@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR6K3_HUMAN: (2016-01-14 )
MCWTMPSPFTGSSTRNMESGNQSTVTEFIFTGFPQLQDGSLLYFFPLLFIYTFIIIDNLLIFSAVRLDTHLHNPMYNFISIFSFLEIWYTTATIPKMLSNLISEKKAISMTGCILQMYFFHSLENSEGILLTTMAIDRYVAICNPLRYQMIMTPRLCAQLSAGSCLFGFLILLPEIVMISTLPFCGPNQIHQIFCDLVPVLSLACTDTSMILIEDVIHAVTIIITFLIIALSYVRIVTVILRIPSSEGRQKAFSTCAGHLMVFPIFFGSVSLMYLRFSDTYPPVLDTAIALMFTVLAPFFNPIIYSLRNKDMNNAIKKLFCLQKVLNKPGG
Atome Classification :
(20 SA)
----------......---.-----..10.......------.20........30..-...----...40..-----------.--------.....50........60.....-...70..-----------......80.--.----...-------------...90..-....-------..100-.......------------110..-------------.--.-----...120.......130.....-------..140--.....---------...150------...--------.....160..-------.---....170-.-----....------..180----------....-...190.......200....--...210....-...220-..-..-----.....-------230---...------.....240..--.------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------..--.250..-.....260.......---270....-...280-----------.-------.......290.--......300--.....-----....310..------.....-320--.........330---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MCWTMP---S-----PFTGSSTRNME------SG
N
Q
S
T
V
T
E
F
I
F
TGF-PQL----QDGS
L
L
Y
-----------
F
--------
F
P
L
L
F
I
Y
T
F
I
I
I
D
N
L
L
I
F
S
A
V
R
-
L
D
T
HLH
N
-----------
P
M
Y
N
F
I
S
I
F
--
S
----
F
L
E
-------------
I
W
Y
TTA
T
-
I
P
K
M
-------
L
S
N
L
I
-SE
K
K
A
I
S
------------
M
T
G
C
I
-------------
L
--
Q
-----
M
Y
F
F
H
SLENSE
G
I
L
L
T
T
M
A
I
D
-------
R
Y
V
A
---
I
CNP
L
---------
R
Y
Q
M
I-------M
T
P
--------
R
L
C
A
QLSA
G
S
-------
C
---
L
F
G
F
L
I
L
-
L
-----
P
E
I
V
------
M
I
STL----------PFCG-
P
N
Q
I
H
Q
I
F
C
D
L
V
P
V
L
S
LACT--D
T
S
M
I
L
I
E
D
V
-
I
H
A
V
---
T
I
-
I
I
-----
T
F
L
I
I
-------
A
L
----
S
Y
V
------
R
I
V
T
V
I
L
RIP--S------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------E
G
--
R
Q
K
A
F
S
-
T
CAG
H
L
M
V
F
P
I
F
FGS---
V
S
L
M
Y
L
R
-FSDTY------------P-------
P
V
L
D
T
A
I
A
L
M
F
--
T
V
L
A
P
F
F
----
N
P
I
I
Y
-----
S
L
RNK
D
M
N
N
------
A
I
K
K
L
-
F
----
C
L
Q
K
V
LNKPGG----------------
52
HHSearch
89.85
21%
-138
- C8 -
3EML
13
ENLYS_BPT4
A:
[21-472]
--------------------------------------------------------------------
S
S
V
Y
-----------
I
--------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
-----------
V
T
N
Y
F
V
V
S
L
--
A
----
A
A
D
-------------
I
A
V
G
V
L
A
-
I
P
F
A
-------
I
T
I
S
T
---
G
F
C
A
A
------------
C
H
G
C
L
-------------
F
--
I
-----
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
-------
R
Y
I
A
---
I
R
I
P
L
---------
R
Y
N
G
L
-------
V
T
G
--------
T
R
A
K
G
I
I
A
I
C
-------
W
---
V
L
S
F
A
I
G
-
L
-----
T
P
M
L
------
G
W
N
N
C
----------
G
Q
--------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
FE
D
V
V
P
M
N
Y
M
V
Y
-
F
N
F
F
---
A
C
V
L
V
-----
P
L
L
L
M
-------
L
G
----
V
Y
L
------
R
I
F
L
A
A
R
R
Q
L
--
