@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR8G5_HUMAN: (2016-01-14 )
MIIYKQGITFLQKENNNTIHLNTMFFLSPAETHQRMAAENHSFVTKFILVGLTEKSELQLPLFLVFLGIYVVTVLGNLGMITLIGLSSHLHTPMYCFLSSLSFIDFCHSTVITPKMLVNFVTEKNIISYPECMTQLYFFLVFAIAECHMLAAMAYDGYVAICSPLLYSIIISNKACFSLILVVYVIGLICASAHIGCMFRVQFCKFDVINHYFCDLISILKLSCSSTYINELLILIFSGINILVPSLTILSSYIFIIASILRIRYTEGRSKAFSTCSSHISAVSVFFGSAAFMYLQPSSVSSMDQGKVSSVFYTIVVPMLNPLIYSLRNKDVHVALKKTLGKRTFL
Atome Classification :
(20 SA)
----------------------------------.........10........20........30........40........50........60-----------------------...--..-----------....--70........80.....----...90........100.--......110-.-......120........-------------130-----------------.......140.......150.......160.-------------------......170-.........180------.........190........-.200.---------......-210.---......220-------...-------.-------...--.230--......-------------..240.....--..250.......260------------------------.....-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------...-270--.........280.......290.....------..300----------.------------..--....-------..310-...-----....320------.........330.......340.----.....-------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------
M
I
I
YKQG
I
T
F
L
QKENN
N
T
I
H
L
N
T
M
F
F
L
S
P
A
E
T
H
Q
R
M
AAE
N
H
S
F
V
T
K
F
I
LVGLTEKSELQ
L
------------------------
P
L
F
--
L
V
-----------
F
L
G
I
--
Y
V
V
T
V
LGNL
G
M
I
T
L
I
GL----SSHLH
T
P
M
Y
C
F
L
S
S
L
S
F
--
I
D
F
C
H
STVI-
T
-
P
K
M
L
V
N
F
V-TEKNII
S
Y
-------------
P
E
C
-----------------
M
T
Q
L
Y
F
F
L
V
F
A
I
A
E
C
H
M
L
A
A
M
AYD
G
Y
V
A
I
C
S
-------------------
P
L
L
Y
S
I
I
---ISN
K
A
C
F
S
L
I
--------
L
V
V
Y
V
I
G
L
I
C
--
A
SAH
I
G
C
M
-
F
R
V
Q
F---------C
K
F
D
V
I
-
N
H
Y
F
---
C
D
L
I
S
I
L
K
--------LSC-------
S
-------
S
T
Y
--
I
N
E
---
L
L
I
L
I
F-------------S
G
I
N
I
L
V
P
S
L
--
T
I
L
S
S
Y
I
F
I
I
A
S
I
--------------------------
L
R
I
RY-----------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------EGR-
S
----
K
A
F
S
T
C
S
S
H
I
S
A
V
S
V
F
FG
S
A
A
F
M
Y
LQP------SSV------------S------------SM--DQG
K
-------
V
S
S
V
F
-
Y
T
I
-----
V
V
P
M
L
--------
N
P
L
I
Y
S
LRNKD
V
H
V
A
L
K
K
T
L--G----KRTFL-------------------
24
HHSearch
84.87
19%
-153
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
-------------------------------------------------------------------------------------------
W
V
V
------------------------
G
M
G
--
I
V
-----------
M
S
L
I
--
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
----
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
--
A
D
L
V
M
G
L
A
V
-
V
-
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
-------------
F
W
C
-----------------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-------------------
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
--------
L
M
V
W
I
V
S
G
L
T
--
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
--------------
Q
-
E
A
I
N
---
C
Y
A
E
------------
E
T
C
-------
C
-------
D
F
F
--
T
N
Q
---
A
Y
A
I
A
S
-------------
S
I
V
S
F
Y
V
P
L
V
--
I
M
V
F
V
Y
S
R
V
F
Q
E
A
--------------------------
K
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
-
H
----
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
------
V
I
Q
------------
D
NL----------
I
R
--
K
E
V
Y
-------
I
L
L
N
W
-
I
G
Y
-----
V
N
S
G
F
--------
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
--
C
----
L
-----------------------
29
HHSearch
83.25
19%
-157
- C3 -
2Z73
5
OPSD_TODPA
A:
[31-332]
-----------------------------------------------------------------------------------------
D
A
V
Y
Y
------------------------
S
L
G
--
I
F
-----------
I
G
I
C
--
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
----
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
G
F
-
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
I
G
P
I
F
G
W
-
G
A
Y
T
L
-------------
E
G
-
V
L
C
N
---
C
S
F
D
Y
I
S
---------------------------
R
D
S
--
T
T
R
---
S
N
I
L
C
M
-------------
F
I
L
G
F
F
G
P
I
L
--
I
I
F
F
C
Y
F
N
I
V
M
S
V
--------------------------
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
-
M
----
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
------
Q
F
G
------------
P
LEW---------
V
T
--
P
Y
A
A
-------
Q
L
P
V
M
-
F
A
K
-----
A
S
A
I
H
--------
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
25
HHSearch
82.43
20%
-153
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
