@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0009: (2016-03-11 )
MLDIRLFRNEPDTVKSKIELRGDDPKVVDEILELDEQRRKLISATEEMKARRNKVSEEIALKKRNKENADDVIAEMRTLGDDIKEKDSQLNEIDNKMTGILCRIPNLISDDVPQGESDEDNVEVKKWGTPREFSFEPKAHWDIVEELKMADFDRAAKVSGARFVYLTNEGAQLERALMNYMITKHTTQHGYTEMMVPQLVNADTMYGTGQLPKFEEDLFKVEKEGLYTIPTAEVPLTNFYRNEIIQPGVLPEKFTGQSACFRSEAGSAGRDTRGLIRLHQFDKVEMVRFEQPEDSWNALEEMTTNAEAILEELGLPYRRVILCTGDIGFSASKTYDIEVWLPSYNDYKEISSCSNCTDFQARRANIRFKRDKAAKPELAHTLNGSGLAVGRTFAAIVENYQNEDGTVTIPEALVPFMGGKTQISKPVK
Atome Classification :
(34 SA)
-----------------------------------------------------------------------------------------------........----.----10---.--........20.---..--.--..--.---------.30........40........50.....---------------------------...60.....--------.-------------.-----------------------------.------------------------70....------------....80.-.......90---.........100.......110.-.....-.-120.......--.130--------------------..--------------------....------------.140.......150...-.-...160.......170.......180.......190.......200.......210...-....220---..---..--.-----------...230.......240...--....--250.......260.......270.......280.......290--.--.--.....300.......310.......320.......330.......340.......350.......360.....--..---370.-----.--.--....380.......390.......400.......410.......420........-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------M
L
D
I
R
L
FR----N----E----P--D
T
V
K
S
K
I
E
LRG---D
D
--
P
--
K
V
--
V
---------
D
E
I
L
E
L
D
E
Q
R
R
K
L
I
S
A
T
E
E
M
K
A
R
R
N
K
V
S
---------------------------
E
E
I
A
L
KKRNK--------E-------------
N
-----------------------------
A
------------------------
D
D
V
I
A
E
------------
M
R
T
LG
D
D
-
I
K
E
K
D
S
Q
L
----
N
E
I
D
N
K
M
T
G
I
L
CRI
P
N
L
ISDDVP-QGESD-E-D-
N
V
E
V
KKWG--TPRE--------------------FS--------------------FEPK------------
A
H
W
D
I
V
E
E
L
K
M
A
D
F
D
R
A
-A-KVSG
A
R
F
V
Y
LTNE
G
A
Q
L
E
R
A
L
M
N
Y
M
I
TKHTTQHG
Y
T
E
M
M
V
P
Q
LVNADTMYGTGQLP
K
F
E
-
E
D
L
F
K
V
----
E
K---EG--
L
-----------
Y
TIPTAEV
P
L
T
N
F
Y
R
N
EII--QPGV--LPEKFTGQ
S
A
C
FRSEAGSAGRDT
R
G
L
I
R
LHQFD
K
V
E
M
V
R
FEQP--E--
D
--
S
W
N
A
L
E
E
MTT
N
A
E
A
I
L
E
E
LGLP
Y
R
R
V
I
L
C
TGDIGFSAS
K
T
Y
D
I
E
V
WLPSYN
D
Y
K
E
I
S
SCSNCT
D
F
Q
ARRA
N
I
R
--
F
K---RDKA-----A--K--P
E
L
A
HTLNGSGL
A
V
G
R
T
F
A
A
I
V
E
N
YQNEDG
T
V
T
I
P
E
A
L
V
P
FMGGK--TQISKPVK-----------
72
HHSearch
91.30
52%
-64
- C4 -
2DQ3
1
SYS_AQUAE
A:
[1-423]
-----------------------------------------------------------------------------------------------
M
I
D
I
N
L
I
R
----
E
----
K
----
P
--
D
Y
V
K
E
R
L
A
T
R
D
---
K
E
L-
V
--
S
L
--
V
---------
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
E
A
L
R
S
E
R
N
K
L
S
---------------------------
K
E
I
G
K
L
K
R
E
G
--------
K
-------------
D
-----------------------------
T
------------------------
T
E
I
Q
N
R
------------
V
K
E
L
K
E
E
-
I
D
R
L
E
E
E
L
----
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
-
V
G
E
D
E
-
K
-
D
-
N
V
E
V
R
R
W
G
--
E
P
R
K
--------------------
F
D
--------------------
F
E
P
K
------------
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
-
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
-
E
D
L
Y
K
C
----
E
R
---
D
N
--
L
-----------
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
E
E
N
--
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
--
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
--
F
K
---
D
S
K
T
-----
G
--
K
--
N
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
--
V
I
R
----------------
1
PsiBlast_PDB
90.99
51%
-64
- C4 -
2DQ3
1
SYS_AQUAE
A:
[2-424]
------------------------------------------------------------------------------------------------
I
D
I
N
L
I
R
----
E
----
K
----
P
--
D
Y
V
K
E
R
L
A
T
R
D
---
K
E
L-
V
--
S
L
--
V
---------
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
E
A
L
R
S
E
R
N
K
L
S
---------------------------
K
E
I
G
K
L
K
R
E
G
--------
K
-------------
D