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
--
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
---
L
H
I
I
N
C
F
-
T
F
F
C
P
DCSH--------
A
-------
P
L
W
L
M
Y
L
A
I
V
L
--
S
H
T
N
S
V
V
----
N
P
F
I
Y
-----
A
Y
R
I
R
E
F
R
Q
------
T
F
R
K
I
-
I
----
R
S
H
V
L
R
Q
--------------------
44
HHSearch
86.96
16%
-139
- C8 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------------------------------
V
F
I
-----------
V
--------
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
-
V
N
R
H
L
Q
T
-----------
V
N
N
Y
F
L
F
S
L
--
A
----
C
A
D
-------------
L
I
I
G
V
F
S
-
M
N
L
Y
-------
T
L
Y
T
V
-
I
G
Y
W
P
L
G
------------
P
V
V
C
D
-------------
L
--
W
-----
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
-------
R
Y
F
C
---
V
T
K
P
L
---------
T
Y
P
V
K
-------
R
T
T
--------
K
M
A
G
M
M
I
A
A
A
-------
W
---
V
L
S
F
I
L
W
-
A
-----
P
A
I
L
------
F
W
Q
F
I
----------
V
G
V
---
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
-
G
T
A
I
---
A
A
F
Y
L
-----
P
V
I
I
M
-------
T
V
----
L
Y
W
------
H
I
S
R
A
S
K
S
R
I
--
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
--
E
K
K
V
T
R
-
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
---
Y
N
V
M
V
L
I
-
N
T
F
C
A
PC----------
I
-------
P
N
T
V
W
T
I
G
Y
W
L
--
C
Y
I
N
S
T
I
----
N
P
A
C
Y
-----
A
L
C
N
A
T
F
K
K
------
T
F
K
H
L
-
L
----
M
--------------------------
47
HHSearch
84.24
17%
-134
- C8 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------------------------------
P
L
-----------
V
--------
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
-
S
E
R
K
L
H
T
-----------
V
G
N
L
Y
I
V
S
L
--
S
----
V
A
D
-------------
L
I
V
G
A
V
V
-
M
P
M
N
-------
I
L
Y
L
L
-
M
S
K
W
S
L
G
------------
R
P
L
C
L
-------------
F
--
W
-----
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
-------
R
Y
R
S
---
V
Q
Q
P
L
---------
R
Y
L
K
Y
-------
R
T
K
--------
T
R
A
S
A
T
I
L
G
A
-------
W
---
F
L
S
F
L
W
V
-
I
-----
P
I
L
G
-------
W
N
H
-------------------
R
R
E
D
K
C
E
T
D
F
Y
--------
D
---
V
T
W
F
K
V
-
M
T
A
I
---
I
N
F
Y
L
-----
P
T
L
L
M
-------
L
W
----
F
Y
A
------
K
I
Y
K
A
V
R
Q
H
C
--
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
--
E
R
K
A
A
K
-
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
---
Y
F
I
F
F
M
V
-
I
A
F
C
K
------------
N
CC-----
N
E
H
L
H
M
F
T
I
W
L
--
G
Y
I
N
S
T
L
----
N
P
L
I
Y
-----
P
L
C
N
E
N
F
K
K
------
T
F
K
R
I
-
L
----
H
I
-------------------------
45
HHSearch
82.99
17%
-131
- C8 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
------------------------------------------------------------------
V
W
V
V
G
M
-----------
G
--------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
-
K
F
E
R
L
Q
T
-----------
V
T
N
Y
F
I
T
S
L
--
A
----
C
A
D
-------------
L
V
M
G
L
A
V
-
V
P
F
G
-------
A
A
H
I
L
-
M
K
M
W
T
F
G
------------
N
F
W
C
E
-------------
F
--
W
-----
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
-------
R
Y
F
A
---
I
T
S
P
F
---------
