@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0133: (2015-11-28 )
MVDYEEIFLNKIKDIKEEGRYREFTHFASLPGRLPYIMDCERNREVIVWCSNNYLGMSQNESVVAAIQNSSVGAGGTRNISGTTKEVVELEQSLACLHNKEAALTFACGYLANQTTLSTLSSVIPDVVIFSDEKNHSSMIEGIKSGKRPKHIFKHNNVDHLEQLLKSVDRKTPKIIAFESIYSMDGDIAPLREICNLADQYNAITYLDEVHAIGMYGLRGGGIAEREGLMDRVTVIQGTLSKAFGVMGGYIASSKSLVDVIRSSAPGFIFTTAMSPVLAAAAKASVEHLKSSNVEREKQRQVVEKVKNSLSSVGINFIPTETHIIPIIIGDPELSKRASKLLFDEYGVYVQHINYPTVPRGTERFRITPTPYHTDEMIEHLTESLIKVFVKLSVSVACLC
Atome Classification :
(20 SA)
.........10........20........30........40-.---...------.....50.........60..----.----....----.70---.........80........90........100.......110.......120.......130.......140.......150.......160.......--170.--.--.....--180.......190.......200.......210.......220.......230.......240..-...-..250.......260.......270.......280.......--290--...--....300...-....310.......320.......330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
D
Y
E
E
I
F
L
N
K
I
K
D
I
K
EEG
R
Y
R
E
F
T
H
F
ASLPGRL
P
Y
I
M
DC--E---RN
R
------
E
V
I
V
W
C-SN
N
Y
LGMSQNE
S
V
----
V
----
A
A
I
Q----NS----SVGAGGTRNISG
T
T
K
E
V
V
E
L
E
Q
S
L
A
C
L
HNKE
A
A
L
T
F
A
C
G
Y
LAN
Q
T
T
L
S
T
L
S
S
VIP
D
V
V
I
FSDEKN
H
S
S
M
I
E
G
I
K
SGKRP
K
H
I
FKHN
N
V
D
H
L
E
Q
L
L
K
S
V
D--RKT
P
--
K
--
I
I
A
F
E
--
S
I
YSMDG
D
I
A
P
L
R
E
I
C
N
L
A
D
Q
Y
N
A
I
T
Y
L
D
E
V
H
A
I
G
MYGLRGGG
I
A
E
R
E
G
L
M
D
R
V
T
V
I
Q
G
T
L
S
K
A
F
-
G
VM-GGYIAS
S
K
S
L
V
D
V
I
RSSAP
G
F
I
F
T
T
A
M
S
P
V
L
A
A
A
A
K
A
S
V
E
H
L
--
K
SS--N
V
E
--
R
E
K
Q
R
Q
V
V
E
K
-
V
K
N
S
L
S
SVG
I
N
F
IPTE
T
H
I
I
P
I
I
IG
D
P
E
L
S
K
R
A
S
K
L
L
F
D
EY
G
V
Y
V
Q
HINYPTVPRGT
E
R
F
R
ITPTPY
H
T
D
E
M
I
E
H
L
T
E
S
L
I
K
V
F
V
K
L
S
V
S
V
A
CLC
29
PsiBlast_CBE
97.16
47%
-91
- C1 -
2BWN
2
HEM1_RHOCB
B:
[1-395]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDG
G
K
Q
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
K
L
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
-------------
28
PsiBlast_CBE
96.67
47%
-92
- C1 -
2BWN
3
HEM1_RHOCB
D:
[1-397]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----------
51
Fugue
96.61
48%
-92
- C1 -
2BWN
4
HEM1_RHOCB
A:
[2-397]
--
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
A
Q
W
N
--
R
PDG
G
K
Q
------
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
L
A
A
M
H
----
E
A
L
E
----
A
V
----
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
K
T
A
E
G
--
Q
K
L
--
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----------
22
PsiBlast_CBE
96.59
47%
-92
- C1 -
2BWP
4
HEM1_RHOCB
D:
[1-398]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
----------
24
PsiBlast_CBE
96.51
47%
-89
- C1 -
2BWO
5
HEM1_RHOCB
E:
[1-399]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
R
---------
30
HHSearch
96.20
48%
-91
- C1 -
2BWN
4
HEM1_RHOCB
A:
[2-397]
--
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
K
A
Q
W
N
RP
D
---
G
G
K
------
Q
D
I
T
V
W
C
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
E
A
L
E
A
V
----
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
E
G
Q
K
L
--
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----------
