@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2021: (2016-03-31 )
MEDKNSVIVFKNVSFQYQSDASFTLKDVSFNIPKGQWTSIVGHNGSGKSTIAKLMIGIEKVKSGEIFYNNQAITDDNFEKLRKDIGIVFQNPDNQFVGSIVKYDVAFGLENHAVPHDEMHRRVSEALKQVDMLERADYEPNALSGGQKQRVAIASVLALNPSVIILDEATSMLDPDARQNLLDLVRKVKSEHNITIISITHDLSEAMEADHVIVMNKGTVYKEGTATEIFDHAEELTRIGLDLPFPIKINQMLGHQTSFLTYEGLVDQL
Atome Classification :
(47 SA)
.........10...--....--.20--...-.--.....30........40........50........60........--70--.--..--.---..--.---..80...-.....90----.-----.......100..-....-.110-........120.......130..-...-....140--------.......150.......160.......170.......180.......190.......200..-.-..-.-.210.......220.......----230---...-.-....-------------------------------.240.......250....--...260.......----------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEDKN
S
V
I
V
F
KN
V
S
--
F
Q
YQ--SD---A
S
F
-
T
--
L
K
D
V
S
FNIPKG
Q
W
T
S
I
VGHNGS
G
K
S
T
I
A
K
L
M
I
G
I
E
KVKSG
E
I
F
YN--N---Q--AI--T---D
D
--
N
---
F
E
K
L
R
K
D-I
G
I
V
F
QN----P-----
D
N
Q
F
V
G
S
I
V
K
Y
D
-
V
AFG-LEN--HAV
P
H
D
E
M
H
R
R
V
S
E
A
L
K
Q
V
--
D
M
-
L
E
R-ADYEPNA--------LSGGQ
K
Q
R
V
A
I
A
S
V
LALN
P
S
V
I
I
LDE
A
T
SMLD
P
D
A
R
Q
N
L
L
D
L
V
R
K
V
KSEH
N
I
T
I
I
S
IT
H
D
L
S
-
E
-
A
M-E-AD
H
V
I
V
MNKG
T
V
YKEG
T
A
T
E
I
----
F
-----
D
H
A
-
E
-
E
L
T
R
-------------------------------IGLDLPFPI
K
I
N
Q
M
LGHQ--TS
F
L
T
Y
E
G
L
VDQL----------------------------------------------------------------------------------
1
PsiBlast_PDB
85.59
45%
-92
- C1 -
4HUQ
-
ECFA1_LACBA
B:
[5-263]
------
I
I
S
V
D
H
L
T
--
Y
Q
Y
D
--
E
N
---
Q
A
P
-
A
--
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
T
V
G
--
G
---
I
--
T
L
--
T
---
P
E
--
T
---
V
W
Q
V
R
E
Q
-
I
G
M
I
F
Q
N
----
P
-----
D
N
Q
F
V
G
A
T
V
E
D
D
-
V
A
F
G
-
L
E
N
--
R
Q
I
S
R
D
E
M
V
P
R
V
Q
A
A
L
A
Q
V
--
G
M
-
T
S
F
-
A
Q
R
E
P
S
S
--------
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
I
V
R
Q
L
R
Q
Q
Q
N
L
T
V
I
S
I
T
H
D
I
D
-
E
-
A
A
-
S
-
A
D
R
V
L
V
I
D
D
G
R
L
V
D
E
A
V
P
S
Q
I
----
F
-----
E
R
G
-
T
-
Q
L
V
E
-------------------------------
M
G
L
D
L
P
F
T
E
K
L
K
A
A
L
R
Q
R
GI
T
P
P
T
T
Y
Q
----------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.18
45%
-94
- C1 -
4HZU
-
ECFA1_LACBA
A:
[5-263]
------
I
I
S
V
D
H
L
T
--
Y
Q
Y
--------
Q
A
P
-
A
--
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
T
V
G
--
G
---
I
--
T
L
--
T
---
P
E
--
T
---
V
W
Q
V
R
E
Q
-
I
G
M
I
F
Q
N
----
P
-----
D
N
Q
F
V
G
A
T
V
E
D
D
-
V
A
F
G
-
L
E
N
--
R
Q
I
S
R
D
E
M
V
P
R
V
Q
A
A
L
A
Q
V
--
G
M
-
T
S
F
-
A
Q
R
E
P
S
S
--------
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
I
V
R
Q
L
R
Q
Q
Q
N
L
T
V
I
S
I
T
H
D
I
D
-
E
-
A
A
-
S
-
A
D
R
V
L
V
I
D
D
G
R
L
V
D
E
A
V
P
S
Q
I
----
F
-----
E
R
G
-
T
-
Q
L
V
E
-------------------------------
M
G
L
D
L
P
F
T
E
K
L
K
A
A
L
R
Q
R
GI
T
P
P
T
T
Y
Q
----------------------------------------------------------------------------------------
21
PsiBlast_CBE
81.41
40%
-99
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-250]
-------
I
K
V
E
N
V
S
--
F
I
Y
N
--
E
G
TPY
A
T
V
-
A
--
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
--
G
---
I
--
D
I
--
T
---
D
K
KV
S
---
L
K
D
I
R
K
Q
-
V
G
L
V
F
Q
Y
----
P
-----
E
Y
Q
L
F
E
E
T
V
F
K
D
-
I
A
F
G
-
P
S
N
--
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
-
A
D
K
S
P
F
E
--------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
