@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR9I1_HUMAN: (2016-01-14 )
MAKNNLTRVTEFILMGFMDHPKLEIPLFLVFLSFYLVTLLGNVGMIMLIQVDVKLYTPMYFFLSHLSLLDACYTSVITPQILATLATGKTVISYGHCAAQFFLFTICAGTECFLLAVMAYDRYAAIRNPLLYTVAMNPRLCWSLVVGAYVCGVSGAILRTTCTFTLSFCKDNQINFFFCDLPPLLKLACSDTANIEIVIIFFGNFVILANASVILISYLLIIKTILKVKSSGGRAKTFSTCASHITAVALFFGALIFMYLQSGSGKSLEEDKVVSVFYTVVIPMLNPLIYSLRNKDVKDAFRKVARRLQVSLSM
Atome Classification :
(20 SA)
----------.........10.-------..----------------..---------------...20--------........30...----.....40.-------------------...----....50----..-.......------60..-.--.....70......-..80-......-...-------90-------........-100.....-------------------------..110-----......---..120.......130--...--..---....------140.......150.---......160------...-..--.-.170...--------------....180...-.....-------190-----....--.....200.---....--..210...-....220.......230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------........240---------------.....---...250---.--..------....260----....------------.------------.------.-.270-------.-----.--.....280----.......290.......300.--.----------------.------....310..--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MAK
N
N
L
T
R
V
T
E
F
-------
I
L
----------------
M
G
---------------FMDHP--------KLE
I
P
L
F
L
V
F
L
S
F
----
Y
L
V
T
L
LGN-------------------V
G
M
----
I
M
L
I
Q
-----
V
D
-
V
K
L
Y
T
P
M
------
Y
F
F
L
-
S
--
H
L
S
L
L
D
A
C
Y
T
SVI-
T
P
Q
--
I
L
A
T
L
A-TG
K
-------
T
V
-------
I
S
Y
G
H
C
A
A
-
Q
F
F
L
F
T
IC-------------------------AG
T
E
------
C
F
L
L
A
V
---
M
A
Y
D
R
Y
A
A
IRN
P
L
----
L
Y
T
--VA---MN
P
R
------
L
C
W
S
L
V
V
G
A
Y
V
CGV---SG
A
I
L
R
T
T
C
------
T
F
T
-
L
S
--F-CKDN
Q
I
N
--------------
F
F
FCD-L
P
P
L
-
L
K
LAC-------S-------DTA
N
--
I
E
I
V
I
I
F
FG---
N
F
V
I
--
L
AN
A
S
V
I
L
-
I
S
Y
L
L
I
I
K
T
I
L
K
VKS------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------------------GGRA
K
T
F
S
T
C
----------------
A
S
H
I
T
---
A
V
A
L
F
F
---
G
--
A
L
------
I
F
M
Y
LQ-----SGSG------------K------------S------L-EED
K
-------
V
-----
V
--
S
V
F
Y
T
V
V
I
----
P
M
L
N
P
L
I
Y
S
LRNK
D
V
K
D
A
F
R
K
--
V
----------------
A
------
R
R
L
Q
VSLSM--------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.42
22%
-142
- C6 -
3VGA
1
AA2AR_HUMAN
A:
[12-304]
-------------------------------------------------------------------------------------
V
E
L
A
I
----
A
V
L
A
I
L
G
N
-------------------
V
L
V
----
C
W
A
V
W
-----
L
N
-
S
N
L
Q
N
V
T
------
N
Y
F
V
-
V
--
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
--
A
I
T
-----------------------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
--------------------
T
Q
S
S
------
I
F
S
L
L
A
---
I
A
I
D
R
Y
I
A
I
R
I
P
L
----
R
Y
N
G
-
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
---
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
------
G
Q
----SQ
G
-
C
G
E
G
Q
V
A
--------------
C
L
F
E
D
-
V
V
P
M
------------------------
N
--
Y
M
V
Y
F
N
F
F
A
---
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
-
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
----------------
E
V
H
A
A
K
--
S
L
A
I
I
V
---
G
L
F
A
L
------
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
------------
P
------------
D
------
C
-
S
H
A
P
-------
L
-----
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
--
I
----------------
I
------
R
S
H
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
86.94
22%
-148
- C6 -
3VG9
8
?
