@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0032: (2015-11-27 )
MMNTDETIFALSTVFGKSGVAVIRISGNHALKALNHFHVNKDMKPRFATLVDLYDSSDQLIDNGIAIYFPAPNSFTGEDVIELQVHGGKAVIKIVLEELSRIFVMAKPGEFLLRAFLNGKFDLTQIEGIADLIDAETKMQAKQAIKQMSGELEKLYSSWRQRLIAVQSKIEAYIDFPEDVATEKNELEKINDEVQTLVQSIQEHLNDNRRGERLREGLHIVITGEPNVGKSTLFNFLARRDIAIVSEYVGTTRDILEAHIDIGGYPIILSDTAGIRESSDPVESEGISRAKKRSCEADLRIELFPFEQRYNINCNVISSNTIYVLSKADDVINDHDIKISDIDFLPVSILKGIGTEKLVSVIKEKVEEKFVYDRDVPVITRQRHRNCMQKAIEHLRRFNMNNPIELVSEDLRLAASELGVVTGIINVEEVLDDIFNNFCVGK
Atome Classification :
(20 SA)
--.........10..--.--.....20........30----....-....40---.-------.....---..50....-----.-...60........70.......-.80...-....----.90......-.-.100.-..-.....110.......120.......130.......140.......150.......160.......170.......180.......190.-......200.......210.......220.......230.......240.......250..-.....260-.......270....-..-.280.-........290.....---..300..------..-----.-..310...-..----------.--------..320----........----330-......-------------.---.340--.-----.......350........360.......-370-.......380.......390...----..----.-.400---.----.......410.......420.........430.......440---------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MMNTD
E
T
I
F
A
L
S
T
--V--FGKS
G
V
A
V
I
R
ISG
N
H
A
L
----
K
A
L
N
-
H
FHVNK---D-------MK
P
R
F
---
A
T
L
V
D
LYD-----S-SD
Q
L
IDN
G
I
A
I
Y
FPAPNSFTGE-
D
V
I
E
L
Q
-VHG
G
----
K
A
V
I
K
I
V
L
E
-
E
-
L
S
R
-
I
-
F
V
-MAK
P
G
E
F
L
L
R
A
F
LNGKFD
L
T
Q
I
E
G
I
A
D
L
ID
A
E
T
K
M
Q
A
K
Q
A
I
K
Q
M
S
G
E
L
E
K
L
Y
S
S
W
R
Q
R
L
I
A
V
Q
S
K
I
E
A
YIDF
P
E
D
VAT
E
K
N
E
L
E
K
I
N
D
E
-
V
Q
T
L
V
Q
S
I
Q
E
HLNDN
R
R
G
E
R
L
REG
L
H
I
V
I
TGEPNV
G
K
S
T
L
F
N
F
L
A
R
R
D
I
A
I
V
S
E
Y
VG
T
T
R
D
-
I
L
E
A
H
IDI-GG
Y
P
I
I
LSDTAGIR-ES-SD--P-V
E
S
E
G
I
S
R
A
K
KRSCEA---
D
L
R
I
E
L
F
------
P
F-----E-
Q
R
Y
N
-
I
N
C
-
N
V
----------I--------SSN
T
-----
I
Y
V
L
SKAD----DV--INDHD
I
-------------
K
---ISD---I-----DF
L
P
V
S
I
L
K-GI
G
T
E
K
L
V
S
V
I
K
E
K
V
E
E
K
-FVY-DRDV
P
V
I
T
R
Q
R
H
R
N
C
M
Q
K
A
I
E
H
L
----
R
R----F-NMN----
N
----
P
I
E
L
V
S
E
D
L
R
L
A
A
S
EL
G
V
--VTGII
N
V
E
E
V
L
D
D
I
F
N
NFCVGK---------------------
2
PsiBlast_PDB
91.16
35%
-90
- C1 -
1XZP
3
MNME_THEMA
A:
[34-482]
-------
D
T
I
V
A
V
A
T
--
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
----
K
I
V
Q
K
H
L
R
T
R
S
---
K
-------
I
V
P
R
K
---
A
I
H
G
W
I
H
E
-----
N
-
G
E
D
V
D
E
V
-
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
-
D
M
V
E
V
M
-
C
H
G
G
----
P
L
V
V
K
K
L
L
D
-
L
F
L
K
S
-
G
-
A
R
-
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
T
N
T
G
E
---
V
V
T
R
-
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
-
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
T
-
N
D
--
L
-
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
---
D
--
I
V
L
F
V
L
D
ASS
P
L
D----
E
-
E
D
R
K
-
I
L
E
-
R
I
----------
K
--------
N
K
R
Y
-----
L
V
V
I
N
K
V
D
----
V
V
EK
I
N
E
E
E
I
-------------
K
N
K
L
G
T
D
---
R
-----
H
M
V
K
I
S
A
L
K
-
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
Q
E
I
-
F
E
R
-
G
S
D
-
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
----
L
-
K
E
G
----
M
----
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
--
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
---------------------
3
PsiBlast_PDB
90.32
35%
-93
- C1 -
1XZQ
2
?