21
PsiBlast_CBE
96.20
47%
-91
- C1 -
2BWP
4
HEM1_RHOCB
E:
[1-398]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
----------
27
PsiBlast_CBE
96.18
47%
-91
- C1 -
2BWN
5
HEM1_RHOCB
E:
[2-399]
--
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
R
---------
3
PsiBlast_PDB
95.58
47%
-92
- C1 -
2BWN
4
HEM1_RHOCB
A:
[2-397]
--
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDG
G
K
Q
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
K
L
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----------
26
PsiBlast_CBE
95.04
47%
-91
- C1 -
2BWO
4
HEM1_RHOCB
A:
[1-398]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDG
G
K
Q
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
K
L
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
----------
1
PsiBlast_PDB
94.80
47%
-90
- C1 -
2BWO
4
HEM1_RHOCB
B:
[1-399]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDG
G
K
Q
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
K
L
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
R
---------
23
PsiBlast_CBE
94.77
47%
-91
- C1 -
2BWP
3
HEM1_RHOCB
B:
[1-396]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
------------
2
PsiBlast_PDB
94.73
47%
-91
- C1 -
2BWP
3
HEM1_RHOCB
A:
[1-398]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDG
G
K
Q
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
L
E
A
V
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
K
L
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
A
----------
25
PsiBlast_CBE
94.45
47%
-89
- C1 -
2BWO
5
HEM1_RHOCB
D:
[1-397]
-
M
D
Y
N
L
A
L
D
K
A
I
Q
K
L
H
D
E
G
R
Y
R
T
F
I
D
I
E
R
E
K
G
A
F
P
---
K
A
--
Q
---
W
N
R
PDGGKQ
D
I
T
V
W
C
-
G
N
D
Y
L
G
M
G
Q
H
P
V
V
----
L
----
A
A
M
H
----
E
A
LEAV
G
A
G
S
G
G
T
R
N
I
S
G
T
T
A
Y
H
R
R
L
E
A
E
I
A
G
L
H
Q
K
E
A
A
L
V
F
S
S
A
Y
N
A
N
D
A
T
L
S
T
L
R
V
L
F
P
G
L
I
I
Y
S
D
S
L
N
H
A
S
M
I
E
G
I
K
R
N
A
G
P
K
R
I
F
R
H
N
D
V
A
H
L
R
E
L
I
A
A
D
D
--
P
A
A
P
--
K
--
L
I
A
F
E
--
S
V
Y
S
M
D
G
D
F
G
P
I
K
E
I
C
D
I
A
E
E
F
G
A
L
T
Y
I
D
E
V
H
A
V
G
M
Y
G
P
R
G
A
G
V
A
E
R
D
G
L
M
H
R
I
D
I
F
N
G
T
L
A
K
A
Y
-
G
V
F
-
G
G
Y
I
A
A
S
A
R
M
V
D
A
V
R
S
Y
A
P
G
F
I
F
S
T
S
L
P
P
A
I
A
A
G
A
Q
A
S
I
A
F
L
--
K
T
A
--
E
G
Q
KL
R
D
A
Q
Q
M
H
A
K
V
-
L
K
M
R
L
K
A
L
G
M
P
I
I
D
H
G
S
H
I
V
P
V
V
I
G
D
P
V
H
T
K
A
V
S
D
M
L
L
S
D
Y
G
V
Y
V
Q
P
I
N
F
P
T
V
P
R
G
T
E
R
L
R
F
T
P
S
P
V
H
D
L
K
Q
I
D
G
L
V
H
A
M
D
L
L
W
-----------
36
HHSearch
80.27
30%
-82
- C1 -
1FC4
2
KBL_ECOLI
A:
[12-399]
-------
L
T
N
D
L
E
T
A
R
A
E
G
L
F
K
E
E
R
-
I
I
T
S
A
Q
Q
A
--
D
I
T
V
--
A
---
D
G
S
------
H
V
I
N
F
C
-
A
N
N
Y
L
G
L
A
N
H
P
D
L
----
I
----
A
A
A
K
----
A
G
M
D
S
H
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
--
E
A
G
A
--
R
--
H
V
L
I
A
T
D
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
I
T
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
A
G
--
S
E
L
--
R
D
R
L
W
A
N
A
R
Q
-
F
R
E
Q
M
S
A
A
G
F
T
L
A
G
A
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
-
L
Q
K
E
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
I
A
----
32
HHSearch
79.57
31%
-80
- C1 -
3TQX
2
?