A:
[12-304]
-------------------------------------------------------------------------------------
V
E
L
A
I
----
A
V
L
A
I
L
G
N
-------------------
V
L
V
----
C
W
A
V
W
-----
L
N
-
S
N
L
Q
N
V
T
------
N
Y
F
V
-
V
--
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
--
A
I
T
-----------------------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
FV
L
V
L
--------------------
T
Q
S
S
------
I
F
S
L
L
A
---
I
A
I
D
R
Y
I
A
I
R
I
P
L
----
R
Y
N
G-
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
---
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
------
G
Q
----SQ
G
-
C
G
E
G
Q
V
A
--------------
C
L
F
E
D
-
V
V
P
M
------------------------
N
--
Y
M
V
Y
F
N
F
F
A
---
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
-
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
PLP----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
----------------
E
V
H
A
A
K
--
S
L
A
I
I
V
---
G
L
F
A
L
------
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
------------
P
------------
D
------
C
-
S
H
A
P
-------
L
-----
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
--
I
----------------
I
------
R
S
H
V
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
84.21
17%
-159
- C6 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
---------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
----
C
L
V
T
V
G
L
N
-------------------
L
L
V
----
L
Y
A
V
R
-----
S
E
-
R
K
L
H
T
V
G
------
N
L
Y
I
-
V
--
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
--
N
I
L
Y
L
L
-
M
S
K
-------
W
S
-------
L
G
R
P
L
C
L
F
-
W
L
S
M
D
Y
V
A
-------------------------
S
T
A
S
------
I
F
S
V
F
I
---
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
----
R
Y
L
--
K
Y
---
R
T
K
T
------
R
A
S
A
T
I
L
G
A
W
F
L
S
F
---
L
W
V
I
P
I
L
G
--------
W
N
-
H
----------
R
R
--------------
E
D
K
C
E
-
T
D
F
Y
-
D
-------------------------
V
T
W
F
K
V
M
T
A
---
I
I
N
F
--
Y
L
P
T
L
L
M
L
-
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
L
----------------
G
F
I
M
A
---
A
F
I
L
C
W
---
I
--
P
Y
------
F
I
F
F
M
V
-----
I
A
F
C
------------
K
NC----------
C
------
N
-
E
H
L
H
-------
M
-----
F
--
T
I
W
L
G
Y
I
N
----
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
--
I
----------------
L
------
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
83.63
17%
-143
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
----
V
L
A
I
V
F
G
N
-------------------
V
L
V
----
I
T
A
I
A
-----
K
F
-
E
R
L
Q
T
V
T
------
N
Y
F
I
-
T
--
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
--
G
A
A
H
I
L
-
M
K
M
-------
W
T
-------
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
-------------------------
V
T
A
S
------
I
E
T
L
C
V
---
I
A
V
D
R
Y
F
A
I
T
S
P
F
----
K
Y
Q
--
S
L
---
L
T
K
N
------
K
A
R
V
I
I
L
M
V
W
I
V
S
G
---
L
T
S
F
L
P
I
Q
M
------
H
W
Y
-
R
A
--
T
-----
H
Q
E
--------------
A
I
N
C
Y
-
A
E
E
-----
T
C
-------
C
-------
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
---
I
V
S
F
--
Y
V
P
L
V
I
M
V
-
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
K
A
L
K
T
L
----------------
G
I
I
M
G
---
T
F
T
L
C
W
---
L
--
P
F
------
F
I
V
N
I
V
-----
H
V
I
Q
------------
D
NL----------
I
------
R
-
K
E
V
Y
-------
I
-----
L
--
L
N
W
I
G
Y
V
N
----
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
--
L
----------------
L
------
C
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
