@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0356: (2015-11-30 )
MSFSSLQDKGMKNSEFLKGEVSFEQKAKILLEALSSIPNFVGETFVIKCGGITISDETLFNTFVHNVVLLKQLGINPVIVHDGEYEIDSVLKILGINSKFVNDIRLTDKDTMRIIEMVLCGSINKKIVQHINSAGGSAIGLCGKDGNLIKAEKISTTLRENGSNNVEKILDMGFIGIPTEINPDILFFIEESDFIPVIAPIGHGKNGETYHIDADGAAGAIAVAVSASKMIIFSDVCEEMDKIDGRKISVKNLNASINCGKIKGERFVEKLTACAKMVEECAGIAHIVNGRIPNIMIDLFTESNSSVSIVNDL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230...---....240..---.-----.---...250....---...260.......270.......280.......290..-.....-300.......310.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSF
S
S
L
Q
DKGMKNSEFLKGEV
S
F
E
Q
K
A
K
I
L
L
E
A
L
S
S
I
P
N
FVG
E
T
F
V
I
K
CG
G
I
T
I
S
D
E
T
L
F
N
T
F
V
H
N
V
V
L
L
K
QLGIN
P
V
I
V
HDGEY
E
I
D
S
V
L
K
I
LGINSK
F
V
N
D
I
RLT
D
K
D
T
M
R
I
I
E
M
V
L
CGS
I
N
K
K
I
V
Q
H
I
N
SAGG
S
A
I
G
L
CGKDG
N
L
I
K
A
E
K
I
S
T
T
L
RENGS
N
N
V
E
K
I
L
D
MGFIGIPTEINP
D
I
L
F
F
IEESD
F
I
P
V
I
A
PIGHGKNG
E
T
Y
H
IDADGAA
G
A
I
A
V
A
VSA
S
K
M
I
I
F
S
D
---
V
C
E
E
M
D
K
ID---G-----
R
---
K
I
S
V
K
NLNA
S
---
I
NCGKI
K
G
E
R
F
V
E
K
L
T
A
C
A
K
M
V
E
E
C
A
G
I
A
H
I
VNGRIP
N
-
I
M
I
D
L
-
F
TESNS
S
V
S
I
VNDL
24
PsiBlast_CBE
95.63
43%
-123
- C4 -
2BUF
1
ARGB_PSEAE
I:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
--------
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
VL
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
-
29
PsiBlast_CBE
94.45
43%
-125
- C4 -
2BUF
1
ARGB_PSEAE
D:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
T
----
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
V
L
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
26
PsiBlast_CBE
93.64
43%
-122
- C4 -
2BUF
2
ARGB_PSEAE
G:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
T
P
E
M
T
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
VLT
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
30
PsiBlast_CBE
93.23
43%
-121
- C4 -
2BUF
1
ARGB_PSEAE
C:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
T
P
E
M
T
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
V
L
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
58
HHSearch
92.78
43%
-122
- C4 -
2BUF
-
ARGB_PSEAE
A:
[5-297]
--------------------
D
D
A
A