K
Y
Q
S
L
-------
L
T
K
--------
N
K
A
R
V
I
I
L
M
V
-------
W
---
I
V
S
G
L
T
S
-
F
-----
L
P
I
Q
------
M
H
W
Y
R
----------
A
T
-----
H
Q
E
A
I
N
C
Y
A
E
E
----
T
C
C
--
D
F
F
T
N
Q
A
Y
A
I
-
A
S
S
I
---
V
S
F
Y
V
-----
P
L
V
I
M
-------
V
F
----
V
Y
S
------
R
V
F
Q
E
A
K
R
Q
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
--
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
---
F
F
I
V
N
I
V
-
H
V
I
Q
D
NL----------
I
-------
R
K
E
V
Y
I
L
L
N
W
I
--
G
Y
V
N
S
G
F
----
N
P
L
I
Y
-----
C
-
R
S
P
D
F
R
I
------
A
F
Q
E
L
-
L
----
C
L
-------------------------
62
Fugue
81.54
19%
-113
- C8 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------
M
N
G
T
E
G
---
P
-----
N
F
Y
V
P
F
S
N
K
T
G
------
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
----
F
S
M
L
A
A
Y
-----------
M
--------
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
T
-----------
P
L
N
Y
I
L
L
N
L
--
A
----
V
A
D
-------------
L
F
M
V
F
G
G
-
F
T
T
T
-------
L
Y
T
S
L
-
H
G
Y
F
V
F
G
------------
P
T
G
C
N
-------------
L
--
E
-----
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
-------
R
Y
V
V
---
V
C
K
P
M
S
N
F
R
F
G
---
E
N
H
A
I
-------
M
G
V
--------
A
F
T
W
V
M
A
L
A
C
-------
A
APP
L
V
G
W
S
R
Y
-
I
-----
P
E
G
M
------
Q
C
--------------
S
C
G
-
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
-
H
F
--------
I
I
-----
P
L
I
V
I
-------
F
F
----
C
Y
G
------
Q
L
V
F
T
V
K
E
A
A
--
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
--
T
Q
K
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
---
C
W
L
P
Y
A
G
-
V
A
F
Y
I
------------
F
T
H
QGSDF
G
P
I
F
M
T
I
P
A
F
F
--
A
K
T
S
A
V
Y
----
N
P
V
I
Y
-----
I
M
M
N
K
Q
F
R
N
------
C
M
V
T
T
-
L
----
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A------
66
Fugue
78.60
20%
-155
- C3 -
4U6D
22
?
A:
[28-409]
--------EG
F
P
F
I
L
P
---
K
EKPNR
P
L
S
A
A
M
Q
R
N
Y
D
N
YMAPR
P
E
N
N
E
L
Y
T
Q
F
K
Y
T
E
L
-
K
G
F
DYNG
H
D
G
T
I
S
R
-----------
R
--------
D
P
S
K
V
I
Y
E
---
N
G
K
Y
Y
V
W
Y
T
Y
R
N
T
P
T
P
P
Q
G
-----------
A
K
N
S
N
D
T
I
P
--
S
ADWD
L
A
E
-------------
I
W
Y
A
T
S
----
K
D
-------
G
F
T
W
E
-
E
Q
G
V
A
V
P
RPPKPNVGWRSV
T
T
T
D
I
-------------
L
--
K
W
KG
K
F
Y
L
Y
Y
Q
G
F
M
E
A
S
G
----
T
R
G
D
D
-------
C
P
V
A
---
V
S
Y
A
D
---------
S
P
D
G
P
-------
W
T
P
--------
H
T
E
V
V
I
P
N
G
K
KGEWDQY
S
---
I
H
D
P
Y
P
I
-
V
Y
K---
D
K
I
Y
------
L
Y
Y
K
S
----------
D
F
D
G
D
P
N
L
V
R
M
Q
G
L
A
I
A
D
N
P
L
G
P
F
K
--
K
S
P
L
N
P
V
I
N
S
-
G
H
E
T
---
T
L
-
F
P
F
KE
G
M
A
A
L
V
I
RDGTEHN
T
V
----
Q
Y
A
EDGVNF
N
I
A
S
I
V
E
F
M
P
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
PY
V
A
D
A
F
T
N
T
K
Y
G
R
G
I
S
W
G
I
S
H
F
---------------
T
N
------------
A
-------
T
T
W
D
Q
N
H
A
V
L
A
--
R
F
D
C
D
L
S
----
L
D
V
-
D
-----
D
P
H
M
K
R
L
G
T
------
Y
F
K
P
E
-
F
----
Y
Y
Q
M
G
L
S
K
K
Q
R
E
R
I-------------
63
Fugue
76.19
18%
-94
- C8 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------
