZE
2
ENLYS_BPT4 (first)
A:
[26-177]
---------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
L
L
V
L
Y
A
V
-
R
S
E
R
K
L
H
T
V
G
N
L
Y
--------
I
-
V
-
S
-----------
L
S
V
A
----
D
L
I
V
G
--------------
A
V
----------
V
-
M
P
M
N
I
L
Y
L
L
M
SKWSLG
R
P
L
---------
C
L
---
F
W
-
L
S
M
------
D
-
Y
V
---
A
-
S
T
A
------
S
I
F
S
V
----------------------------------------
F
I
L
C
I
D
----
R
Y
R
S
V
-----------------------------
Q
Q
--------------------
P
L
R
Y
L
K
Y
---
R
---
T
K
T
-
R
A
S
A
T
I
L
------
G
------
A
W
F
L
S
F
L
W
V
I
P
I
L
GWNH-----
R
----------------
R
E
D
-----
K
------------
C
E
T
D
F
Y
D
V
T
----
W
F
K
V
M
T
------
A
I
I
N
F
Y
L
P
--
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
---------
I
D
---
E
G
L
R
L
K
I
Y
K
D
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Y
T
I
G
I
G
----
H
L
L
T
K
S
-----
P
S
L
N
----
A
A
K
--------
S
E
L
D
K
A
I
G
R
N
T
N
--
G
-
V
I
---------
T
---------
K
---
D
E
A
E
K
L
F
-----
N
Q
----------
D
V
D
A
A
V
R
-
G
I
L
R
---
N
A
K
L
K
P
V
Y
D
S
-
L
D
A
V
R
R
A
A
L
I
N
M
V
---
F
Q
M
----------------------
9
PsiBlast_PDB
53.80
27%
-154
- C7 -
2YDO
1
?
A:
[8-118]
-----------------------------------------------------------------------------------------------------------------------------
V
Y
I
T
V
----
E
L
-
A
I
A
V
L
A
I
L
-------
G
N
-----
V
L
V
C
W
A
V
-
W
L
N
S
N
L
Q
N
V
T
N
Y
F
--------
V
-
V
S
A
-----------
A
A
-
A
----
D
I
L
V
G
--------------
V
L
----------
A
-
I
P
--------------
F
A
I
---------
A
I
S
T
G
F
C
-
A
A
C
H
G
C
---
L
-
F
I
---
A
-
C
-----------
F
V
L
V
----
L
T
---------------------
A
---
S
S
I
F
S
L
-
L
A
I
A
I
D
----
R
Y
I
A
I
-----------------------------
R
I
--------------------
P
L
R
Y
N
G
L
---
V
---
T
G
T
-
R
A
K
G
I
I
A
------
I
------
C
W
V
L
S
F
A
I
G
L
T
P
-----
M
L
G
-
W
N
----------------
N
C
G
-----
Q
------------
P
K
E
G
K
A
H
S
Q
----
G
C
G
E
G
Q
------
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
---------
L
R
---
I
F
L
A
A
R
R
Q
L
K
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
T
L
Q
K
E
V
----
H
A
A
K
S
L
-----
A
I
I
V
----
G
L
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
--
F
-
T
F
---------
F
---------
C
---
P
D
C
S
H
A
P
-----
L
W
----------
L
M
Y
L
A
I
V
-
L
S
H
T
---
N
S
V
V
N
P
F
I
Y
A
-
Y
R
I
R
E
F
R
Q
T
F
R
K
I
---
I
R
S
----------------------