@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MATK_HUMAN: (2013-07-23 )
MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
Atome Classification :
(100 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......--140-........150.......160-----.......170...-.-....180.......190.......200.....--..210......-----------.220.....-..230...--....-240.......250..--.----.---------.----..260...-.------.---.---.---270.......280.-......290..-...--.--.-300.......310.......320-------------........330.......340.......350.......360.......370...----.------.--.-----.----380..-----.....390.....--..400.......410.......420.....-..430.......440...---....450.......460.......470.......480.......490.......500.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPP--ED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRV-LHR-D-GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKS-----------AEEELARAG-WLLNLQHL--TLGA-QIGEGEFGAVLQGEY--L----G---------Q----KVAVKNIK-C------D---V---T---AQAFLDETAVMTKM-QHENLVRLLGV-ILH--Q--G-LYIVMEHVSKGNLVNFLRTRGR--------------ALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAK----A------E--R-----K----GLDSS-----RLPVKWTAPEALK--HGKFTSKSDVWSFGVLLWEVFSYGRAPYPK-MSLKEVSEAVEKGYRMEP---PEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
5
PsiBlast_PDB
86.41
39%
-104
- C2 -
2H8H
1
SRC_HUMAN
A:
[101-512]
-----------------------------------------------------------------
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---------------------------------
7
PsiBlast_PDB
85.12
39%
-104
- C2 -
2SRC
1
SRC_HUMAN
A:
[18-429]
-----------------------------------------------------------------
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---------------------------------
8
PsiBlast_PDB
84.48
39%
-109
- C2 -
1Y57
1
SRC_HUMAN
A:
[18-431]
-----------------------------------------------------------------
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10
PsiBlast_PDB
82.50
37%
-101
- C2 -
1QCF
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
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9
PsiBlast_PDB
82.30
39%
-101
- C2 -
1KSW
1
SRC_HUMAN
A:
[18-429]
-----------------------------------------------------------------
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P
T
F
E
Y
L
---------------------------------
23
PsiBlast_CBE
81.63
37%
-103
- C2 -
3VS6
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
25
PsiBlast_CBE
81.52
37%
-105
- C2 -
3VS5
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
32
PsiBlast_CBE
81.47
37%
-106
- C2 -
3VRY
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
31
PsiBlast_CBE
81.40
37%
-105
- C2 -
3VRZ
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
35
PsiBlast_CBE
81.28
37%
-104
- C2 -
2C0I
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
115
HHSearch
80.98
35%
-92
- C2 -
1OPK
3
ABL1_MOUSE
A:
[44-479]
--------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
-
N
T
A
-
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
I----------
Y
G
V
S
P
N
Y
D
K
-
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
----
K
YS-------
L
----
T
V
A
V
K
T
L
K
E
D
------
T
---
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
P-
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
MTG
D
------
T
--
Y
-----
T
----
A
H
A
G
A
-----
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-----------------------
33
PsiBlast_CBE
80.72
37%
-102
- C2 -
2C0T
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
11
PsiBlast_PDB
80.72
37%
-105
- C2 -
2C0I
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
116
HHSearch
80.38
37%
-107
- C2 -
2OZO
1
ZAP70_HUMAN
A:
[155-600]
-----------------------------------------------------------------------------------------------------------------
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
AQ
T
D
--
G
K
F
L
L
R
P
R
-
K
E
Q
G
T
Y
A
L
S
L
I
Y
-----
G
K
T
V
Y
H
Y
L
I
-
S
Q
D
K
A
-
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
--
K
E
A
C
P
N
-----MDTSVFESPFS
D
P
E
E
L
K
D
K
K
-
L
F
L
K
R
D
N
L
--
L
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
M
RK
K
Q
---------
I
----
D
V
A
I
K
V
L
K
-
Q
------
G
TEK
A
---
D
---
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
-
D
N
P
Y
I
V
R
L
I
G
V
-
C
Q
A
--
E
--
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
--------------
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
----
A
LG------------------------------
P
L
K
W
Y
A
P
E
C
I
N
--
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
-
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
---
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
S
L
----------------------
22
PsiBlast_CBE
80.23
37%
-104
- C2 -
3VS6
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
30
PsiBlast_CBE
80.14
37%
-102
- C2 -
3VS0
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
13
PsiBlast_PDB
80.00
37%
-102
- C2 -
2C0T
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
19
PsiBlast_PDB
79.93
37%
-103
- C2 -
3VS3
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
36
PsiBlast_CBE
79.85
37%
-98
- C2 -
2HCK
1
HCK_HUMAN
B:
[18-421]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
-----------------------
G
A
-----
K
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
24
PsiBlast_CBE
79.77
37%
-105
- C2 -
3VS5
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
29
PsiBlast_CBE
79.65
37%
-103
- C2 -
3VS1
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
34
PsiBlast_CBE
79.45
37%
-103
- C2 -
2C0O
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
YDPRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
26
PsiBlast_CBE
79.39
37%
-103
- C2 -
3VS4
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
12
PsiBlast_PDB
79.30
37%
-102
- C2 -
2C0O
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
20
PsiBlast_PDB
79.15
37%
-102
- C2 -
3VS4
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
IE-----------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
28
PsiBlast_CBE
78.95
37%
-105
- C2 -
3VS2
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
-
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
18
PsiBlast_PDB
78.85
37%
-104
- C2 -
3VS2
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
L
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
14
PsiBlast_PDB
78.36
37%
-104
- C2 -
3VRY
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
-------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I------------------------------
F
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
40
PsiBlast_CBE
78.24
36%
-99
- C2 -
2FO0
4
ABL1_HUMAN
A:
[57-466]
------------------------------------------------------------------
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
--
C
E
A
Q
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
-----------
V
Y
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
21
PsiBlast_CBE
77.70
37%
-100
- C2 -
3VS7
1
HCK_HUMAN
B:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
T