A:
[34-482]
-------
D
T
I
V
A
V
A
T
--
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
----
K
I
V
Q
K
H
L
R
T
R
S
---
K
-------
I
V
P
R
K
---
A
I
H
G
W
I
H
E
-----
N
-
G
E
D
V
D
E
V
-
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
-
D
M
V
E
V
M
-
C
H
G
G
----
P
L
V
V
K
K
L
L
D
-
L
F
L
K
S
-
G
-
A
R
-
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
T
N
T
G
E
---
V
V
T
R
-
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
-
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
T
-
N
D
--
L
-
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
---
D
--
I
V
L
F
V
L
D
ASS
P
L
D----
E
-
E
D
R
K
-
I
L
E
-
R
I
----------
K
--------
N
K
R
Y
-----
L
V
V
I
N
K
V
D
----
V
V
EK
I
N
E
E
E
I
-------------
K
N
K
L
G
T
D
---
R
-----
H
M
V
K
I
S
A
L
K
-
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
Q
E
I
-
F
E
R
-
G
S
D
-
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
----
L
-
K
E
G
----
M
----
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
--
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
---------------------
87
HHSearch
89.11
33%
-83
- C1 -
1XZP
3
MNME_THEMA
A:
[30-482]
---
D
K
L
M
D
T
I
V
A
V
A
T
--
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
----
K
I
V
Q
-
K
H
L
R
T
R
S--
K
-------
I
V
P
R
K
---
A
I
H
G
W
I
H
E
-----
N
--
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
-
D
M
V
E
V
M
-
C
H
G
G
----
P
L
V
V
K
K
L
L
D
-
L
-
F
L
K
S
G
-
A
R
-
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
-
E
T
--
N
T
G
E
V
V
T
R
-
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
-
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
-
S
E
T
N
D
--
L
-
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
---
D
I
V
L
F
V
L
------
D
A
-----
S
-
S
P
L
D
-
E
E
D
-
R
K
I
L
E
R
I
-----
K
--------
N
K
R
Y
-----
L
V
V
I
N
K
V
D
----
V
V
--
E
K
I
N
E
E
E
I
K
N
K
--------
L
---
G
T
D
---
R
-----
H
M
V
K
I
S
A
L
K
-
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
Q
E
I
-
F
E
R
--
G
S
D
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
----
E
D
----
A
-
I
K
S
L
K
E
G
M
----
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
--
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
---------------------
5
PsiBlast_PDB
86.92
31%
-103
- C1 -
3GEI
2
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
--
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
V
F
R
-
K
V
H
G
S
G
---
K
-------
L
A
E
A
A
GY
T
A
H
F
G
R
L
Y
D
-----
G
--
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
-
Q
M
V
E
F
T
-
C
H
G
G
----
P
V
V
V
G
R
V
L
R
L
M
-
L
D
N
-
G
-
C
R
-
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
-
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
-------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
---
D
L
I
L
Y
L
L
------
D
L
G----
T
-
E
R
L
D
-
D
E
L
-
T
E
----------
I
R
E
L
K
A
A
H
P
A
A
K
F
-----
L
T
V
A
