@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2119: (2016-04-01 )
MATQDPRTKFKTTEYEKQEQEVPGLQSEMTPAPDCGETSYQGHQRLQGYKMLVTGGDSAIGRAAAIAYAKEGADVAINYLPSEEQDAQEVRQVIEESGQKAVLIPGDIRDEQFNYDLVEQAYQQLGGLDNVTLVAGHQQYHDDIHGFTTEAFTETFETNVYPLFWTVQKALEYLKPGASITTTSSVQGYNPSPILHDYAASKAAIISLTKSFSEELGPKGIRVNCVAPGPFWSPLQISGGQPQSKIPTFGQKTPLGRAGQPVELCGTYVLLASEESSYTTGQVFGVSGGVQID
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140........150.......160.......170....--...180.......190-.......200.......210.......220.......230......---.240.....--..250.......260.......270.......280.......290.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATQDPRTKFKTT
E
Y
E
K
Q
E
Q
EVPGLQSEMTPAPDCGETSYQGHQRLQ
G
Y
K
M
L
V
TGGDS
A
I
G
R
A
A
A
I
AYAKEG
A
D
V
A
I
N
YLPSE
E
Q
D
A
Q
E
V
R
Q
V
I
E
ESG
Q
K
A
V
L
IPGDIRDEQF
N
Y
D
L
V
E
Q
A
Y
Q
Q
LGGLD
N
V
T
L
V
AG
H
Q
Q
Y
-
H
D
D
IHG
F
T
T
E
A
F
T
E
T
FETN
V
Y
P
L
F
W
T
V
Q
K
A
L
E
Y
LKP--GA
S
I
T
T
TSSVQGYNPS-
P
I
L
H
D
YAAS
K
A
A
I
I
S
L
T
K
S
F
S
E
ELGPK
G
I
R
V
N
C
VAPGPFWS
P
L
QIS---GGQPQSKIP--TFGQKTPLGRAGQ
P
V
E
L
C
G
T
Y
V
L
L
ASEESSYTT
G
Q
V
F
GVSG
G
V
QID
113
HHSearch
96.01
61%
-77
- C2 -
3R3S
3
?
A:
[30-293]
----------------------------
M
T
P
V
P
D
C
G
E
K
S
Y
V
G
S
G
R
L
K
D
R
K
A
L
V
T
G
G
D
S
G
I
G
R
A
A
A
I
A
Y
A
R
E
G
A
D
V
A
I
N
Y
L
P
A
E
E
E
D
A
Q
Q
V
K
A
L
I
E
E
C
G
R
K
A
V
L
L
P
G
D
L
S
D
E
S
F
A
R
S
L
V
H
K
A
R
E
A
L
G
G
L
D
I
L
A
L
V
A
G
K
Q
T
A
-
I
P
E
I
K
D
L
T
S
E
Q
F
Q
Q
T
F
A
V
N
V
F
A
L
F
W
I
T
Q
E
A
I
P
L
L
P
K
--
G
A
S
I
I
T
T
S
S
I
Q
A
Y
Q
P
S
-
P
H
L
L
D
Y
A
A
T
K
A
A
I
L
N
Y
S
R
G
L
A
K
Q
V
A
E
K
G
I
R
V
N
I
V
A
P
G
P
I
W
T
A
L
Q
I
S
---
G
G
Q
T
Q
D
K
I
P
--
Q
F
G
Q
Q
T
P
M
K
R
A
G
Q
P
A
E
L
A
P
V
Y
V
Y
L
A
S
Q
E
S
S
Y
V
T
A
E
V
H
G
V
C
G
G
E
H
L
-
22
PsiBlast_CBE
93.25
60%
-61
- C2 -
3R3S
3
?