M
N
G
T
E
G
---
P
-----
N
F
Y
V
P
F
S
N
K
T
G
------
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-
P
W
Q
----
F
S
M
L
A
A
Y
-----------
M
--------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
----
K
L
R
T
-----------
P
L
N
Y
I
L
L
N
L
--
A
----
V
A
D
-------------
L
F
M
V
F
G
G
-
F
T
T
T
-------
L
Y
T
S
L
-
H
G
Y
F
V
F
G
------------
P
T
G
C
N
-------------
L
--
E
-----
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
-------
R
Y
V
V
---
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-------
A
F
T
--------
W
V
M
A
L
A
C
A
A
P
-------
P
---
L
V
G
W
S
R
Y
-
I
-----
P
E
G
M
------
Q
C
--------------
S
C
G
-
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
-
H
F
I
I
---
P
L
-
I
V
-----
I
F
F
C
Y
-------
G
Q
----
L
V
F
------
T
V
K
E
A
A
A
Q
Q
Q
--
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
--
T
Q
K
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
---
C
W
L
P
Y
A
G
-
V
A
F
Y
I
------------
F
T
H
QGSDF
G
P
I
F
M
T
I
P
A
F
F
--
A
K
T
S
A
V
Y
----
N
P
V
I
Y
-----
I
M
M
N
K
Q
F
R
N
------
C
M
V
T
T
-
L
----
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
54
HHSearch
75.37
18%
-130
- C8 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------
Y
-----------
A
--------
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
-
K
E
R
A
L
Q
T
-----------
T
T
N
Y
L
V
V
S
L
--
A
----
V
A
D
-------------
L
L
V
A
T
L
V
-
M
P
W
V
-------
V
Y
L
E
V
T
G
G
V
W
N
F
S
------------
R
I
C
C
D
-------------
V
--
F
-----
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
-------
R
Y
T
A
---
V
V
M
P
V
---------
H
Y
Q
H
G
T
G
Q
----
S
S
C
--------
R
R
V
A
L
M
I
T
A
V
-------
W
---
V
L
A
F
A
V
S
-
C
-----
P
L
L
F
------
G
F
N
T
T
------------------
G
D
P
T
V
C
S
I
S
N
--------------
P
D
F
V
I
-
Y
S
S
V
---
V
S
F
Y
L
-----
P
F
G
V
T
-------
V
L
----
V
Y
A
------
R
I
Y
V
V
L
K
Q
R
R
--
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
--
E
K
K
A
T
Q
-
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
---
F
F
L
T
H
V
L
-
N
T
H
C
Q
TCH---------
V
-------
S
P
E
L
Y
S
A
T
T
W
L
--
G
Y
V
N
S
A
L
----
N
P
V
I
Y
-----
T
T
F
N
I
E
F
R
K
------
A
F
L
K
I
-
L
----
S
C
-------------------------
50
HHSearch
75.04
18%
-128
- C8 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------------------------------------------
E
N
S
I
K
L
T
-----------
S
--------
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
-
K
T
K
K
F
H
R
-----------
P
M
Y
Y
F
I
G
N
L
--
A
----
L
S
D
-------------
L
L
A
G
V
A
Y
-
T
A
N
L
-------
L
L
S
G
A
--
T
T
Y
K
L
T
------------
P
A
Q
W
F
-------------
L
--
R
-----
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
-------
R
Y
I
T
---
M
L
K
------------------------
N
N
--------
F
R
L
F
L
L
I
S
A
C
-------
W
---
V
I
S
L
I
L
G
-
G
-----
L
P
I
M
------
G
W
N
C
I
------------------
S
A
L
S
S
C
S
T
V
L
P
--------
L
--
Y
H
K
-
H
Y
I
-
L
F
C
T
---
T
V
F
T
L
-----
L
L
L
S
I
-------
V
I
----
L
Y
C
------
R
I
Y
S
L
V
R
T
R
N
--