N
K
L
D
----
R
A
--
A
N
A
D
A
L
I
R
-----------
A
---
I
A
D
G
T
G
T
-----
E
V
I
G
I
S
A
L
N
-
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
K
N
L
------
E
A
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
----
Q
N
A
L
E
L
I
-
A
H
E
----
S
----
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
--
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
---------------------
75
Fugue
86.23
32%
-79
- C1 -
1XZP
3
MNME_THEMA
A:
[27-482]
SS
V
D
K
L
M
D
T
I
V
A
V
A
T
--
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
----
K
I
V
Q
-
K
H
L
R
T
R
---
S
-------
K
I
V
P
R
---
K
A
I
H
G
W
I
H
-----
E
-
N
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
-
D
M
V
E
V
M
-
C
H
G
G
----
P
L
V
V
K
K
L
L
D
-
L
-
F
L
K
-
S
G
A
R
-
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
---
I
E
T
N
T
G
E
V
V
T
R
-
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
-
V
I
S
E
E
I
V
I
-
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
T
-
N
D
--
L
-
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
---
D
I
V
L
F
V
L
------
D
A
SSPLD
E
-
E
D
R
K
-
I
L
E
-
R
I
----------
K
--------
N
K
R
Y
-----
L
V
V
I
N
K
V
D
----
V
V
--
E
K
I
N
E
E
-------------
E
---
I
K
N
---
K
L
GTDR
H
M
V
K
I
S
A
L
K
-
G
E
G
L
E
K
L
E
E
S
I
Y
R
E
T
-
Q
E
-
I
F
E
-
R
G
S
D
S
L
I
T
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
----
E
D
----
A
-
I
K
S
----
L
K
E
GM
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
--
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
---------------------
21
PsiBlast_CBE
86.07
31%
-100
- C1 -
3GEI
1
MNME_CHLTE
B:
[18-476]
---------
I
A
A
I
A
T
--
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
V
F
R
-
K
V
H
G
S
G
---
K
-------
L
A
E
A
A
GY
T
A
H
F
G
R
L
Y
D
-----
G
--
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
-
Q
M
V
E
F
T
-
C
H
G
G
----
P
V
V
V
G
R
V
L
R
L
M
-
L
D
N
-
G
-
C
R
-
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
-
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
-------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
---
D
L
I
L
Y
L
L
------
D
L
G----
T
-
E
R
L
D
-
D
E
L
-
T
E
----------
I
R
E
L
KAAHP
A
A
K
F
-----
L
T
V
A
N
K
L
D
----
R
A
--
A
N
A
D
A
L
IR-----------
A
---
I
A
D
GTG
T
-----
E
V
I
G
I
S
A
L
N
-
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
K
----------
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
----
Q
N
ALEL
I
-
A
H
E
----
S
----
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
--
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
---------------------
86
HHSearch
85.95
33%
-86
- C1 -
3GEH
4
MNME_NOSS1
A:
[4-462]
---
M
A
I
T
G
T
I
A
A
I
A
T
--
A
I
V
P
Q
Q
G
S
V
G
I
V
R
V
S
G
S
Q
A
I
----
A
I
A
Q
-
T
L
F
D
A
P
GKQ
V
-------
W
E
S
H
R
---
I
L
Y
G
Y
I
R
H
-----
P
Q
T
R
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
-
D
V
V
E
F
H
-
C
H
G
G
----
I
I
A
V
Q
Q
V