80.69
16%
-131
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------
M
N
G
T
E
G
P
N
F
-------
Y
V
PFSNKTGVVRSPFEAP
Q
Y
---------------
Y
L
A
E
P
--------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
G
F
P
I
N
-------------------
F
L
T
----
L
Y
V
T
V
-----
Q
H
-
K
K
L
R
T
P
L
------
N
Y
I
L
-
L
--
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
-
H
G
Y
-------
F
V
-------
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
-------------------------
G
E
I
A
------
L
W
S
L
V
V
---
L
A
I
E
R
Y
V
V
V
C
K
P
M
-------------------------------
S
N
F
R
F
G
E
---
N
H
A
I
M
G
V
A
F
------
T
W
V
-
M
A
--
L
-
A
C
A
A
P
P
L
--------------
V
G
W
S
R
-
Y
I
P
E
G
M
Q
C
S
C
-------
G
I
DYYTPH
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
--
I
I
P
L
I
V
I
F
-
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
----------------
T
R
M
V
I
---
I
M
V
I
A
F
---
L
--
I
C
------
W
L
P
Y
A
G
-----
V
A
F
Y
------------
I
------------
F
------
T
-
H
Q
G
S
DFGPIFM
T
-----
I
--
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
----------------
L
------
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A--------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
79.60
15%
-134
* C6 *
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
----
G
I
I
G
C
G
G
N
-------------------
G
I
V
----
I
Y
L
F
T
-----
K
T
-
K
S
L
Q
T
P
A
------
N
M
F
I
-
I
--
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
--
M
T
I
S
C
F
-
L
K
K
-------
W
I
-------
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
G
I
F
-------------------------
G
F
M
S
------
I
M
T
M
A
M
---
I
S
I
D
R
Y
N
V
I
G
R
P
M
----
A
A
S
--
K
K
---
M
S
H
R
------
R
A
F
I
M
I
I
F
V
W
L
W
S
V
---
L
W
A
I
G
P
I
F
G
------
W
G
A
--------
Y
T
L
E
G
V
--------------
L
C
N
C
S
-
F
D
Y
I
-
S
R
-------------------
D
S
T
--
T
R
S
N
I
L
C
M
F
---
I
L
G
F
--
F
G
P
I
L
I
I
F
-
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
----------------
I
V
I
V
S
---
Q
F
L
L
S
W
---
S
--
P
Y
------
A
V
V
A
L
L
-----
A
Q
F
G
------------
P
LEW---------
V
------
T
-
P
Y
A
A
-------
Q
-----
L
--
P
V
M
F
A
K
A
S
----
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
--
T
----------------
F
------
P
W
V
L
T
C
C
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
79.57
16%
-150
- C6 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
--------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
----
S
L
V
T
I
I
G
N
-------------------
I
L
V
----
M
V
S
I
K
-----
V
N
-
R
H
L
Q
T
V
N
------
N
Y
F
L
-
F
--
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
--
Y
T
L
Y
T
V
-
I
G
Y
-------
W
P
-------
L
G
P
V
V
C
D
L
-
W
L
A
L
D
Y
V
V
-------------------------
S
N
A
S
------
V
M
N
L
L
I
---
I
S
F
D
R
Y
F
C
V
T
K
P
L
----
T
Y
P
--
V
K
---
R
T
T
K
------
M
A
G
M
M
I
A
A
A
W
V
L
S
F
---
I
L
W
A
P
A
I
L
F
-------
W
Q
-
F
I
--
V
--
G
V
R
T
V
E
--------------
D
G
E
C
Y
-
I
Q
F
F
-
S
-------------------------
N
A
A
V
T
F
G
T
A
---
I
A
A
F
--
Y
L
P
V
I
I
M
T
-
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
I
----------------
L
A
I
L
L
---
A
F
I
I
T
W
---
A
--
P
Y
------
N
V
M
V
L
I
-----
N
T
F
C
------------
A
PC----------
I
------
P
-
N
T
V
W
-------
T
-----
I
--
G
Y
W
L
C
Y
I
N
----
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
--
L
----------------
L
------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.51
22%
-155
- C6 -
2YDO
3
?