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-------------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
38
PsiBlast_CBE
77.54
36%
-105
- C2 -
1OPL
1
ABL1_HUMAN
B:
[140-508]
-------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
-------------------------
D
K
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
39
PsiBlast_CBE
77.36
36%
-101
- C2 -
1OPL
2
ABL1_HUMAN
A:
[99-508]
------------------------------------------------------------------
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
--
C
E
A
Q
T
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
------
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
-
D
-
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
Y
P
A
P
K
R
N
K
P
T
-----------
V
Y
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
17
PsiBlast_PDB
76.98
37%
-97
- C2 -
3VS1
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
----------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
16
PsiBlast_PDB
76.29
37%
-101
- C2 -
3VS0
1
HCK_HUMAN
A:
[24-437]
-----------------------------------------------------------------
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
--
E
S
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
------
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
--
G
N
ML
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
-
R
------
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
--
S
V
P
C
M
S
S
K
P
Q
K
-----------
P
W
E
K
D
A
----
W
E
I
P
R
E
S
L
--
K
L
E
K
-
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
----
K
---------
H
T
---
K
V
A
V
K
T
M
K
P
G
------
S
---
M
---
S
---
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
-
V
T
K
--
E
--
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
--------------
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
----
V
I-------------------------------
P
I
K
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
-
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
---
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
-----------------------------
134
HHSearch
75.20
57%
-109
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
W
A
L
N
M
K
E
L
--
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
--
R
----
G
---------
N
----
K
V
A
V
K
C
I
K
-
N
------
D
---
A
--------
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
E
--
E
--
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
--------------------------------------
L
P
V
K
W
T
A
P
E
A
L
R
--
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
-
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
---
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
-----------------------
2
PsiBlast_PDB
70.59
58%
-108
- C2 -
3D7T
1
CSK_HUMAN
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
L
N
M
K
E
L
--
K
L
L
Q
-
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
--
R
----
G
---------
N
----
K
V
A
V
K
C
I
K
-
N
------
D
---
A
---
T
---
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
E
--
E
KG
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
--------------
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
----------------------------------------
P
V
K
W
T
A
P
E
A
L
R
--
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
-
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
---
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
-----------------------------
42
PsiBlast_CBE
70.32
40%
-92
- C2 -
3BKB
9
A:
[15-369]
-------------------------------------------------------------------------------------------------------------------------
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
--
G
D
F
L
V
R
E
S
-
Q
G
K
Q
E
Y
V
L
S
V
L
W
-----
D
G
L
P
R
H
F
I
I
-
Q
S
L
-
D
--
N
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
----------
Q
P
L
T
K
K
S
G
V
V
-----------
L
H
R
A
V
P
K
D
K
-
W
V
L
N
H
E
D
L
--
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--
R
----
A
---------
D
----
N
T
L
V
A
V
K
S
-
C
R
ETLP
P
D
---
L
---
K
---
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
-
C
T
Q
K-
Q
--
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
---------------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
----
E
------
E
--
A
-----
D
----
G
V
Y
A
A
SGGLR
Q
V
P
V
K
W
T
A
P
E
A
L
N
--
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
-
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
---
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
-----------------------------
120
HHSearch
68.80
37%
-104
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[34-321]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
-
H
H
I
K
R
R
D
I
--
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
NLLP
K
---------
M
----
L
V
A
V
K
A
L
K
-
E
A-----
S
---
E
S
--
A
---
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
-
C
T
E
G-
R
--
P
-
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
DP------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------------------
T
-----
M
L
P
I
R
W
M
P
P
E
S
I
L
--
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
---
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
----------------------
57
PsiBlast_CBE
68.29
44%
-108
- C2 -
3CS9
1
ABL1_HUMAN
B:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
----------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
----------------------------------------
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
133
HHSearch
68.26
44%
-95
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[61-354]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
-
W
E
L
P
R
D
R
L
--
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
--
I
----
G
LDKDKPN
R
V
T
----
K
V
A
V
K
M
L
K
-
S
------
D
---
A
---
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
-
C
T
Q
--
D
G-
P
-
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
PGLEYSYNPSHNP
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
------
I
--
H
H
I
D
YY
K
----
K
T
T
N
G
-----
R
L
P
V
K
W
M
A
P
E
A
L
F
--
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
---
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
----------------------
80
PsiBlast_CBE
68.22
43%
-102
- C2 -
3IK3
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
---------------------------
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
66
PsiBlast_CBE
67.72
44%
-99
- C2 -
2G1T
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HA
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
121
HHSearch
67.35
41%
-96
- C2 -
4FYO
1
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
--
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
----
M
---------
K
K
V
V
K
T
V
A
V
K
I
L
-------------
P
A
--
L
---
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
-
C
E
A
--
E
--
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
N
----------------
R
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
----
A
L
R
ADEN
Y
--
Y
-----
K
----
A
---------
K
W
P
V
K
W
Y
A
P
E
C
I
N
--
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