-
D
I
A
R
-
I
-
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
----
F
-----
R
E
A
-
E
-
R
L
E
K
-------------------------------
I
G
L
S
V
P
-------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.37
40%
-99
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-250]
-------
I
K
V
E
N
V
S
--
F
I
Y
N
--
E
G
TPY
A
T
V
-
A
--
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
--
G
---
I
--
D
I
--
T
---
D
K
KV
S
---
L
K
D
I
R
K
Q
-
V
G
L
V
F
Q
Y
----
P
-----
E
Y
Q
L
F
E
E
T
V
F
K
D
-
I
A
F
G
-
P
S
N
--
L
G
L
S
E
E
E
V
K
E
R
V
Y
E
A
M
E
I
V
--
G
I
S
K
E
L
-
A
D
K
S
P
F
E
--------
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
-
D
I
A
R
-
I
-
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
----
F
-----
R
E
A
-
E
-
R
L
E
K
-------------------------------
I
G
L
S
V
P
-------------------------------------------------------------------------------------------------------------
125
HHSearch
75.83
38%
-101
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[4-254]
---
E
D
Y
I
L
K
V
E
E
L
N
--
Y
N
Y
S
--
D
G
----
T
H
-
A
--
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
--
N
---
K
--
P
I
--
D
---
Y
S
R
K
G
---
I
M
K
L
R
E
S
-
I
G
I
V
F
Q
D
----
P
-----
D
N
Q
L
F
S
A
S
V
Y
Q
D
-
V
S
F
G
-
A
V
N
--
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
--
G
I
-
E
H
L
-
K
D
K
P
T
H
C
--------
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
-
I
-
V
P
L
Y
-
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
----
F
-----
A
E
K
-
E
-
V
I
R
K
-------------------------------
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.05
38%
-101
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[4-254]
---
E
D
Y
I
L
K
V
E
E
L
N
--
Y
N
Y
---
S
D
---
G
T
H
-
A
--
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
--
N
---
K
--
P
I
DY
S
---
R
K
--
G
---
I
M
K
L
R
E
S
-
I
G
I
V
F
Q
D
----
P
-----
D
N
Q
L
F
S
A
S
V
Y
Q
D
-
V
S
F
G
-
A
V
N
--
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
--
G
I
-
E
H
L
-
K
D
K
P
T
H
C
--------
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
-
P
L
-
Y
-
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
N
P
K
E
V
----
F
-----
A
E
K
-
E
-
V
I
R
K
-------------------------------
V
N
L
R
L
P
R
I
G
H
L
M
E
I
-----------------------------------------------------------------------------------------------------
117
Fugue
73.63
31%
-106
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-----
H
M
I
K
L
S
N
I
T
--
K
V
F
H
--
Q
G
---
T
R
T
-
I
QA
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----
F
------
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
SHPKT
P
L
A
-
Q
-
K
F
I
Q
STLHLDIPEDYQERLQAEPFTDCVPMLRLEF
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
--
V
N
N
N
I
I
S
A
Q
M
D
Y
A
GGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-----------------------------------------------
128
HHSearch
73.08
35%
-100
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
-----
H
M
I
K
L
S
N
I
T
--
K
V
F
H
--
Q
G
TR-
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
---
T
L
--
S
ESE
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----
F
-----
N
-
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
R
I
-
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.80
34%
-99
- C1 -
3TUI
1
METN_ECOLI
C:
[23-256]
-----
H
M
I
K
L
S
N
I
T
KV
F
H
Q
G
--
T
R
---
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.60
37%
-99
- C1 -
1Z47
1
?
