@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR5T2_HUMAN: (2016-01-13 )
MSYSIYKSTVNIPLSHGVVHSFCHNMNCNFMHIFKFVLDFNMKNVTEVTLFVLKGFTDNLELQTIFFFLFLAIYLFTLMGNLGLILVVIRDSQLHKPMYYFLSMLSSVDACYSSVITPNMLVDFTTKNKVISFLGCVAQVFLACSFGTTECFLLAAMAYDRYVAIYNPLLYSVSMSPRVYMPLINASYVAGILHATIHTVATFSLSFCGANEIRRVFCDIPPLLAISYSDTHTNQLLLFYFVGSIELVTILIVLISYGLILLAILKMYSAEGRRKVFSTCGAHLTGVSIYYGTILFMYVRPSSSYASDHDMIVSIFYTIVIPLLNPVIYSLRNKDVKDSMKKMFGKNQVINKVYFHTKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.......--.80--.........90........100.......110....-...-120...-....-------130.......140..---..---...150.......160....-----...170..---..-...180.......190.......200.....---------------------..210......-.220.....------------------..-------230--.......240.......250.......260.......------------------------------------------------------------------------------------------------------------------------------------------------------------------270-----------------------------------------------------------------------------------------------------------------------------------------------------------------.........280.......------------290..-----------.....300...----..---.-------.310.......320.......330.......340..--.....350.......--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
Y
S
I
Y
K
S
T
VNIPLSH
G
V
V
H
S
F
C
HNMNC
N
F
M
H
I
F
K
F
V
L
DFNMKNV
T
E
V
T
L
F
V
LKGFTDNL
E
L
Q
T
I
F
F
F
L
F
L
A
I
Y
L
F
T
L
--MG---NL
G
L
I
L
V
V
I
RDSQLH
K
P
M
Y
Y
F
L
S
M
L
S
S
V
D
A
C
Y
S
SVI-TP
N
-
M
L
V
D
FT-TK
N
K
-------
V
I
S
F
L
G
C
V
A
Q
V
F
L
A
C---SF---G
T
T
E
C
F
L
L
A
A
M
A
Y
D
R
Y
V
A
I
Y
-----
N
P
L
L
Y
SVS---MS-
P
R
V
Y
M
P
LI
N
A
S
Y
V
A
G
I
L
H
A
T
I
H
T
V
A
T
F
S
L
SF---------------------C
G
A
N
E
I
R
R
V
F
C-DIP
P
L
L
A
I
S
------------------YS-------DTH--T
N
Q
L
L
L
F
Y
F
VG
S
I
E
L
V
T
I
L
I
V
L
I
S
Y
G
L
I
L
L
A
I
L
K
M
YS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
R
R
K
V
F
S
TCGAHLT
G
V
S
I
------------
Y
Y
G
T
I
-----------
L
F
M
Y
VRPSSSY----AS---
D
-------
H
D
M
I
V
S
I
F
Y
T
I
V
I
P
L
L
N
P
V
I
Y
S
LRNK
D
V
K
D
S
M
K
K
M
F--GKN
Q
V
I
N
K
V
Y
F
HTKK--------------------
28
HHSearch
81.40
17%
-144
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
-
A
I
T
I
S
T
---
G
F
-------
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
---
V
L
---
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
G
L
---
V
T
-
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
----------------------------
S
Q
G
C
-
G
E
G
Q
---
V
A
------------------
C
L
-------
F
E
D
VV
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
------------
C
W
L
P
L
-----------
H
I
I
N
C
F
T
F
F
C
P
DCSH
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
----------------------------
5
PsiBlast_PDB
79.75
20%
-160
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-----
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
A
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPG--------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
---------------------------------
2
PsiBlast_PDB
79.63
20%
-155
- C4 -
3PWH
1
?
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-----
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
A
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPG--------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
---------------------------------
3
PsiBlast_PDB
79.49
20%
-158
- C4 -
3REY
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-----
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
A
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPG--------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
---------------------------------
4
PsiBlast_PDB
79.10
20%
-158
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-----
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
A
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPG--------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
---------------------------------
6
PsiBlast_PDB
79.02
20%
-156
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-----
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
A
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPG--------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
------------
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
---------------------------------
12
PsiBlast_PDB
77.96
20%
-165
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----
V
S
A
A
A
A
D
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
A
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPKEGKAG---
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QPLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
--------------------
10
PsiBlast_PDB
77.32
20%
-165
- C4 -
2YDV
6
?
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----
V
S
A
A
A
A
D
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
A
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
--------------------
9
PsiBlast_PDB
77.16
20%
-162
- C4 -
2YDO
3
?
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----
V
S
A
A
A
A
D
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
A
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
--------------------
8
PsiBlast_PDB
77.00
21%
-157
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
------
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQSQG-------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
------------------------------
7
PsiBlast_PDB
75.91
21%
-156
- C4 -
3VG9
8
?
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
------
F
A
-
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
FV
L
V
L
---
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
TPMLGWNNCGQSQG-------
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
-----------------------------
11
PsiBlast_PDB
75.12
20%
-166
- C4 -
4UG2
3
?