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
R
Q
---------
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
Q
G
---
Q
VL---
T
---
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
-
G
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
-
A
V
L
L
E
I
F
T
D
S
G
V
G
T
L
I
S
N
R
K
1
PsiBlast_PDB
92.63
43%
-125
- C4 -
2BUF
-
ARGB_PSEAE
A:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
--------
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
VLT
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
31
PsiBlast_CBE
92.38
43%
-116
- C4 -
2BUF
2
ARGB_PSEAE
B:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
--
E
M
T
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
V
L
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
21
PsiBlast_CBE
92.36
43%
-118
- C4 -
2BUF
22
ARGB_PSEAE
L:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
-----
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
VLT
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
28
PsiBlast_CBE
92.23
43%
-120
- C4 -
2BUF
1
ARGB_PSEAE
E:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-----------
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
V
L
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
R
K
60
HHSearch
88.78
39%
-124
- C4 -
2BTY
3
ARGB_THEMA
A:
[3-280]
-----------------------
I
D
T
V
N
V
L
L
E
A
L
P
Y
I
K
E
F
Y
G
K
T
F
V
I
K
F
G
G
S
A
M
K
Q
E
N
A
K
K
A
F
I
Q
D
I
I
L
L
K
Y
T
G
I
K
P
I
I
V
H
G
G
G
P
A
I
S
Q
M
M
K
D
L
G
I
E
P
V
F
K
N
G
H
R
V
T
D
E
K
T
M
E
I
V
E
M
V
L
V
G
K
I
N
K
E
I
V
M
N
L
N
L
H
G
G
R
A
V
G
I
C
G
K
D
S
K
L
I
V
A
E
K
E
T
------------
K
H
G
D
I
G
Y
V
G
K
V
K
K
V
N
P
E
I
L
H
A
L
I
E
N
D
Y
I
P
V
I
A
P
V
G
I
G
E
D
G
H
S
Y
N
I
N
A
D
T
A
A
A
E
I
A
K
S
L
M
A
E
K
L
I
L
L
T
D
---
V
D
G
V
L
K
-
D
G
---
K
LI---
S
---
T
L
T
P
D
E
A
E
E
L
---
I
R
D
G
T
V
T
G
-
G
M
I
P
K
V
E
C
A
V
S
A
V
R
G
G
V
G
A
V
H
I
I
N
G
G
L
E
H
-
A
I
L
L
E
I
F
S
R
K
G
I
G
T
M
I
K
E
L
E
25
PsiBlast_CBE
88.78
43%
-69
- C- -
2BUF
2
ARGB_PSEAE
H:
[9-296]
------------------------
Q
V
A
K
V
L
S
E
A
L
P
Y
I
R
R
F
V
G
K
T
L
V
I
K
Y
G
G
N
A
M
E
S
E
E
L
K
A
G
F
A
R
D
V
V
L
M
K
A
V
G
I
N
P
V
V
V
H
G
G
G
P
Q
I
G
D
L
L
K
R
L
S
I
E
S
H
F
I
D
G
M
R
V
T
D
A
A
T
M
D
V
V
E
M
V
L
G
G
Q
V
N
K
