@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4X2_HUMAN: (2016-01-13 )
MTEFIFLVLSPNQEVQRVCFVIFLFLYTAIVLGNFLIVLTVMTSRSLGSPMYFFLSYLSFMEICYSSATAPKLISDLLAERKVISWWGCMAQLFFLHFFGGTEIFLLTVMAYDHYVAICKPLSYTTIMNWQVCTVLVGIAWVGGFMHSFAQILLIFHLLFCGPNVINHYFCDLVPLLKLACSDTFLIGLLIVANGGTLSVISFGVLLASYMVILLHLRTWSSEGWCKALSTCGSHFAVVILFFGPCVFNSLRPSTTLPIDKMVAVFYTVITAILNPVIYSLRNAEMRKAMKRLWIRTLRLNEK
Atome Classification :
(20 SA)
----------------------......-----------------...10........20.....-------...30........40........50....-....60........-70........80---.........90........100.......110.......120.......--130.......140-.........150.----------......160.......170-........180---...---.--...190.......200.----...---...210.......220------------.---------------------...--...230-----..-------------......240....--------...250-...--.------.----.--.---.260--------.-.......270.......280.......290.---......300.--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------M
T
E
F
I
F
-----------------
L
V
LSP
N
Q
E
V
Q
R
V
C
F
V
I
F
L
F
L
-------
Y
T
A
I
V
LGN
F
L
I
V
L
T
V
MTSRSLG
S
P
M
Y
F
F
L
-
S
Y
L
S
F
M
E
I
C
YSSAT-
A
P
K
L
I
S
D
L
L
AE----
R
K
V
I
S
W
W
G
C
M
A
Q
L
F
F
L
H
FFGG
T
E
I
F
L
L
T
V
MAYD
H
Y
V
A
I
CKPL
S
Y
T
T
I
MN--
W
Q
V
C
T
V
L
V
G
I
A
---
W
V
G
G
F
M
H
S
F
A
Q
I
L
----------
L
I
F
H
L
L
FCG
P
N
V
I
N
H
Y
F
C
--
D
L
V
P
L
L
K
L
ACS---D
T
F
---
L
--
I
G
L
L
I
V
ANGG
T
L
S
V
I
S
F
----
G
V
L
---
L
A
S
Y
M
V
I
L
L
H
L
RTWSS------------E---------------------
G
W
C
--
K
A
L
S
T------CG-------------S
H
F
A
V
V
I
L
F
F
G
P
C
--------
V
F
NSL--RPS--T------T----L--
P
---
I
D
K
---------
M
-
V
A
V
F
Y
T
V
I
T
A
I
L
N
P
V
I
Y
S
LR
N
A
E
M
R
K
A
M
K
R
L
---
W
I
R
T
LRLNEK--------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
94.22
21%
-167
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[21-311]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQPKE
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
ACV
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------
Q
---------------------
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
-------H---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
R
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
92.59
21%
-171
- C1 -
2YDV
6
?
A:
[21-311]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------
Q
-----------------------------
S
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
------
S
H---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
R
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.83
21%
-167
- C1 -
2YDO
3
?
A:
[21-311]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-------------------------------------------
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
------
S
H---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
R
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
90.04
22%
-163
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[21-308]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQ-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
ACV
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------
Q
---------------------
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
------
S
H
---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.78
21%
-174
- C1 -
4UG2
3
?
A:
[21-309]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
A
C
V
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
---------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
------
S
H---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.41
22%
-167
- C1 -
3VG9
8
?