-
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
---
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
-----------------------
51
PsiBlast_CBE
67.16
44%
-97
- C2 -
2G2H
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
54
PsiBlast_CBE
67.10
44%
-110
- C2 -
3PYY
3
ABL1_HUMAN
B:
[21-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
---------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
----------------------------------GA---
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
65
PsiBlast_CBE
66.86
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
C:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
59
PsiBlast_CBE
66.77
44%
-102
- C2 -
2HZI
1
ABL1_HUMAN
B:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
-------------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
60
PsiBlast_CBE
66.69
44%
-97
- C2 -
2HZI
1
ABL1_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
64
PsiBlast_CBE
66.46
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
D:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
83
PsiBlast_CBE
66.43
45%
-98
- C2 -
3GVU
2
A:
[27-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
--
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--------------------
G
----
D
T
Y
T
-A----
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
---
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
------------------------------------
129
HHSearch
66.35
38%
-100
* C2 *
2J0J
1
FAK1_CHICK
A:
[383-651]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
-
Y
E
I
Q
R
E
R
I
--
E
L
G
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
----
S
PEN
P
A
----
M
----
A
V
A
I
K
T
C
K
-
N
------
C
---
T
S
D
S
V
---
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
T
E
--
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
---------------
F
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----
Y
------
M
ED----------------------
L
P
I
K
W
M
A
P
E
S
I
N
--
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
---
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
------------------------
82
PsiBlast_CBE
66.33
45%
-94
- C2 -
3HMI
1
A:
[27-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
--
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
---
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
------------------------------------
53
PsiBlast_CBE
66.16
44%
-95
- C2 -
2G2F
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
P
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
67
PsiBlast_CBE
65.88
44%
-98
- C2 -
2G1T
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HA
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
43
PsiBlast_CBE
65.66
44%
-96
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
62
PsiBlast_CBE
65.64
44%
-99
- C2 -
3UE4
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
50
PsiBlast_CBE
65.46
44%
-98
- C2 -
2G2H
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
122
HHSearch
65.31
38%
-100
- C2 -
4I4E
1
A:
[9-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
Y
E
I
Q
R
E
R
I
--
E
L
G
R
-
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
----
S
---------
P
NP
A
L
A
V
A
I
K
T
C
K
-
N
------
C
---
T
S
D
S
V
---
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
-
I
T
E
--
N
--
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
Y
---------------
S
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
----------------------------------------
L
P
I
K
W
M
A
P
E
S
I
N
--
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
---
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
------------------------
44
PsiBlast_CBE
65.25
44%
-97
- C2 -
3QRK
1
ABL1_HUMAN
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
45
PsiBlast_CBE
65.20
44%
-97
- C2 -
3QRI
1
ABL1_HUMAN
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AG
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
88
PsiBlast_CBE
65.16
43%
-94
- C2 -
3MS9
2
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
----------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
76
PsiBlast_CBE
65.16
44%
-96
- C2 -
2HZ0
1
ABL1_HUMAN
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
55
PsiBlast_CBE
64.92
44%
-98
- C2 -
3PYY
1
ABL1_HUMAN
A:
[21-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
94
PsiBlast_CBE
64.79
43%
-95
- C2 -
1OPJ
2
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
91
PsiBlast_CBE
64.79
43%
-96
- C2 -
3K5V
2
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
---
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
135
HHSearch
64.67
38%
-106
- C2 -
3C1X
1
A:
[80-362]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
-
V
V
I
G
P
S
S
L
I
V
H
F
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
--
L
----
D
ND
G
K
K
----
I
----
H
C
A
V
K
S
L
N
-
R
ITD---
I
---
G
---
E
---
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
-
C
L
R
SE
G
--
S
-
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
N
E
T
H
---------------
N
P
T
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
----------------------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
--
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
-
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
---
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
-----------------
93
PsiBlast_CBE
64.66
43%
-100
- C2 -
1OPJ
2
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
96
PsiBlast_CBE
64.62
43%
-95
- C2 -
1M52
1
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
89
PsiBlast_CBE
64.50
43%
-93
- C2 -
3MS9
2
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
---------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
---------------
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
75
PsiBlast_CBE
64.39
44%
-107
- C2 -
2HZ0
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
------
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
-------------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
---------------------------------------
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
56
PsiBlast_CBE
64.38
44%
-90
- C2 -
3CS9
1
ABL1_HUMAN
D:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
----------------------
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
95
PsiBlast_CBE
64.33
43%
-95
- C2 -
1M52
3
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
87
PsiBlast_CBE
64.31
45%
-98
- C2 -
3GEQ
1
SRC_CHICK
B:
[8-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
K
D
A
-
W
E
I
P
R
E
S
L
--
R
L
E
V
-
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
----
G
---------
T
T
---
R
V
A
I
K
T
L
K
P
G
------
T
---
M
---
S
---
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
-
V
S
E
--
E
--
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
--------------
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
LI-----------------------------------
P
I
K
W
T
A
P
E
A
A
L
--
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
-
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