A:
[12-304]
-------------------------------------------------------------------------------------
V
E
L
A
I
----
A
V
L
A
I
L
G
N
-------------------
V
L
V
----
C
W
A
V
W
-----
L
N
-
S
N
L
Q
N
V
T
------
N
Y
F
V
-
V
--
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
--
A
I
A
-----------------------
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
--------------------
T
A
S
S
------
I
F
S
L
L
A
---
I
A
I
D
R
Y
I
A
I
R
I
P
L
----
R
Y
N
G
-
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
---
S
F
A
I
G
L
---
T
P
M
L
G
W
N
N
C
GQPK
E
G
K
A
H
-
S
Q
--
G
-
C
G
E
G
Q
V
A
--------------
C
L
F
E
D
-
V
V
P
M
------------------------
N
--
Y
M
V
Y
F
N
F
F
A
---
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
-
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
----------------
E
V
H
A
A
K
--
S
L
A
I
I
V
---
G
L
F
A
L
------
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
------------
P
------------
D
------
C
-
S
H
A
P
-------
L
-----
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
--
I
----------------
I
------
R
S
H
V
L
R
Q
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
78.18
15%
-140
- C6 -
2KS9
1
NK1R_HUMAN
A:
[33-324]
--------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
----
V
V
T
S
V
V
G
N
-------------------
V
V
V
----
M
W
I
I
L
-----
A
H
-
K
R
M
R
T
V
T
------
N
Y
F
L
-
V
--
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
--
N
F
T
Y
A
V
-
H
N
E
-------
W
Y
-------
Y
G
L
F
Y
C
K
F
-
H
N
F
F
P
I
A
A
-------------------------
V
F
A
S
------
I
Y
S
M
T
A
---
V
A
F
D
R
Y
M
A
I
I
H
P
L
----
Q
P
R
--
L
-----
S
A
T
------
A
T
K
V
V
I
C
V
I
W
V
L
A
L
---
L
L
A
F
P
Q
G
Y
Y
------
S
T
T
---------
E
T
M
P
S
--------------
R
V
V
C
M
-
I
E
W
P
-
E
H
P
-----------------
N
K
I
Y
--
E
K
V
Y
H
I
C
V
T
---
V
L
I
Y
--
F
L
P
L
L
V
I
G
-
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
----------------
I
V
V
V
C
---
T
F
A
I
C
W
---
L
--
P
F
------
H
I
F
F
L
L
-----
P
Y
I
N
------------
P
------------
D
LYLKKF
I
-
Q
Q
V
Y
-------
L
-----
A
--
I
M
W
L
A
M
S
S
----
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
--
A
----------------
F
------
R
C
C
P
F
I
S
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
77.75
16%
-150
- C6 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
----
I
L
A
I
V
F
G
N
-------------------
G
L
V
----
C
M
A
V
L
-----
K
E
-
R
A
L
Q
T
T
T
------
N
Y
L
V
-
V
--
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
--
V
V
Y
L
E
V
T
G
G
V
-------
W
N
-------
F
S
R
I
C
C
D
V
-
F
V
T
L
D
V
M
M
-------------------------
C
T
A
S
------
I
W
N
L
C
A
---
I
S
I
D
R
Y
T
A
V
V
M
P
V
----
H
Y
Q
--
H
G
T
G
Q
S
S
C
R
------
R
V
A
L
M
I
T
A
V
W
V
L
A
F
---
A
V
S
C
P
L
L
F
G
-------
F
N
-----
T
-----
T
G
D
--------------
P
T
V
C
S
-
I
S
N
-----------------------------
P
D
F
V
I
Y
S
S
---
V
V
S
F
--
Y
L
P
F
G
V
T
V
-
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
----------------
A
I
V
L
G
---
A
F
I
V
C
W
---
L
--
P
F
------
F
L
T
H
V
L