----------------------------------------------------------------------------------------------------------------------
P
L
V
--
V
V
-----------
L
S
T
I
--
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
----
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
--
A
D
L
I
V
G
A
V
V
-
M
-
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
-------------
P
L
C
-----------------
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
-------------------
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
--------
L
G
A
W
F
L
S
F
L
W
--
V
I
P
I
L
-
G
W
-
N
H
-----------------
R
-
R
E
D
K
---
C
E
T
D
F
Y
---------------------------------
D
V
T
---
W
F
K
V
M
T
-------------
A
I
I
N
F
Y
L
P
T
L
--
L
M
L
W
F
Y
A
K
I
Y
K
A
V
--------------------------
R
Q
H
C
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
R
E
-
R
----
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
------
A
F
C
------------
K
NC----------
C
N
--
E
H
L
H
-------
M
F
T
I
W
-
L
G
Y
-----
I
N
S
T
L
--------
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
--
H
----
I
-----------------------
30
HHSearch
81.93
17%
-148
- C3 -
3EML
13
ENLYS_BPT4
A:
[21-469]
--------------------------------------------------------------------------------------------
S
S
------------------------
V
Y
I
--
T
V
-----------
E
L
A
I
--
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
----
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
--
A
D
I
A
V
G
V
L
A
-
I
-
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
-------------
H
G
C
-----------------
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-------------------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
--------
A
I
C
W
V
L
S
F
A
I
--
G
L
T
P
M
L
G
W
-
N
N
C
G
Q
-----------------
S
Q
G
---
C
G
E
G
Q
V
-----------
A
C
-------
L
-------
F
E
D
VV
P
M
N
---
Y
M
V
Y
F
N
-------------
F
F
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
L
R
I
F
L
A
A
--------------------------
R
R
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
K
E
-
V
----
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
------
F
F
C
PDCS--------
H
------------
A
P
--
L
W
L
M
-------
Y
L
A
I
V
-
L
S
H
-----
T
N
S
V
V
--------
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
----
S
H
V
L
R
-------------------
40
Fugue
78.60
15%
-111
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
------------------------
Y
V
T
--
V
Q
-----------
H
---------------------------
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
--
A
D
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
-------------
T
G
C
-----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------------
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
--------
F
T
W
V
M
A
L
A
C
A
--
A
P
P
L
V
G
----------------------
W
-
S
R
Y
I
---
P
E
G
---
M
Q
--------
C
S
C
-------
G
I
DYYTPH
E
E
T
--
N
N
E
---
S
F
V
I
Y
M
-------------
F
V
V
H
F
I
I
P
L
I
--
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
-
Q
----
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
F
Y
------------
I
------------
F
T
--
H
Q
G
S
DFGPIFM
T
I
P
A
F
-
F
A
K
-----
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
----
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A----
32
HHSearch
76.89
17%
-151
- C3 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
--------------------------------------------------------------------------------------------
I
V
------------------------
L
W
A
--
A
A
-----------
Y
T
V
I
--
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
----
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
--
A
E
A
S
M
A
A
F
N
-
T
-
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
-------------
F
Y
C
-----------------
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-------------------
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
--------
C
V
I
W
V
L
A
L
L
L
--
A
F
P
Q
G
Y
Y
S
-
T
T
E
--------------
T
M
P
-
S
R
V
V
---
C
M
I
E
W
P
E
H
------------------
P
-------
N
K
I
--
Y
E
K
---
V
Y
H
I
C
V
-------------
T
V
L
I
Y
F
L
P
L
L
--
V
I
G
Y
A
Y
T
V
V
G
I
T
L
--------------------------
W
A
S
E
I
PGDSSDRYH
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
-
R
----
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
------
Y
I
N
------------
P
DLYLKK------
F
I
--
Q
Q
V
Y
-------
L
A
I
M
W
-
L
A
M
-----
S
S
T
M
Y
--------
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
----
C
C
P
F
I
-------------------
43
Fugue
76.60
18%
-142
* C2 *
4L9B
5
?