---
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
---------------------------------
69
PsiBlast_CBE
64.10
44%
-100
- C2 -
2HZ4
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
-----
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
63
PsiBlast_CBE
63.94
44%
-91
- C2 -
3UE4
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
97
PsiBlast_CBE
63.44
43%
-89
- C2 -
1IEP
1
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
81
PsiBlast_CBE
63.39
43%
-94
- C2 -
2Z60
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
--------------
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
58
PsiBlast_CBE
63.27
44%
-95
- C2 -
3CS9
1
ABL1_HUMAN
A:
[12-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------------------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
78
PsiBlast_CBE
63.07
43%
-91
- C2 -
3OY3
1
ABL1_MOUSE
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
99
PsiBlast_CBE
63.06
43%
-94
- C2 -
1FPU
1
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
--------------------------
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
72
PsiBlast_CBE
63.04
44%
-95
- C2 -
2HYY
1
ABL1_HUMAN
C:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
-------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
------------
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
71
PsiBlast_CBE
62.84
44%
-93
- C2 -
2HYY
1
ABL1_HUMAN
D:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
----------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
90
PsiBlast_CBE
62.82
43%
-93
- C2 -
3K5V
2
ABL1_MOUSE
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
------------
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
61
PsiBlast_CBE
62.78
44%
-91
- C2 -
2F4J
1
ABL1_HUMAN
A:
[9-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
47
PsiBlast_CBE
62.76
44%
-95
- C2 -
2HIW
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
52
PsiBlast_CBE
62.71
44%
-94
- C2 -
2G2F
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
-----
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
P
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
79
PsiBlast_CBE
62.56
43%
-96
- C2 -
3IK3
1
ABL1_MOUSE
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
86
PsiBlast_CBE
62.41
45%
-92
- C2 -
2XYN
2
ABL2_HUMAN
A:
[27-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
---------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
--
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
---
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
------------------------------------
48
PsiBlast_CBE
62.31
44%
-98
- C2 -
2G2I
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
----
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
85
PsiBlast_CBE
62.26
45%
-91
- C2 -
2XYN
4
ABL2_HUMAN
B:
[27-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
---------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
--
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
---
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
------------------------------------
73
PsiBlast_CBE
62.19
44%
-91
- C2 -
2HYY
1
ABL1_HUMAN
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
-------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
100
PsiBlast_CBE
61.83
43%
-93
- C2 -
1FPU
1
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
77
PsiBlast_CBE
61.83
43%
-90
- C2 -
3OY3
1
ABL1_MOUSE
B:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
84
PsiBlast_CBE
61.64
45%
-90
- C2 -
2XYN
4
C:
[27-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
---------T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
--
P
--
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
---
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
------------------------------------
98
PsiBlast_CBE
61.48
43%
-93
- C2 -
1IEP
1
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
74
PsiBlast_CBE
61.38
44%
-92
- C2 -
2HYY
1
ABL1_HUMAN
A:
[8-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
--------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
AGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
92
PsiBlast_CBE
60.87
43%
-91
- C2 -
2HZN
1
ABL1_MOUSE
A:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
---
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
---------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
H
A
GA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
49
PsiBlast_CBE
60.09
44%
-95
- C2 -
2G2I
1
ABL1_HUMAN
A:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
K
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
PAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
46
PsiBlast_CBE
58.33
44%
-90
- C2 -
2HIW
1
ABL1_HUMAN
B:
[10-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
--
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
KK
Y
----
S
---------
L
----
T
V
A
V
K
T
L
K
-
E
------
D
T--
M
---
E
---
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
-
C
T
R
--
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
--------------
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
----
L
------
M
--
T
-----
G
----
D
T
Y
T
A
HAGA-
K
F
P
I
K
W
T
A
P
E
S
L
A
--
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
---
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
---------------------------------
126
HHSearch
54.14
33%
-93
- C2 -
4ITJ
1
RIPK1_HUMAN
A:
[8-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
-
I
K
M
K
S
S
D
F
--
L
E
---------
F
G
K
V
S
L
A
F
H
--
R
----
T
---------
Q
G
---
L
M
I
M
K
T
V
Y
K
G
------
P
---
N
CIE
H
---
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
-
I
I
E
--
E
G-
K
-
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
K
A
E
M
----------------
S
T
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
K
G
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
----
F
------
K
--
M
-----
W
S
K
L
N-----------
G
T
L
Y
Y
M
A
P
E
H
L
N
DV
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
K
E
P
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
DDI
T
E
Y
C
P
R
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
-----------------------
Add PDB User Result:
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGRGSLVSWRAFHGCDSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
136
-
100%
-115
- C2 -
U136
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
V
R
E
S
A
R
H
P
G
D
Y
V
L
C
V
S
F
G
R
D
V
I
H
Y
R
V
L
H
R
D
G
H
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
Y
S
K
D
K
G
A
I
C
T
K
L
V
R
P
K
R
K
H
G
T
K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
E
G
E
F
G
A
V
L
Q
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E
Y
L
G
Q
K
V
A
V
K
N
I
K
C
D
V
T
A
Q
A
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L
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E
T
A
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M
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K
M
Q
H
E
N
L
V
R
L
L
G
V
I
L
H
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G