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
--
N
V
A
L
L
K
-
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
---
L
F
I
L
L
L
L
-
D
V
G
C
K
------------
V
KTC
D
---
I
L
F
R
A
E
Y
F
L
V
L
--
A
V
L
N
S
G
T
----
N
P
I
I
Y
-----
T
L
T
N
K
E
M
R
R
------
A
F
I
R
I
-
M
----
G
R
P
L
-----------------------
51
HHSearch
73.30
14%
-130
- C8 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
--------------------------------------------------------------------
I
V
L
W
-----------
A
--------
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
-
A
H
K
R
M
R
T
-----------
V
T
N
Y
F
L
V
N
L
--
A
----
F
A
E
-------------
A
S
M
A
A
F
N
-
T
V
V
N
-------
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
------------
L
F
Y
C
K
-------------
F
--
H
-----
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
-------
R
Y
M
A
---
I
I
H
P
L
---------
Q
P
R
L
---------
S
A
--------
T
A
T
K
V
V
I
C
V
I
-------
W
---
V
L
A
L
L
L
A
-
F
-----
P
Q
G
Y
------
Y
S
T
T
E
----------
T
------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---
P
--
N
K
I
Y
E
K
V
Y
H
I
-
C
V
T
V
---
L
I
Y
F
L
-----
P
L
L
V
I
-------
G
Y
----
A
Y
T
------
V
V
G
I
T
L
W
A
S
E
--
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
--
K
R
K
V
V
K
-
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
---
F
H
I
F
F
L
L
-
P
Y
I
N
P
------------
D
LYLKKF-
I
Q
Q
V
Y
L
A
I
M
W
L
--
A
M
S
S
T
M
Y
----
N
P
I
I
Y
-----
C
C
L
N
D
R
F
R
L
------
G
F
K
H
A
-
F
----
R
C
C
P
F
I
S
A
G
D
Y
----------------
70
Fugue
73.15
19%
-105
- C5 -
4UX8
-
GFRA1_RAT
C:
[25-343]
DRLDCVKASD
Q
C
L
K
-----
E
-----
Q
S
C
S
T
K
Y
R
T
L
R
------
Q
C
V
A
G
K
E
T
N
F
S
L
T
S
G
-
L
E
A
----
K
D
E
C
R
S
A
-----------
M
--------
E
A
L
K
------------------------
Q
K
-----------
S
L
Y
N
-------------------------------------
C
R
C
-------
K
R
G
M
K
-
K
E
K
N
C
L
R
------------
I
Y
W
S
M
-------------
Y
--
Q
-----
S
K
G
N
N
C
L
D
A
A
K
A
C
N
L
D
D
T
C
K
K
-------
Y
R
S
A
---
Y
I
T
P
C
---------
T
T
S
M
---------
S
N
--------
E
V
C
N
R
R
K
C
H
K
-------
A
---
L
R
Q
F
F
D
K
-
V
-----
P
A
K
H
------
S
Y
G
M
L
-----------
F
C
S
---------
C
R
-----
D
I
A
C
T
--
E
R
R
R
Q
T
I
------------------------
V
P
-------
V
C
----
S
Y
E
------
E
R
E
R
--
P
N
C
L
--
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
D
--
S
C
K
T
N
Y
-
I
C
R
S
R
L
A
D
F
F
T
N
C
Q
P
---
E
S
R
S
V
S
N
C
L
K
E
N
Y
------------
A
-------
D
C
L
L
A
Y
S
G
L
I
G
--
T
V
M
T
P
N
Y
VDSS
S
L
S
V
A
PWCDC
S
N
S
G
N
D
L
E
D
CL----
K
F
L
N
F
-
F
KDNT
C
L
K
N
A
I
Q
A
F
G
N
G---------------
53
HHSearch
71.48
15%
-112
- C8 -
1U19
14
OPSD_BOVIN
A:
[38-329]
------------------------------------------------------------------
W
Q
F
S
M
L
-----------
A
--------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-
Q
H
K
K
L
R
T
-----------
P
L
N
Y
I
L
L
N
L
--
A
----
V
A
D
-------------
L
F
M
V
F
G
G
-
F
T
T
T
-------
L
Y
T
S
L
-
H
G
Y
F
V
F
G
------------
P
T
G
C
N
-------------
L
--
E
-----