B:
[15-235]
-------
I
E
F
V
G
V
E
--
K
I
Y
P
--
G
G
---
A
R
--
S
--
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
---
K
--
R
V
--
T
---
D
L
--
P
---
P
Q
K
--
R
N
-
V
G
L
V
F
Q
N
-----------
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
--
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
-
E
S
Y
-
A
N
R
F
P
H
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
-
E
-
A
L
-
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----
Y
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.03
34%
-99
- C1 -
3TIF
7
Y796_METJA
A:
[1-226]
------
M
V
K
L
K
N
V
T
--
K
T
Y
K
M
G
E
E
---
I
I
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
IKT
N
--
D
L
--
D
---
D
D
--
E
---
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
FNLI
P
LLT
A
L
E
N
V
E
L
P
L
I
F
K
Y
---------
R
--
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
--
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
-
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.00
34%
-100
- C1 -
3TUI
1
METN_ECOLI
D:
[24-256]
------
M
I
K
L
S
N
I
T
KV
F
H
Q
G
--
T
R
---
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
71.90
37%
-97
- C1 -
1Z47
1
?
A:
[15-235]
-------
I
E
F
V
G
V
E
--
K
I
Y
P
--
G
G
---
A
R
--
S
--
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
---
K
--
R
V
--
T
---
D
L
--
P
---
P
Q
K
--
R
N
-
V
G
L
V
F
Q
N
-----------
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
-
L
R
E
--
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
-
E
S
Y
-
A
N
R
F
P
H
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
-
E
-
A
L
-
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----
Y
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
71.37
34%
-103
- C1 -
3TIF
7
Y796_METJA
B:
[1-226]
------
M
V
K
L
K
N
V
T
--
K
T
Y
K
MG
E
E
---
I
I
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
IKT
N
--
D
L
--
D
---
D
D
--
E
---
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
FNLI
P
LLTAL
E
N
V
E
L
P
L
I
F
K
Y
---------
R
--
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
--
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
-
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.23
34%
-101
- C1 -
3TUZ
1
METN_ECOLI
C:
[23-256]
-----
H
M
I
K
L
S
N
I
T
KV
F
H
Q
G
--
T
R
---
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.15
34%
-96
- C1 -
3TUI
1
METN_ECOLI
G:
[24-256]
------
M
I
K
L
S
N
I
T
KV
F
H
Q
G
--
T
R
---
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
69.97
36%
-92
- C1 -
1Z47
1
?
A:
[12-237]
----
S
M
T
I
E
F
V
G
V
E
--
K
I
Y
P
--
G
----
G
A
R
-
S
--
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
---
K
--
R
V
--
T
---
D
L
--
P
-----
P
Q
K
R
N
-
V
G
L
V
F
Q
N
----
Y
-----
A
-
L
F
Q
H
M
T
V
Y
D
N
-
V
S
F
G
-
L
R
E
--
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
-
E
S
Y
-
A
N
R
F
P
H
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
-
E
-
A
L
E
V
-
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----
Y
-----
E
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.83
34%
-97
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-256]
------
M
I
K
L
S
N
I
T
KV
F
H
Q
G
--
T
R
---
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
--
G
---
Q
--
E
L
--
T
TLS
E
S
--
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
----------
F
N
L
L
S
S
R
T
V
F
G
N
-
V
A
L
P
-
L
E
L
--
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
--
G
L
-
G
D
K
-
H
D
S
Y
P
S
N
--------
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
-
V
-
V
K
-
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
----
F
-----
S
H
P
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
69.49
34%
-88
- C1 -
4U02
1
?