N
L
V
N
F
L
R
T
R
G
R
A
L
V
N
T
A
Q
L
L
Q
F
S
L
H
V
A
E
G
M
E
Y
L
E
S
K
K
L
V
H
R
D
L
A
A
R
N
I
L
V
S
E
D
L
V
A
K
V
S
D
F
G
L
A
K
A
----------
P
V
K
W
T
A
P
E
A
L
K
H
G
K
F
T
S
K
S
D
V
W
S
F
G
V
L
L
W
E
V
F
S
Y
G
R
A
P
Y
P
K
M
S
L
K
E
V
S
E
A
V
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K
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Y
R
M
E
P
P
E
G
C
P
G
P
V
H
V
L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
137
-
100%
-115
- C2 -
U137
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
V
R
E
S
A
R
H
P
G
D
Y
V
L
C
V
S
F
G
R
D
V
I
H
Y
R
V
L
H
R
D
G
H
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
Y
S
K
D
K
G
A
I
C
T
K
L
V
R
P
K
R
K
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G
T
K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
E
G
E
F
G
A
V
L
Q
G
E
Y
L
G
Q
K
V
A
V
K
N
I
K
C
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V
T
A
Q
A
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L
D
E
T
A
V
M
T
K
M
Q
H
E
N
L
V
R
L
L
G
V
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L
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I
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G
N
L
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N
F
L
R
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R
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R
A
L
V
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T
A
Q
L
L
Q
F
S
L
H
V
A
E
G
M
E
Y
L
E
S
K
K
L
V
H
R
D
L
A
A
R
N
I
L
V
S
E
D
L
V
A
K
V
S
D
F
G
L
A
K
A
----------
P
V
K
W
T
A
P
E
A
L
K
H
G
K
F
T
S
K
S
D
V
W
S
F
G
V
L
L
W
E
V
F
S
Y
G
R
A
P
Y
P
K
M
S
L
K
E
V
S
E
A
V
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K
G
Y
R
M
E
P
P
E
G
C
P
G
P
V
H
V
L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
138
-
100%
-117
- C2 -
U138
1
B:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
V
R
E
S
A
R
H
P
G
D
Y
V
L
C
V
S
F
G
R
D
V
I
H
Y
R
V
L
H
---
H
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
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S
K
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K
G
A
I
C
T
K
L
V
R
P
K
R
K
H
G
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K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
E
G
E
F
G
A
V
L
Q
G
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Y
L
G
Q
K
V
A
V
K
N
I
K
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M
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L
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L
L
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L
Q
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S
L
H
V
A
E
G
M
E
Y
L
E
S
K
K
L
V
H
R
D
L
A
A
R
N
I
L
V
S
E
D
L
V
A
K
V
S
D
F
G
L
A
K
A
---------
L
P
V
K
W
T
A
P
E
A
L
K
H
G
K
F
T
S
K
S
D
V
W
S
F
G
V
L
L
W
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A
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P
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L
K
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S
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A
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P
P
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L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
139
-
100%
-115
- C2 -
U139
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
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A
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H
P
G
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Y
V
L
C
V
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F
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R
D
V
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V
L
H
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H
L
T
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D
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A
V
F
F
C
N
L
M
D
M
V
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K
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K
G
A
I
C
T
K
L
V
R
P
K
R
K
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G
T
K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
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L
G
A
Q
I
G
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G
E
F
G
A
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L
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A
V
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L
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L
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K
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A
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L
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S
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L
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A
K
V
S
D
F
G
L
A
K
A
----------
P
V
K
W
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A
P
E
A
L
K
H
G
K
F
T
S
K
S
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V
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L
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L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
140
-
100%
-117
- C2 -
U140
1
B:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
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L
V
R
E
S
A
R
H
P
G
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Y
V
L
C
V
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F
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D
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I
H
Y
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V
L
H
---
H
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
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S
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A
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C
T
K
L
V
R
P
K
R
K
H
G
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K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
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G
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L
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A
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L
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L
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L
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K
L
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A
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L
V
S
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L
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A
K
V
S
D
F
G
L
A
K
A
---------
L
P
V
K
W
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A
P
E
A
L
K
H
G
K
F
T
S
K
S
D
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W
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G
V
L
L
W
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A
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L
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A