A:
[21-309]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQ-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
ACV
L
--
V
P
L
L
L
M
----------
L
----
G
V
Y
---
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------
Q
---------------------
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
-------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
--
C
P
D
--
C
------
S
H
---
A
--
P
---
L
W
L
---------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
----
I
R
S
H
V
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
86.25
16%
-157
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-335]
-----------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
-------
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
-
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
----
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
--
H
R
R
A
F
I
M
I
I
F
V
---
W
L
W
S
V
L
W
A
I
G
P
I
F
----------
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
--
S
F
D
Y
I
S
--------
R
D
S
---
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
----
L
I
I
---
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
--
R
L
A
K
I
------
S
I
-------------
V
I
V
S
Q
F
L
L
S
W
S
P
Y
--------
A
V
V
A
L
--
L
A
Q
--
F
------
G
PLE-
W
VT
P
---
Y
A
A
---------
Q
-
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
---
F
P
W
V
L
T
C
C
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
81.61
18%
-145
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------MN
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSPFEAPQ
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-------
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
--
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
E
G
M
Q
C
--
S
C
G
I
--
D
Y
Y
T
P
H
E
E
T
N
N
---
E
S
F
---
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
K
A
E
------------
K
---------------------
E
V
T
--
R
M
V
I
I
------
M
V
-------------
I
A
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
--
D
------
F
----
G
--
P
---
I
F
M
---------
T
-
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
78.41
18%
-134
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFSNKTGVVRS
P
F
E
A
P
Q
-----------------
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-------
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
--
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
---
E
S
F
---
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
----
C
Y
G
---
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
------------
A
---------------------
T
T
Q
--
K
A
E
K
E
------
V
T
-------------
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
--
G
V
A
--
F
------
Y
----
I
--
F
---
T
H
Q
GSDFGPIFM
T
-
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
76.99
15%
-156
* C1 *
2KS9
1
NK1R_HUMAN
A:
[34-326]
--------------------------------------------------------
L
W
A
A
A
Y
T
V
I
-------
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
-
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
----
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
--
A
T
A
T
K
V
V
I
C
V
I
---
W
V
L
A
L
L
L
A
F
P
Q
G
Y
----------
Y
S
T
T
-
E
T
----
M
P
S
R
V
V
C
--
M
I
E
W
P
E
H
P
------
N
K
I
---
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
----
L
V
I
---
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
K
R
--
K
V
V
K
M
------
M
I
-------------
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
--
L
P
Y
--
I
NPD---
L
YL--
K
--
K
FI
Q
Q
V
Y
---------
L
-
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
---
F
R
C
C
P
F
I
S
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
75.04
13%
-128
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
-------
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
----
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
S
G
L
T
S
F
L
P
I
Q
----------
M
-------
H
W
Y
R
A
T
H
Q
E
A
--
I
N
C
Y
A
E
E
T
C
C
D
---
F
F
T
---
N
--
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
P
L
----
V
I
M
---
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------
I
---------------------
F
E
M
--
L
R
I
D
E
------
G
L
-------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
--
L
L
T
--
K
------
S
----
P
--
S
---
L
N
A
---------
A
-
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
33
HHSearch
74.14
16%
-152
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-329]
-------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
-------
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
-
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
----
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
--
E
N
H
A
I
M
G
V
A
F
T
---
W
V
M
A
L
A
C
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
--
G
I
D
Y
Y
T
P
---
H
---
E
E
T
---
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
----
I
V
I
---
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------
Q
QQESA
T
T
Q
K
------------
A
E
K
--
E
V
T
R
M
------
V
I
-------------
I
M
V
I
A
F
L
I
C
W
L
P
Y
--------
A
G
V
A
F
--
Y
I
F
T
H
Q
------
G
SDF-
G
--
P
---
I
F
M
---------
T
-
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
---
L
C
C
G
K
N
P
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
69.89
21%
-171
- C1 -
3EML
8
ENLYS_BPT4
A:
[21-220]
------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
-------
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
------
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
G
Q
-------
S
Q
G
C
--
G
E
G
Q
---
V
A
C
L
---
F
E
D
---
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
----
L
L
M
---
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
------------
I
---------------------
F
E
M
--
L
R
I
D
E
------
G
L
-------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
--
L
L
T
--
K
------
S
----
P
--
S
---
L
N
A
---------
A
-
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---
A
V
R
G
I
L
R
N
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
69.40
15%
-172
* C2 *
3ZPJ
-
?