A:
[2-393]
-------------------------------------
V
L
K
G
I
N
F
P
----------------
E
N
E
A
S
I
L
D
L
A
M
Q
N
R
S
G
V
L
D
G
M
T
I
D
I
L
N
T
T
S
N
Q
L
------------------------
A
L
F
H
G
T
A
-----------
V
L
Q
G
--
Y
G
I
E
I
T
G
A
P
D
V
L
V
D
T
T
G
----
Q
S
N
-
E
T
M
L
L
C
L
T
I
D
L
N
Q
--
V
N
V
P
S
G
T
A
V
-
D
Y
K
Q
I
R
L
E
F
L
-
D
V
P
T
L
L
K
Q
YWRDHSLHDLIDP
R
R
V
-----------------
I
S
M
P
L
Y
W
I
T
F
G
Q
T
G
T
T
P
L
Y
E
Q
I
K
S
N
Y
I
D
N
S
G
-------------------
N
P
A
Y
G
I
A
---
A
R
C
E
N
F
N
H
F
I
--------
N
K
V
A
V
Q
S
I
P
I
NG
V
A
N
R
P
V
S
S
-
T
A
S
Q
L
---------
T
N
Y
K
V
W
R
N
P
Y
L
---
C
S
Q
D
P
R
D
K
--------
F
A
P
-------
D
-------
N
L
V
--
I
E
E
DGI
Y
R
I
D
I
S
-------------
G
S
I
N
I
A
N
Y
T
F
PA
R
V
G
G
R
Y
F
Q
I
V
C
A
R
N
SSANNLAEFGAE
Q
H
L
P
P
S
GVWTRRV
L
V
G
E
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
M
-
T
-------
E
Q
A
F
S
S
V
A
T
I
S
L
F
K
G
D
N
F
F
L
Q
F
E
T
------
G
T
N
------------
T
------------
S
R
--
D
S
---------
A
Y
N
N
G
-
Y
G
T
-----
S
G
T
H
L
--------
R
N
F
S
Y
T
L
E
R
V
G
-
D
L
N
G
T
A
Y
Y
--
D
----
N
G
T
F
--------------------
23
HHSearch
74.80
18%
-151
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
---------------------------------------------------------------------------------------------
V
------------------------
F
I
V
--
L
V
-----------
A
G
S
L
--
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
----
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
--
A
D
L
I
I
G
V
F
S
-
M
-
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
-------------
V
V
C
-----------------
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
-------------------
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
--------
A
A
A
W
V
L
S
F
I
L
--
W
A
P
A
I
L
F
W
-
Q
F
I
V
G
-----------
V
R
T
V
-
E
D
G
E
---
C
Y
I
Q
F
F
---------------------------------
S
N
A
---
A
V
T
F
G
T
-------------
A
I
A
A
F
Y
L
P
V
I
--
I
M
T
V
L
Y
W
H
I
S
R
A
S
--------------------------
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
-
K
----
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
------
T
F
C
------------
A
PC----------
I
P
--
N
T
V
W
-------
T
I
G
Y
W
-
L
C
Y
-----
I
N
S
T
I
--------
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
--
M
----------------------------
31
HHSearch
74.43
17%
-151
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------------------------------------------------
Y
A
--
L
S
-----------
Y
C
A
L
--
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
----
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
--
A
D
L
L
V
A
T
L
V
-
M
-
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
-------------
I
C
C
-----------------
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
-------------------
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
--------
T
A
V
W
V
L
A
F
A
V
--
S
C
P
L
L
F
G
F
-
N
T
T
----------------
G
-
D
P
T
V
---
C
S
I
S
N
------------------------------------
P
---
D
F
V
I
Y
S
-------------
S
V
V
S
F
Y
L
P
F
G
--
V
T
V
L
V
Y
A
R
I
Y
V
V
L
--------------------------
K
Q
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
-
K
----
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
------
T
H
C
------------
Q
TCH---------
V
S
--
P
E
L
Y
-------
S
A
T
T
W
-
L
G
Y
-----
V
N
S
A
L
--------
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
--
S
----
C
-----------------------
2
PsiBlast_PDB
73.45
22%
-127
- C3 -
4WW3
5
OPSD_TODPA
A:
[54-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
