@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK3_HUMAN: (2015-10-18 )
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSSVPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Atome Classification :
(23 SA)
.........10..-......20.-.-......30........40--..----------------.---.....50.-------.---------.-------....--------.60........70.......-.80........90........100....---..---.----110.-----...--...120---.......130.--------......140.......150.......160..-.....170--------.-.-......180-....--....190--.-.......200.......210....--..---------------.-220.-.....--.230.---.--.....240..--...-..250.......260.......270.......280......-.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
C
V
KLWPSGAPA-
P
L
V
S
I
E
ELE-N-QELVGKGG
F
G
T
V
F
R
A
Q
H
R--KW----------------G---
Y
D
V
A
V
K
I
V-------
N
---------
S
-------
K
A
I
S
--------
R
E
V
K
A
M
A
SLD
N
E
F
V
L
R
L
E
G
V
-
I
E
KVNWDQDP
K
P
A
L
V
T
K
F
M
ENGS
L
S
G
L
L
---
Q
S---Q----CPR
P
-----
W
P
L
--
L
C
R
L
L
K
---
E
V
V
L
G
M
F
Y
LHD--------QN
P
V
L
L
HRDLKPS
N
V
L
LDPE
L
H
V
K
L
ADFGLS-TFQGGSQ---------S-G-TGSGEPGG--TLGY--L
A
P
E
L
F
---
V
-NVNRKAS
T
A
S
D
V
Y
S
F
G
I
L
M
W
A
V
LA--GR---------------E-VELP-TE
P
S
L
--
V
Y
E
A
V
---C--NRQNRP
S
L
A
E--LPQ-AGPETP
G
L
E
G
L
K
E
L
M
Q
L
CWSSEPKDRP
S
F
Q
E
CLP
K
T
D
E
V
F
Q
-
M
V
E
NNM
N
A
A
V
S
T
V
K
D
F
L
S
Q
L
R
SSNRRFSIPESGQGGT
E
M
D
G
F
R
R
T
I
E
NQHSRND
V
M
V
S
E
W
L
N
KLNLEEPPSSV
P
K
KC
P
S
L
T
K
R
SR
A
Q
E
E
QVPQAWTAGTSSDSMAQPPQTPET
S
T
F
RNQMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGR
P
L
V
N
I
YNCS
G
V
Q
VGDN
N
Y
L
T
M
Q
QTTALPTWGLAPSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
1
PsiBlast_PDB
90.55
69%
-108
- C2 -
4M69
1
RIPK3_MOUSE
A:
[12-312]
-----------
S
A
V
P
L
V
S
R
E
E
L
K
-
K
-
L
E
F
V
G
K
G
G
F
G
V
V
F
R
A
H
H
R
--
T
W
----------------
N
---
H
D
V
A
V
K
I
V
-------
N
---------
S
-------
K
K
I
S
--------
W
E
V
K
A
M
V
N
L
R
N
E
N
V
L
L
L
L
G
V
-
T
E
D
L
Q
W
D
F
V
S
G
Q
A
L
V
T
R
F
M
E
N
G
S
L
A
G
L
L
---
Q
P
---
E
----
C
P
R
P
-----
W
P
L
--
L
C
R
L
L
Q
---
E
V
V
L
G
M
C
Y
L
H
S
--------
L
D
P
P
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
G
L
S
-
T
F
Q
---------------------
D
S
G
G
--
T
L
A
Y
--
L
D
P
E
L
L
---
F
-
K
V
N
L
K
A
S
K
A
S
D
V
Y
S
F
G
I
L
V
W
A
V
L
A
--
G
R
---------------
E
-
A
E
L
V
-
D
K
T
S
L
--
I
R
E
T
V
---
C
--
D
R
Q
S
R
P
P
L
T
E
--
L
P
P
-
G
S
P
E
T
P
G
L
E
K
L
K
E
L
M
I
H
C
W
G
S
Q
S
E
N
R
P
S
F
Q
D
C
E
P
K
T
N
E
V
Y
N
-
L
V
K
D
K
V
D
A
A
V
S
E
V
K
H
Y
L
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.21
32%
-113
- C2 -
4C8B
1
RIPK2_HUMAN
B:
[26-315]
-----------
A
L
-
P
T
I
P
Y
H
K
L
A
-
D
-
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
--
D
W
----------------
R
---
V
Q
V
A
V
K
H
L
--------LLDS
E
----
R
-------
K
D
V
L
--------
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
-
C
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
---
H
R
---
K
----
T
E
Y
P
DVA--
W
P
L
--
R
F
R
I
L
H
---
E
I
A
L
G
V
N
Y
L
H
N
--------
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
-------------------------------
G
--
T
I
I
Y
--
M
P
P
E
N
Y
---
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
--
R
K
---------------
Q
P
F
E
D
V
-
T
N
P
L
Q
--
I
M
Y
S
V
------
S
Q
G
H
R
P
V
I
N
E
ES
L
P
Y
----
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
-
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.14
32%
-116
- C2 -
4C8B
2
RIPK2_HUMAN
A:
[25-315]
----------
S
A
L
-
P
T
I
P
Y
H
K
L
A
-
D
-
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
--
D
W
----------------
R
---
V
Q
V
A
V
K
H
L
-------
H
IHTPL
L
D
S
E
R
-------
K
D
V
L
--------
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