-----------------------------
T
------------------------
T
E
I
Q
N
R
------------
V
K
E
L
K
E
E
-
I
D
R
L
E
E
E
L
----
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
-
V
G
E
D
E
-
K
-
D
-
N
V
E
V
R
R
W
G
--
E
P
R
K
--------------------
F
D
--------------------
F
E
P
K
------------
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
-
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
-
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
-
E
D
L
Y
K
C
----
E
R
---
D
N
--
L
-----------
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
--
K
E
E
N
--
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
--
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
--
F
K
---
D
S
K
T
-----
G
--
K
--
N
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
----
T
D
V
I
R
P
-------------
22
PsiBlast_CBE
86.89
41%
-61
- C4 -
2DQ0
4
SYS_PYRHO
B:
[1-441]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
--
E
--
K
V
KW
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
--------------------
W
K
GHLERFLEQSQGKMEYEILE
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
-
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
---------------------
21
PsiBlast_CBE
86.45
41%
-60
- C4 -
2ZR2
4
SYS_PYRHO
B:
[1-441]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
--
E
--
K
V
KW
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
--------------------
W
K
GHLERFLEQSQGKMEYEILE
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
-
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
---------------------
74
HHSearch
86.13
43%
-56
- C4 -
2DQ0
5
SYS_PYRHO
A:
[1-447]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
EK
V
--
K
W
--
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
--------------------
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
--
E
I
V
P
V
E
-------------
2
PsiBlast_PDB
86.00
41%
-58
- C4 -
2DQ0
5
SYS_PYRHO
A:
[1-441]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
--
E
--
K
V
K
W
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
-
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
---------------------
4
PsiBlast_PDB
85.93
41%
-58
- C4 -
2ZR3
-
SYS_PYRHO
A:
[1-441]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
--
E
--
K
V
K
W
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
-
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
---------------------
3
PsiBlast_PDB
85.90
41%
-59
- C4 -
2ZR2
5
SYS_PYRHO
A:
[1-441]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
----
E
----
N
----
P
--
E
L
V
K
N
D
L
I
K
R
G
---
E
L
--
E
--
K
V
K
W
V
---------
D
E
I
L
K
L
D
T
E
W
R
T
K
L
K
E
I
N
R
L
R
H
E
R
N
K
I
A
---------------------------
V
E
I
G
K
R
R
K
K
G
--------
E
-------------
P
-----------------------------
V
------------------------
D
E
L
L
A
K
------------
S
R
E
I
V
K
R
-
I
G
E
L
E
N
E
V
----
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
-
V
G
K
D
E
-
N
-
D
-
N
V
P
I
R
F
W
G
--
K
A
R
V
--------------------
W
K
GH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
------------
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
-
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
-
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
-
D
V
I
Y
K
V
----
E
D
---
E
D
--
L
-----------
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
--
D
G
K
D
--
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
--
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
--
F
R
---
D
R
T
D
-----
E
--
K
--
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
---------------------
76
HHSearch
82.98
35%
-56
- C4 -
3QNE
-
SYSC_CANAL
A:
[1-438]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
VEKG
G
----
D
----
P
--
E
I
I
K
A
S
Q
K
K
R
G
---
D
S
--
V
--
E
L
--
V
---------
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
---------------------------
K
E
I
G
K
R
F
K
A
K
--------
E
-------------
D
-----------------------------
A
------------------------
K
D
L
I
A
E
------------
K