D
I
V
N
L
I
N
R
H
G
G
S
A
I
G
L
T
G
K
D
A
E
L
I
R
A
K
K
L
T
V
T
-
R
Q
T
P
E
M
T
K
P
E
I
I
D
I
G
H
V
G
E
V
T
G
V
N
V
G
L
L
N
M
L
V
K
G
D
F
I
P
V
I
A
P
I
G
V
G
S
N
G
E
S
Y
N
I
N
A
D
L
V
A
G
K
V
A
E
A
L
K
A
E
K
L
M
L
L
T
N
---
I
A
G
L
M
D
K
-
Q
---
G
-----
Q
V
L
T
G
L
S
T
E
Q
V
N
E
L
---
I
A
D
G
T
I
Y
G
G
-
M
L
P
K
I
R
C
A
L
E
A
V
Q
G
G
V
T
S
A
H
I
I
D
G
R
V
P
N
A
V
L
L
E
I
-
F
T
D
S
G
V
G
T
L
I
S
N
--
59
HHSearch
88.63
32%
-123
* C4 *
2RD5
3
NAGK_ARATH
A:
[18-298]
-----------------------
D
Y
R
V
E
I
L
S
E
S
L
P
F
I
Q
K
F
R
G
K
T
I
V
V
K
Y
G
G
A
A
M
T
S
P
E
L
K
S
S
V
V
S
D
L
V
L
L
A
C
V
G
L
R
P
I
L
V
H
G
G
G
P
D
I
N
R
Y
L
K
Q
L
N
I
P
A
E
F
R
D
G
L
R
V
T
D
A
T
T
M
E
I
V
S
M
V
L
V
G
K
V
N
K
N
L
V
S
L
I
N
A
A
G
A
T
A
V
G
L
S
G
H
D
G
R
L
L
T
A
R
P
V
P
------------
N
S
A
Q
L
G
F
V
G
E
V
A
R
V
D
P
S
V
L
R
P
L
V
D
Y
G
Y
I
P
V
I
A
S
V
A
A
D
D
S
G
Q
A
Y
N
I
N
A
D
T
V
A
G
E
L
A
A
A
L
G
A
E
K
L
I
L
L
T
D
---
V
A
G
I
L
E
N
K
E
---
D
PSSLI
K
---
E
I
D
I
K
G
V
K
K
M
---
I
E
D
G
K
V
A
G
-
G
M
I
P
K
V
K
C
C
I
R
S
L
A
Q
G
V
K
T
A
S
I
I
D
G
R
R
Q
H
-
S
L
L
H
E
I
M
S
D
E
G
A
G
T
M
I
T
G
--
57
HHSearch
87.41
34%
-117
- C4 -
2V5H
2
ARGB_SYNE7
A:
[28-311]
--------------------
A
G
A
A
D
R
V
R
I
L
S
E
A
L
P
Y
L
Q
Q
F
A
G
R
T
V
V
V
K
Y
G
G
A
A
M
K
Q
E
E
L
K
E
A
V
M
R
D
I
V
F
L
A
C
V
G
M
R
P
V
V
V
H
G
G
G
P
E
I
N
A
W
L
G
R
V
G
I
E
P
Q
F
H
N
G
L
R
V
T
D
A
D
T
M
E
V
V
E
M
V
L
V
G
R
V
N
K
D
I
V
S
R
I
N
T
T
G
G
R
A
V
G
F
C
G
T
D
G
R
L
V
L
A
R
P
H
-------------
D
Q
E
G
I
G
F
V
G
E
V
N
S
V
N
S
E
V
I
E
P
L
L
E
R
G
Y
I
P
V
I
S
S
V
A
A
D
E
N
G
Q
S
F
N
I
N
A
D
T
V
A
G
E
I
A
A
A
L
N
A
E
K
L
I
L
L
T
D
---
T
R
G
I
L
E
D
P
K
RPE
S
LI---
P
---
R
L
N
I
P
Q
S
R
E
L
---
I
A
Q
G
I
V
G
G
-
G
M
I
P
K
V
D
C
C
I
R
S
L
A
Q
G
V
R
A
A
H
I
I
D
G
R
I
P
H
-
A
L
L
L
E
I
F
T
D
A
G
I
G
T
M
I
V
G
S
-
32
PsiBlast_CBE
86.65
40%
-126
- C4 -
2BTY
2
ARGB_THEMA
C:
[8-271]
----------------------------
V
L
L
E
A
L
P
Y
I
K
E
F
Y
G
K
T
F
V
I
K
F
G
G
S
A
M
K
Q
E
N
A
K
K
A
F
I
Q
D
I
I
L
L
K
Y
T
G
I
K
P
I
I
V
H
G
G
G
P
A
I
S
Q
M
M
K
D
L
G
I
E
P
V
F
K
N
G
H
R
V
T
D
E
K
T
M
E
I
V
E
M
V
L
V
G
K
I
N
K
E
I
V
M
N
L
N
L
H
G
G
R
A
V
G
I
C
G
K
D
S
K
L
I
V
A
E
K
E
T
------------
K
H
G
D
I
G
Y
V
G
K
V
K
K
V
N
P
E
I
L
H
A
L
I
E
N
D
Y
I
P