---
I
G
P
I
-
F
G
W
G
A
Y
T
L
E
G
VLC
N
C
S
F
D
Y
I
-
S
R
D
S
---
T
T
R
S
N
I
L
C
--------
M
F
I
-------
L
-------
G
-
F
--
F
G
P
---
I
L
I
I
F
F
-------------
C
Y
F
N
I
V
---
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
--------------------------
K
R
L
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
K
A
----
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
------------
V
------------
A
L
L
A
Q
F
G
P
-------
L
E
W
V
T
P
Y
A
A
-----
Q
L
P
V
M
F
A
K
A
SAIH
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
41
Fugue
73.07
17%
-112
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
------------------------
Y
V
T
--
V
Q
-----------
H
K
K
L
RT
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
----------------------
Y
F
V
------
F
G
P
-------------
T
G
C
-----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------------
P
M
-
S
N
F
R
---
F
G
E
N
H
A
I
M
G
V
--------
A
F
T
W
V
M
A
L
A
C
--
A
A
P
P
L
------
V
G
W
---------
S
R
Y
-------------
I
P
E
G
M
Q
--------
C
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
N
E
---
S
F
V
I
Y
M
-------------
F
V
V
H
F
I
I
P
L
I
--
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
-
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------
A
F
Y
------------
I
------------
F
T
--
H
Q
G
S
DFGPIFM
T
I
P
A
F
-
F
A
K
-----
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
----
K
N
P
L
G
DDEA
S
T
T
V
S
K
TETSQVAPA
22
HHSearch
72.64
16%
-146
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-496]
-----------------------------------------------------------------------------------------
N
F
N
K
I
------------------------
F
L
P
--
T
I
-----------
Y
S
I
I
--
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
----
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
--
A
D
L
L
F
V
-
I
T
-
L
-
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
-------------
F
L
C
-----------------
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
-------------------
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
--------
V
G
V
W
I
P
A
L
L
L
--
T
I
P
D
F
I
F
A
-
N
V
S
E
--------------
A
D
-
D
R
Y
I
---
C
D
R
F
Y
P
N
----------------------------
D
L
--
W
V
V
---
V
F
Q
F
Q
H
-------------
I
M
V
G
L
I
L
P
G
I
--
V
I
L
S
C
Y
C
I
I
I
S
K
L
--------------------------
S
H
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
-
R
----
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
------
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
V
--
H
K
W
I
-------
S
I
T
E
A
-
L
A
F
-----
F
H
C
C
L
--------
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
--
T
----
S
G
R
P
L
-------------------
1
PsiBlast_PDB
72.42
22%
-126
- C3 -
2ZIY
2
OPSD_TODPA
A:
[61-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
---
I
G
P
I
-
F
G
W
G
A
Y
T
L
E
GVLC
N
C
S
F
D
Y
I
-
S
R
D
S
---
T
T
R
S
N
I
L
C
--------
M
F
I
-------
L
-------
G
-
F
--
F
G
P
---
I
L
I
I
F
F
-------------
C
Y
F
N
I
V
---
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
--------------------------
K
R
L
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
K
A
----
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
------------
V
------------
A
L
L
A
Q
F
G
P
-------
L
E
W
V
T
P
Y
A
A
-----
Q
L
P
V
M
F
A
K
A
SAIH
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
5
PsiBlast_PDB
72.04
22%
-126
- C3 -
3AYN
3
OPSD_TODPA
A:
[62-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
---
I
G
P
I
-
F
G
W
G
