@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0178: (2015-11-29 )
MNNTHASVKNLSLWYGSKQALFDINLDICKKKVTAFIGPSGCGKSTFLRCFNRMNDYVPGCKVAGKLDIDGLGDIYSRNVDVVLLRAKVGMVFQKPNPFPKSIYDNVAYGPKLHGMVKNKQKLDEIVENSLTKVGLWEELKDRLQDSALDLSGGQQQRLCISRAIAVKPTILLMDEPCSALDPMATNAIENLIQELKLRFTIIMVTHSMKQAKKLSDSIIFFCNGKIVESGSVQEIFENARSPLTKEYILDH
Atome Classification :
(30 SA)
.........10.....-----...20........30........40........50........60........------70.......-----------.80........90.......--.100-........110........120.........130.......140.......150.......160.......170.......180.......190....--.-..-200--.........210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNTHASV
K
N
L
S
L
W
YG-----SK
Q
A
L
F
D
I
N
L
D
I
C
K
K
K
V
T
A
FIGPSGC
G
K
S
T
F
L
R
C
F
N
R
M
N
DYVPGCKVAGKLDI------DG
L
G
D
I
Y
SR-----------N
V
D
V
V
L
L
R
A
KV
G
M
V
FQKPNP--F
P
-
K
-
S
I
Y
DNVAYGP-
K
L
H
G
M
VK
N
K
--
Q
K
L
D
E
I
V
E
N
SLTKVG
L
W
E
E
L
K
D
R
L
Q
D
SALDLSGGQ
Q
Q
R
L
C
ISRAIAVK
P
T
I
L
L
MDEPCSALD
P
M
A
T
N
A
I
E
N
L
I
Q
E
L
--
K
-
L
R
-
F
----
T
I
I
M
V
TH
S
M
K
Q
A
K
KLSD
S
I
I
F
F
CN
G
K
I
VESG
S
V
Q
E
I
F
E
NARSPL
T
K
E
YILDH
22
PsiBlast_CBE
94.72
39%
-114
- C1 -
4YMU
2
?
A:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
21
PsiBlast_CBE
94.63
39%
-113
- C1 -
4YMV
1
?
A:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
5
PsiBlast_PDB
94.48
39%
-113
- C1 -
4YMW
-
?
J:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
3
PsiBlast_PDB
94.15
39%
-114
- C1 -
4YMU
2
?
J:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
1
PsiBlast_PDB
94.06
39%
-116
- C1 -
4YMS
-
?
J:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
4
PsiBlast_PDB
93.62
39%
-114
- C1 -
4YMV
1
?
J:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
2
PsiBlast_PDB
92.75
39%
-110
- C1 -
4YMT
-
?
J:
[11-236]
--------------
F
G
-----
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
-----
P
T
K
G
E
V
F
I
------
D
G
V
-
K
I
N
N
G
-----------
K
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
--
F
P
-
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
K
M
--
N
K
--
K
E
A
E
E
L
A
V
D
L
L
A
K
V
G
L
L
----
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
130
HHSearch
90.96
35%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[5-254]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
-----
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
-----
S
E
G
A
I
I
V
------
N
G
Q
-
N
I
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
--
W
S
H
M
-
T
V
L
E
N
V
M
E
A
P
-
I
Q
V
L
G
L
-
S
K
--
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
---
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
E
E
G
-
K
----
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
19
PsiBlast_PDB
90.77
34%
-103
- C1 -
1B0U
4
HISP_SALTY
A:
[5-253]
---
N
K
L
H
V
I
D
L
H
K
R
Y
G
-----
G
H
E
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
N
I
N
L
V
R
D
K
D
G
Q
L
K
V
A
D
K
-----------
N
-
Q
L
R
L
L
R
T
R
L
T
M
V
F
Q
H
F
N
L
--
W
S
-
H
M
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
S
K
H
D
--
A
R
--
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
Y
---
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
-
E
E
-
G
K
---
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
S
129
HHSearch
87.74
35%
-103
- C1 -
2OLJ
4
?
A:
[22-261]
--
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
-----
D
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
H
M
-
T
V
L
N
N
I
T
L
A
P
-
M
K
V
R
K
W
P
-
R
--
E
K
A
E
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
----
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
N
E
G
-
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
10
PsiBlast_PDB
86.04
35%
-110
- C1 -
2OUK
1
?
A:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
26
PsiBlast_CBE
85.76
35%
-111
- C1 -
3C4J
4
?
B:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
33
PsiBlast_CBE
85.55
35%
-109
- C1 -
2OLK
2
?
B:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
31
PsiBlast_CBE
85.50
35%
-109
- C1 -
2OLK
1
?
D:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
8
PsiBlast_PDB
84.96
35%
-109
- C1 -
2OLJ
4
?
A:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
28
PsiBlast_CBE
84.83
35%
-105
- C1 -
2OUK
2
?
D:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
35
PsiBlast_CBE
84.76
35%
-105
- C1 -
3C41
3
?
K:
[6-238]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
36
PsiBlast_CBE
84.66
33%
-107
- C1 -
4MKI
4
ECFA2_CALS4
A:
[9-239]
-------
V
E
N
V
S
F
I
Y
N
EGTPY
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
---
Q
L
N
G
L
L
K
P
S
K
--
G
K
I
Y
I
------
N
G
I
-
D
I
T
D
K
-----------
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
P
E
Y
QL
F
E
-
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G
L
--
S
E
--
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
---
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
-
Y
K
-
M
----
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
11
PsiBlast_PDB
84.63
35%
-103
- C1 -
2Q0H
4
?
A:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
14
PsiBlast_PDB
84.56
33%
-106
- C1 -
4MKI
4
ECFA2_CALS4
B:
[9-239]
-------
V
E
N
V
S
F
I
Y
N
EGTPY
A
T
V
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
---
Q
L
N
G
L
L
K
P
S
K
--
G
K
I
Y
I
------
N
G
I
-
D
I
T
D
K
-----------
K
V
S
L
K
D
I
R
K
Q
V
G
L
V
F
Q
Y
P
E
Y
QL
F
E
-
E
-
T
V
F
K
D
I
A
F
G
P
-
S
N
L
G
L
--
S
E
--
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
G
I
S
K
E
L
A
D
K
---
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
-
Y
K
-
M
----
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
A
E
R
L
E
K
I
G
L
S
V
P
Q
32
PsiBlast_CBE
84.45
35%
-105
- C1 -
2OLK
1
?
C:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
12
PsiBlast_PDB
84.28
35%
-104
- C1 -
3C4J
3
?
A:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
13
PsiBlast_PDB
83.73
35%
-102
- C1 -
3C41
3
?
J:
[6-238]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
27
PsiBlast_CBE
83.45
35%
-106
- C1 -
2Q0H
4
?
B:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
9
PsiBlast_PDB
83.35
35%
-105
- C1 -
2OLK
1
?
A:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
34
PsiBlast_CBE
83.28
35%
-105
- C1 -
2OLJ
3
?
B:
[27-259]
-------
V
H
Q
L
K
K
S
F
G
-----
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
-----
E
G
E
I
I
I
------
D
G
I
-
N
L
K
A
K
-----------
D
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
--
F
P
-
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
R
E
K
--
A
E
A
K
A
M
--
E
L
L
D
K
V
G
L
----
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
6
PsiBlast_PDB
82.76
34%
-103
- C1 -
4U00
3
?
A:
[7-238]
-------
I
R
N
L
H
K
W
F
G
-----
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
-----
V
------
D
G
L
S
V
K
D
D
R
-----------
A
L
R
E
I
--
R
R
E
V
G
M
V
F
Q
Q
F
N
L
--
F
P
-
H
M
T
V
L
E
N
V
T
L
A
P
--
M
R
V
R
R
W
P
R
--
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
----
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
-
M
----
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
82
PsiBlast_CBE
49.95
34%
-74
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[362-569]
---------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
------
D
G
-
H
D
I
--
R
-----------
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
--
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
-
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
--
A
E
N
--
E
Y
L
V
Q
E
A
--
L
-
D
R
-
L
M
DGR
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
----------
84
PsiBlast_CBE
48.05
34%
-68
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[362-567]
---------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
------
D
G
-
H
D
I
--
R
-----------
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
--
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
-
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
--
A
E
N
--
E
Y
L
V
Q
E
A
--
L
-
D
R
-
L
M
DGR
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------
83
PsiBlast_CBE
46.99
34%
-68
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[393-598]
---------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
-----
P
A
S
G
T
I
S
L
------
D
G
-
H
D
I
--
R
-----------
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
--
F
S
-
C
-
S
I
A
E
N
I
A
Y
G
A
-
D
D
P
S
S
V
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
--
A
E
N
--
E
Y
L
V
Q
E
A
--
L
-
D
R
-
L
M
DGR
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------