-----
N
T
H
C
------------
Q
TCH---------
V
------
S
-
P
E
L
Y
-------
S
-----
A
--
T
T
W
L
G
Y
V
N
----
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
--
I
----------------
L
------
S
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
77.07
17%
-150
- C6 -
3EML
13
ENLYS_BPT4
A:
[21-470]
-------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
----
A
V
L
A
I
L
G
N
-------------------
V
L
V
----
C
W
A
V
W
-----
L
N
-
S
N
L
Q
N
V
T
------
N
Y
F
V
-
V
--
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
--
A
I
T
I
S
T
---
G
-------
F
C
-------
A
A
C
H
G
C
L
F
-
I
A
C
F
V
L
V
L
-------------------------
T
Q
S
S
------
I
F
S
L
L
A
---
I
A
I
D
R
Y
I
A
I
R
I
P
L
----
R
Y
N
--
G
L
---
V
T
G
T
------
R
A
K
G
I
I
A
I
C
W
V
L
S
F
---
A
I
G
L
T
P
M
L
G
------
W
N
N
-
C
G
--
Q
----------------------
S
Q
G
C
G
-
E
G
Q
V
----
A
C
-------
L
-------
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
---
F
A
C
V
--
L
V
P
L
L
L
M
L
-
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
L
----------------
A
I
I
V
G
---
L
F
A
L
C
W
---
L
--
P
L
------
H
I
I
N
C
F
-----
T
F
F
C
------------
P
DCSH--------
A
------
P
-
L
W
L
M
-------
Y
-----
L
--
A
I
V
L
S
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
--
I
----------------
I
------
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
75.93
16%
-138
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
-----------------------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
----
F
L
T
G
I
V
G
N
-------------------
G
L
V
----
I
L
V
M
G
-----
Y
Q
-
K
K
L
R
S
M
T
------
D
K
Y
R
-
L
--
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
--
W
A
V
D
A
V
--
A
N
-------
W
Y
-------
F
G
N
F
L
C
K
A
-
V
H
V
I
Y
T
V
N
-------------------------
L
Y
S
S
------
V
W
I
L
A
F
---
I
S
L
D
R
Y
L
A
I
V
H
A
T
----
N
S
Q
--
R
P
---
R
K
L
L
------
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
---
L
L
T
I
P
D
F
I
F
------
A
N
V
---------
S
E
A
D
D
--------------
R
Y
I
C
D
-
R
F
Y
P
-
N
D
--------------------
L
W
--
V
V
V
F
Q
F
Q
H
I
---
M
V
G
L
--
I
L
P
G
I
V
I
L
-
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
----------------
V
I
L
I
L
---
A
F
F
A
C
W
---
L
--
P
Y
------
Y
I
G
I
S
I
-----
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
------
V
-
H
K
W
I
-------
S
-----
I
--
T
E
A
L
A
F
F
H
----
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
--
A
----------------
L
------
T
S
G
R
P
L
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
74.60
19%
-176
- C2 -
4R5O
10
?
A:
[2-427]
--------DD
C
E
D
L
H
L
G
N
L
A
H
Y
P
N
-----
V
L
----------------
K
G
---------------
T
F
P
T
E
S
Q
V
L
E
LG
E
T
L
E
I
T
P
E
L
L
N
P
E
G
----
A
T
Y
S
W
L
V
N
GKEYSTEP
T
F
S
Y
K
IDNP
C
R
A
D
L
----
S
C
I
I
K
N
KY
G
K
V
E
M
S
T
S
F
S
S
N
HNFSK
G
F
F
Y
V
-
A
DG
T
F
N
F
Y
D
T
-
E
K
K
T
A
-
Y
Q
D
--
C
Y
A
S
L
N
-
A
G
K
-------
T
L
GIGNY
D
S
A
N
I
I
H
S
N
G
-
K
F
Y
L
L
V
G
T
-------------------------
S
T
S
N
RD----
H
F
Y
I
V
D
AKT
L
Y
Y
E
N
S
A
V
V
G
A
N
L