A
Y
T
L
E
GVLC
N
C
S
F
D
Y
I
-
S
R
D
S
---
T
T
R
S
N
I
L
C
--------
M
F
I
-------
L
-------
G
-
F
--
F
G
P
---
I
L
I
I
F
F
-------------
C
Y
F
N
I
V
---
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
--------------------------
K
R
L
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
K
A
----
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
------------
V
------------
A
L
L
A
Q
F
G
P
-------
L
E
W
V
T
P
Y
A
A
-----
Q
L
P
V
M
F
A
K
A
SAIH
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
4
PsiBlast_PDB
71.72
22%
-126
- C3 -
3AYM
3
OPSD_TODPA
A:
[62-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
---
I
G
P
I
-
F
G
W
G
A
Y
T
L
E
GVLC
N
C
S
F
D
Y
I
-
S
R
D
S
---
T
T
R
S
N
I
L
C
--------
M
F
I
-------
L
-------
G
-
F
--
F
G
P
---
I
L
I
I
F
F
-------------
C
Y
F
N
I
V
---
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
--------------------------
K
R
L
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
K
A
----
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
------------
V
------------
A
L
L
A
Q
F
G
P
-------
L
E
W
V
T
P
Y
A
A
-----
Q
L
P
V
M
F
A
K
A
SAIH
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
3
PsiBlast_PDB
71.62
22%
-127
- C3 -
2Z73
5
OPSD_TODPA
A:
[62-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
--
S
D
F
T
F
S
L
V
N
-
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-------------
A
A
C
-----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-------------------
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
--------
I
F
V
W
L
W
S
V
L
W
--
A
---
I
G
P
I
-
F
G
W
G
A
Y
T
L
E
GVLC
N
C
S
F
D
Y
I
-
S
R
D
S
---
T
T
R
S
N
I
L
C
--------
M
F
I
-------
L
-------
G
-
F
--
F
G
P
---
I
L
I
I
F
F
-------------
C
Y
F
N
I
V
---
M
--
S
V
S
N
H
E
K
E
M
A
A
M
A
--------------------------
K
R
L
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
R
K
A
----
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
------------
V
------------
A
L
L
A
Q
F
G
P
-------
L
E
W
V
T
P
Y
A
A
-----
Q
L
P
V
M
F
A
K
A
SAIH
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
----
W
V
L
T
C
-------------------
28
HHSearch
70.37
18%
-141
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
-----------------------------------------------------------------------------------------
E
N
S
I
K
------------------------
L
T
S
--
V
V
-----------
F
I
L
I
--
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
----
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
--
S
D
L
L
A
G
V
A
Y
-
T
-
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
-------------
A
Q
W
-----------------
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
------------------------------
N
N
F
R
L
F
L
L
I
--------
S
A
C
W
V
I
S
L
I
L
--
G
G
L
P
I
M
G
W
-
N
C
I
----------------
S
-
A
L
S
S
---
C
S
T
V
L
P
L
---------------------------------
Y
H
---
K
H
Y
I
L
F
-------------
C
T
T
V
F
T
L
L
L
L
--
S
I
V
I
L
Y
C
R
I
Y
S
L
V
--------------------------
R
T
R
N
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
E
N
-
V
----
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
------
V
G
C
------------
K
VKTC--------
D
I
--
L
F
R
A
-------
E
Y
F
L
V
-
L
A
V
-----
L
N
S
G
T
--------
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
--
G
----
R
P
L
---------------------
33
HHSearch
66.73
14%
-126
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-326]
-------------------------------------------------------------------------------------------
Q
F
S