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
-------
R
Y
V
V
---
V
C
K
P
M
---------
S
N
F
R
F
--------
G
E
--------
N
H
A
I
M
G
V
A
F
T
-------
W
---
V
M
A
L
A
C
A
-
A
-----
P
P
L
V
------
G
W
S
R
Y
----------
I
P
-----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
--
E
E
T
N
N
E
S
F
V
I
-
Y
M
F
V
---
V
H
F
I
I
-----
P
L
I
V
I
-------
F
F
----
C
Y
G
------
Q
L
V
F
T
V
K
E
A
A
--
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
--
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
---
Y
A
G
V
A
F
Y
-
I
F
T
H
Q
GSD---------
F
-------
G
P
I
F
M
T
I
P
A
F
F
--
A
K
T
S
A
V
Y
----
N
P
V
I
Y
-----
I
M
M
N
K
Q
F
R
N
------
C
M
V
T
T
-
L
----
C
C
G
K
N
P
L
G
D
D
E
----------------
48
HHSearch
71.00
15%
-125
- C8 -
2Z73
5
OPSD_TODPA
A:
[30-334]
------------------------------------------------------------
P
----
D
A
V
Y
Y
S
L
-----------
G
--------
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
-
K
T
K
S
L
Q
T
-----------
P
A
N
M
F
I
I
N
L
--
A
----
F
S
D
-------------
F
T
F
S
L
V
N
G
F
P
L
M
-------
T
I
S
C
F
-
L
K
K
W
I
F
G
------------
F
A
A
C
K
-------------
V
--
Y
-----
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
-------
R
Y
N
V
---
I
G
R
P
M
---------
A
A
S
K
K
-------
M
S
H
--------
R
R
A
F
I
M
I
I
F
V
-------
W
---
L
W
S
V
L
W
A
-
I
-----
G
P
I
F
------
G
W
G
A
Y
----------
T
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
D
S
T
T
R
S
N
I
L
-
C
M
F
I
---
L
G
F
F
G
-----
P
I
L
I
I
-------
F
F
----
C
Y
F
------
N
I
V
M
S
V
S
N
H
E
--
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
--
E
M
R
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
---
Y
A
V
V
A
L
L
-
A
Q
F
G
P
LEW---------
V
-------
T
P
Y
A
A
Q
L
P
V
M
F
--
A
K
A
S
A
I
H
----
N
P
M
I
Y
-----
S
V
S
H
P
K
F
R
E
------
A
I
S
Q
T
-
F
----
P
W
V
L
T
C
C
Q
F
D
D
----------------
64
Fugue
70.92
16%
-144
- C8 -
1A6Q
3
PPM1A_HUMAN
A:
[2-368]
------------
G
A
F
L
---
D
-----
K
P
K
M
E
K
H
N
A
Q
G
------
Q
G
N
G
L
R
Y
G
L
S
S
M
Q
G
W
R
V
E
M
----
E
D
A
H
T
A
V
-----------
I
G
LPSGLES
W
S
F
F
A
V
Y
D
G
H
A
G
S
Q
V
A
K
Y
C
C
E
H
-
L
L
D
H
I
T
N
NQDFKGSAGAP
S
V
E
N
V
K
N
G
I
R
T
G
----
F
L
E
-------------
I
D
E
H
M
R
V
-
M
S
E
K
-------
K
H
G
A
---
D
R
S
G
S
T
------------
A
V
G
V
L
-------------
I
SP
Q
-----
H
T
Y
F
I
N
C
G
D
S
R
G
L
L
C
R
N
R
K
V
H
-------
F
F
T
Q
D
H
K
P
S
N
P
L
---------
E
K
E
R
I
Q
N
A
G
G
S
V
M
I
Q
--------
R
V
N
G
S
L
A
V
S
R
-------
A
---
L
G
D
F
D
Y
K
-
C
VHGKG
P
T
E
Q
------
L
V
S
P
E
----------
P
-------------
E
V
H
D
I
E
R
S
E
E
D
--
D
Q
F
I
I
L
A
C
D
G
-
I
W
D
V
MG
N
E
E
-
L
C
-----
D
F
V
R
S
-------
R
L
E
V
TD
D
L
E
------
K
V
C
N
E
V
V
D
T
C
--
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
--
S
R
D
--------
N
M
S
V
I
L
I
C
F
P
N
APK
V
S
P
E
A
V
K
-
K
E
A
E
L
------------
D
-------
K
Y
L
E
C
R
V
E
E
I
I
--
K
G
V
-
P
D
L
----
V
H
V
M
R
-----
T
L
A
S
E
N
I
P
S
LPPGGE
L
A
S
K
R
-
N
----
V
I
E
A
V
Y
N
R
L
N
P
Y---------------
65
Fugue
70.70
16%
-153
- C4 -
4R2F
1
?