----
S
G
L
--
T
I
---
L
N
E
Q
--------
Y
G
L
V
T
G
D
G
I
R
R
I
D
LK
S
L
N
N
V
R
I
K
N
------
E
R
L
-
L
C
--
F
-
Y
N
S
I
I
Y
N
G
K
V
L
S
N
DTYKDES
K
V
K
Y
Y
D
-
V
N
E
L
-
I
A
A
K
E
-------
G
-------
E
A
P
A
--
V
T
E
L
D
I
I
Q
K
Q
K
I
N
F
V
L
--
A
K
D
G
N
V
Y
T
-
L
E
S
A
D
N
G
C
N
I
V
K
I
K
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
L
E
K
V
F
A
N
F
QPAKGPYHSSPTI
G
M
V
A
S
E
T
E
---
N
I
I
Y
L
V
S
TD
G
--
A
I
------
Y
K
Y
I
L
-------
G
D
S
------------
D
------------
S
------
L
-
K
A
P
F
-------
I
A
A
E
S
G
V
--
S
I
T
A
P
L
Q
L
----
N
Q
Q
S
G
E
L
Y
V
T
Y
T
E
E
R
K
D
E
S
K
I
--
V
----------------
V
Y
S
KDGK
V
L
H
T
V
D
C
G
E
SVPS
Q
I
L
F
NN----------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
74.23
16%
-109
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------
M
N
G
T
E
G
P
N
F
Y
-------
V
P
----------------
F
S
NKTGVVRSPFEAPQY
Y
L
A
E
P
--------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
G
F
P
I
N
-------------------
F
L
T
----
L
Y
V
T
V
-----
Q
H
-
K
K
L
R
T
P
L
------
N
Y
I
L
-
L
--
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
-
H
G
Y
-------
F
V
-------
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
-------------------------
G
E
I
A
------
L
W
S
L
V
V
---
L
A
I
E
R
Y
V
V
V
C
K
P
M
-------------------------------
S
N
F
R
F
G
E
---
N
H
A
I
M
G
V
A
F
------
T
W
V
-
M
A
--
L
-
A
C
A
A
P
P
L
--------------
V
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
C
G
I
DYYTP
H
-------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
--
I
I
P
L
I
V
I
F
-
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
QQQE--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
----------------
T
R
M
V
I
---
I
M
V
I
A
F
---
L
--
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
H
Q
G
------------
S
------------
D
------
F
G
P
I
F
M
-------
T
-----
I
--
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
L
C
CGKNPLGDDEA
S
T
T
V
------
S
K
T
E
T
S
Q
V
A
PA------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
71.62
17%
-123
- C3 -
3WI3
17
SLD3_YEAST
A:
[8-275]
---------------
Y
S
D
P
K
E
Y
-------
I
E
----------------
S
K
---------------
Y
Y
D
A
L
--------
F
----------------------------------------------------------------
S
I
H
T
P
L
------
A
Y
F
V
K
S
--
N
L
V
R
L
K
N
T
C
R
T
K
Y
-
G
S
-----------
D
S
-------
Y
K
-------
I
A
Y
Q
A
M
L
Q
-
K
F
--------------------------------------------------------------
L
----
L
S
I
--
V
Q
---
F
K
D
R
------
H
D
N
R
L
L
L
E
P
F
S
-
S
P
---
I
A
D
E
K
R
K
N
C
------
L
T
K
-
F
V
--
I
-
Q
D
E
N
K
N
S
--------------
S
------------------------------------------
T
I
A
---
D
L
C
V
--
V
L
K
S
R
E
I
K
-
L
Q
I
L
L
L
L
E
-
I
I
G
L
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
N
F
R
D
F
D
Y
C
----------------
E
Q
--
L
---
D
L
Y
L
D
R
---
A
--
C
I
------
L
D
I
L
L
S
-----
S
E
T
G
------------
T
------------
I
------
Q
-
E
H
K
K
-------
N
-----
I
L
D
K
S
K
E
A
S
L
V
----
G
F
I
N
Y
V
L
I
P
Y
F
N
K
K
V
P
H
A
V
E
F
--
I