E
K
L
S
N
E
-
K
K
E
I
I
E
K
E
----
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
-
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
T
--
P
E
N
Y
KKPEQIAAAT----------
G
A
--------------------
P
A
K
L
------------
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
F
L
S
-
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
----
I
D
GE-
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
ES
P
A
E
Q
--
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
--
C
G
---
I
-----------
E
--
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
-
L
V
I
P
E
V
L
R
K
Y
I
P
G
E
---------------------
13
PsiBlast_PDB
82.60
33%
-59
- C4 -
4L87
4
SYSC_HUMAN
A:
[1-459]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
VDKG
G
----
D
----
P
--
A
L
I
R
E
T
Q
E
K
R
F
---
K
D
--
P
--
G
L
--
V
---------
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
L
K
N
L
C
S
---------------------------
K
T
I
G
E
K
M
K
K
K
--------
E
PVGDDESVPENVL
S
-----------------------------
F
------------------------
D
D
L
T
A
D
A
L
A
N
LK
V
S
Q
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
----
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
-
V
-
D
-
N
K
V
E
R
I
W
G
DC
T
V
R
K
--------------------------------------------
K
Y
------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
-
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
----
I
G
---
K
G
--
S
EKSDDN
S
Y
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
E
D
--
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
---
Q
T
K
K
-----
M
MD
K
--
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
6
PsiBlast_PDB
82.45
33%
-58
- C4 -
3QO7
1
SYSC_CANAL
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
----
V
----
E
KGGD
P
--
E
I
I
K
A
S
Q
K
K
R
G
---
D
S
--
V
--
E
L
--
V
---------
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
---------------------------
K
E
I
G
K
R
F
K
A
K
--------
E
-------------
D
-----------------------------
A
------------------------
K
D
L
I
A
E
------------
K
E
K
L
S
N
E
-
K
K
E
I
I
E
K
E
----
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
-
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
---
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
QIAAATGAPAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
-
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D--
G
E
---
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
P
A
EQ
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
----------------
E
--
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
Y
I
K
-----------
8
PsiBlast_PDB
82.17
33%
-57
- C4 -
3QO5
-
SYSC_CANAL
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
----
V
----
E
KGGD
P
--
E
I
I
K
A
S
Q
K
K
R
G
---
D
S
--
V
--
E
L
--
V
---------
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
---------------------------
K
E
I
G
K
R
F
---------------------------------------------------------------------------------
D
L
I
A
E
------------
K
E
K
L
S
N
E
-
K
K
E
I
I
E
K
E
----
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
-
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
---
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
QIAAATGAPAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
L
-
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D--
G
E
---
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
P
A
EQ
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
----------------
E
--
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
Y
I
K
-----------
75
HHSearch
82.15
35%
-57
- C4 -
3VBB
2
SYSC_HUMAN
A:
[2-471]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
----
V
DKGG
D
----
P
--
A
L
I
R
E
T
Q
E
K
R
F
---
K
D
--
P
--
G
L
--
V
---------
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
L
K
N
L
C
S
---------------------------
K
T
I
G
E
K
M
K
K
K
--------
E
--------------------------------------------DESVPENVLSFDDLT
A
D
A
L
A
N
L
KV
S
Q
I
K
K
V
------------
R
L
L
I
D
E
A
-
