@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA0727: (2016-03-18 )
MAVKVAINGFGRIGRLAFRRIQEVEGLEVVAVNDLTDDDMLAHLLKYDTMQGRFTGEVEVVDGGFRVNGKEVKSFSEPDASKLPWKDLNIDVVLECTGFYTDKDKAQAHIEAGAKKVLISAPATGDLKTIVFNTNHQELDGSETVVSGASCTTNSLAPVAKVLNDDFGLVEGLMTTIHAYTGDQNTQDAPHRKGDKRRARAAAENIIPNSTGAAKAIGKVIPEIDGKLDGGAQRVPVATGSLTELTVVLEKQDVTVEQVNEAMKNASNESFGYTEDEIVSSDVVGMTYGSLFDATQTRVMSVGDRQLVKVAAWYDNEMSYTAQLVRTLAYLAELSK
Atome Classification :
(28 SA)
.........10........20.....--...30...-.....40........50........60...---.....70.......-.80........90........100.......110.......120.......130.......140.-......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250........260......-----------.270--.----........280........290.......300..-......310.......320.......330....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
V
K
V
A
INGFG
R
I
G
R
L
A
F
R
R
I
Q
E
VEG--
L
E
V
V
A
VND-LT
D
D
D
M
L
A
H
L
L
K
Y
DTMQGRFT
G
E
V
E
V
VDG
G
---
F
R
V
N
G
K
E
V
KSFSEP-DASKLPWKDL
N
I
D
V
V
L
E
CTGFYTD
K
D
K
A
Q
A
H
I
EAGA
K
K
V
L
I
SAPATG
D
L
K
T
I
V
FNTNHQELDGSE-
T
V
VSGASCTTN
S
L
A
P
V
A
K
V
LND
D
F
G
L
V
E
G
L
M
T
T
I
H
AYTGDQNTQDAPHRKG
D
K
R
R
A
R
A
A
A
E
NIIPNST
G
A
A
K
A
I
G
K
V
I
P
E
IDGKLDGGAQRVPVATGS
L
T
E
L
T
V
V
L
EK-QDV
T
V
E
Q
V
N
E
A
M
KNASN-----------ES----F----GY
T
E
D
E
IVS-SDV
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S-VG-D
R
Q
L
V
K
V
A
A
W
YDN
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
LSK
7
PsiBlast_PDB
98.78
99%
-89
- C4 -
3LC1
3
G3P1_STAAR
P:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
21
PsiBlast_CBE
98.49
100%
-90
- C4 -
3LVF
2
G3P1_STAAR
R:
[4-338]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
1
PsiBlast_PDB
98.27
100%
-88
- C4 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
23
PsiBlast_CBE
97.89
100%
-89
- C4 -
3LVF
2
G3P1_STAAR
O:
[4-337]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
44
PsiBlast_CBE
97.87
99%
-92
- C4 -
3KV3
3
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
24
PsiBlast_CBE
97.86
100%
-90
- C4 -
3LC2
3
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
40
PsiBlast_CBE
97.47
99%
-92
- C4 -
3LC1
3
G3P1_STAAR
Q:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
120
HHSearch
97.31
99%
-88
- C4 -
3LVF
2
G3P1_STAAR
P:
[3-338]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
Q
D
-
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
V
G
D
-
R
-
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
22
PsiBlast_CBE
97.25
100%
-89
- C4 -
3LVF
2
G3P1_STAAR
Q:
[4-337]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
39
PsiBlast_CBE
97.23
99%
-89
- C4 -
3LC1
2
G3P1_STAAR
R:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
41
PsiBlast_CBE
97.19
99%
-91
- C4 -
3LC1
3
G3P1_STAAR
O:
[2-335]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
N
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
36
PsiBlast_CBE
97.08
100%
-88
- C4 -
3VAZ
4
G3P1_STAAR
O:
[10-343]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
42
PsiBlast_CBE
97.04
99%
-91
- C4 -
3KV3
3
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
38
PsiBlast_CBE
97.01
100%
-89
- C4 -
3VAZ
5
G3P1_STAAR
A:
[10-343]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
-
46
PsiBlast_CBE
96.99
99%
-90
- C4 -
3HQ4
2
G3P1_STAAR
P:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
43
PsiBlast_CBE
96.93
99%