V
I
A
P
V
G
I
G
E
D
G
H
S
Y
N
I
N
A
D
T
A
A
A
E
I
A
K
S
L
M
A
E
K
L
I
L
L
T
D
---
V
D
G
V
L
K
--
D
---
G
-----
K
---
L
I
S
T
L
T
P
D
E
A
EEL
I
R
D
G
T
V
T
G
-
G
M
I
P
K
V
E
C
A
V
S
A
V
R
G
G
V
G
A
V
H
I
I
N
G
G
L
E
H
A
I
L
L
E
I
-
F
S
R
K
G
I
G
T
M
I
K
E
L
E
34
PsiBlast_CBE
86.24
33%
-120
- C4 -
2V5H
2
ARGB_SYNE7
F:
[26-309]
----------------
I
--
E
A
G
A
A
D
R
V
R
I
L
S
E
A
L
P
Y
L
Q
Q
F
A
G
R
T
V
V
V
K
Y
G
G
A
A
M
K
Q
E
E
L
K
E
A
V
M
R
D
I
V
F
L
A
C
V
G
M
R
P
V
V
V
H
G
G
G
P
E
I
N
A
W
L
G
R
V
G
I
E
P
Q
F
H
N
G
L
R
V
T
D
A
D
T
M
E
V
V
E
M
V
L
V
G
R
V
N
K
D
I
V
S
R
I
N
T
T
G
G
R
A
V
G
F
C
G
T
D
G
R
L
V
L
A
R
----------
P
H
D
Q
E
G
I
---
G
F
V
G
E
V
N
S
V
N
S
E
V
I
E
P
L
L
E
R
G
Y
I
P
V
I
S
S
V
A
A
D
E
N
G
Q
S
F
N
I
N
A
D
T
V
A
G
E
I
A
A
A
L
N
A
E
K
L
I
L
L
T
D
TRG
I
L
E
D
P
K
R
P
E
---
S
LI---
P
---
R
L
N
I
P
Q
S
R
E
L
---
I
A
Q
G
-
I
V
G
G
G
M
I
P
K
V
D
C
C
I
R
S
L
A
Q
G
V
R
A
A
H
I
I
D
G
R
I
P
H
A
L
L
L
E
I
-
F
T
D
A
G
I
G
T
M
I
V
G
S
G
33
PsiBlast_CBE
85.97
40%
-122
- C4 -
2BTY
2
ARGB_THEMA
B:
[8-271]
----------------------------
V
L
L
E
A
L
P
Y
I
K
E
F
Y
G
K
T
F
V
I
K
F
G
G
S
A
M
K
Q
E
N
A
K
K
A
F
I
Q
D
I
I
L
L
K
Y
T
G
I
K
P
I
I
V
H
G
G
G
P
A
I
S
Q
M
M
K
D
L
G
I
E
P
V
F
K
N
G
H
R
V
T
D
E
K
T
M
E
I
V
E
M
V
L
V
G
K
I
N
K
E
I
V
M
N
L
N
L
H
G
G
R
A
V
G
I
C
G
K
D
S
K
L
I
V
A
E
K
E
T
------------
K
H
G
D
I
G
Y
V
G
K
V
K
K
V
N
P
E
I
L
H
A
L
I
E
N
D
Y
I
P
V
I
A
P
V
G
I
G
E
D
G
H
S
Y
N
I
N
A
D
T
A
A
A
E
I
A
K
S
L
M
A
E
K
L
I
L
L
T
D
---
V
D
G
V
L
K
--
D
---
G
-----
K
---
L
I
S
T
L
T
P
D
E
A
EEL
I
R
D
G
T
V
T
G
-
G
M
I
P
K
V
E
C
A
V
S
A
V
R
G
G
V
G
A
V
H
I
I
N
G
G
L
E
H
A
I
L
L
E
I
-
F
S
R
K
G
I
G
T
M
I
K
E
L
E
36
PsiBlast_CBE
85.60
33%
-121
- C4 -
2V5H
3
ARGB_SYNE7
D:
[28-309]
--------------------
A
G
A
A
D
R
V
R
I
L
S
E
A
L
P
Y
L
Q
Q
F
A
G
R
T
V
V
V
K
Y
G
G
A
A
M
K
Q
E
E
L
K
E
A
V
M
R
D
I
V
F
L
A
C
V
G
M
R
P
V
V
V
H
G
G
G
P
E
I
N
A
W
L
G
R
V
G
I
E
P
Q
F
H
N
G
L
R
V
T
D
A
D
T
M
E
V
V
E
M
V
L
V
G
R
V
N
K
D
I
V
S
R
I
N
T
T
G
G
R
A
V
G
F
C
G
T
D
G
R
L
V
L
A
R
----------
P
H
D
Q
E
G
I
---
G
F
V
G
E
V
N
S
V
N
S
E
V
I
E
P
L
L
E
R
G
Y
I
P
V
I
S
S
V
A
A
D
E
N
G
Q
S
F
N
I
N
A
D
T
V
A
G
E
I
A
A
A
L
N
A
E
K
L
I
L
L
T
D
TRG
I
L
E
D
P
K
R
P
E
---
S
LI---
P
---
R
L
N
I
P
Q