I
L
K
C
D
A
E
R
----
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
-
I
S
N
D
E
D
V
-
D
-
N
K
V
E
R
I
W
G
--
D
C
T
V
------------------------------------------
R
K
K
Y
------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
-
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
-
E
E
L
Y
K
V
----
I
----
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
E
D
--
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
--
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
---
Q
T
--M----
D
--
K
--
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
LQ
E
L
I
P
F
V
-------------
5
PsiBlast_PDB
82.08
33%
-58
- C4 -
3QNE
-
SYSC_CANAL
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
----
V
----
E
KGGD
P
--
E
I
I
K
A
S
Q
K
K
R
G
---
D
S
--
V
--
E
L
--
V
---------
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
---------------------------
K
E
I
G
K
R
F
K
A
K
--------
E
-------------
D
-----------------------------
A
------------------------
K
D
L
I
A
E
------------
K
E
K
L
S
N
E
-
K
K
E
I
I
E
K
E
----
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
-
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
---
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
QIAAATGAPAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
-
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D--
G
E
---
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
P
A
EQ
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
-----
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
----------------
E
--
K
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
Y
I
K
-----------
27
PsiBlast_CBE
81.48
33%
-63
- C4 -
3VBB
1
SYSC_HUMAN
D:
[2-460]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
V
DKG
G
----
D
----
P
--
A
L
I
R
E
T
Q
E
K
R
F
---
K
D
--
P
--
G
L
--
V
---------
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
L
K
N
L
C
S
---------------------------
K
T
I
G
E
K
M
K
K
K
--------
E
GDDEENVL-----
S
-----------------------------
F
------------------------
D
D
L
T
A
D
ALANLK
V
S
Q
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
----
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
-
V
-
D
-
N
K
V
E
R
I
W
G
DC
T
V
R
K
--------------------------------------------
K
Y
------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
-
R
T
L
G
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
-
E
E
L
Y
K
V
----
I
G
---
K
----D
E
K
--------
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
E
D
--
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
------
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
---
Q
--------
M
M
D
K
--
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
7
PsiBlast_PDB
81.46
33%
-55
- C4 -
3QO8
4
SYSC_CANAL
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
N
A
F
L
----
V
----
E
KGGD
P
--
E
I
I
K
A
S
Q
K
K
R
G
---
D
S
--
V
--
E
L
--
V
---------
D
E
I
I
A
E
Y
K
E
W
V
K
L
R
F
D
L
D
E
H
N
K
K
L
N
S
V
Q
---------------------------
K
E
I
G
K
R
F
K
------------------------
D
-----------------------------
A
------------------------
K
D
L
I
A
E
------------
K
E
K
L
S
N
E
-
K
K
E
I
I
E
K
E
----
A
E
A
D
K
N
L
R
S
K
I
N
Q
V
G
N
I
V
H
E
S
V
V
-
D
S
Q
D
E
-
E
-
N
-
N
E
L
V
R
T
W
---
T
P
E
N
--------------------
Y
K
---------------------
K
P
E
QIAAATGAPAKL
S
H
H
E
V
L
L
R
L
D
G
Y
D
P
E
R
G
-
V
-
R
I
V
G
H
R
G
Y
F
L
R
N
Y
G
V
F
L
N
Q
A
L
I
N
Y
G
L
S
-
F
L
S
S
K
G
Y
V
P
L
Q
A
P
V
M
M
N
K
E
V
M
A
K
T
A
Q
L
S
Q
F
D
-
E
E
L
Y
K
V
I
D
--
G
E
---
D
E
--
K
-----------
Y
L
I
A
T
S
E
Q
P
I
S
A
Y
H
A
G
E
W
F
--
E
S
P
A
EQ
L
P
V
R
Y
A
G
Y
S
S
C
F
R
R
E
A
G
S
H
G
K
D
A
W
G
I
F
R
V
H
A
F
E
K
I
E
Q
F
V
L
T
E
P
--
E
--
K
--
S
W
E
E
F
D
R
M
I
G
C
S
E
E
F
Y
Q
S
L
G
L
P
Y
R
V
V
G
I
V
S
G
E
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
F
Q
Q
E
Y
K
E
L
V
S
C
S
N
C
T
D
Y
Q
S
R
N
L
E
I
R
CG
I
K
-------------------
K
Y
V
H
C
L
N
S
T
L
S
A
T
E
R
T
I
C
C
I
L
E
N
Y
Q
K
E
D
G
L
V
-
I
P
E
V
L
R
K
Y
I
P
G
E
--