L
Q
-
L
-
C
L
E
S
G
-
A
R
-
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
E
E
D
L
P
P
L
--
D
D
E
A
I
I
S
D
-
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
-
V
V
E
S
Q
L
V
V
-
G
G
I
P
V
Q
V
L
D
-------------------------
Q
A
A
N
T
A
---
D
L
V
L
L
T
I
------
D
A
-----
A
-
T
G
W
T
-
T
G
D
-
Q
E
I
Y
E
Q
V
-----
K
--------
H
R
P
L
-----
I
L
V
M
N
K
I
D
----
L
V
--
E
K
Q
L
I
T
SLEY---------
P
---
E
N
I
---
T
-----
Q
I
V
H
T
A
A
A
Q
-
K
Q
G
I
D
S
L
E
T
A
I
L
E
I
V
Q
T
G
-
K
V
Q
-
A
A
D
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
----
E
Q
----
V
-
Q
A
T
I
T
Q
Q
L
----
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
--
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
---------------------
1
PsiBlast_PDB
84.23
32%
-90
- C1 -
3GEH
4
MNME_NOSS1
A:
[4-462]
---
M
A
I
T
G
T
I
A
A
I
A
T
A
I
V
--
P
Q
Q
G
S
V
G
I
V
R
V
S
G
S
Q
A
I
-----
A
I
A
-
Q
T
L
F
D
A
---
P
-------
G
K
Q
V
W
---
E
S
H
R
I
L
Y
G
Y
IRHP
Q
-
T
R
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
-
D
V
V
E
F
H
-
C
H
G
G
II
A
V
Q
Q
V
L
Q
L
C
L
E
-
S
-
G
A
R
------
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
E
E
D
L
P
P
L
D
D
E
--
A
I
I
S
D
-
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
-
V
V
E
S
Q
L
V
V
-
G
G
I
P
V
Q
V
L
D
-------------------------
Q
A
A
N
T
A
---
D
L
V
L
L
T
I
------
D
A
-----
A
-
T
G
W
T
-
T
G
D
-
Q
E
----------
I
--------
Y
E
Q
V
KHRP
L
I
L
V
M
N
K
I
D
LVEK
Q
L
--
I
T
S
L
E
Y
-------------
P
---
E
N
I
---
T
-----
Q
I
V
H
T
A
A
A
Q
-
K
Q
G
I
D
S
L
E
T
A
I
L
E
I
V
Q
T
G
-
K
V
Q
-
A
A
D
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
----
E
Q
V
Q
A
T
I
-
T
Q
Q
----
L
----
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
--
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
---------------------
85
HHSearch
83.27
32%
-92
- C1 -
3GEE
2
MNME_CHLTE
A:
[13-476]
----
V
P
G
H
P
I
A
A
I
A
T
--
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
----
D
L
A
D
-
R
V
F
R
K
V
---
H
GSGKLAE
A
A
G
Y
T
---
A
H
F
G
R
L
Y
D
-------
G
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
-
Q
M
V
E
F
T
-
C
H
G
G
----
P
V
V
V
G
R
V
L
R
-
L
-
M
L
D
N
G
-
C
R
-
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
D
V
E
F
Q
-
S
R
D
E
L
T
M
Q
-
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
-------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
---
D
L
I
L
Y
L
L
------
D
L
-----
G
-
T
E
R
L
-
D
D
E
-
L
T
E
I
R
E
L
K
A
A
H
-
P
--------
A
A
K
F
-----
L
T
V
A
N
K
L
D
----
R
A
--
A
N
A
D
A
L
I
R
A
I
A
--------
D
---
G
T
G
---
T
-----
E
V
I
G
I
S
A
L
N
-
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
K
N
L
-
D
K
L
-
H
E
A
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
----
Q
N
----
A
-
L
E
L
IAHE
S
----
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
--
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
---------------------
4
PsiBlast_PDB