A:
[38-431]
-------G
A
I
K
F
W
D
M
P
WAT
P
-----
A
Y
N
D
A
A
K
K
I
A
E
G
FSG--
A
N
S
K
A
T
Y
Q
I
I
Q
W
N
N
F
-
Y
Q
T
----
F
S
S
A
I
A
S
KTGPA
V
S
T
G
G
G
F
--------
Q
A
F
Q
F
E
E
Q
G
Q
I
A
Y
A
D
K
V
I
E
K
L
K
-
S
N
G
Q
F
D
D
-----------
F
L
P
G
V
V
E
P
F
--
K
----
T
S
K
GYV
A
V
P
W
Q
L
D
I
R
P
L
W
Y
R
K
S
L
-
F
E
K
A
GVGVPTD
W
A
S
L
L
-
E
A
G
K
K
L
K
------------
G
V
G
A
V
G
F
A
T
G
SGAGNN
I
G
N
--
H
-----
L
M
I
M
M
M
L
N
N
G
G
G
V
F
T
K
D
G
E
L
D
VLN
D
R
N
V
E
A
V
E
---
F
L
L
E
L
---------
V
S
N
G
V
-------
I
D
P
AAVSYT
T
D
N
L
N
A
Q
W
K
D
S
K
-------
A
---
A
Y
G
M
L
T
L
G
V
-----
P
E
R
V
GDTSGD
I
V
V
A
S
----------
P
I
A
G
-
P
H
G
---------
D
K
A
A
L
I
F
P
--
N
N
I
M
M
Y
T
N
T
P
S
Q
E
A
S
---
E
E
-
F
V
-----
V
Y
Y
L
G
-------
K
L
----
K
E
L
------
W
Q
Q
K
L
M
N
A
L
P
VF
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
--
E
M
P
E
F
T
-
A
D
P
N
N
V
K
I
V
N
E
Y
V
P
I
---
A
K
T
F
A
S
Q
------------------
G
-------
T
A
L
S
A
N
L
A
A
L
D
GG
Q
A
L
N
Q
F
T
----
Q
T
V
L
T
-----
G
--
K
T
D
A
K
S
------
A
L
T
A
F
D
T
----
G
L
K
S
V
L
K
K
-------------------
43
HHSearch
68.98
14%
-128
- C8 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-498]
------------------------------------------------------------
A
----
N
F
N
K
I
F
L
-----------
P
--------
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
-
Y
Q
K
K
L
R
S
-----------
M
T
D
K
Y
R
L
H
L
--
S
----
V
A
D
-------------
L
L
F
V
-
I
T
-
L
P
F
W
-------
A
V
D
A
V
--
A
N
W
Y
F
G
------------
N
F
L
C
K
-------------
A
--
V
-----
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
-------
R
Y
L
A
---
I
V
H
A
T
---------
N
S
Q
R
P
-------
R
K
L
--------
L
A
E
K
V
V
Y
V
G
V
-------
W
---
I
P
A
L
L
L
T
-
I
-----
P
D
F
I
------
F
A
N
V
S
----------
E
------
A
D
D
R
Y
I
C
D
R
F
Y
P
--------
N
D
L
W
V
V
V
F
Q
F
-
Q
H
I
M
---
V
G
L
I
L
-----
P
G
I
V
I
-------
L
S
----
C
Y
C
------
I
I
I
S
K
L
S
H
S
G
--
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
--
K
R
K
A
L
K
-
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
---
Y
Y
I
G
I
S
I
-
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
-------
V
H
K
W
I
S
I
T
E
A
L
--
A
F
F
H
C
C
L
----
N
P
I
L
Y
-----
A
F
L
G
A
K
F
K
T
------
S
A
Q
H
A
-
L
----
T
S
G
R
P
L
E
V
L
F
Q
----------------
12
PsiBlast_PDB
68.40
28%
-129
- C8 -
2YDV
6
?
A:
[5-173]
-------------------------------------------------------------------
G
S
S
V
Y
-----------
I
--------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
-----------
V
T
N
Y
F
V
V
S
A
--
A
----
A
A
D
-------------
I
L
V
G
V
L
A
-
I
P
F
A
-------
I
A
--
I
-
S
T
G
F
C
A
A
------------
C
H
G
C
L
-------------
F
--
I
-----
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
-------
R
Y
I
A
---
I
R
I
P
L
---------
R
Y
N
G
L
-------
V
T
G
--------
T
R
A
K
G
I
I
A
I
C
-------
W
---
V
L
S
F
A
I
G
-
L
-----
T
P
M
L
------
G
W
N
N
C
GQPK
E
G
K
A
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
---
G
V
-
Y
L
-----
R
I
F
L
A
-------
A
R
----
R
Q
L
------
K
Q
M
E
S
Q
S
T
L
Q
--
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
A
A
K
S
L
A
-
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
---
I
N
C
F
T
F
F
-
C
P
D
C
S
------------
H
-------
A
P
L
W
L
M
Y
L
A
I
V
--
L
S
H
T
N
S
V
----
V
N
P
F
I
-----
Y
A
Y
R
I
R
E
F
R
------
Q
T
F
R
K
-
I
----
I
R
S
H
V
L
R
Q
Q
E
P
----------------
11
PsiBlast_PDB
68.21
28%
-129
- C8 -
2YDO
3
?