-90
- C4 -
3KV3
3
G3P1_STAAR
Q:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
31
PsiBlast_CBE
96.89
100%
-87
- C4 -
3K73
4
G3P1_STAAR
P:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
49
PsiBlast_CBE
96.68
99%
-86
- C4 -
3L4S
3
G3P1_STAAR
P:
[2-334]
-
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
G
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
8
PsiBlast_PDB
96.66
99%
-90
- C4 -
3HQ4
2
G3P1_STAAR
R:
[1-334]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
S
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
--
30
PsiBlast_CBE
96.57
100%
-86
- C4 -
3K73
4
G3P1_STAAR
R:
[1-336]
M
A
V
K
V
A
I
N
G
F
G
R
I
G
R
L
A
F
R
R
I
Q
E
V
E
G
--
L
E
V
V
A
V
N
D
-
L
T
D
D
D
M
L
A
H
L
L
K
Y
D
T
M
Q
G
R
F
T
G
E
V
E
V
V
D
G
G
---
F
R
V
N
G
K
E
V
K
S
F
S
E
P
-
D
A
S
K
L
P
W
K
D
L
N
I
D
V
V
L
E
C
T
G
F
Y
T
D
K
D
K
A
Q
A
H
I
E
A
G
A
K
K
V
L
I
S
A
P
A
T
G
D
L
K
T
I
V
F
N
T
N
H
Q
E
L
D
G
S
E
-
T
V
V
S
G
A
S
C
T
T
N
S
L
A
P
V
A
K
V
L
N
D
D
F
G
L
V
E
G
L
M
T
T
I
H
A
Y
T
G
D
Q
N
T
Q
D
A
P
H
R
K
G
D
K
R
R
A
R
A
A
A
E
N
I
I
P
N
S
T
G
A
A
K
A
I
G
K
V
I
P
E
I
D
G
K
L
D
G
G
A
Q
R
V
P
V
A
T
G
S
L
T
E
L
T
V
V
L
E
K
-
Q
D
V
T
V
E
Q
V
N
E
A
M
K
N
A
S
N
-----------
E
S
----
F
----
G
Y
T
E
D
E
I
V
S
-
S
D
V
V
G
M
T
Y
G
S
L
F
D
A
T
Q
T
R
V
M
S
-
V
G
-
D
R
Q
L
V
K
V
A
A
W
Y
D
N
E
M
S
Y
T
A
Q
L
V
R
T
L
A
Y
L
A
E
L
S
K
101
Fugue
79.74
54%
-84
- C4 -
1HDG
3
G3P_THEMA
O:
[1-332]
--
A
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
PD
I
E
V
V
A
I
N
D
L-
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
---ENS
L
I
V
D
G
K
E
I
K
V
F
A
E
-P
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
-H
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
D
-
L
R
R
A
R
A
A
-
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
--
E
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-----------
G
R
LKGI
I
----
G
Y
N
D
E
P
I
V
S
S-
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
-----I
G
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
69
PsiBlast_CBE
79.23
49%
-81
- C4 -
4P8R
2
?
C:
[10-339]
-
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
--
I
E
I
V
G
I
N
D
-
L
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
V
E
V
Q
G
G
A
---
L
V
V
N
G
K
K
I
R
V
T
S
E
R
-
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
-
E
-
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
K
-
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
-
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-----------
G
E
LKGI
L
----
G
Y
V
D
E
E
I
V
S
-
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
--
I
S
-
L
N
-
D
-
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
17
PsiBlast_PDB
79.03
49%
-82
- C4 -
4P8R
3
?
A:
[9-339]
M
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
--
I
E
I
V
G
I
N
D
-
L
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
V
E
V
Q
G
G
A
---
L
V
V
N
G
K
K
I
R
V
T
S
E
R
-
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
-
E
-
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
K
-
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
-
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-----------
G
E
LKGI
L
----
G
Y
V
D
E
E
I
V
S
-
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
--
I
S
-
L
N
-
D
-
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
70
PsiBlast_CBE
77.68
49%
-82
- C4 -
4P8R
3
?