P
E
F
I
P
Y
I
K
-----------
14
PsiBlast_PDB
81.45
33%
-62
- C4 -
3VBB
2
SYSC_HUMAN
A:
[2-460]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
VDKG
G
----
D
----
P
--
A
L
I
R
E
T
Q
E
K
R
F
---
K
D
--
P
--
G
L
--
V
---------
D
Q
L
V
K
A
D
S
E
W
R
R
C
R
F
R
A
D
N
L
N
K
L
K
N
L
C
S
---------------------------
K
T
I
G
E
K
M
K
K
K
--------
E
DESVPENVL----
S
-----------------------------
F
------------------------
D
D
L
T
A
D
A
L
A
N
L
KV
S
Q
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
----
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
-
V
-
D
-
N
K
V
E
R
I
W
G
DC
T
V
R
K
--------------------------------------------
K
Y
------------
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
-
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
-
R
T
L
G
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R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
-
F
D
-
E
E
L
Y
K
V
----
I
---------DE
K
--------
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
--
R
P
E
D
--
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
----
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
--
D
N
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
--
Y
G
---
Q
T
--------M
D
K
--
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
------------------------
15
PsiBlast_PDB
81.07
33%
-60
- C4 -
3LSQ
2
?
A:
[7-463]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
--
A
--
N
I
I
R
E
S
Q
R
R
R
F
---
A
D
--
P
--
D
I
--
V
---------
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEA---------------------------------------------------------------------------------------------------------
V
L
Q
------------
L
K
Q
L
S
K
D
-
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
-
I
A
Q
D
E
-
E
T
G
-
N
T
V
V
R
T
F
G
--
N
T
T
K
--------------------
R
A
----------------------
K
L
------------
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
-
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
K
-----------
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
L
K
--
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
-------
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
PNL
R
G
T
A
-----
A
--
Q
N
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
----------------------
12
PsiBlast_PDB
81.05
35%
-54
- C4 -
1SET
1
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
--
E
V
F
H
R
A
I
R
E
K
G
VAL
D
L
--
E
--
A
L
--
L
---------
A
L
D
R
E
V
Q
E
L
K
K
R
L
----
Q
E
V
Q
T
E
R
N
Q
V
A
---------------------------
K
R
V
P
--
K
A
P
P
--------
E
-------------
E
-----------------------------
K
------------------------
E
A
L
I
A
R
------------
G
K
A
L
G
E
E
-
A
K
R
L
E
E
A
L
----
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
-
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
73
HHSearch
81.01
35%
-51
- C4 -
1SES
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
--
E
V
F
H
R
A
I
R
E
K
G
---
V
A
-----
L
D
--
L
---------
E
A
L
L
A
L
D
R
E
V
Q
E
L
K
K
R
L
Q
E
V
Q
T
E
R
N
Q
V
A
---------------------------
K
R
V
P
K
A
P
P
E
E
----------------------------------------------------
K
------------------------
E
A
L
I
A
R
------------
G
K
A
L
G
E
E
-
A
K
R
L
E
E
A
L
----
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
G
E
E
---
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
---
D
P
E
------
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
---------------
11
PsiBlast_PDB
80.83
35%
-55
- C4 -
1SES
1
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
--
E
V
F
H
R
A
I
R
E
K
G
VAL
D
L
--
E
--
A
L
--
L
---------
A
L
D
R
E
V
Q
E
L
K
K
R
L
----
Q
E
V
Q
T
E
R
N
Q
V
A
---------------------------
K
R
V
P
--
K
A
P
P
--------
E
-------------
E
-----------------------------
K
------------------------
E
A
L
I
A
R
------------
G
K
A
L
G
E
E
-
A
K
R
L
E
E
A
L
----
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
-
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
71
HHSearch
80.34
35%
-51
- C4 -
3LSS
4
?