A:
[7-302]
---------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
--
L
G
---
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
-----
V
S
A
A
A
A
D
I
L
-
V
G
V
-
L
A
I
P
F
A
-
I
A
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
-----
I
P
L
R
Y
N
-------------
G
L
V
T
G
T
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
TPMLGWNNCGQPK
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
-
D
V
V
P
M
-------------------------------------
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
------------
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
P
---
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
V
L
R
-----------------------------
32
HHSearch
74.84
17%
-139
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
--
F
G
---
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
-
V
V
Y
L
E
V
T
G
G
V
W
-------
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
---
M
M
---
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
-----
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
-
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
----------------------------
T
G
D
P
T
V
C
-
S
I
S
N
-------------------------------------
P
D
--
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
------------
C
W
L
P
F
-----------
F
L
T
H
V
L
N
T
H
C
Q
TCH-
V
S
---
P
-------
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
--
S
C
---------------------------------
20
PsiBlast_PDB
73.75
19%
-126
- C4 -
4BEZ
4
OPSD_BOVIN
A:
[40-327]
-------------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
---------
V
F
G
D
F
T
-
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
G
---
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
-----
K
P
M
--------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---------------------
A
---------
C
-
A
A
P
P
L
V
G
W
S
R
Y
I
PEGMQCSCGIDYYTP
H
E
-------
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-----------
F
Y
I
F
T
H
Q
G
S
C
F
----
G
P
---
I
-------
F
-
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------
47
Fugue
73.11
18%
-139
- C3 -
4FHL
10
YEKI_SCHPO
A:
[2-392]
G
S
M
T
L
S
S
N
Q
Y
Q
L
P
L
N
V
R
P
Y
T
T
T
W
C
S
Q
S
P
S
C
S
N
L
L
A
I
G
H
D
------
T
G
I
T
I
Y
C
A
S
E
E
S
T
G
L
T
L
Q
E
L
F
T
I
Q
-------
T
G
--
L
P
---
T
L
H
L
S
F
S
S
S
C
S
Y
S
E
N
S
P
V
Y
S
L
F
L
A
C
V
C
Q
D
N
T
V
R
L
I
I
-
T
K
N
E
T
I
I
T
Q
H
-
V
L
G
G
-------
K
S
G
H
H
N
F
V
N
D
I
D
I
A
D
---
V
Y
S
AD
N
R
L
A
E
Q
V
I
A
S
V
G
D
D
C
T
L
I
I
W
R
LTDE
G
P
I
L
A
G
Y
P
---
L
S
S
P
G
I
S
V
Q
F
R
P
S
N
P
N
Q
L
I
V
G
E
R
N
G
N
I
R
I
F
D
W
T
L
---------------------
N
L
T
E
L
V
K
N
------
P
W
L
L
T
L
N
------------------
T
L
-------
P
L
V
--
N
S
S
L
A
N
V
R
W
I
G
S
------------
D
G
S
G
I
L
A
M
C
K
-
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
R
W
N
L
F
K
N
L
L
P
N
V
Q
G
I
S
L
------------
F
---------------------
P
S
L
L
G
----
A
C
---
P
-------
H
P
R
Y
M
D
Y
F
A
T
A
H
S
Q
H
G
---
L
I
Q
L
I
N
T
Y
E
K
D
S
N
S
I
P
I
--
Q
L
G
M
P
I
V
D
F
C
W
H
Q
D
G
S
H
L
A
I
A
T
EG
S
V
L
L
T
R
L
MGFT
22
HHSearch
72.03
17%
-134
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
----------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
--
I
G
---
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
-
Y
T
L
Y
T
V
-
I
G
Y
W
-------
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
---
V
V
---
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
-----
K
P
L
T
Y
P
V
K
---
R
T
-
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
-----------------------
G
V
R
T
V
E
D
G
E
C
-
Y
I
Q
F
F
------------------------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
------------
T
W
A
P
Y
-----------
N
V
M
V
L
I
N
T
F
C
A
PC--
I
P
---
N
-------
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
--
M
----------------------------------
27
HHSearch
71.76
16%
-136
* C4 *
2Z73
5
OPSD_TODPA
A:
[32-334]
------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
--
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
-
M
T
I
S
C
F
-
L
K
K
W
-------
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
---
I
F
---
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
-----
R
P
M
A
A
S
K
K
---
M
S
-
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
-------------------------
L
E
G
V
L
C
N
C
-
S
F
D
Y
I
S
R
------------------------------
D
S
--
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
------------
S
W
S
P
Y
-----------
A
V
V
A
L
L
A
Q
F
G
P
LEW-
V
T
---
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
--------------------
30
HHSearch
71.37
16%
-139
- C4 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
---------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
--
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
-
N
F
T
Y
A
V
-
H
N
E
W
-------
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
---
A
A
---
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
-----
H
P
L
Q
P
R
L
-----
S
-
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
--------------------------
E
T
M
P
S
R
V
V
C
-
M
I
E
W
P
E
H
P
----------------------------
N
K
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
------------
C
W
L
P
F
-----------
H
I
F
F
L
L
P
Y
I
N
P
----
D
L
YLK
K
FI
Q
----
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
--------------------
23
HHSearch
71.19
16%
-132
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
--
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-
G
A
A
H
I
L
-
M
K
M
W
-------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
---
L
C
---
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
-----
S
P
F
K
Y
Q
S
L
---
L
T
-
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-------------------------
T
H
Q
E
A
I
N
C
-
Y
A
E
----
E
T
------------------
C
C
-------
D
F
F
--
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
------------
C
W
L
P
F
-----------
F
I
V
N
I
V
H
V
I
Q
D
NL--
I
R
---
K
-------
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
L
---------------------------------
41
Fugue
70.90
17%
-114
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
--
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
-
T
L
Y
T
S
L
-
H
G
Y
F
-------
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
---
L
G
---
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
-----
K
P
M
--------------------
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---------------------
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
------------------
C
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
------------
A
F
L
I
C
-----------
W
L
P
Y
A
G
V
A
F
Y
I
----
F
T
---
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A--------------