-
C
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
---
H
R
---
K
----
T
E
Y
P
DVA--
W
P
L
--
R
F
R
I
L
H
---
E
I
A
L
G
V
N
Y
L
H
N
--------
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
-------------------------------
G
--
T
I
I
Y
--
M
P
P
E
N
Y
-----------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
--
R
K
---------------
Q
P
F
E
D
V
-
T
N
P
L
Q
--
I
M
Y
S
V
------
S
Q
G
H
R
P
V
I
N
E
ES
L
P
Y
----
D
I
P
H
R
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
-
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
66.86
32%
-96
- C2 -
1U59
1
A:
[6-272]
----------------
L
K
R
D
N
L
L
-
I
A
D
I
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
R
---
K
----------------
Q
---
I
D
V
A
I
K
V
L
-------
K
---------
Q
GTE
K
A
D
T
E
E
M
M
--------
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
-
C
Q
A
------
E
A
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
---
V
G
K--
R
----
E
E
I
P
-----
V
S
N
--
V
A
E
L
L
H
---
Q
V
S
M
G
M
K
Y
L
E
E
--------
K
N
--
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
G
A
D
D
---------
S
Y
Y
-
T
A
R
S
A
G
K
W
--
P
L
K
W
--
Y
A
P
E
C
I
---
N
-
F
--
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y-
G
Q
---------------
K
-
P
Y
K
K
-
M
K
G
P
E
--
V
M
A
F
----
I
--
E
Q
G
K
R
M
E
C
-----
P
P
-
E
C
P
-----
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
-
S
L
A
S
K
V
E
G
H
H
H
H
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
66.59
32%
-94
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[6-304]
---------------
D
F
P
R
S
R
L
R
-
F
-
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
--
S
P
QDLVSLDFPLNVRKG
H
P
---
L
L
V
A
V
K
I
L
-------
R
---------
P
DAT
K
N
A
R
N
D
F
L
--------
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
-
C
V
Q
-----
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
---
S
A
---
H
QLED
P
T
I
S
-----
Y
P
M
--
L
L
H
V
A
A
---
Q
I
A
S
G
M
R
Y
L
A
T
--------
L
N
--
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
-
R
N
L
Y
A
G
D
---------
Y
-
Y
-----
R
A
V
L
--
P
I
R
W
--
M
A
W
E
C
I
---
L
-
M
--
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
LC
R
A
---------------
Q
-
P
F
G
Q
-
L
T
D
E
Q
--
V
I
E
N
A
G
E
F
F
--
R
D
Q
G
R
Q
V
Y
L
S
--
R
P
P
-
A
C
P
-----
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
-
N
T
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
66.07
33%
-92
- C2 -
4NEU
1
RIPK1_HUMAN
A:
[21-315]
----------------
M
K
S
S
D
F
L
-
E
-
S
A
E
L
D
S
G
G
F
G
K
V
S
L
C
F
H
R
--
T
Q
----------------
G
----
L
M
I
M
K
T
V
-------
Y
KGPN
C
I
E
H
-
N
-------
E
A
L
L
--------
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
-
I
I
E
-----
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
---
K
A
---
E
----
M
S
T
P
-----
L
S
V
--
K
G
R
I
I
L
---
E
I
I
E
G
M
C
Y
L
H
G
--------
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
-
S
F
K
M
W
----------------------
G
--
T
L
Y
Y
--
M
A
P
E
H
L
---
N
-
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
--
N
K
---------------
E
-
P
Y
E
N
-
A
I
C
E
Q
--
Q
L
I
M
C
---
I
--
K
S
G
N
R
P
D
V
D
D
--
I
T
E
-
Y
C
P
R
-----
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
64.43
31%
-92
- C2 -
4FYO
1
A:
[12-283]
---------------
Y
L
D
R
K
L
L
T
L
E
-
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
K
K
V
----------------
V
---
K
T
V
A
V
K
I
L
------------------P
A
L
K
---
D
E
L
L
--------
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
-
C
E
A
------
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
---
Q
Q
---
N
----
R
H
V
K
-----
D
K
N
--
I
I
E
L
V
H
---
Q
V
S
M
G
M
K
Y
L
E
E
--------
S
N
--
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
-
K
A