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G
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L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
141
-
100%
-115
- C2 -
U141
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
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L
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A
R
H
P
G
D
Y
V
L
C
V
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F
G
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V
L
H
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G
H
L
T
I
D
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A
V
F
F
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L
M
D
M
V
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K
D
K
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A
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C
T
K
L
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K
S
A
E
E
E
L
A
---
W
L
L
N
L
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L
T
L
G
A
Q
I
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E
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L
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A
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L
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L
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E
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M
E
Y
L
E
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K
K
L
V
H
R
D
L
A
A
R
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I
L
V
S
E
D
L
V
A
K
V
S
D
F
G
L
A
K
A
----------
P
V
K
W
T
A
P
E
A
L
K
H
G
K
F
T
S
K
S
D
V
W
S
F
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V
L
L
W
E
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F
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R
A
P
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P
K
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L
K
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V
S
E
A
V
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Y
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M
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P
P
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C
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P
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L
M
S
S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
142
-
100%
-115
- C2 -
U142
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
E
A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
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A
R
H
P
G
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Y
V
L
C
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V
L
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L
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A
V
F
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L
M
D
M
V
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A
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A
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E
E
L
A
---
W
L
L
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L
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L
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L
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A
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V
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F
G
L
A
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A
----------
P
V
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W
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A
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A
L
K
H
G
K
F
T
S
K
S
D
V
W
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L
L
W
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L
M
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S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
143
-
100%
-105
- C2 -
U143
1
A:
[228-474]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
E
G
E
F
G
A
V
L
Q
G
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Y
L
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A
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L
L
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W
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L
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L
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S
C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
---------------------------------
144
-
100%
-115
- C2 -
U144
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
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G
Q
E
G
L
L
A
A
G
A
L
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E
R
E
A
L
S
A
D
P
------
W
F
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G
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A
V
Q
Q
L
Q
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P
E
D
G
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L
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R
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S
A
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H
P
G
D
Y
V
L
C
V
S
F
G
R
D
V
I
H
Y
R
V
L
-----
L
T
I
D
E
A
V
F
F
C
N
L
M
D
M
V
E
H
Y
S
K
D
K
G
A
I
C
T
K
L
V
R
P
K
R
K
H
G
T
K
S
A
E
E
E
L
A
---
W
L
L
N
L
Q
H
L
T
L
G
A
Q
I
G
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G
E
F
G
A
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L
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L
G
Q
K
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A
V
K
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I
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L
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Y
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L
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L
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L
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K
V
S
D
F
G
L
A
K
A
----------
P
V
K
W
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A
L
K
H
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F
T
S
K
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D
V
W
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C
W
E
A
E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
145
-
100%
-117
- C2 -
U145
1
B:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
H
G
K
I
S
G
Q
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A
V
Q
Q
L
Q
P
P
E
D
G
L
F
L
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A
R
H
P
G
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Y
V
L
C
V
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F
G
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V
I
H
Y
R
V
L
H
---
H
L
T
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A
V
F
F
C
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L
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D
M
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C