A:
[6-173]
--------------------------------------------------------------------
S
S
V
Y
-----------
I
--------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
-----------
V
T
N
Y
F
V
V
S
A
--
A
----
A
A
D
-------------
I
L
V
G
V
L
A
-
I
P
F
A
-------
I
A
--
I
-
S
T
G
F
C
A
A
------------
C
H
G
C
L
-------------
F
--
I
-----
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
-------
R
Y
I
A
---
I
R
I
P
L
---------
R
Y
N
G
L
-------
V
T
G
--------
T
R
A
K
G
I
I
A
I
C
-------
W
---
V
L
S
F
A
I
G
-
L
-----
T
P
M
L
------
G
W
N
N
C
GQPK
E
G
K
A
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
---
G
V
-
Y
L
-----
R
I
F
L
A
-------
A
R
----
R
Q
L
------
K
Q
M
E
S
T
L
Q
K
E
--
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
--
K
S
L
A
I
I
-
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
---
C
F
T
F
F
C
P
-
D
C
S
H
A
------------
P
-------
L
W
L
M
Y
L
A
I
V
L
S
--
H
T
N
S
V
V
N
----
P
F
I
Y
A
-----
Y
R
I
R
E
F
R
Q
T
------
F
R
K
I
I
-
R
----
S
H
V
L
R
Q
Q
E
P
F
K
----------------
6
PsiBlast_PDB
67.67
27%
-140
- C8 -
3EML
8
ENLYS_BPT4
A:
[20-189]
-------------------------------------------------------------------
G
S
S
V
Y
-----------
I
--------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
-----------
V
T
N
Y
F
V
V
S
L
--
A
----
A
A
D
-------------
I
A
V
G
V
L
A
-
I
P
F
A
-------
I
T
--
I
-
S
T
G
F
C
A
A
------------
C
H
G
C
L
-------------
F
--
I
-----
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
-------
R
Y
I
A
---
I
R
I
P
L
---------
R
Y
N
G
L
-------
V
T
G
--------
T
R
A
K
G
I
I
A
I
C
-------
W
---
V
L
S
F
A
I
G
-
L
-----
T
P
M
L
------
G
W
N
N
C
GQS-------
Q
G
C
G
-
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
---
G
V
-
Y
L
-----
R
I
F
L
A
-------
A
R
----
R
Q
L
------
N
I
F
E
M
L
R
I
D
E
--
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
--
K
I
Y
K
D
T
-
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
---
P
S
L
N
A
A
K
-
S
E
L
D
K
------------
A
-------
I
G
R
N
T
N
G
V
I
T
K
--
D
E
A
E
K
L
F
----
N
Q
D
V
D
-----
A
A
V
R
G
I
L
R
N
------
A
K
L
K
P
-
V
----
Y
D
S
L
D
A
V
R
R
A
A
----------------
8
PsiBlast_PDB
67.59
27%
-135
- C8 -
4EIY
19
AA2AR_HUMAN (first)
A:
[30-199]
-------------------------------------------------------------------
G
S
S
V
Y
-----------
I
--------
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-
L
N
S
N
L
Q
N
-----------
V
T
N
Y
F
V
V
S
L
--
A
----
A
A
D
-------------
I
A
V
G
V
L
A
-
I
P
F
A
-------
I
T
--
I
-
S
T
G
F
C
A
A
------------
C
H
G
C
L
-------------
F
--
I
-----
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
-------
R
Y
I
A
---
I
R
I
P
L
---------
R
Y
N
G
L
-------
V
T
G
--------
T
R
A
K
G
I
I
A
I
C
-------
W
---
V
L
S
F
A
I
G
-
L
-----
T
P
M
L
------
G
W
N
N
C
GQPK
E
G
K
N
H
S
Q
G
C
G
-
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
--
N
F
F
A
C
V
L
V
P
L
-
L
L
M
L
---
G
V
-
Y
L
-----
R
I
F
L
A
-------
A
R
----
R
Q
L
------
A
D
L
E
D
N
W
E
T
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
--
K
V
I
E
K
A
-
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
A
---
A
A
L
D
A
Q
K
-
M
K
D
F
R
------------
H
-------
G
F
D
I
L
V
G
Q
I
D
D
--
A
L
K
L
A
N
E
----
G
K
V
K
E
-----
A
Q
A
A
A
E
Q
L
K
------
T
T
R
N
A
-
Y
----
I
Q
K
Y
L
E
R
A
R
S
T
----------------