82.72
31%
-96
- C1 -
3GEE
2
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
--
P
--
V
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
V
F
R
-
K
V
H
G
S
G
---
K
-------
L
A
E
A
A
GY
T
A
H
F
G
R
L
Y
D
-----
G
--
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
-
Q
M
V
E
F
T
-
C
H
G
G
----
P
V
V
V
G
R
V
L
R
L
M
-
L
D
N
-
G
-
C
R
-
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
S
R
D
E
L
T
M
Q
-
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
-------------------
E
E
C
F
I
H
-
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
---
D
L
I
L
Y
L
L
------
D
L
G----
T
-
E
R
L
D
-
D
E
L
-
T
E
----------
I
R
E
L
K
A
A
H
P
A
A
K
F
-----
L
T
V
A
N
K
L
D
----
R
A
--
A
N
A
D
A
L
I
R
-----------
A
---
I
A
D
G
T
G
T
-----
E
V
I
G
I
S
A
L
N
-
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
K
N
L
-
D
K
L
-
H
E
A
S
V
L
V
T
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
----
Q
N
A
L
EL
I
-
A
H
E
----
S
----
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
--
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
---------------------
89
HHSearch
57.01
29%
-75
- C1 -
3IEV
2
ERA_AQUAE
A:
[10-183]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
Y
V
A
I
V
G
K
P
N
V
G
K
S
T
L
L
N
N
L
L
G
T
K
V
S
I
I
S
P
K
A
G
T
T
R
M
-
R
V
L
G
V
K
N
I
P
N
E
A
Q
I
I
F
L
D
T
P
G
I
Y
-
E
P
-
K
K
SD
V
-
L
G
H
S
M
V
E
I
A
K
Q
S
L
E
E
A
---
D
V
I
L
F
M
I
------
D
A
-----
T
-
E
G
W
R
-
P
R
D
-
E
E
I
Y
Q
N
FIKP--
L
--------
N
K
P
V
-----
I
V
V
I
N
K
I
D
----
K
I
--
G
P
A
K
N
V
L
P
L
I
D
E
I
H
K
K
---
H
---
P
E
L
---
T
-----
E
I
V
P
I
S
A
L
K
-
G
A
N
L
D
E
L
V
K
T
I
L
K
Y
L
P
E
G
-
E
P
L
-
F
P
E
D
M
I
T
D
L
P
L
R
L
L
A
A
E
I
V
R
E
K
A
----
M
M
----
L
-
T
R
E
----
E
----
V
P
T
S
I
A
V
K
I
N
E
I
K
P
G
D
A
N
--
P
N
M
L
V
I
K
G
E
I
I
V
D
R
E
N
L
K
P
I
I
I
---------------------
99
HHSearch
56.38
35%
-71
- C1 -
2GJ8
5
MNME_ECOLI
A:
[4-164]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
-
V
L
R
E
H
I
H
I
-
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
A
-
S
D
--
E
-
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
---
D
R
V
L
F
M
V
------
D
G
-----
T
-
T
T
D
A
-
V
D
P
-
A
E
IW
P
E
F
I
A
R
LP
A
--------
K
L
P
I
-----
T
V
V
R
N
K
A
D
----
I
T
--
G
E
T
L
G
M
S
------------
E
---
V
N
G
---
H
-----
A
L
I
R
L
S
A
R
T
-
G
E
G
V
D
V
L
R
N
H
L
K
Q
S
M
----------------------------------------------------------------------------------------------------------------------
90
HHSearch
52.34
27%
-87
- C1 -
1MKY
3
DER_THEMA
A:
[177-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
-------
V
D
D
E
V
F
I
-
D
G
R
K
Y
V
F
V
D
T
A
G
L
------------
E
K
Y
S
N
Y
R
V
V
D
S
I
E
K
A
---
D
V
V
V
I
V
L
------
D
A
-----
T
-
Q
G
I
T
-
R
Q
D
-
Q
R
M
A
G
L
M
E
R
---
R
--------
G
R
A
S
-----
V
V
V
F
N
K
W
D
----
L
V
--
V
H
R
E
K
R
Y
D
E
F
T
K
L
F
R
E
K
L
Y
F
---
I
D
Y
---
S
-----
P
L
I
F