C:
[6-290]
----
D
P
T
T
Q
Y
Y
T
G
E
Y
P
K
Q
K
Q
P
A
P
G
V
Q
A
K
M
T
P
V
P
D
C
G
E
K
S
Y
V
G
S
G
R
L
K
D
R
K
A
L
V
T
G
G
D
S
G
I
G
R
A
A
A
I
A
Y
A
R
E
G
A
D
V
A
I
N
Y
L
P
A
E
E
E
D
A
Q
Q
V
K
A
L
I
E
E
C
G
R
K
A
V
L
L
P
G
D
L
S
D
E
S
F
A
R
S
L
V
H
K
A
R
E
A
L
G
G
L
D
I
L
A
L
V
A
G
K
Q
T
A
-
I
P
E
I
K
D
L
T
S
E
Q
F
Q
Q
T
F
A
V
N
V
F
A
L
F
W
I
T
Q
E
A
I
P
L
L
P
K
--
G
A
S
I
I
T
T
S
S
I
Q
A
Y
Q
P
S
-
P
H
L
L
D
Y
A
A
T
K
A
A
I
L
N
Y
S
R
G
L
A
K
Q
V
A
E
K
G
I
R
V
N
I
V
A
P
G
P
I
W
T
A
L
Q
I
S
---
G
G
Q
T
Q
D
K
I
P
--
Q
F
G
Q
Q
T
P
M
K
R
A
G
Q
P
A
E
L
A
P
V
Y
V
Y
L
A
S
Q
E
S
S
Y
V
T
A
E
V
H
G
V
C
G
G
----
23
PsiBlast_CBE
92.43
60%
-59
- C2 -
3R3S
4
?
B:
[6-290]
----
D
P
T
T
Q
Y
Y
T
G
E
Y
P
K
Q
K
Q
P
A
P
G
V
Q
A
K
M
T
P
V
P
D
C
G
E
K
S
Y
V
G
S
G
R
L
K
D
R
K
A
L
V
T
G
G
D
S
G
I
G
R
A
A
A
I
A
Y
A
R
E
G
A
D
V
A
I
N
Y
L
P
A
E
E
E
D
A
Q
Q
V
K
A
L
I
E
E
C
G
R
K
A
V
L
L
P
G
D
L
S
D
E
S
F
A
R
S
L
V
H
K
A
R
E
A
L
G
G
L
D
I
L
A
L
V
A
G
K
Q
T
A
-
I
P
E
I
K
D
L
T
S
E
Q
F
Q
Q
T
F
A
V
N
V
F
A
L
F
W
I
T
Q
E
A
I
P
L
L
P
K
--
G
A
S
I
I
T
T
S
S
I
Q
A
Y
Q
P
S
-
P
H
L
L
D
Y
A
A
T
K
A
A
I
L
N
Y
S
R
G
L
A
K
Q
V
A
E
K
G
I
R
V
N
I
V
A
P
G
P
I
W
T
A
L
Q
I
S
---
G
G
Q
T
Q
D
K
I
P
--
Q
F
G
Q
Q
T
P
M
K
R
A
G
Q
P
A
E
L
A
P
V
Y
V
Y
L
A
S
Q
E
S
S
Y
V
T
A
E
V
H
G
V
C
G
G
----
1
PsiBlast_PDB
91.94
60%
-60
- C2 -
3R3S
3
?
A:
[6-290]
----
D
P
T
T
Q
Y
Y
T
G
E
Y
P
K
Q
K
Q
P
A
P
G
V
Q
A
K
M
T
P
V
P
D
C
G
E
K
S
Y
V
G
S
G
R
L
K
D
R
K
A
L
V
T
G
G
D
S
G
I
G
R
A
A
A
I
A
Y
A
R
E
G
A
D
V
A
I
N
Y
L
P
A
E
E
E
D
A
Q
Q
V
K
A
L
I
E
E
C
G
R
K
A
V
L
L
P
G
D
L
S
D
E
S
F
A
R
S
L
V
H
K
A
R
E
A
L
G
G
L
D
I
L
A
L
V
A
G
K
Q
T
A
-
I
P
E
I
K
D
L
T
S
E
Q
F
Q
Q
T
F
A
V
N
V
F
A
L
F
W
I
T
Q
E
A
I
P
L
L
P
K
--
G
A
S
I
I
T
T
S
S
I
Q
A
Y
Q
P
S
-
P
H
L
L
D
Y
A
A
T
K
A
A
I
L
N
Y
S
R
G
L
A
K
Q
V
A
E
K
G
I
R
V
N
I
V
A
P
G
P
I
W
T
A
L
Q
I
S
---
G
G
Q
T
Q
D
K
I
P
--
Q
F
G
Q
Q
T
P
M
K
R
A
G
Q
P
A
E
L
A
P
V
Y
V
Y
L
A
S
Q
E
S
S
Y
V
T
A
E
V
H
G
V
C
G
G
----
21
PsiBlast_CBE
91.61
60%
-59
- C2 -
3R3S
3
?
