@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Wbm0429: (2015-12-01 )
MKYFLRIDNVRVVGIDVEIKKQSSVCEQMRFRIGRTSLLSTLSRVSGVVERRNAIDILACINIKAQHGSIKLMATDLDISIFASLAADVLTEGEVKVSAHTLHDIVKKLPADLDVNFEVNDQGKLLISYGNANFSLPNVVLNKLPVLEEGDHKYDFTLLNTDLIDLLNKTKFAVSLDDTRYNLNGIYLHTDEQFLYCVATDGHRLSCVKKPKPQNINSEFGVIIPRKTVIELLKVLDDCDEINIKLSDRKIKFTCGKYIIISKLIDGAFPDYKCVIPASQDKQMVVESSKLASVIDRVSVVVSDRIKSIEFSLQEKSLTLHSNSQECSDATEFIEVDYNGAPIEIGFNSRYLLDALSCIKSKCKFSLSDSSSATVITDENDPNVLYIVMPVRT
Atome Classification :
(62 SA)
.........10........20........30........40........50........60........70........80.....-...90.-.......100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360-........370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
Y
F
L
R
ID
N
V
R
V
V
G
I
D
V
E
I
K
K
Q
S
S
V
C
E
Q
M
R
F
RIG
R
T
S
L
L
S
T
L
S
R
V
S
G
V
V
E
RRN
A
I
D
I
L
A
C
I
N
I
K
AQHG
S
I
K
L
M
A
TDL
D
I
S
I
F
A
S
L
A
-
A
D
V
LTE-G
E
V
K
V
S
A
H
T
L
H
D
I
V
K
KLPAD
L
D
V
N
F
E
VNDQ
G
K
L
L
I
S
YGNANFS
L
P
N
V
V
L
NKLPVLEEGDH
K
Y
D
F
T
LL
N
T
D
L
I
D
L
L
NKT
K
F
A
V
S
LDDT
R
Y
NL
N
G
I
Y
L
HTD
E
Q
F
L
Y
C
V
ATDG
H
R
L
S
CVKKPKPQNINSEF
G
V
I
I
P
R
K
T
V
I
E
L
L
K
V
LDDCD-E
I
N
I
K
LSD
R
K
I
K
F
TCG
K
Y
I
I
I
S
K
L
IDGAFPD
Y
K
C
VIPASQD
K
Q
M
V
V
E
S
S
K
L
A
S
V
I
D
R
V
S
V
V
V
S
D
R
I
K
S
I
E
F
S
LQE
K
S
L
T
LHSNSQECSDAT
E
F
I
E
V
DYNG
A
P
I
E
I
GFN
S
R
Y
L
L
D
A
L
S
C
I
K
-
S
-K
C
K
F
SLSDSS
S
A
T
V
I
TDENDP
N
V
L
Y
I
V
M
PVRT
33
PsiBlast_CBE
95.56
35%
-125
- C6 -
4TSZ
1
?
C:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
32
PsiBlast_CBE
95.41
35%
-126
- C6 -
4TSZ
1
?
D:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
35
PsiBlast_CBE
95.16
35%
-126
- C6 -
4TSZ
2
?
A:
[A-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
34
PsiBlast_CBE
95.16
35%
-126
- C6 -
4TSZ
1
?
B:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
25
PsiBlast_CBE
95.14
35%
-126
- C6 -
4TSZ
1
?
L:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
26
PsiBlast_CBE
94.99
35%
-125
- C6 -
4TSZ
1
?
K:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
24
PsiBlast_CBE
94.99
35%
-126
- C6 -
4TSZ
1
?
M:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
31
PsiBlast_CBE
94.78
35%
-125
- C6 -
4TSZ
1
?
E:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
27
PsiBlast_CBE
94.51
35%
-126
- C6 -
4TSZ
1
?
J:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
19
PsiBlast_PDB
94.36
32%
-123
- C6 -
4K3P
6
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
--------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
58
PsiBlast_CBE
94.22
32%
-125
- C6 -
4N95
10
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
2
PsiBlast_PDB
94.21
35%
-126
- C6 -
4TSZ
1
?
H:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
18
PsiBlast_PDB
94.08
32%
-128
- C6 -
4K3O
9
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
1
PsiBlast_PDB
94.01
35%
-126
- C6 -
4TR8
1
?
A:
[16-382]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
-
62
PsiBlast_CBE
93.98
32%
-125
- C6 -
4MJR
4
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
29
PsiBlast_CBE
93.98
35%
-125
- C6 -
4TSZ
1
?
G:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
28
PsiBlast_CBE
93.97
35%
-124
- C6 -
4TSZ
1
?
I:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
93
PsiBlast_CBE
93.84
32%
-123
- C6 -
3F1V
1
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
A
A
A
A
A
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
67
PsiBlast_CBE
93.55
32%
-125
- C6 -
4K74
1
?