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K
L
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K
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K
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A
E
E
E
L
A
---
W
L
L
N
L
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L
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L
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G
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L
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K
L
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L
V
A
K
V
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D
F
G
L
A
K
A
---------
L
P
V
K
W
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A
L
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W
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L
L
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W
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E
P
A
R
R
P
P
F
R
K
L
A
E
-------------------------------
146
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100%
-115
- C2 -
U146
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
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V
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I
L
E
--
E
N
K
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Y
R
V
K
H
H
T
S
G
Q
E
G
L
L
A
A
G
A
L
R
E
R
E
A
L
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A
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P
------
W
F
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G
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G
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V
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Q
L
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G
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H
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----
L
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V
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F
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L
M
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M
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A
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E
E
L
A
---
W
L
L
N
L
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L
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L
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----------
P
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W
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A
E
-------------------------------
147
-
100%
-115
- C2 -
U147
1
A:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
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Y
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H
H
T
S
G
Q
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G
L
L
A
A
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A
L
R
E
R
E
A
L
S
A
D
P
------
W
F
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G
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E
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A
---
W
L
L
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----------
P
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A
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A
R
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P
F
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K
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A
E
-------------------------------
148
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U148
1
B:
[223-474]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
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A
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L
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H
L
T
L
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A
Q
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D
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A
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-----------
P
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A
R
R
P
P
F
R
K
L
---------------------------------
149
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100%
-115
- C2 -
U149
1
A:
[66-476]
-----------------------------------------------------------------
E
L
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V
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I
L
E
--
E
N
K
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Y
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G
L
L
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A
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----
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L
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---
W
L
L
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L
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V
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L
A
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A
----------
P
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A
L
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W
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A
R
R
P
P
F
R
K
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A
E
-------------------------------
150
-
100%
-116
- C2 -
U150
1
B:
[66-476]
-----------------------------------------------------------------
E
L
A
F
R
K
G
D
V
V
T
I
L
E
--
E
N
K
S
W
Y
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H
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S
G
Q
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G
L
L
A
A
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A
L
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L
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A
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------
W
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E
L
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---
W
L
L
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L
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----------
P
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K
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A
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-------------------------------
151
-
100%
-116
- C2 -
U151
1
B:
[66-476]
-----------------------------------------------------------------
E
L
A
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--
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K
L
A
E
-------------------------------
152
-
100%
-104
- C2 -
U152
1
A:
[228-474]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
L
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F
R
K
L
---------------------------------
153
-
100%
-104
- C2 -
U153
1
A:
[228-474]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
L
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---------------------------------