T
S
A
D
K
-
G
W
N
I
D
R
M
I
D
A
M
N
L
A
Y
A
S
Y
-
T
T
K
-
V
P
S
S
A
I
N
S
A
L
Q
K
V
L
A
F
T
N
L
P
R
G
L
----
K
I
----
F
-
F
G
V
----
Q
----
V
D
I
K
P
P
T
F
L
F
F
V
N
S
I
E
K
V
--
K
N
P
Q
K
I
F
L
R
K
L
I
R
D
Y
V
F
P
F
E
G
S
---------------------
98
HHSearch
51.73
28%
-79
- C1 -
1MKY
3
DER_THEMA
A:
[2-166]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
V
L
I
V
G
R
P
N
V
G
K
S
T
L
F
N
K
L
V
K
--------------
D
-
P
V
Q
D
T
V
E
W
-
Y
G
K
T
F
K
L
V
D
T
C
G
V
F
-
D
N
-
P
Q
--
D
I
I
S
Q
K
M
K
E
V
T
L
N
M
I
R
E
A
---
D
L
V
L
F
V
V
------
D
G
-----
K
-
R
G
I
T
-
K
E
D
-
E
S
L
A
D
F
L
R
K
---
S
--------
T
V
D
T
-----
I
L
V
A
N
K
A
E
----
N
L
--
R
E
F
E
R
E
V
K
P
E
L
Y
-------
S
---
L
G
F
---
G
-----
E
P
I
P
V
S
A
E
H
-
N
I
N
L
D
T
M
L
E
T
I
I
K
K
L
E
E
K
-
G
L
D
-
L
E
S
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
----
S
T
----
L
-
F
N
A
----
I
----
L
N
K
E
R
A
L
V
S
P
I
P
V
D
D
E
V
F
--
I
D
G
R
K
Y
V
F
V
D
T
A
G
L
E
K
Y
S
N
Y
R
V
---------------------
82
Fugue
51.66
17%
-30
- C1 -
1MKY
6
DER_THEMA
A:
[2-439]
-----------
A
T
V
L
--
I
--
V
G
R
P
N
V
G
-----------------
K
-
S
T
L
F
N
K
---
L
-------
V
K
D
P
V
---
Q
D
T
V
E
W
Y
G
-----
K
-
T
F
K
L
V
D
T
C
-
G
V
F
D
N
P
Q
D
I
I
S
Q
K
M
K
E
V
T
L
N
M
I
R
E
A
----
D
L
V
L
F
V
V
D
G
-
K
-
R
G
-------
I
T
K
E
D
E
S
L
A
D
F
L
R
K
S
T
V
D
T
I
L
V
A
N
K
A
E
N
L
R
E
F
E
R
E
V
K
P
E
L
Y
S
L
G
F
G
E
P
I
P
V
S
A
E
H
N
I
N
L
----------------------------
D
T
M
L
E
T
I
I
K
K
L
E
E
K
G
L
D
L
E
S
K
P
E
I
T
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
V
D
D
E
V
-
F
I
-------
D
G
R
K
Y
V
F
V
D
T
A
G
L
E
-
K
Y
-
S
N
--
Y
-
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
---
D
A
T
Q
G
I
T
-------------
R
-
Q
D
Q
R
M
A
G
L
M
E
R
----------
R
--------
G
R
A
S
-----
V
V
V
F
N
K
W
D
----
L
V
--
V
H
R
E
K
R
-------------
Y
---
D
E
F
---
T
-----
K
L
F
R
E
K
L
Y
F
I
D
Y
S
P
L
I
F
T
S
A
D
K
G
W
N
I
D
R
M
I
D
A
M
N
L
A
Y
A
S
Y
T
T
K
V
P
S
S
A
I
N
S
A
L
Q
K
V
----
L
A
----
F
-
T
-
N
----
L
----
P
R
G
L
K
I
F
F
G
V
Q
V
D
I
K
P
P
T
--
F
L
F
F
V
N
S
I
E
K
V
K
N
P
Q
K
I
F
L
R
K
L
I
R
D
YVFPFEG
S
P
I
F
L
K
F
K
R
S
R
14
PsiBlast_PDB
51.41
24%
-63
- C1 -
3IEU
5
ERA_ECOLI
A:
[11-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
N
K
L
L
G
Q
K
I
S
I
T
S
R
K
A
Q
T
T
R
H
R
I
V
G
I
H
T
E
--
G
A
Y
Q
A
I
Y
V
D
T
P
G
L
H
-
M
E
--------
E
K
R
A
I
N
R
L
M
N
K
A
A
S
S
S
I
G
D
V
E
L
V
I
F
------
V
V
-----
E
G
T
R
W
T
-
P
D
D
-
E
M
----------
V
L
N
K
L
R
E
G
-
K
A
P
V
-----
I
L
A
V
N
K
V
D
----
N
V
--
Q
E
K
A
D
L
L
P
H
L
Q
F
L
A
S
----
Q
---
M
N
F
---
L
-----
D
I
V
P
I
S
A
E
T
-
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
-
T
H
H
-
F
P
E
D
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
----
M
R
----
F
L
G
A
E
----
L
----
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
K
G
A
---------------------
100
HHSearch
51.38
25%
-63
- C1 -
3A1S
3
?