------------------------
M
L
A
--
A
Y
-----------
M
F
L
L
--
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
----
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
--
A
D
L
F
M
V
F
G
G
-
F
-
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
-------------
T
G
C
-----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-------------------
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
--------
A
F
T
W
V
M
A
L
A
C
--
A
A
P
P
L
V
G
W
-
S
R
Y
I
P
-------------
E
G
-
M
Q
C
S
---
C
G
I
D
Y
Y
T
P
------------------
H
-------
E
E
T
--
N
N
E
---
S
F
V
I
Y
M
-------------
F
V
V
H
F
I
I
P
L
I
--
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--------------------------
K
E
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
-
K
----
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
------
F
T
H
QGS---------
D
------------
F
G
--
P
I
F
M
-------
T
I
P
A
F
-
F
A
K
-----
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
----
C
G
K
N
P
-------------------
45
Fugue
63.47
15%
-161
- C1 -
4Q0C
-
BVGS_BORPE
A:
[66-578]
S
Q
E
L
T
LVGKA
A
V
P
D
V
EVALDGD
D
W
R
W
L
A
R
K
R
V
L
T
L
G
V
Y
A
P
D
I
P
P
F
D
V
T
Y
G
E
R
Y
E
G
L
T
A
D
Y
M
A
I
I
A
H
N
L
G
M
Q
A
K
V
L
R
Y
P
T
R
E
Q
A
L
S
A
L
E
S
G
Q
I
D
L
I
G
TVN
G
T
D
G
R
Q
QS
L
R
L
S
VPY
A
A
D
H
P
V
I
--
V
M
P
IGARHVPASN
L
A
G
Q
--
R
L
A
V
D
I
N
Y
L
P
K
E
T
L
A
R
A
YPQ
A
T
L
H
Y
F
P
S
S
E
Q
A
L
A
A
V
A
Y
GQ
A
D
V
F
I
G
D
A
L
-
T
-
T
S
H
L
V
S
Q
S
-
Y
F
N
D
V
R
V
V
-------------
A
P
A
H
I
A
T
G
G
E
S
F
G
V
RADN
T
R
L
L
R
V
V
N
A
V
L
E
A
I
P
P
S
E
H
R
S
L
I
Y
R
W
G
L
G
S
S
I
S
L
DFAH
P
A
Y
S
A
R
E
Q
Q
W
M
A
D
H
P
V
V
K
V
A
V
---
L
N
L
F
A
P
F
T
L
F
R
TDE
Q
F
G
G
I
S
A
A
V
L
Q
L
L
Q
--
L
R
T
G
L
D
F
E
-
I
I
G
V
D
---------
T
V
E
E
L
I
-
A
K
L
R
S
GE
A
D
M
A
G
A
L
F
VNSARESF
L
S
F
-------
S
-------
R
P
Y
--
V
R
N
---
G
M
V
I
V
T
R
QDPDAPVDADHL
D
G
R
T
V
A
L
V
R
N
--
S
A
A
I
P
L
L
Q
R
R
Y
P
Q
--------------------------
A
K
V
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
P
-
S
----
E
A
M
L
M
V
A
N
G
Q
A
D
A
V
V
Q
T
Q
I
S
A
S
Y
Y
V
N
R
YFAGKL
R
I
A
------------
S
------------
A
L
--
D
L
P
P
-------
A
E
I
A
L
-
A
T
T
RGQ
T
E
L
M
S
I
L
--------
N
K
A
L
Y
S
I
S
N
D
E
L
A
S
I
I
S
R
W
R
--
G
S
D
G
D
P
R
T
W
Y
A
Y
R
N
E
I
Y
L
E----------
34
HHSearch
60.17
13%
-119
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
------------------------------------------------------------------------------------------
L
N
K
Y
------------------------
V
V
I
--
I
A
-----------
Y
A
L
V
--
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
----
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
--
A
D
L
L
F
A
L
T
--
L
-
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
-------------
F
L
C
-----------------
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
-------------------
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
--------
L
G
C
W
G
L
S
M
N
L
--
S
L
P
F
F
L
F
R
-
Q
A
Y
H
-------------
P
N
N
-
S
S
P
V
---
C
Y
E
V
L
G
N
-------------------
D
-------
T
A
K
--
W
R
M
---
V
L
R
I
L
P
-------------
H
T
F
G
F
I
V
P
L
F
--
V
M
L
F
C
Y
G
F
T
L
R
T
L
--------------------------
F
K
A
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
-
H
----
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
------
T
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
I
--
G
R
A
L
-------
D
A
T
E
I
-
L
G
F
-----
L
H
S
C
L
--------
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
--
A
----
M
H
G
---------------------