L
R
A
D
E
---------
N
-
Y
Y
K
A
----
K
W
--
P
V
K
W
--
Y
A
P
E
C
I
---
N
-
Y
--
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y-
G
Q
---------------
K
-
P
Y
R
G
-
M
K
G
S
E
--
V
T
A
M
----
L
--
E
K
G
E
R
M
G
C
-----
P
A
-
G
C
P
-----
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
-
D
V
V
N
E
G
H
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.91
33%
-93
- C2 -
4ITI
1
RIPK1_HUMAN
A:
[18-286]
---------------------
L
E
-
S
-
A
E
L
-
D
S
G
G
F
G
K
V
S
L
A
F
H
R
--
T
Q
----------------
G
---
L
M
I
M
K
T
V
Y
KGPNCIE
H
---------
N
-------
E
A
L
L
--------
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
-
I
-----
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
---
K
A
---
E
----
M
S
T
P
-----
L
S
V
--
K
G
R
I
I
L
---
E
I
I
E
G
M
A
Y
L
H
G
--------
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
-
S
F
K
M
W
S
K
L
N
N
EEHNEL----------
G
G
--
T
L
Y
Y
--
M
A
P
E
H
L
---
N
-
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
--
N
K
---------------
E
----
P
-
Y
E
-------
Q
Q
L
I
M
A
I
--
K
S
G
N
R
P
D
V
D
D
--
I
T
E
-
Y
C
P
R
E
-----
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
----
P
G
I
E
E
K
F
R
-
P
F
Y
L
S
Q
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
62.82
31%
-102
- C2 -
4CSV
1
?
A:
[12-268]
--------------------
E
I
T
-
L
-
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
Y
----------------
N
---
I
E
V
A
V
K
T
L
-------
K
---------
E
-------
G
T
M
S
V
E
E
F
L
---
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
-
C
T
K
-----
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C-----------
V
N
A
-----
Q
A
L
--
L
-
D
M
A
A
---
Q
V
A
S
G
M
A
Y
L
E
S
--------
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
------------------------------
F
--
P
I
K
W
--
T
A
P
E
A
----
I
-
S
Y
N
R
-
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
--
Y
G
---------------
Q
-
V
P
Y
P
G
M
S
G
S
E
--
V
I
E
Q
V
---
E
--
R
G
Y
R
M
P
R
------
P
Q
-
G
C
P
E
E
-----
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
61.13
34%
-98
- C2 -
4ITJ
1
RIPK1_HUMAN
A:
[12-289]
----------------
M
K
S
S
D
F
L
-
E
---------
F
G
K
V
S
L
A
F
H
R
--
T
Q
----------------
G
---
L
-
M
I
M
K
T
V
-------
Y
KGPNCIEH-
N
-------
E
A
L
L
--------
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
-
I
I
E
-----
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
---
K
A
---
E
----
M
S
T
P
-----
L
S
V
--
K
G
R
I
I
L
---
E
I
I
E
G
M
A
Y
L
H
G
--------
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
-
S
F
K
M
W
S
K
---------
L
N---------
G
--
T
L
Y
Y
--
M
A
P
E
H
L
---
N
-
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
--
N
K
---------------
E
-
P
Y
E
N
-
A
I
A
E
Q
--
Q
L
I
M
A
---
I
--
K
S
G
N
R
P
D
V
D
D
--
I
T
E
-
Y
C
P
R
-----
E
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
I
E
E
K
F
R
P
F
Y
L
-
S
Q
L
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
59.61
33%
-87
- C2 -
4ITJ
1
RIPK1_HUMAN
B:
[18-286]
---------------------
L
E
-
S
-
A
E
L
-
D
S
G
G
F
G
K
V
S
L
A
F
H
R
--
T
Q
----------------
G
---
L
M
I
M
K
T
V
Y
K
G
P
N
CIE
H
---------
N
-------
E
A
L
L
--------
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
-
I
-----
I
E
E
G
K
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
V
L
---
K
A
---
E
----
M
S
T
P
-----
L
S
V
--
K
G
R
I
I
L
---
E
I
I
E
G
M
A
Y
L
H
G
--------
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
-
S
F
K
M
W
S
K
L
N
N
EEHNEL--------------
T
L
Y
Y
--
M
A
P
E
H
L
---
N
-
D
V
N
A
K
P
T
E
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
--
N
K
---------------
E
----
P
-
Y
E
N
A
I
--
A
E
Q
Q
L
I
M
A
I
--
K
S
G
N
R
P
D
V
D
D
--
I
T
E
-
Y
C
P
R
E
-----