S
R
E
L
---
I
A
Q
G
-
I
V
G
G
G
M
I
P
K
V
D
C
C
I
R
S
L
A
Q
G
V
R
A
A
H
I
I
D
G
R
I
P
H
A
L
L
L
E
I
-
F
T
D
A
G
I
G
T
M
I
V
G
S
G
38
PsiBlast_CBE
85.38
33%
-119
- C4 -
2V5H
2
ARGB_SYNE7
B:
[28-309]
--------------------
A
G
A
A
D
R
V
R
I
L
S
E
A
L
P
Y
L
Q
Q
F
A
G
R
T
V
V
V
K
Y
G
G
A
A
M
K
Q
E
E
L
K
E
A
V
M
R
D
I
V
F
L
A
C
V
G
M
R
P
V
V
V
H
G
G
G
P
E
I
N
A
W
L
G
R
V
G
I
E
P
Q
F
H
N
G
L
R
V
T
D
A
D
T
M
E
V
V
E
M
V
L
V
G
R
V
N
K
D
I
V
S
R
I
N
T
T
G
G
R
A
V
G
F
C
G
T
D
G
R
L
V
L
A
R
----------
P
H
D
Q
E
G
I
---
G
F
V
G
E
V
N
S
V
N
S
E
V
I
E
P
L
L
E
R
G
Y
I
P
V
I
S
S
V
A
A
D
E
N
G
Q
S
F
N
I
N
A
D
T
V
A
G
E
I
A
A
A
L
N
A
E
K
L
I
L
L
T
D
TRG
I
L
E
D
P
K
R
P
E
---
S
LI---
P
---
R
L
N
I
P
Q
S
R
E
L
---
I
A
Q
G
-
I
V
G
G
G
M
I
P
K
V
D
C
C
I
R
S
L
A
Q
G
V
R
A
A
H
I
I
D
G
R
I
P
H
A
L
L
L
E
I
-
F
T
D
A
G
I
G
T
M
I
V
G
S
G
2
PsiBlast_PDB
85.34
40%
-123
- C4 -
2BTY
3
ARGB_THEMA
A:
[8-271]
----------------------------
V
L
L
E
A
L
P
Y
I
K
E
F
Y
G
K
T
F
V
I
K
F
G
G
S
A
M
K
Q
E
N
A
K
K
A
F
I
Q
D
I
I
L
L
K
Y
T
G
I
K
P
I
I
V
H
G
G
G
P
A
I
S
Q
M
M
K
D
L
G
I
E
P
V
F
K
N
G
H
R
V
T
D
E
K
T
M
E
I
V
E
M
V
L
V
G
K
I
N
K
E
I
V
M
N
L
N
L
H
G
G
R
A
V
G
I
C
G
K
D
S
K
L
I
V
A
E
K
E
T
------------
K
H
G
D
I
G
Y
V
G
K
V
K
K
V
N
P
E
I
L
H
A
L
I
E
N
D
Y
I
P
V
I
A
P
V
G
I
G
E
D
G
H
S
Y
N
I
N
A
D
T
A
A
A
E
I
A
K
S
L
M
A
E
K
L
I
L
L
T
D
---
V
D
G
V
L
K
--
D
---
G
-----
K
---
L
I
S
T
L
T
P
D
E
A
E
E
L
I
R
D
G
T
V
T
G
-
G
M
I
P
K
V
E
C
A
V
S
A
V
R
G
G
V
G
A
V
H
I
I
N
G
G
L
E
H
A
I
L
L
E
I
-
F
S
R
K
G
I
G
T
M
I
K
E
L
E
39
PsiBlast_CBE
85.08
33%
-125
- C4 -
2JJ4
1
ARGB_SYNE7
B:
[28-309]
--------------------
A
G
A
A
D
R
V
R
I
L
S
E
A
L
P
Y
L
Q
Q
F
A
G
R
T
V
V
V
K
Y
G
G
A
A
M
K
Q
E
E
L
K
E
A
V
M
R
D
I
V
F
L
A
C
V
G
M
R
P
V
V
V
H
G
G
G
P
E
I
N
A
W
L
G
R
V
G
I
E
P
Q
F
H
N
G
L
R
V
T
D
A
D
T
M
E
V
V
E
M
V
L
V
G
R
V
N
K
D
I
V
S
R
I
N
T
T
G
G
R
A
V
G
F
C
G
T
D
G
R
L
V
L
A
R
----------
P
H
D
Q
E
G
I
---
G
F
V
G
E
V
N
S
V
N
S
E
V
I
E
P
L
L
E
R
G
Y
I
P
V
I
S
S
V
A
A
D
E
N
G
Q
S
F
N
I
N
A
D
T
V
A
G
E
I
A
A
A
L
N
A
E
K
L
I
L
L
T
D
TRG
I
L
E
D
P
K
R
P
E
---
S
LI---
P
---
R
L
N
I
P
Q
S
R
E
L
---
I
A
Q
G
-
I
V
G
G
G
M
I
P
K
V
D
C
C
I
R
S
L
A
Q
G
V
R
A
A
H
I
I
D
G
R
I
P
H
A
L
L
L
E
I
-
F
T
D
A
G
I
G
T
M
I
V
G
S
-