B:
[19-235]
-------------------------------
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
--
G
---
L
--
S
V
--
K
---
D
D
--
R
A--
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
----------
F
N
L
F
P
H
M
T
V
L
E
N
-
V
T
L
A
P
M
R
V
--
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
-
A
R
K
Y
P
A
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
----
F
-----
T
R
P
K
E
-
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
119
Fugue
69.41
33%
-81
- C1 -
1Z47
1
?
A:
[11-355]
---
G
S
M
T
I
E
F
V
G
V
E
--
K
I
Y
P
--
G
G
---
A
R
--
S
--
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
--
G
---
K
--
R
V
--
T
---
D
L
-------
P
P
Q
K
R
N
-
V
G
L
V
F
Q
N
----
Y
------
A
L
F
Q
H
M
T
V
Y
D
N
-
V
S
F
G
-
L
R
E
--
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
--
R
L
-
E
S
Y
-
A
N
R
F
P
H
E
--------
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
-
E
-
A
L
-
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
----
Y
-----
E
K
P
-
G
-
T
L
F
V
-------------------------------
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
--
I
E
V
A
G
A
A
L
P
V
D
P
A
VSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
30
PsiBlast_CBE
68.84
35%
-102
- C1 -
1L2T
4
Y796_METJA
B:
[1-226]
------
M
I
K
L
K
N
V
T
--
K
T
Y
K
MG
E
E
---
I
I
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
--
N
IKT
N
--
D
L
--
D
---
D
D
--
E
---
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
FNLI
P
LLTAL
E
N
V
E
L
P
L
I
F
K
Y
---------
R
--
G
A
M
S
G
E
E
R
R
K
R
A
L
E
C
L
K
M
A
--
E
L
-
E
E
R
F
A
N
H
K
P
N
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
-
V
-
A
R
-
F
-
G
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
66.36
32%
-92
- C1 -
2OLK
1
?
C:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
66.26
32%
-92
- C1 -
2OLK
1
?
A:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.78
37%
-98
- C1 -
4HLU
3
ECFA1_THEMA
C:
[12-247]
-------
I
E
L
N
S
V
S
--
F
R
Y
N
--
G
D
-----
Y
-
V
--
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
-
L
A
A
A
G
E
I
F
L
D
--
G
---
S
--
P
A
-------
D
--
P
---
F
-
L
L
R
K
N
-
V
G
Y
V
F
Q
N
----
P
-----
S
S
Q
I
I
G
A
T
V
E
E
D
-
V
A
F
S
-
L
E
I
--
M
G
L
D
E
S
E
M
R
K
R
I
K
K
V
L
E
L
V
--
G
L
-
S
G
L
-
A
A
A
D
P
L
N
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
E
S
L
K
N
E
G
K
-
G
I
I
L
V
T
H
E
L
E
-
Y
-
L
D
-
D
-
M
D
F
I
L
H
I
S
N
G
T
I
D
F
C
G
S
W
E
E
F
VERE
F
-----
D
D
V
-
E
----------------------------------------
I
P
F
K
W
K
L
W
K
K
C
G
---------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
65.64
35%
-91
- C1 -
4YMU
2
?
J:
[8-233]
------------------
Y
K
--
N
F
---
G
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
---
V
--
K
I
--
N
---
N
G
KV
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
FNLF
P
-----
H
L
T
A
I
E
N
I
T
L
A
P
-
V
K
V
K
-
K
M
N
--
K
----
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
----
F
-----
Y
R
A
-
K
N
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
65.56
32%
-89
- C1 -
2OLK
1
?
D:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
65.55
35%
-91
- C1 -
4YMV
1
?
A:
[8-233]
------------------
Y
K
--
N
F
---
G
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
---
V
--
K
I
--
N
---
N
G
KV
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
FNLF
P
-----
H
L
T
A
I
E
N
I
T
L
A
P
-
V
K
V
K
-
K
M
N
--
K
----
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
----
F
-----
Y
R
A
-
K
N
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.48
34%
-89
- C1 -
4U00
3
?
A:
[19-235]
-------------------------------
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
--
G
---
L
--
S
V
--
K
---
D
D
--
R
A--
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
----------
F
N
L
F
P
H
M
T
V
L
E
N
-
V
T
L
A
P
M
R
V
--
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
--
G
I
-
L
D
Q
-
A
R
K
Y
P
A
Q
--------
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
----
F
-----
T
R
P
K
E
-
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
64.60
32%
-89
- C1 -
2OLJ
4
?
A:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.51
35%
-96
- C1 -
4YMV
1
?
J:
[8-233]
------------------
Y
K
--
N
F
---
G
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
---
V
--
K
I
--
N
---
N
G
KV
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
FNLF
P
-----
H
L
T
A
I
E
N
I
T
L
A
P
-
V
K
V
K
-
K
M
N
--
K
----
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
----
F
-----
Y
R
A
-
K
N
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
64.31
35%
-92
- C1 -
4YMU
2
?
A:
[8-233]
------------------
Y
K
--
N
F
---
G
S
L
E
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
--
G
---
V
--
K
I
--
N
---
N
G
KV
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
FNLF
P
-----
H
L
T
A
I
E
N
I
T
L
A
P
-
V
K
V
K
-
K
M
N
--
K
----
K
E
A
E
E
L
A
V
D
L
L
A
K
V
--
G
L
-
L
D
K
-
K
D
Q
Y
P
I
K
--------
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
----
F
-----
Y
R
A
-
K
N
E
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
64.24
32%
-89
- C1 -
2OLK
2
?
B:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.03
32%
-88
- C1 -
3C41
3
?
J:
[18-230]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
63.26
35%
-77
- C1 -
4HLU
2
ECFA2_THEMA
A:
[24-229]
-------------------------------
A
--
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
--
G
---
E
------
R
---
K
K
--
G
---
Y
E
-
I
R
R
N
-
I
G
I
A
F
Q
Y
----
P
-----
E
D
Q
F
F
A
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
--
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
GL
D
F
-
D
S
F
-
K
D
R
V
P
F
F
--------
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
-
T
V
I
L
I
S
H
D
I
E
-
T
-
V
I
N
H
-
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
----
L
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.89
32%
-90
- C1 -
2Q0H
4
?
A:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
62.60
32%
-85
- C1 -
3C4J
3
?
A:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.59
35%
-78
- C1 -
4HLU
3
ECFA2_THEMA
B:
[24-229]
-------------------------------
A
--
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
--
G
---
E
------
R
---
K
K
--
G
---
Y
E
-
I
R
R
N
-
I
G
I
A
F
Q
Y
----
P
-----
E
D
Q
F
F
A
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
--
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
GL
D
F
-
D
S
F
-
K
D
R
V
P
F
F
--------
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
-
T
V
I
L
I
S
H
D
I
E
-
T
-
V
I
N
H
-
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
----
L
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.60
32%
-94
- C1 -
3C41
3
?
K:
[18-230]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
61.58
32%
-91
- C1 -
3C4J
4
?
B:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
61.54
32%
-86
- C1 -
2OLJ
3
?
B:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
60.25
32%
-88
- C1 -
2Q0H
4
?