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
----
P
G
I
E
E
K
F
R
-
P
F
Y
L
S
Q
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
59.04
31%
-126
- C2 -
3QUP
1
A:
[30-289]
----------------------------
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
-------------------------
V
K
V
A
V
K
M
L
-----------------------------SSDI
E
E
F
L
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
---
L
A
S
R
I------
P
F
N
-----
L
P
L
Q
T
L
V
R
F
M
V
---
D
I
A
C
G
M
E
Y
L
S
S
--------
R
N
--
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
L
--------------------------
L
P
V
K
--
W
L
A
L
E
S
L
A
D
N
L
Y
-----------
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R-
G
Q
---------------
T
-
P
Y
A
G
-
I
E
N
A
E
--
I
Y
N
Y
L
---
I
G
G
N
R
L
K
Q
P
------------
P
E
C
--
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
-
C
L
R
M
E
L
E
N
I
L
-
G
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.62
32%
-88
- C2 -
3PPZ
1
CTR1_ARATH
A:
[38-290]
--------------------
D
L
N
-
I
-
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--------------------
G
---
S
D
V
A
V
K
I
L
-------
M
---------
E
-----------AE
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
-
V
T
-----
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
---
H
K
---
S
----
G
A
R
E
-----
Q
L
D
--
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
--------
R
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
-
R
L
K
--
A
S
---------
T
-
F
-
L
S
S
K
S
A
A
G
--
T
P
E
W
--
M
A
P
E
V
L
------
R
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
--
L
Q
---------------
Q
-
P
W
G
N
-
L
N
P
A
Q
--
V
V
A
A
V
---
G
--
F
K
C
K
R
---
L
E
--
I
P
R
N
L
N
P
Q
V
A
A
------
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
58.47
31%
-95
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------
G
-
W
A
L
N
M
K
E
L
K
-
L
-
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G-----------------------
N
K
V
A
V
K
C
I
-------
K
----------NDA----
Q
A
F
L
--------
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
-
I
V
------
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
---
R
S
---
R
----
G
---RSVLG
G
D
C
--
L
L
K
F
S
L
---
D
V
C
E
A
M
E
Y
L
E
G
--------
N
N
--
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-------------------------------LL
P
V
K
W
--
T
A
P
E
A
L
---
R
-
E
--
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
--
F
G
---------------
R
-
V
P
Y
P
-
R
I
P
L
---------------
K
D
V
V
P
R
V
E
K
--
G
Y
K
-
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
-
H
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.65
31%
-72
- C2 -
3SOC
7
AVR2A_HUMAN
A:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
GLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
-
G
-
D
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAAD
G
P
V
D
E
YMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.57
31%
-103
- C2 -
3P86
1
CTR1_ARATH
A:
[38-290]
--------------------
D
L
N
-
I
-
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
--------------------
G
---
S
D
V
A
V
K
I
L
-------
M
---------
E
-------
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
-
V
T
-----
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
---
H
K
---
S
----
G
A
R
E
-----
Q
L
D
--
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
--------
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
-------------------------------
G
--
T
P
E
W
--
M
A
P
E
V
L
------
R
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
--
L
Q
---------------
Q
-
P
W
G
N
-
L
N
P
A
Q
--
V
V
A
A
V
---
G
--
F
K
C
K
R
---
L
E
--
I
P
R
N
L
N
P
Q
V
A
A
------
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
57.52
31%
-92
- C2 -
4UEU
1
?