A:
[7-471]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
--
A
--
N
I
I
R
E
S
Q
R
R
R
F
---
A
D
--
P
--
D
I
--
V
---------
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
I
C
S
---------------------------
K
A
V
G
A
K
K
K
A
K
--------
E
-------------
A
C----------------------------
V
------------------------
L
Q
L
K
Q
L
------------
S
K
D
L
S
D
Q
-
V
A
G
L
A
K
E
A
----
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
-
I
A
Q
D
E
E
T
-
G
-
N
T
V
V
R
T
F
G
--
N
T
T
K
------------------------------------------
R
A
K
L
------------
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
D
G
-
D
K
--
K
-----------
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
L
K
--
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
QE
E
--
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
---
P
N
L
R
Q----
N
--
V
--
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
F
E
N
------------
16
PsiBlast_PDB
80.22
33%
-57
- C4 -
3LSS
4
?
A:
[7-463]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
--
A
--
N
I
I
R
E
S
Q
R
R
R
F
---
A
D
--
P
--
D
I
--
V
---------
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEA--------------------------------------------------------------------------------------------------------
C
V
L
Q
------------
L
K
Q
L
S
K
D
-
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
-
I
A
Q
D
E
-
E
T
G
-
N
T
V
V
R
T
F
G
--
N
T
T
K
--------------------
R
A
----------------------
K
L
------------
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
-
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
K
-----------
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
L
K
--
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
PNL
R
-----------
Q
N
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
----------------------
23
PsiBlast_CBE
80.17
35%
-54
- C4 -
1SET
1
SYS_THET2
B:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
--
E
V
F
H
R
A
I
R
E
K
G
VAL
D
L
--
E
--
A
L
--
L
---------
A
L
D
R
E
V
Q
E
L
K
K
R
L
----
Q
E
V
Q
T
E
R
N
Q
V
A
---------------------------
K
R
V
P
--
K
A
P
P
--------
E
-------------
E
-----------------------------
K
------------------------
E
A
L
I
A
R
------------
G
K
A
L
G
E
E
-
A
K
R
L
E
E
A
L
----
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
-
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
30
PsiBlast_CBE
79.29
33%
-54
- C4 -
3LSS
2
?
B:
[7-463]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
----
D
----
E
T
G
--
A
--
N
I
I
R
E
S
Q
R
R
R
F
---
A
D
--
P
--
D
I
--
V
---------
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEADGDTSEIP
P
Q
V
K
E
A
Y
E
N
G
T
L
K
G
E
Q
V
--------
E
-------------
Q
-----------------------------
L
--------------------------
C
V
L
Q
------------
L
K
Q
L
S
K
D
-
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
-
I
A
Q
D
E
-
E
T
G
-
N
T
V
V
R
T
F
G
--
N
T
T
K
--------------------
R
A
----------------------
K
L
------------
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
-
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
-
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
K
-----------
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
L
K
--
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
P
N
L
R
G
T
A
-----
A
--
Q
N
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
----------------------
62
Fugue
79.06
35%
-54
- C4 -
3LSS
2
?