A:
[7-397]
---
I
L
S
Q
L
N
K
E
I
E
G
L
K
K
A
G
L
Y
K
S
E
R
I
I
T
S
-
P
Q
N
A
--
E
I
-
K
--
V
---
G
E
K
------
E
V
L
N
F
C
-
A
N
N
Y
L
G
L
A
D
H
P
A
L
----
I
----
K
T
A
Q
T
V
V
E
Q
Y
----
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
L
G
--
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
E
K
G
A
R
F
--
K
--
L
I
A
T
D
--
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
A
D
R
V
D
I
L
T
G
T
L
G
K
A
L
-
G
G
A
S
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
E
G
-
P
Q
L
--
R
K
Q
L
Q
E
N
S
R
Y
-
F
R
A
G
M
E
K
L
G
F
Q
L
V
P
G
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
-
L
L
Q
E
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
-----
5
PsiBlast_PDB
77.61
31%
-93
- C1 -
1FC4
2
KBL_ECOLI
A:
[47-399]
--------------------------------------------------------
V
I
N
F
C
-
A
N
N
Y
L
G
L
A
N
H
P
D
L
----
I
----
A
A
A
K
A
G
M
D
S
H
----
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
D
S
H
K
E
L
E
Q
K
L
A
A
F
L
G
M
E
D
A
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
--
L
G
A
E
D
A
I
I
S
D
A
L
N
H
A
S
I
I
D
G
V
R
L
C
K
A
K
R
Y
R
Y
A
N
N
D
M
Q
E
L
E
A
R
L
K
E
A
R
--
E
A
G
A
--
R
H
V
L
I
A
T
D
--
G
V
F
S
M
D
G
V
I
A
N
L
K
G
V
C
D
L
A
D
K
Y
D
A
L
V
M
V
D
D
S
H
A
V
G
F
V
G
E
N
G
R
G
S
H
E
Y
C
D
V
M
G
R
V
D
I
I
T
G
T
L
G
K
A
L
G
G
A
S
-
G
G
Y
T
A
A
R
K
E
V
V
E
W
L
R
Q
R
S
R
P
Y
L
F
S
N
S
L
A
P
A
I
V
A
A
S
I
K
V
L
E
M
V
--
E
A
G
--
S
E
L
--
R
D
R
L
W
A
N
A
R
Q
-
F
R
E
Q
M
S
A
A
G
F
T
L
A
G
A
D
H
A
I
I
P
V
M
L
G
D
A
V
V
A
Q
K
F
A
R
E
L
Q
K
E
-
G
I
Y
V
T
G
F
F
Y
P
V
V
P
K
G
Q
A
R
I
R
T
Q
M
S
A
A
H
T
P
E
Q
I
T
R
A
V
E
A
F
T
R
I
G
K
Q
L
G
V
I
A
----
6
PsiBlast_PDB
75.45
30%
-84
- C1 -
3A2B
2
?
A:
[43-392]
------------------------------------------------
R
------
R
V
L
M
F
G
-
S
N
S
Y
L
G
L
T
T
D
T
R
I
----
I
----
K
A
A
Q
----
D
A
L
E
K
Y
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
--
E
D
S
A
--
K
--
L
I
C
T
D
--
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
-
A
S
L
-
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
--
P
E
H
--
I
E
K
L
W
K
N
T
D
Y
-
A
K
A
Q
L
L
D
H
G
F
D
L
G
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
L
Q
D
D
-
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
--------
33
HHSearch
75.06
29%
-75
* C1 *
3A2B
2
?