A:
[12-268]
--------------------
E
I
T
-
L
-
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
--
N
Y
----------------
N
---
I
E
V
A
V
K
T
L
-------
K
---------
E
-------
G
T
M
S
V
E
E
F
L
---
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
-
C
T
K
-----
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
DC
E
G
---
H
----
T
V
N
A
-----
Q
A
L
--
L
-
D
M
A
A
---
Q
V
A
S
G
M
A
Y
L
E
S
--------
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
-
R
L
I
----------------------
A
K
F
--
P
I
K
W
--
T
A
P
E
A
----
I
-
S
Y
N
R
-
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
--
Y
G
---------------
Q
-
V
P
Y
P
G
M
S
G
S
E
--
V
I
E
Q
V
---
E
--
R
G
Y
R
M
P
R
------
P
Q
-
G
C
P
E
E
-----
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.33
31%
-74
- C2 -
3Q4T
13
AVR2A_HUMAN
A:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
GLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
-
G
-
D
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAAD
G
P
V
D
E
YMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
55.27
31%
-72
- C2 -
3SOC
5
AVR2A_HUMAN
B:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
GLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
----
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAADGPVDEYMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.19
31%
-72
- C2 -
4ASX
4
AVR2A_HUMAN
A:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
DIPGLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
-
G
--
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAADGPVDEYMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
54.86
31%
-70
- C2 -
4ASX
6
AVR2A_HUMAN
B:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
GLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
-
G
-
D
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAADGPVDEYMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
54.51
31%
-133
- C2 -
4FEQ
1
A:
[30-289]
----------------------------
M
L
G
K
---
G
S
V
R
E
A
Q
L
K
--------------------
D
G
S
F
V
K
V
A
V
K
M
L
-----------------------------F
L
------
R
E
A
A
C
M
K
E
F
D
H
P
H
V
A
K
L
V
G
V
S-----------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
---
L
A
S
R
I---------------
P
L
Q
T
L
V
R
F
M
V
---
D
I
A
C
G
M
E
Y
L
S
S
--------
R
N
--
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
M
T
V
C
V
A
D
F
G
-----------------------------
V
K
--
W
L
A
L
E
S
L
A
D
N
L
Y
-----------
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R-
G
Q
---------------
T
-
P
Y
A
G
-
I
E
N
A
E
--
I
Y
N
Y
L
---
I
G
G
N
R
L
K
Q
P
------------
P
E
C
--
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
-
C
L
R
M
E
L
E
N
I
L
-
G
H
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
53.69
31%
-71
- C2 -
3Q4T
9
AVR2A_HUMAN
B:
[26-305]
---------------------
L
Q
-
L
-
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
----
L
L
----------------
N
---
E
Y
V
A
V
K
I
F
P
IQD
K
--
Q
---------
S
-------
W
Q
N
E
--------
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
--
E
K
R
G
T
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
---
K
A
---
N
----
V
V
-
S
-----
W
N
E
--
L
C
H
I
A
E
---
T
M
A
R
G
L
A
Y
L
H
E
DIPGLKDG
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
---------
A
----
T
H
G
Q
V
-
G
--
T
R
R
Y
--
M
A
P
E
V
L
E
GA
I
-
N
F
Q
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
-
L
A
--
S
R
CTAADGPVDEYMLPF
E
-
E
E
I
G
-
Q
H
P
S
L
E
D
M
Q
E
V
V
---
V
--
H
K
K
K
R
P
V
L
R
D
--
Y
W
Q
----
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------