B:
[9-339]
M
V
I
R
V
G
I
N
G
F
G
R
I
G
R
V
V
F
R
A
A
Q
R
R
N
D
--
I
E
I
V
G
I
N
D
-
L
L
D
A
D
Y
M
A
Y
M
L
K
Y
D
S
T
H
G
R
F
E
G
A
V
E
V
Q
G
G
A
---
L
V
V
N
G
K
K
I
R
V
T
S
E
R
-
D
P
A
N
L
K
W
N
E
I
N
V
D
V
V
V
E
S
T
G
L
F
L
S
D
D
T
A
R
K
H
I
Q
A
G
A
K
K
V
V
I
T
G
P
S
K
D
D
T
P
M
F
V
M
G
V
N
H
T
T
Y
K
G
-
E
-
A
I
V
S
N
A
S
C
T
T
N
C
L
A
P
L
A
K
V
L
N
D
K
F
G
I
V
E
G
L
M
T
T
V
H
A
T
T
A
T
Q
K
T
V
D
G
P
S
Q
K
-
D
W
R
G
G
R
G
A
A
Q
N
I
I
P
S
S
T
G
A
A
K
A
V
G
K
I
I
P
S
L
N
G
K
L
T
G
M
A
F
R
V
P
T
P
N
V
S
V
V
D
L
T
V
R
L
E
R
-
P
-
A
T
Y
K
Q
I
C
D
A
I
K
A
A
S
E
-----------
G
E
LKGI
L
----
G
Y
V
D
E
E
I
V
S
-
S
D
I
N
G
I
P
L
T
S
V
F
D
A
R
A
G
--
I
S
-
L
N
-
D
-
N
F
V
K
L
V
S
W
Y
D
N
E
T
G
Y
S
N
K
V
L
D
L
I
A
H
I
T
K
---
14
PsiBlast_PDB
77.35
53%
-81
- C4 -
1HDG
3
G3P_THEMA
O:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
PD
I
E
V
V
A
I
N
D
-
L
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
---
L
I
V
D
G
K
E
I
K
V
F
A
E
P
-
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-----------
G
R
----
L
KGII
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
-----
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--
15
PsiBlast_PDB
77.06
51%
-77
- C4 -
2EP7
1
G3P_AQUAE
A:
[3-339]
--
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
E
E
--
I
E
I
V
A
I
N
D
-
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
---
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYLK
E
I
----
L
----
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
D
------
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
---
64
PsiBlast_CBE
76.69
51%
-79
- C4 -
2EP7
1
G3P_AQUAE
B:
[2-339]
-
A
I
K
V
G
I
N
G
F
G
R
I
G
R
S
F
F
R
A
S
W
G
R
E
E
--
I
E
I
V
A
I
N
D
-
L
T
D
A
K
H
L
A
H
L
L
K
Y
D
S
V
H
G
I
F
K
G
S
V
E
A
K
D
D
S
---
I
V
V
D
G
K
E
I
K
V
F
A
Q
K
-
D
P
S
Q
I
P
W
G
D
L
G
V
D
V
V
I
E
A
T
G
V
F
R
D
R
E
N
A
S
K
H
L
Q
G
G
A
K
K
V
I
I
T
A
P
A
K
N
P
D
I
T
V
V
L
G
V
N
E
E
K
Y
N
P
K
E
H
N
I
I
S
N
A
S
C
T
T
N
C
L
A
P
C
V
K
V
L
N
E
A
F
G
V
E
K
G
Y
M
V
T
V
H
A
Y
T
N
D
Q
R
L
L
D
L
P
H
K
--
D
F
R
R
A
R
A
A
A
I
N
I
V
P
T
T
T
G
A
A
K
A
I
G
E
V
I
P
E
L
K
G
K
L
D
G
T
A
R
R
V
P
V
P
D
G
S
L
I
D
L
T
V
V
V
N
K
-
A
P
S
S
V
E
E
V
N
E
K
F
R
E
A
A
Q
K
Y
R
E
SGKVYLK
E
I
----
L
----
Q
Y
C
E
D
P
I
V
S
-
T
D
I
V
G
N
P
H
S
A
I
F
D
A
P
L
T
Q
V
I
D
------
N
L
V
H
I
A
A
W
Y
D
N
E
W
G
Y
S
C
R
L
R
D
L
V
I
Y
L
A
E
---
63
PsiBlast_CBE
76.52
53%
-80
- C4 -
1HDG
3
G3P_THEMA
Q:
[2-332]
---
R
V
A
I
N
G
F
G
R
I
G
R
L
V
Y
R
I
I
Y
E
R
K
N
PD
I
E
V
V
A
I
N
D
-
L
T
D
T
K
T
L
A
H
L
L
K
Y
D
S
V
H
K
K
F
P
G
K
V
E
Y
T
E
N
S
---
L
I
V
D
G
K
E
I
K
V
F
A
E
P
-
D
P
S
K
L
P
W
K
D
L
G
V
D
F
V
I
E
S
T
G
V
F
R
N
R
E
K
A
E
L
H
L
Q
A
G
A
K
K
V
I
I
T
A
P
A
K
G
E
D
I
T
V
V
I
G
C
N
E
D
Q
L
K
P
E
H
-
T
I
I
S
C
A
S
C
T
T
N
S
I
A
P
I
V
K
V
L
H
E
K
F
G
I
V
S
G
M
L
T
T
V
H
S
Y
T
N
D
Q
R
V
L
D
L
P
H
K
--
D
L
R
R
A
R
A
A
A
V
N
I
I
P
T
T
T
G
A
A
K
A
V
A
L
V
V
P
E
V
K
G
K
L
D
G
M
A
I
R
V
P
T
P
D
G
S
I
T
D
L
T
V
L
V
E
K
-
E
-
T
T
V
E
E
V
N
A
V
M
K
E
A
T
E
-----------
G
R
----
L
KGII
G
Y
N
D
E
P
I
V
S
-
S
D
I
I
G
T
T
F
S
G
I
F
D
A
T
I
T
N
V
I
G
-----
G
K
L
V
K
V
A
S
W
Y
D
N
E
Y
G
Y
S
N
R
V
V
D
T
L
E
L
L
L
K
M
--