A:
[1-356]
----M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
A
K
V
Y
-----------------
E
I
E
D
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
DGPME
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
L
R
D
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
E
---
Y
E
E
D
-
A
M
D
F
F
N
R
A
I
D
E
A
N
E
I
E
S
P
I
E
K
G
M
V
L
S
T
L
A
Y
H
L
A
I
A
G
Y
P
D
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
A
E
T
S
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
L
P
S
N
E
A
M
D
F
Y
K
M
A
F
----------
D
I
F
D
K
L
--
H
V
N
Q
R
A
A
I
V
E
--
K
K
I
E
L
A
K
T
V
Y
D
VGL
P
Q
I
---
R
--
A
A
L
L
K
G
K
N
H
Y
A
L
A
I
I
K
K
K
YSG
V
M
R
---
L
I
G
E
L
E
V
A
L
W
M
K
R
V
N
N
------------
M
---------------------
E
Y
L
--
D
V
V
D
K
------
A
F
E
C
CESPRFT
D
V
N
V
Q
H
I
A
R
L
L
T
E
L
G
------------
N
L
R
--
R
A
L
--
K
------
F
----
A
--
K
---
E
I
Q
---------
N
-
I
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
K
K
F
E
E
V
K
K
I
I
E
S
I
PD
P
K
I
R
E
E
A
L
N
E
I
GTIE----------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
68.70
16%
-149
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[38-323]
-----------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
-------
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
-
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
----
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
--
R
H
L
V
K
F
V
C
L
G
C
---
W
G
L
S
M
N
L
S
L
P
F
F
L
----------
F
R
Q
A
Y
H
P
----
N
N
S
S
P
V
C
--
Y
E
V
L
G
N
D
---
T
----
A
K
---
W
--
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
----
F
V
M
---
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
------------
G
---------------------
Q
K
H
--
R
A
M
R
V
------
I
F
-------------
A
V
V
L
I
F
L
L
C
W
L
P
Y
--------
N
L
V
L
L
--
A
D
T
L
M
R
TQVIQE
S
C
E
R
R
N
--
N
I
G
-
R
A
L
---------
D
-
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
---
L
A
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
67.19
23%
-160
- C1 -
3QAK
1
ENLYS_BPT4
A:
[36-189]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCG---------
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
---
A
--
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
----
L
A
A
---
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
------------
R
---------------------
L
K
I
--
Y
K
D
T
E
------
G
Y
-------------
Y
T
I
G
I
G
H
L
L
T
K
S
P
--------
S
L
N
A
A
--
K
S
E
--
L
------
D
----
K
--
A
---
I
G
R
---------
N
-
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---
K
P
V
Y
D
S
L
D
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
66.52
18%
-152
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-234]
-------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
-------
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
-
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
----
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
S
G
L
T
S
F
L
P
I
Q
----------
M
H
W
Y
R
A
T
--
H
--
Q
E
A
I
N
C
--
Y
A
E
----
E
T
C
C
---
D
F
F
---
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
----
V
I
M
---
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------
I
---------------------
F
E
M
--
L
R
I
D
E
------
G
L
-------------
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
--
L
L
T
--
K
------
S
----
P
--
S
---
L
N
A
---------
A
-
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
---
A
V
R
G
I
L
R
N
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.88
23%
-168
- C1 -
3PWH
1
?
A:
[21-174]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
---
A
--
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
----
A
A
A
---
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
------------
A
---------------------
R
S
T
--
L
Q
K
E
V
------
H
A
-------------
A
K
S
A
A
I
I
A
G
L
F
A
L
--------
C
W
L
P
L
--
H
I
I
--
N
------
C
----
F
--
T
---
F
F
C
---------
P
-
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
---
I
R
E
F
R
Q
T
F
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.79
23%
-166
- C1 -
3EML
8
ENLYS_BPT4
A:
[36-189]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
K
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQ-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
---
A
--
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
----
L
A
A
---
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
------------
R
---------------------
L
K
I
--
Y
K
D
T
E
------
G
Y
-------------
Y
T
I
G
I
G
H
L
L
T
K
S
P
--------
S
L
N
A
A
--
K
S
E
--
L
------
D
----
K
--
A
---
I
G
R
---------
N
-
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---
K
P
V
Y
D
S
L
D
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.79
23%
-168
- C1 -
3REY
1
AA2AR_HUMAN
A:
[21-174]
----------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--
G
T
R
A
A
G
I
I
A
I
C
---
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQP--------
G
C
G
E
G
Q
V
A
C
L
F
E
--
D
V
V
P
M
N
Y
M
V
Y
F
---
N
F
F
---
A
--
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
----
A
A
A
---
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
------------
A
---------------------
R
S
T
--
L
Q
K
E
V
------
H
A
-------------
A
K
S
A
A
I
I
A
G
L
F
A
L
--------
C
W
L
P
L
--
H
I
I
--
N
------
C
----
F
--
T
---
F
F
C
---------
P
-
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
---
I
R
E
F
R
Q
T
F
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------