B:
[39-251]
-------------------------------
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
GI
N
---
L
--
K
A
--
K
---
D
T
--
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
----------
F
N
L
F
P
H
M
T
V
L
N
N
-
I
T
L
A
P
M
K
V
--
R
K
W
P
R
E
K
A
E
A
K
A
M
E
L
L
D
K
V
--
G
L
-
K
D
K
-
A
H
A
Y
P
D
S
--------
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
-
F
-
A
R
-
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
----
F
-----
D
R
P
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
60.09
35%
-84
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[23-228]
-------------------------------
A
--
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
L
Y
D
--
G
---
E
-----------
K
--
G
---
Y
E
-
I
R
R
N
-
I
G
I
A
F
Q
Y
----
P
-----
E
D
Q
F
F
A
E
R
V
F
D
E
-
V
A
F
A
-
V
K
N
--
F
Y
P
D
R
D
P
V
P
L
-
V
K
K
A
M
E
F
V
GL
D
F
-
D
S
F
-
K
D
R
V
P
F
F
--------
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
K
T
L
G
K
-
T
V
I
L
I
S
H
D
I
E
-
T
-
V
I
N
H
-
V
D
R
V
V
V
L
E
K
G
K
K
V
F
D
G
T
R
M
E
F
----
L
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
56.22
33%
-91
- C1 -
4S0F
2
?
A:
[489-710]
-------
I
E
F
R
N
V
D
--
F
R
Y
G
--
L
R
---
K
P
--
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
--
G
---
H
--
S
I
--
K
---
N
I
--
S
---
L
E
L
I
R
K
K
-
I
A
F
V
S
Q
-----------
D
V
F
I
F
S
G
T
V
K
E
N
-
L
C
L
G
-
N
E
N
----
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
---
D
F
-
I
E
K
-
L
P
L
K
Y
D
T
FLNESGAN
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
D
D
V
T
V
I
I
I
A
H
R
L
S
-
T
-
I
V
-
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
54.30
33%
-90
- C1 -
4S0F
2
?
B:
[489-710]
-------
I
E
F
R
N
V
D
--
F
R
Y
G
--
L
R
---
K
P
--
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
--
G
---
H
--
S
I
--
K
---
N
I
--
S
---
L
E
L
I
R
K
K
-
I
A
F
V
S
Q
-----------
D
V
F
I
F
S
G
T
V
K
E
N
-
L
C
L
G
-
N
E
N
----
V
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
---
D
F
-
I
E
K
-
L
P
L
K
Y
D
T
FLNESGAN
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
D
D
V
T
V
I
I
I
A
H
R
L
S
-
T
-
I
V
-
N
-
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
53.09
31%
-96
- C1 -
2FF7
1
A:
[8-237]
-------
I
T
F
R
N
I
R
--
F
R
Y
K
--
P
D
---
S
P
V
-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
--
G
---
H
DL
A
L
--
A
---
D
P
--
N
---
W
--
L
R
R
Q
-
V
G
V
V
L
Q
D
----
N
VLL--
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
M
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
--
N
T
-
I
---
V
G
E
Q
G
A
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
-
T
-
V
K
-
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
----
L
-----
S
E
P
-
E
-
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
51.32
31%
-96
- C1 -
2PMK
1
A:
[4-233]
-------
I
T
F
R
N
I
R
--
F
R
Y
K
--
P
D
---
S
P
V
-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
--
G
---
H
DL
A
L
--
A
---
D
P
--
N
---
W
--
L
R
R
Q
-
V
G
V
V
L
Q
D
----
N
VLL--
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
M
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
--
N
T
-
I
---
V
G
E
Q
G
A
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
-
T
-
V
K
-
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
----
L
-----
S
E
P
-
E
-
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
50.43
31%
-93
- C1 -
3B5J
1
A:
[4-233]
-------
I
T
F
R
N
I
R
--
F
R
Y
K
--
P
D
---
S
P
V
-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
--
G
---
H
DL
A
L
--
A
---
D
P
--
N
---
W
--
L
R
R
Q
-
V
G
V
V
L
Q
D
----
N
VLL--
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
M
S
-
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
--
N
T
-
I
---
V
G
E
Q
G
A
G
--------
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
-
T
-
V
K
-
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
----
L
-----
S
E
P
-
E
-
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------