A:
[4-167]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
K
V
A
L
A
G
C
P
N
V
G
K
T
S
L
F
N
A
L
T
G
T
K
Q
Y
-
V
A
N
W
P
G
V
T
V
E
-
K
K
E
G
V
F
T
Y
-
K
G
Y
T
I
N
L
I
D
L
P
G
T
Y
-
S
L
-
G
Y
--
S
-
S
I
D
E
K
I
A
R
D
Y
L
L
K
G
D
A
---
D
L
V
I
L
V
A
------
D
S
-----
V
-
N
P
E
Q
-
S
L
Y
-
L
L
L
E
I
L
E
-----
M
--------
E
K
K
V
-----
I
L
A
M
T
A
I
D
----
E
A
--
K
K
T
G
M
K
I
D
R
Y
E
L
Q
------
K
---
H
L
G
---
I
-----
P
V
V
F
T
S
S
V
T
-
G
E
G
L
E
E
L
K
E
K
I
V
E
Y
A
Q
K
N
-
T
I
L
-
H
R
M
I
L
D
Y
G
E
K
V
E
S
E
I
K
K
V
E
N
F
L
R
----
D
K
----
K
-
L
R
I
----
N
----
P
R
Y
F
A
L
K
Y
L
S
G
D
P
E
F
Y
S
E
--
G
V
K
L
G
L
P
E
L
S
E
E
E
R
I
G
Y
R
L
L
I
A
---------------------
105
HHSearch
51.09
26%
-68
- C1 -
2DYK
1
?
A:
[2-160]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
V
V
I
V
G
R
P
N
V
G
K
S
S
L
F
N
R
L
L
K
K
R
S
-----------
D
-
L
K
E
G
V
V
E
T
-
D
R
G
R
F
L
L
V
D
T
G
G
L
W
-
S
G
-
D
K
--
W
--
E
K
K
I
Q
E
K
V
D
R
A
L
E
D
A
---
E
V
V
L
F
A
V
------
D
G
-----
R
-
A
E
L
T
-
Q
A
D
-
Y
E
V
A
E
Y
L
R
R
---
K
--------
G
K
P
V
-----
I
L
V
A
T
K
V
D
----
D
P
--
K
H
E
L
Y
L
G
P
L
Y
---------
G
---
L
G
F
---
G
-----
D
P
I
P
T
S
S
E
H
-
A
R
G
L
E
E
L
L
E
A
I
W
E
R
L
P
---------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
51.07
24%
-66
- C1 -
1EGA
3
ERA_ECOLI
A:
[11-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
I
V
G
R
P
N
V
G
K
S
T
L
L
N
K
L
L
G
Q
K
I
S
I
T
S
R
K
A
Q
T
T
R
H
R
I
V
G
I
H
T
E
--
G
A
Y
Q
A
I
Y
V
D
T
P
G
L
H
-
M
E
--------
E
K
R
A
I
N
R
L
M
N
K
A
A
S
S
S
I
G
D
V
E
L
V
I
F
------
V
V
-----
E
G
T
R
W
T
-
P
D
D
-
E
M
----------
V
L
N
K
L
REG-
K
A
P
V
-----
I
L
A
V
N
K
V
D
----
N
V
--
Q
E
K
A
D
L
L
P
H
L
Q
F
L
A
S
----
Q
---
M
N
F
---
L
-----
D
I
V
P
I
S
A
E
T
-
G
L
N
V
D
T
I
A
A
I
V
R
K
H
L
P
E
A
-
T
H
H
-
F
P
E
D
Y
I
T
D
R
S
Q
R
F
M
A
S
E
I
I
R
E
K
L
----
M
R
----
F
L
G
A
E
----
L
----
P
Y
S
V
T
V
E
I
E
R
F
V
S
N
E
R
G
G
Y
D
I
N
G
L
I
L
V
E
R
E
G
Q
K
K
M
V
I
G
N
K
G
A
---------------------
30
PsiBlast_CBE
50.98
35%
-108
- C1 -
1XZQ
2
?
B:
[34-149]
-------
D
T
I
V
A
V
A
T
--
P
--
P
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
----
K
I
V
Q
K
H
L
R
T
R
S
---
K
-------
I
V
P
R
K
---
A
I
H
G
W
I
H
E
-----
N
-
G
E
D
V
D
E
V
-
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
-
D
M
V
E
V
M
-
C
H
G
G
----
P
L
V
V
K
K
L
L
D
-
L
-
F
L
K
-
S
-
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------