@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2098: (2016-04-01 )
MEKVYVAGAIPEVGLKLLQEHFEVEMYEGKGLVDKDTLIKGVKNATALISLLSTNVDKDVIDAGKDLKIIANYGAGFNNIDIEYAREKSIDVTNTPKASTNATADLTIGLVLAVARRIVEGDQLSRTTGFDGWAPLFFRGREVSGKTIGIIGLGEIGSAVARRARAFDMDVLYTGPNRKEEKEREIGAKYVDLDTLLKNADFITINAAYNPKMHHLIDTEQFKMMKSTVYLINASRGPIVHEQALVQALKDNEIEGAALDVYEFEPDITDDLKSLNNVVLTPHIGNATFEARDMMSKIVANAAISAVQGEKPQFVVN
Atome Classification :
(29 SA)
-.........10...-......--20-.-........30........40.........50........60..-.-.....70........80........90........100.......110.......120..----.....130--.----..----..----....140.......150.......160.......170........180..-.....-190.-.......200.......210.......220.......230.......240.......250.......260....-..--.270--........280.......290.......300.......310---.....-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
E
K
V
Y
VAGA
I
-
P
E
V
-
G
L
K
L
L
Q
--
E
--H-F
E
V
E
M
YEGKGLV
D
K
D
T
L
I
K
-
G
V
K
N
A
T
A
L
I
S
L
L
S
TNVD
K
D
V
IDA-G-K
D
L
K
I
I
A
NYGAGFNNI
D
I
E
Y
AREKSIDVTNTPKASTNAT
A
D
L
T
I
G
L
V
L
A
V
A
R
R
I
VEGDQL----SRTTGF----D----GW----A
P
----
L
F
F
RGREVSG
K
T
I
G
I
I
G
L
G
E
I
G
S
A
V
A
R
R
A
RAFD
M
D
-
V
L
YTGPNR
K
E
E
K
E
R
-
E
IG
A
K
-
Y
V-
D
-
L
D
T
L
LKNA
D
F
I
T
I
NAAYNP
K
M
H
H
LI
D
T
E
Q
F
K
M
M
K
S
T
V
Y
L
I
NASRGPI
V
H
E
Q
A
L
V
Q
A
L
KDNEIEG
A
A
L
D
V
Y
EFEP-D
I
--
T
D
-
D
--
L
K
SLN
N
V
V
LTPHIGNA
T
F
E
A
R
D
M
M
S
K
I
V
A
N
A
A
I
S
AVQGEKP---
Q
F
VVN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
95.99
46%
-112
- C1 -
2DBR
3
GYAR_PYRHO
B:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.11
46%
-114
* C1 *
2DBR
3
GYAR_PYRHO
A:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
K
R
GV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
95.01
46%
-111
- C1 -
2DBR
4
GYAR_PYRHO
C:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.67
45%
-110
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
K
R
GV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.42
46%
-110
- C1 -
2DBZ
3
GYAR_PYRHO
A:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
K
R
GV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
94.38
46%
-107
- C1 -
2DBR
3
GYAR_PYRHO
E:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
94.26
46%
-111
- C1 -
2DBR
3
GYAR_PYRHO
D:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
94.21
46%
-108
- C1 -
2DBQ
8
GYAR_PYRHO
A:
[2-322]
-
K
P
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
----
K
R
GVAW
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
94.02
46%
-108
- C1 -
2DBR
3
GYAR_PYRHO
F:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.56