B:
[3-470]
-------------------------------------------------------------------------------------------G
S
M
M
V
L
D
I
Q
L
F
R
----
D
----
E
----
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
---
A
D
--
P
--
D
I
--
V
---------
D
A
I
I
E
A
D
K
K
W
R
R
T
Q
F
L
T
E
A
S
K
K
L
I
N
I
C
S
---------------------------
K
A
V
G
A
K
K
K
A
K
--------
E
-------------
A
DGDTSEIP
P
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
LC
V
------------------------
L
Q
L
K
Q
L
------------
S
K
D
L
S
D
Q
-
V
A
G
L
A
K
E
A
----
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
-
I
A
Q
D
E
-
E
-
T
G
N
T
V
V
R
T
F
G
--
N
T
T
K
--------------------
R
----------------------
A
K
L
------------
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
-
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
-
E
E
L
Y
Q
V
----
S
G
---
D
G
D
K
K
-----------
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
--
T
E
L
K
--
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
RQ
E
--
E
--
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
--
Y
G
---
P
N
L
R
GTAAQ
N
--
V
--
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
--
E
M
I
R
F
E
-------------
24
PsiBlast_CBE
78.52
35%
-52
- C4 -
1SES
1
SYS_THET2
B:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
----
Q
----
E
----
P
--
E
V
F
H
R
A
I
R
E
K
G
VAL
D
L
--
E
--
A
L
--
L
---------
A
L
D
R
E
V
Q
E
L
K
K
R
L
----
Q
E
V
Q
T
E
R
N
Q
V
A
---------------------------
K
R
V
P
--
K
A
P
P
--------
E
-------------
E
-----------------------------
K
------------------------
E
A
L
I
A
R
------------
G
K
A
L
G
E
E
-
A
K
R
L
E
E
A
L
----
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
-
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
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H
F
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A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
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Y
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A
--
L
P
L
R
Y
A
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A
P
A
F
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A
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D
V
R
G
L
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R
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F
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E
--
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A
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L
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V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
18
PsiBlast_PDB
77.31
32%
-50
- C4 -
1WLE
1
SYSM_BOVIN
A:
[61-469]
-----------------------------------------------------------------------------------------------------------------------------
K
G
E
L
R
S
---
K
D
L
-
P
--
G
I
--
I
---------
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
---------------------------
A
L
V
V
N
Q
D
N
S
Q
--------
V
-------------
Q
-----------------------------
Q
------------------------
D
P
Q
Y
Q
S
------------
L
R
A
R
G
R
E
-
I
R
K
Q
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
-
V
G
D
E
S
-
Q
-
A
-
R
V
-
L
H
V
V
G
--
D
K
P
A
--------------------
F
S
--------------------
F
Q
P
R
------------
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
-
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
Y
N
I
----
D
P
SRF
E
D
--
L
-----------
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
F
R
D
--
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
--
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
--
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
---
T
E
-
A
-----
G
--
E
--
L
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
-----------------------
61
Fugue
76.79
30%
-50
- C4 -
1WLE
1
SYSM_BOVIN
A:
[24-490]
-------------------------------------------------------------------------------RN
L
L
Y
E
H
A
R
E
GYSALP
L
L
D
M
E
S
L
C
----
A
----
Y
----
P
--
E
D
A
A
R
A
L
D
L
R
K
---
G
E
--
L
RS
K
D
--
L
---------
P
G
I
I
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
R
S
L
E
E
E
K
E
A
V
T
---------------------------
E
A
V
R
A
L
V
V
N
Q
DNSQVQQD
P
-------------
Q
-----------------------------
Y
------------------------
Q
S
L
R
A
R
------------
G
R
E
I
R
K
Q
-
L
T
L
L
Y
P
K
E
----
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
-
V
G
-
D
E
-
S
-
Q
-
A
R
V
L
H
V
V
G
--
D
K
P
A
--------------------
F
S