A:
[11-392]
-------
Q
F
K
I
V
E
E
L
K
A
K
G
L
Y
A
Y
F
R
P
I
Q
S
K
Q
D
T
----
E
V
K
--
I
---
D
G
R
------
R
V
L
M
F
G
-
S
N
S
Y
L
G
L
T
T
D
T
R
I
----
I
----
K
A
A
Q
D
A
L
E
K
Y
----
G
T
G
C
A
G
S
R
F
L
N
G
T
L
D
I
H
V
E
L
E
E
K
L
S
A
Y
V
G
K
E
A
A
I
L
F
S
T
G
F
Q
S
N
L
G
P
L
S
C
L
M
G
--
R
N
D
Y
I
L
L
D
E
R
D
H
A
S
I
I
D
G
S
R
L
S
F
S
K
V
I
K
Y
G
H
N
N
M
E
D
L
R
A
K
L
S
R
L
P
--
E
D
S
A
--
K
--
L
I
C
T
D
--
G
I
F
S
M
E
G
D
I
V
N
L
P
E
L
T
S
I
A
N
E
F
D
A
A
V
M
V
D
D
A
H
S
L
G
V
I
G
H
K
G
A
G
T
A
S
H
F
G
L
N
D
D
V
D
L
I
M
G
T
F
S
K
S
L
-
A
S
L
-
G
G
F
V
A
G
D
A
D
V
I
D
F
L
K
H
N
A
R
S
V
M
F
S
A
S
M
T
P
A
S
V
A
S
T
L
K
A
L
E
I
I
--
Q
N
E
--
P
E
H
--
I
E
K
L
W
K
N
T
D
Y
-
A
K
A
Q
L
L
D
H
G
F
D
L
G
A
T
E
S
P
I
L
P
I
F
I
R
S
N
E
K
T
F
W
V
T
K
M
-
L
Q
D
D
G
V
F
V
N
P
V
V
S
P
A
V
P
A
E
E
S
L
I
R
F
S
L
M
A
T
H
T
Y
D
Q
I
D
E
A
I
E
K
M
V
K
V
F
K
Q
A
--------
4
PsiBlast_PDB
75.06
32%
-87
- C1 -
3TQX
2
?
A:
[43-398]
------------------------------------------------
K
------
E
V
L
N
F
C
-
A
N
N
Y
L
G
L
A
D
H
P
A
L
----
I
K
T
A
Q
T
V
V
E
----
Q
Y
----
G
F
G
M
A
S
V
R
F
I
C
G
T
Q
T
I
H
K
E
L
E
K
D
I
S
E
F
L
G
T
D
D
T
I
L
Y
S
S
C
F
D
A
N
G
G
L
F
E
T
L
--
L
G
P
E
D
A
I
I
S
D
E
L
N
H
A
S
I
I
D
G
I
R
L
C
K
A
Q
R
Y
R
Y
K
N
N
A
M
G
D
L
E
A
K
L
K
E
A
D
--
E
K
G
A
R
F
K
--
L
I
A
T
D
--
G
V
F
S
M
D
G
I
I
A
D
L
K
S
I
C
D
L
A
D
K
Y
N
A
L
V
M
V
D
D
S
H
A
V
G
F
I
G
E
N
G
R
G
T
P
E
Y
C
G
V
A
D
R
V
D
I
L
T
G
T
L
G
K
A
L
G
G
A
S
-
G
G
Y
T
S
G
H
K
E
I
I
E
W
L
R
N
R
S
R
P
Y
L
F
S
N
T
V
A
P
V
I
V
A
T
S
L
K
V
L
E
L
L
--
K
T
E
--
G
P
Q
--
L
R
K
Q
L
Q
E
N
S
R
Y
F
R
A
G
M
E
K
L
G
F
Q
L
V
P
G
N
H
P
I
I
P
V
M
L
G
D
A
Q
L
A
T
N
M
A
D
H
L
L
Q
E
-
G
I
Y
V
V
G
F
S
Y
P
V
V
P
M
G
K
A
R
I
R
V
Q
M
S
A
V
H
T
Q
Q
Q
L
D
R
A
I
E
A
F
G
Q
V
G
K
K
L
G
A
I
-----