46%
-111
- C1 -
2DBZ
3
GYAR_PYRHO
B:
[4-322]
---
K
V
F
I
T
R
E
I
-
P
E
V
-
G
I
K
M
L
E
--
D
--
E
-
F
E
V
E
V
W
G
D
E
K
E
I
P
R
E
I
L
L
K
-
K
V
K
E
V
D
A
L
V
T
M
L
S
E
R
I
D
K
E
V
F
E
N
-
A
-
P
K
L
R
I
V
A
N
Y
A
V
G
Y
D
N
I
D
I
E
E
A
T
K
R
G
I
Y
V
T
N
T
P
D
V
L
T
D
A
T
A
D
L
A
F
A
L
L
L
A
T
A
R
H
V
V
K
G
D
R
F
----
V
R
S
G
E
W
----
K
KRGV
A
W
----
H
P
----
K
W
F
L
G
Y
D
V
Y
G
K
T
I
G
I
I
G
L
G
R
I
G
Q
A
I
A
K
R
A
K
G
F
N
M
R
-
I
L
Y
Y
S
R
T
R
K
E
E
V
E
R
-
E
L
N
A
E
-
F
K
-
P
-
L
E
D
L
L
R
E
S
D
F
V
V
L
A
V
P
L
T
R
E
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
I
A
R
G
K
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
Y
Y
--
N
E
-
E
--
L
F
K
L
D
N
V
V
L
T
P
H
I
G
S
A
S
F
G
A
R
E
G
M
A
E
L
V
A
K
N
L
I
A
F
K
R
G
E
I
P
---
P
T
L
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
89.62
35%
-110
- C1 -
2GCG
3
GRHPR_HUMAN
B:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
89.22
35%
-109
- C1 -
2GCG
5
GRHPR_HUMAN
C:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Fugue
88.83
34%
-100
- C1 -
1YGY
1
SERA_MYCTU
A:
[3-529]
S
L
P
V
V
L
I
A
D
K
L
-
A
P
S
-
T
V
A
A
L
G
--
D
--
Q
-
V
E
V
R
W
V
D
G
P
---
D
R
D
K
L
L
A
-
A
V
P
E
A
D
A
L
L
V
R
S
A
T
T
V
D
A
E
V
L
A
A
-
A
-
P
K
L
K
I
V
A
R
A
G
V
G
L
D
N
V
D
V
D
A
A
T
A
R
G
V
L
V
V
N
A
P
T
S
N
I
H
S
A
A
E
H
A
L
A
L
L
L
A
A
S
R
Q
I
P
A
A
D
A
S
----
L
R
E
-------
H
----
T
W
----
K
R
----
S
S
F
S
G
T
E
I
F
G
K
T
V
G
V
V
G
L
G
R
I
G
Q
L
V
A
Q
R
I
A
A
F
G
A
Y
-
V
V
A
Y
D
P
Y
V
S
P
A
R
A
A
-
Q
L
G
I
E
-
L
L
-
S
-
L
D
D
L
L
A
R
A
D
F
I
S
V
H
L
P
K
T
P
E
T
A
G
L
I
D
K
E
A
L
A
K
T
K
P
G
V
I
I
V
N
A
A
R
G
G
L
V
D
E
A
A
L
A
D
A
I
T
G
G
H
V
R
A
A
G
L
D
V
F
A
T
E
P
-
C
T
--
D
S
-
P
--
L
F
E
L
A
Q
V
V
V
T
P
H
L
G
A
S
T
A
E
A
Q
D
R
A
G
T
D
V
A
E
S
V
R
L
A
L
A
G
E
F
V
---
P
D
A
V
N
VGGGVVNEEV
A
P
W
L
D
L
V
R
K
L
G
V
L
A
G
V
L
SDELPV
S
L
S
V
Q
V
R
G
ELAAEEV
E
V
L
R
L
S
A
L
R
G
L
F
SAVIEDAVTFVN
A
P
A
L
A
A
E
RG
V
T
A
E
I
C
K
A
SESPNHR
S
V
V
D
V
R
A
V
G
ADG
S
V
V
T
V
S
G
T
L
Y
G
PQLSQKIVQING
R
H
F
D
L
R
AQ
G
I
N
L
I
I
H
Y
V
DRPG
A
L
G
K
I
G
T
L
L
G
T
A
GVNIQ
A
A
Q
L
S
E
D
AEGP
G
A
T
I
L
L
R
L
D
Q
D
V
P
D
D
V
R
T
A
I
A
A
A
VDAY
K
L
E
V
V
D
LS
29
PsiBlast_CBE
88.76
35%
-111
- C1 -
2WWR
1
GRHPR_HUMAN
B:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.36
35%
-108
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
88.23
35%
-112
- C1 -
2WWR
1
GRHPR_HUMAN
C:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
88.12
35%
-109
- C1 -
2GCG
6
GRHPR_HUMAN
D:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
88.02
43%
-106
- C1 -
1WWK
1
?