B:
[7-370]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
--
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
9
PsiBlast_PDB
93.50
32%
-123
- C6 -
3BEP
2
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
30
PsiBlast_CBE
93.45
35%
-126
- C6 -
4TSZ
1
?
F:
[1-367]
---------------------------
H
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
-
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
-
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
-
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
20
PsiBlast_PDB
93.29
32%
-125
- C6 -
4K3Q
12
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
45
PsiBlast_CBE
93.28
32%
-124
- C6 -
4OVG
10
?
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-----
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
10
PsiBlast_PDB
93.27
32%
-121
- C6 -
3D1E
1
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
17
PsiBlast_PDB
93.21
32%
-124
- C6 -
4K3M
6
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
15
PsiBlast_PDB
93.19
32%
-124
- C6 -
4K3K
8
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
47
PsiBlast_CBE
93.11
32%
-125
- C6 -
4OVF
7
?
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
91
PsiBlast_CBE
92.94
32%
-128
- C6 -
3Q4L
1
DPO3B_ECOLI
A:
[3-367]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
72
PsiBlast_CBE
92.86
32%
-124
- C6 -
4K3R
6
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
87
PsiBlast_CBE
92.81
32%
-123
- C6 -
3D1F
2
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
90
PsiBlast_CBE
92.80
32%
-128
- C6 -
3Q4L
2
DPO3B_ECOLI
B:
[3-367]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
---
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
52
PsiBlast_CBE
92.75
32%
-126
- C6 -
4N98
6
DPO3B_ECOLI
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
56
PsiBlast_CBE
92.64
32%
-127
- C6 -
4N96
8
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
83
PsiBlast_CBE
92.43
32%
-123
- C6 -
3Q4J
1
DPO3B_ECOLI
D:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
61
PsiBlast_CBE
92.43
32%
-123
- C6 -
4MJR
7
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
37
PsiBlast_CBE
92.42
32%
-125
- C6 -
4PNW
3
?
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
14
PsiBlast_PDB
92.42
32%
-126
- C6 -
3Q4K
1
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
-------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
--
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
89
PsiBlast_CBE
92.35
32%
-122
- C6 -
1OK7
1
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
80
PsiBlast_CBE
92.25
32%
-123
- C6 -
3Q4K
1
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
------
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
11
PsiBlast_PDB
92.24
32%
-124
- C6 -
3D1F
4
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
82
PsiBlast_CBE
92.21
32%
-125
- C6 -
3Q4J
1
DPO3B_ECOLI
E:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
49
PsiBlast_CBE
92.21
32%
-124
- C6 -
4N9A
7
DPO3B_ECOLI
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
77
PsiBlast_CBE
92.15
32%
-122
- C6 -
4K3L
17
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
85
PsiBlast_CBE
91.99
32%
-125
- C6 -
3Q4J
1
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
--
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
64
PsiBlast_CBE
91.97
32%
-122
- C6 -
4MJQ
8
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
----
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
43
PsiBlast_CBE
91.94
32%
-123
- C6 -
4OVH
8
?
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
--
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
36
PsiBlast_CBE
91.90
32%
-128
- C6 -
4PNW
7
?
B:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
40
PsiBlast_CBE
91.87
32%
-125
- C6 -
4PNU
5
?
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
86
PsiBlast_CBE
91.83
32%
-123
- C6 -
3D1G
1
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
54
PsiBlast_CBE
91.77
32%
-119
- C6 -
4N97
6
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
84
PsiBlast_CBE
91.75
32%
-122
- C6 -
3Q4J
1
DPO3B_ECOLI
C:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
44
PsiBlast_CBE
91.66
32%
-124
- C6 -
4OVG
7
?
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
41
PsiBlast_CBE
91.64
32%
-127
- C6 -
4PNU
7
?
A:
[1-364]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
60
PsiBlast_CBE
91.60
32%
-121
- C6 -
4N94
3
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
12
PsiBlast_PDB
91.59
32%
-122
- C6 -
3D1G
1
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
65
PsiBlast_CBE
91.50
32%
-124
- C6 -
4MJP
6
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
-------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
79
PsiBlast_CBE
91.45
32%
-124
- C6 -
3QSB
1
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
4
PsiBlast_PDB
91.22
32%
-119
- C6 -
3QSB
1
DPO3B_ECOLI
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
16
PsiBlast_PDB
91.16
32%
-128
- C6 -
4K3L
7
DPO3B_ECOLI
A:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
---N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
81
PsiBlast_CBE
91.09
32%
-126
- C6 -
3Q4J
1
DPO3B_ECOLI
F:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
46
PsiBlast_CBE
91.02
32%
-125
- C6 -
4OVF
7
?
B:
[1-365]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
68
PsiBlast_CBE
90.52
32%
-126
- C6 -
4K74
1
?
A:
[7-370]
----------------------------
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
-
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
-
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
H
-
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
---N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
-
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--