----------------
I
------
Q
K
L
K
G
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
71.49
15%
-121
- C6 -
1U19
14
OPSD_BOVIN
A:
[39-328]
------------------------------------------------------------------------------
Q
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
G
F
P
I
N
-------------------
F
L
T
----
L
Y
V
T
V
-----
Q
H
-
K
K
L
R
T
P
L
------
N
Y
I
L
-
L
--
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
--
T
L
Y
T
S
L
-
H
G
Y
-------
F
V
-------
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
-------------------------
G
E
I
A
------
L
W
S
L
V
V
---
L
A
I
E
R
Y
V
V
V
C
K
P
M
----
S
N
F
--
R
F
----
G
E
N
------
H
A
I
M
G
V
A
F
T
W
V
M
A
L
---
A
C
A
A
P
P
L
V
G
------
W
S
R
--------
Y
I
P
E
G
M
--------------
Q
C
S
C
G
-
I
D
Y
Y
-
T
P
H
-----------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
--
I
I
P
L
I
V
I
F
-
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
----------------
I
I
M
V
I
---
A
F
L
I
C
W
---
L
--
P
Y
------
A
G
V
A
F
Y
-----
I
F
T
H
QGS---------
D
------------
F
------
G
-
P
I
F
M
-------
T
-----
I
--
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
--
T
----------------
L
------
C
C
G
K
N
P
L
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
71.04
14%
-121
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
------------
P
C
F
R
E
E
------------------------------------------------
N
A
N
--------
F
N
K
I
F
L
P
T
I
Y
S
I
I
----
F
L
T
G
I
V
G
N
-------------------
G
L
V
----
I
L
V
M
G
-----
Y
Q
-
K
K
L
R
S
M
T
------
D
K
Y
R
-
L
--
H
L
S
V
A
D
L
L
F
V
I
T
L
---
P
--
F
W
A
V
D
A
-
V
A
N
-------
W
Y
-------
F
G
N
F
L
C
K
A
-
V
H
V
I
Y
T
V
N
-------------------------
L
Y
S
S
------
V
W
I
L
A
F
---
I
S
L
D
R
Y
L
A
I
V
H
A
T
NS
Q
R
P
R
K
--
L
L
---
A
E
K
V
------
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
---
P
D
F
I
F
A
N
V
S
------
E
A
D
D
R
Y
--
I
-
C
D
R
F
Y
P
N
--------------
D
L
W
V
V
-
V
F
Q
F
-
Q
H
I
M
V
-------
G
-------
L
I
L
P
--
G
I
V
I
L
S
C
Y
C
---
I
I
I
S
--
K
L
S
H
S
G
S
N
-
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
T
E
G
Y
Y
T
I
G
----------------
I
G
H
L
L
TKS
P
S
L
N
A
A
---
K
--
S
E
------
L
D
K
A
I
G
-----
R
N
T
N
------------
G
------------
V
------
I
-
T
K
D
E
-------
A
-----
E
--
K
L
F
N
Q
D
V
D
----
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
--
V
----------------
R
------
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
29
HHSearch
70.18
19%
-138
- C6 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
-----------------------------------------------------------------------------
N
S
I
K
L
T
S
V
V
F
I
L
I
----
C
C
F
I
I
L
E
N
-------------------
I
F
V
----
L
L
T
I
W
-----
K
T
-
K
K
F
H
R
P
M
------
Y
Y
F
I
-
G
--
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
--
L
L
L
S
G
A
--
T
T
-------
Y
K
-------
L
T
P
A
Q
W
F
L
-
R
E
G
S
M
F
V
A
-------------------------
L
S
A
S
------
V
F
S
L
L
A
---
I
A
I
E
R
Y
I
T
M
L
K
-----------------
N
N
F
------
R
L
F
L
L
I
S
A
C
W
V
I
S
L