A:
[4-307]
--
M
K
V
L
V
A
A
P
L
-
H
E
K
-
A
I
Q
V
L
K
D
-
A
--
G
-
L
E
V
I
Y
E
E
Y
---
P
D
E
D
R
L
V
E
-
L
V
K
D
V
E
A
I
I
V
R
S
K
P
K
V
T
R
R
V
I
E
S
-
A
-
P
K
L
K
V
I
A
R
A
G
V
G
L
D
N
I
D
V
E
A
A
K
E
K
G
I
E
V
V
N
A
P
A
A
S
S
R
S
V
A
E
L
A
V
G
L
M
F
S
V
A
R
K
I
A
F
A
D
R
K
----
M
R
E
G
V
W
----
A
----
K
K
-----------
E
A
M
G
I
E
L
E
G
K
T
I
G
I
I
G
F
G
R
I
G
Y
Q
V
A
K
I
A
N
A
L
G
M
N
-
I
L
L
Y
D
P
Y
P
N
E
E
R
A
K
-
E
V
N
G
K
-
F
V
-
D
-
L
E
T
L
L
K
E
S
D
V
V
T
I
H
V
P
L
V
E
S
T
Y
H
L
I
N
E
E
R
L
K
L
M
K
K
T
A
I
L
I
N
T
S
R
G
P
V
V
D
T
N
A
L
V
K
A
L
K
E
G
W
I
A
G
A
G
L
D
V
F
E
E
E
P
-
L
P
K-
D
H
-
P
--
L
T
K
F
D
N
V
V
L
T
P
H
I
G
A
S
T
V
E
A
Q
E
R
A
G
V
E
V
A
E
K
V
V
K
I
L
K
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.87
35%
-109
- C1 -
2WWR
1
GRHPR_HUMAN
A:
[8-322]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
--
R
AA
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
A
G
-
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
-
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
-------
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
--
T
N
H
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
87.19
37%
-115
- C1 -
2CUK
1
?
C:
[2-306]
---
R
V
L
V
T
R
T
L
-
P
G
K
-
A
L
D
R
L
R
--
E
--
R
G
L
E
V
E
V
H
R
G
L
-
F
L
P
K
A
E
L
L
K
-
R
V
E
G
A
V
G
L
I
P
T
V
E
D
R
I
D
A
E
V
M
D
R
-
A
-
K
G
L
K
V
I
A
C
Y
S
V
G
V
D
H
V
D
L
E
A
A
R
E
R
G
I
R
V
T
H
T
P
G
V
L
T
E
A
T
A
D
L
T
L
A
L
L
L
A
V
A
R
R
V
V
E
G
A
A
Y
----
A
R
D
G
L
W
----
K
----
A
W
----
H
P
----
E
L
L
L
G
L
D
L
Q
G
L
T
L
G
L
V
G
M
G
R
I
G
Q
A
V
A
K
R
A
L
A
F
G
M
R
-
V
V
Y
H
A
-----
R
T
P
K
-
P
L
P
Y
P
-
F
L
-
S
-
L
E
E
L
L
K
E
A
D
V
V
S
L
H
T
P
L
T
P
E
T
H
R
L
L
N
R
E
R
L
F
A
M
K
R
G
A
I
L
L
N
T
A
R
G
A
L
V
D
T
E
A
L
V
E
A
L
R
G
H
-
L
F
G
A
G
L
D
V
T
D
P
E
P
L
P
P
--
G
H
-
P
--
L
Y
A
L
P
N
A
V
I
T
P
H
I
G
S
A
G
R
T
T
R
E
R
M
A
E
V
A
V
E
N
L
L
A
V
L
E
G
R
E
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
84.40
34%
-100
- C1 -
2GCG
3
GRHPR_HUMAN
A:
[8-329]
-
L
M
K
V
F
V
T
R
R
I
-
P
A
E
-
G
R
V
A
L
A
R
A
A
--
D
-
C
E
V
E
Q
W
D
S
D
E
P
I
P
A
K
E
L
E
R
-
G
V
A
G
A
H
G
L
L
C
L
L
S
D
H
V
D
K
R
I
L
D
A
-
A
G
A
N
L
K
V
I
S
T
M
S
V
G
I
D
H
L
A
L
D
E
I
K
K
R
G
I
R
V
G
Y
T
P
D
V
L
T
D
T
T
A
E
L
A
V
S
L
L
L
T
T
C
R
R
L
P
E
A
I
E
E
----
V
K
N
G
G
W
----
T
----
S
W
----
K
P
----
L
W
L
C
G
Y
G
L
T
Q
S
T
V
G
I
I
G
L
G
R
I
G
Q
A
I
A
R
R
L
K
P
F
G
V
Q
-
R
F
L
Y
T
G
R
Q
P
R
P
E
E
A
A
E
F
Q
A
E
-
F
V
-
S
-
T
P
E
L
A
A
Q
S
D
F
I
V
V
A
C
S
L
T
P
A
T
E
G
L
C
N
K
D
F
F
Q
K
M
K
E
T
A
V
F
I
N
I
S
R
G
D
V
V
N
Q
D
D
L
Y
Q
A
L
A
S
G
K
I
A
A
A
G
L
D
V
T
S
P
E
P
-
L
P
T-
N
H
-
P
--
L
L
T
L
K
N
C
V
I
L
P
H
I
G
S
A
T
H
R
T
R
N
T
M