D:
[6-290]
----
D
P
T
T
Q
Y
Y
T
G
E
Y
P
K
Q
K
Q
P
A
P
G
V
Q
A
K
M
T
P
V
P
D
C
G
E
K
S
Y
V
G
S
G
R
L
K
D
R
K
A
L
V
T
G
G
D
S
G
I
G
R
A
A
A
I
A
Y
A
R
E
G
A
D
V
A
I
N
Y
L
P
A
E
E
E
D
A
Q
Q
V
K
A
L
I
E
E
C
G
R
K
A
V
L
L
P
G
D
L
S
D
E
S
F
A
R
S
L
V
H
K
A
R
E
A
L
G
G
L
D
I
L
A
L
V
A
G
K
Q
T
A
-
I
P
E
I
K
D
L
T
S
E
Q
F
Q
Q
T
F
A
V
N
V
F
A
L
F
W
I
T
Q
E
A
I
P
L
L
P
K
--
G
A
S
I
I
T
T
S
S
I
Q
A
Y
Q
P
S
-
P
H
L
L
D
Y
A
A
T
K
A
A
I
L
N
Y
S
R
G
L
A
K
Q
V
A
E
K
G
I
R
V
N
I
V
A
P
G
P
I
W
T
A
L
Q
I
S
---
G
G
Q
T
Q
D
K
I
P
--
Q
F
G
Q
Q
T
P
M
K
R
A
G
Q
P
A
E
L
A
P
V
Y
V
Y
L
A
S
Q
E
S
S
Y
V
T
A
E
V
H
G
V
C
G
G
----
27
PsiBlast_CBE
80.42
43%
-60
- C2 -
3I3O
3
?
E:
[13-290]
-------------
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
26
PsiBlast_CBE
80.20
43%
-67
- C2 -
3I3O
1
?
F:
[22-290]
----------------------
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
29
PsiBlast_CBE
79.38
43%
-59
- C2 -
3I3O
3
?
C:
[11-290]
-----------
V
T
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
24
PsiBlast_CBE
79.31
43%
-69
- C2 -
3I3O
6
?
H:
[17-290]
-----------------
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
-----
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
3
PsiBlast_PDB
79.18
43%
-59
- C2 -
3IJR
5
?
A:
[11-290]
-----------
V
T
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
30
PsiBlast_CBE
77.67
43%
-58
- C2 -
3I3O
5
?
B:
[9-290]
---------
N
F
V
T
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
28
PsiBlast_CBE
76.97
43%
-55
- C2 -
3I3O
5
?
D:
[9-290]
---------
N
F
V
T
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
2
PsiBlast_PDB
76.83
43%
-57
- C2 -
3I3O
5
?
A:
[10-290]
----------
F
V
T
M
P
A
Q
H
Q
N
K
Q
P
G
I
E
S
L
M
N
P
L
P
Q
F
E
D
P
N
Y
K
G
S
E
K
L
K
G
K
N
V
L
I
T
G
G
D
S
G
I
G
R
A
V
S
I
A
F
A
K
E
G
A
N
I
A
I
A
Y
L
-
D
E
E
G
D
A
N
E
T
K
Q
Y
V
E
K
E
G
V
K
C
V
L
L
P
G
D
L
S
D
E
Q
H
C
K
D
I
V
Q
E
T
V
R
Q
L
G
S
L
-
N
I
L
V
N
N
V
A
Q
Q
Y
P
Q
Q
G
L
E
Y
I
T
A
E
Q
L
E
K
T
F
R
I
N
I
F
S
Y
F
H
V
T
K
A
A
L
S
H
L
K
Q
--
G
D
V
I
I
N
T
A
S
I
V
A
Y
E
G
N
-
E
T
L
I
D
Y
S
A
T
K
G
A
I
V
A
F
T
R
S
L
S
Q
S
L
V
Q
K
G
I
R
V
N
G
V
A
P
G
P
I
W
T
P
L
-
I
P
---
S
S
F
D
E
K
K
V
S
--
Q
F
G
S
N
V
P
M
Q
R
P
G
Q
P
Y
E
L
A
P
A
Y
V
Y
L
A
S
S
D
S
S
Y
V
T
G
Q
M
I
H
V
N
G
G
V
I
V
N
74
PsiBlast_CBE
70.71
32%
-61
- C2 -
3TOX
1
?
E:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
LG
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
NLP
G
A
A
P
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-
31
PsiBlast_CBE
70.24
35%
-68
- C2 -
4MOW
3
?
B:
[10-256]
-------------------------------------------
S
K
L
A
G
K
V
A
I
V
T
G
A
S
K
G
I
G
A
A
I
A
K
A
L
A
D
E
G
A
A
V
V
V
N
Y
-
A
S
S
K
A
G
A
D
A
V
V
S
A
I
T
E
A
G
G
R
A
V
A
V
G
G
D
V
S
K
A
A
D
A
Q
R
I
V
D
T
A
I
E
T
Y
G
R
L
D
V
L
V
N
N
S
G
V
Y
E
F
-
A
P
-
I
E
A
I
T
E
E
H
Y
R
R
Q
F
D
T
N
V
F
G
V
L
L
T
T
Q
A
A
V
K
H
L
G
E
--
G
A
S
I
I
N
I
S
S
V
V
T
S
I
T
P
-
P
A
S
A
V
Y
S
G
T
K
G
A
V
D
A
I
T
G
V
L
A
L
E
L
G
P
R
K
I
R
V
N
A
I
N
P
G
M
I
V
T
E
G
T
H
S
---
A
---
G
S
D
L
E
A
Q
V
L
G
Q
-
T
P
L
G
R
L
G
E
P
N
D
I
A
S
V
A
V
F
L
A
S
D
D
A
R
W
M
T
G
E
H
L
V
V
S
G
G
L
N
--
77
PsiBlast_CBE
70.12
32%
-66
- C2 -
3TOX
1
?
B:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
LG
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
N------
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-
78
PsiBlast_CBE
70.11
32%
-62
- C2 -
3TOX
1
?
A:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
L
G
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
NLP
G
A
A
P
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-
73
PsiBlast_CBE
69.68
32%
-64
- C2 -
3TOX
1
?
F:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
LG
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
N-----
P
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-
72
PsiBlast_CBE
69.66
32%
-64
- C2 -
3TOX
1
?
G:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
LG
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
NL---
A
P
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-
75
PsiBlast_CBE
69.61
32%
-62
- C2 -
3TOX
1
?
D:
[4-255]
-------------------------------------------
S
R
L
E
G
K
I
A
I
V
T
G
A
S
S
G
I
G
R
A
A
A
L
L
F
A
R
E
G
A
K
V
V
V
T
--
A
R
N
G
N
A
L
A
E
L
T
D
E
I
A
G
G
G
G
E
A
A
A
L
A
G
D
V
G
D
E
A
L
H
E
A
L
V
E
L
A
V
R
R
F
G
G
L
D
T
A
F
N
N
A
G
A
L
G
A
-
M
G
E
I
S
S
L
S
V
E
G
W
R
E
T
L
D
T
N
L
T
S
A
F
L
A
A
K
Y
Q
V
P
A
I
A
A
LG
G
G
S
L
T
F
T
S
S
F
V
G
H
T
A
G
F
A
G
V
A
P
Y
A
A
S
K
A
G
L
I
G
L
V
Q
A
L
A
V
E
L
G
A
R
G
I
R
V
N
A
L
L
P
G
G
T
D
T
P
A
N
F
A
NLP
G
A
A
P
E
T
R
G
F
--
V
E
G
L
H
A
-
L
K
R
I
A
R
P
E
E
I
A
E
A
A
L
Y
L
A
S
D
G
A
S
F
V
T
G
A
A
L
L
A
D
G
G
A
S
V
-