---
I
L
G
G
L
P
I
M
G
------
W
N
-----------
C
I
S
A
--------------
L
S
S
C
S
-
T
V
L
P
-
L
-------------------------
Y
H
K
H
Y
I
L
F
C
---
T
T
V
F
--
T
L
L
L
L
S
I
V
-
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
V
----------------
I
I
V
L
S
---
V
F
I
A
C
W
---
A
--
P
L
------
F
I
L
L
L
L
-----
D
V
G
C
------------
K
------------
V
KTC
D
--
I
-
L
F
R
A
-------
E
-----
Y
--
F
L
V
L
A
V
L
N
----
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
--
I
----------------
M
------
G
R
P
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
69.27
15%
-122
- C6 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-----------------------------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
----
F
L
L
S
L
L
G
N
-------------------
S
L
V
----
M
L
V
I
L
-----
Y
S
-
R
V
G
R
S
V
T
------
D
V
Y
L
-
L
--
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
--
W
A
A
S
K
--
V
N
G
-------
W
I
-------
F
G
T
F
L
C
K
V
-
V
S
L
L
K
E
V
N
-------------------------
F
Y
S
G
------
I
L
L
L
A
C
---
I
S
V
D
R
Y
L
A
I
V
H
A
T
----
R
T
L
--
T
----
Q
K
R
H
------
L
V
K
F
V
C
L
G
C
W
G
L
S
M
---
N
L
S
L
P
F
F
L
F
------
R
-
Q
--
A
-----
Y
H
P
N
N
S
--------------
S
P
V
C
Y
-
E
V
L
G
-
N
D
------------------
T
A
K
W
--
R
M
V
L
R
I
L
P
H
---
T
F
G
F
--
I
V
P
L
F
V
M
L
-
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
----------------
F
A
V
V
L
---
I
F
L
L
C
W
---
L
--
P
Y
------
N
L
V
L
L
A
-----
D
T
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
------
I
-
G
R
A
L
-------
D
-----
A
--
T
E
I
L
G
F
L
H
----
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
--
I
----------------
L
------
A
M
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
64.85
14%
-146
- C5 -
4JP0
-
?
A:
[2-381]
LDTN
K
V
Y
E
I
S
N
H
A
N
G
L
Y
A
A
T
Y
L
SLDD
S
G
V
S
L
----------------
M
N
---------------
K
N
D
D
D
--------
I
D
D
Y
N
L
K
W
F
L
F
P
I
D
DD
Q
Y
I
I
T
S
Y
A
A
-------------------
N
N
C
K
V
W
N
V
N
N
D
K
-----
I
N
-
V
S
T
Y
S
-
S
------
T
N
S
I
-
Q
--
K
W
Q
I
K
A
N
G
S
S
Y
V
I
-
Q
S
D
NG
K
V
L
T
A
G
-
T
G
Q
ALG
L
I
R
L
T
D
-------
E
S
S
N
N
P
N
Q
-
Q
W
N
L
T
S
V
Q
T
I
Q
L
PQKPIIDTKLKDYPKYSGNID
N
G
T
S
PQLM
G
W
T
L
V
P
C
I
---
M
V
N
D
P
N
I
D
K
N
T
Q
I
----
K
T
T
P
Y
Y
I
---
L
K
K
Y
------
Q
Y
W
Q
R
A
V
G
S
N
V
A
L
R
---
P
H
----
E
K
K
------
S
Y
T
-
Y
E
--
W
G
T
E
I
D
Q
K
T
--------------
T
I
I
N
T
-
L
--
G
-
F
Q
I
N
I
-------
D
-------
S
G
M
K
--
F
D
I
P
E
V
G
G
G
---
T
D
E
I
--
K
T
Q
L
N
E
E
L
K
I
E
Y
---
S
H
E
T
K
I
M
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
Q
S
E
I
D
N
P
T
----------------
D
Q
S
M
N
---
S
I
G
F
L
T
---
I
--
T
S
------
L
E
L
Y
R
Y
-----
N
G
S
E
------------
I
------------
R
------
I
-
M
Q
I
Q
-------
T
-----
S
D
N
D
T
Y
N
V
T
S
Y
----
P
N
H
Q
Q
A
L
L
L
L
T
N
H
S
Y
E
E
V
E
E
I
T
N
I
----------------
P
------
K
S
T
L
I
K
L
K
K
H-------------------------------------------------------------------------------------------------------------------------------------------------------------