S
L
L
A
A
N
N
L
L
A
G
L
R
G
E
P
M
---
P
S
E
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
77.21
33%
-89
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-346]
-
M
P
L
V
A
L
L
D
G
R
D
C
T
V
-
E
M
P
I
L
K
--
D
--
V
-
A
T
V
A
F
C
D
A
Q
S
--
T
Q
E
I
H
E
K
-
V
L
N
E
A
V
G
A
L
M
Y
H
T
I
T
L
T
R
E
D
L
E
K
-
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
----
L
R
E
G
T
R
V
Q
S
V
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
-
R
V
S
T
-
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
CVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
76.18
32%
-90
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[21-346]
-
M
P
L
V
A
L
L
D
G
R
-
D
C
T
V
E
M
P
I
L
K
--
D
--
V
-
A
T
V
A
F
C
D
---
A
Q
S
T
Q
E
I
H
E
K
V
L
N
E
A
V
G
A
L
M
Y
H
T
I
T
L
T
R
E
D
L
E
K
-
F
-
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
----
L
R
E
G
T
R
----
V
----
Q
S
----
V
E
Q
I
R
E
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
R
V
S
-
T
-
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
FS
Q
G
-
P
--
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
DSL
K
N
C
V
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.13
37%
-89
- C1 -
4U6S
3
CTBP1_HUMAN
A:
[84-343]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
72.11
36%
-99
- C1 -
3GA0
2
CTBP1_RAT
A:
[87-346]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
E
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
I
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.88
37%
-86
- C1 -
4U6Q
3
CTBP1_HUMAN
A:
[84-343]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
70.52
37%
-88
- C1 -
1MX3
2
CTBP1_HUMAN
A:
[84-343]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
70.48
37%
-85
- C1 -
4LCE
2
CTBP1_HUMAN
A:
[84-343]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
A
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
V
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
69.85
37%
-86
- C1 -
1HKU
4
CTBP1_RAT
A:
[87-346]
---------------------------------------------------------------------------
K
A
L
R
I
I
V
R
I
G
S
G
F
D
N
I
D
I
K
S
A
G
D
L
G
I
A
V
C
N
V
P
A
A
S
V
E
E
T
A
D
S
T
L
C
H
I
L
N
L
Y
R
R
T
T
W
L
H
Q
A
L
R
E
G
T
R
V
Q
S
V
----
E
----
Q
I
----
R
E
----
V
A
S
G
A
A
R
I
R
G
E
T
L
G
I
I
G
L
G
R
V
G
Q
A
V
A
L
R
A
K
A
F
G
F
N
-
V
L
F
Y
D
P
Y
L
S
D
G
I
E
R
-
A
L
G
L
Q
-
R
V
-
S
T
L
Q
D
L
L
F
H
S
D
C
V
T
L
H
C
G
L
N
E
H
N
H
H
L
I
N
D
F
T
V
K
Q
M
R
Q
G
A
F
L
V
N
T
A
R
G
G
L
V
D
E
K
A
L
A
Q
A
L
K
E
G
R
I
R
G
A
A
L
D
V
H
E
S
E
P
-
F
S
--
F
S
-
Q
GP
L
K
D
A
P
N
L
I
C
T
P
H
A
A
W
Y
S
E
Q
A
S
I
E
M
R
E
E
A
A
R
E
I
R
R
A
I
T
G
R
I
P
---
D
S
L
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------