--------------------
F
Q
P
R
------------
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
L
I
H
-
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
-
P
S
Q
I
Y
N
I
DPS
R
F
---
E
D
--
L
-----------
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
F
R
D
--
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
---
G
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
--
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
---
T
E
A
G
--------
E
--
L
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
T
D
--
R
I
T
T
P
T
H
V
PLQYIGPNQPQ
32
PsiBlast_CBE
75.65
32%
-47
- C4 -
1WLE
1
SYSM_BOVIN
B:
[61-469]
-----------------------------------------------------------------------------------------------------------------------------
K
G
E
L
R
S
---
K
D
L
-
P
--
G
I
--
I
---------
S
T
W
Q
E
L
R
Q
L
R
E
Q
I
R
S
L
E
E
E
K
E
A
V
T
E
A
V
R
---------------------------
A
L
V
V
N
Q
D
N
S
Q
--------
V
-------------
Q
-----------------------------
Q
------------------------
D
P
Q
Y
Q
S
------------
L
R
A
R
G
R
E
-
I
R
K
Q
L
T
L
L
Y
P
K
E
A
Q
L
E
E
Q
F
Y
L
R
A
L
R
L
P
N
Q
T
H
P
D
V
P
-
V
G
D
E
S
-
Q
-
A
-
R
V
-
L
H
V
V
G
--
D
K
P
A
--------------------
F
S
--------------------
F
Q
P
R
------------
G
H
L
E
I
A
E
K
L
D
I
I
R
Q
K
R
L
-
S
-
H
V
S
G
H
R
S
Y
Y
L
R
G
A
G
A
L
L
Q
H
G
L
V
N
F
T
L
N
K
-
L
I
H
R
G
F
T
P
M
T
V
P
D
L
L
R
G
V
V
F
E
G
C
G
M
T
P
N
A
K
P
S
Q
I
Y
N
I
----
D
P
SRF
E
D
--
L
-----------
N
L
A
G
T
A
E
V
G
L
A
G
Y
F
M
D
H
S
V
--
A
F
R
D
--
L
P
I
R
M
V
C
S
S
T
C
Y
R
A
E
T
D
T
-
G
K
E
P
W
G
L
Y
R
V
H
H
F
T
K
V
E
M
F
G
V
T
G
P
G
L
E
--
Q
--
S
S
E
L
L
E
E
F
L
S
L
Q
M
E
I
L
T
E
L
G
L
H
F
R
V
L
D
M
P
T
Q
E
L
G
L
P
A
Y
R
K
F
D
I
E
A
W
M
P
G
R
G
R
F
G
E
V
T
S
A
S
N
C
T
D
F
Q
S
R
R
L
H
I
M
--
F
Q
---
T
E
-
A
-----
G
--
E
--
L
Q
F
A
H
T
V
N
A
T
G
C
A
V
P
R
L
L
I
A
L
L
E
S
Y
Q
Q
K
D
G
S
V
L
V
P
P
A
L
Q
P
Y
L
G
-----------------------
63
Fugue
73.12
32%
-39
- C4 -
3ERR
1
DYHC1_MOUSE (first)
A:
[3-529]
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
GVALD
L
E
A
L
L
A
V
D
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
IK
K
Q
H
L
V
E
V
R
S
MANPP
A
A
V
K
L
A
L
E
S
I
A
L
L
L
G
E
S
T
----
T
----
D
----
W
--
K
Q
I
R
S
I
I
M
R
E
N
---
F
I
--
P
--
T
I
--
V
N
FSAEEIS
D
A
I
R
E
K
M
K
K
N
Y
M
S
N
P
S
Y
N
Y
E
I
V
N
R
A
S
L
A
A
---------------------------
G
P
M
V
K
W
A
I
A
Q
--------
L
-------------
N
-----------------------------
Y
------------------------
A
D
M
L
K
R
------------
V
E
P
L
R
N
E
-
L
Q
K
L
E
D
D
A
----
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
-
W
E
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
-
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
----
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
G
--------------
31
PsiBlast_CBE
71.76
36%
-58
- C4 -
3ERR
1
SYS_THET2
B:
[174-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------------------------
Y
------------------------
A
D
M
L
K
R
------------
V
E
P
L
R
N
E
-
L
Q
K
L
E
D
D
A
----
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
-
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
17
PsiBlast_PDB
71.20
36%
-55
- C4 -
3ERR
1
DYHC1_MOUSE (first)
A:
[174-522]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----------------------------
Y
------------------------
A
D
M
L
K
R
------------
V
E
P
L
R
N
E
-
L
Q
K
L
E
D
D
A
----
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
-
G
E
-
E
-
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
-
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
----
R
D
P
E
-----
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-----------------------
77
HHSearch
69.74
36%
-51
- C4 -
3ERR
1
DYHC1_MOUSE (first)
A:
[178-529]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
K
R
------------
V
E
P
L
R
N
E
-
L
Q
K
L
E
D
D
A
----
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
-
V
G
G
E
E
---
A
-
N
R
E
I
K
R
V
G
--
G
P
P
E
--------------------
F
S
--------------------
F
P
P
L
------------
D
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
-
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
-
D
Q
V
W
A
I
----
A
E
---
T
D
--
L
-----------
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
--
P
Y
E
A
--
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
--
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
--
Y
R
---
D
P
E
------
G
--
R
--
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
--
V
L
E
P
G
--------------