@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2405: (2016-04-03 )
MSNKNKSYDYVIIGGGSAGSVLGNRLSEDKDKEVLVLEAGRSDYFWDLFIQMPAALMFPSGNKFYDWIYSTDEEPHMGGRKVAHARGKVLGGSSSINGMIYQRGNPMDYEGWAEPEGMETWDFAHCLPYFKKLEKTYGAAPYDKFRGHDGPIKLKRGPATNPLFQSFFDAGVEAGYHKTPDVNGFRQEGFGPFDSQVHRGRRMSASRAYLHPAMKRKNLTVETRAFVTEIHYEGRRATGVTYKKNGKLHTIDANEVILSGGAFNTPQLLQLSGIGDSEFLKSKGIEPRVHLPGVGENFEDHLEVYIQHKCKEPVSLQPSLDIKRMPFIGLQWIFTRTGAAASNHFEGGGFVRSNNEVDYPNLMFHFLPIAVRYDGQKAAVAHGYQVHVGPMYSNSRGSLKIKSKDPFEKPSIRFNYLSTEEDKKEWVEAIRVARNILSQKAMDPFNGGEISPGPEVQTDEEILDWVRRDGETALHPSCSAKMGPASDPMAVVDPLTMKVHGMENLRVVDASAMPRTTNGNIHAPVLMLAEKAADIIRGRKPLEPQYIDYYKHGVHDENEGAIEVKPYAK
Atome Classification :
(22 SA)
.........10........20........30........40---.........50.....-...60......----..70......--..80-........90........100.......110.......120.......130....--...140-------........150.......---160.......170.--.----.....180....--...190....-...---200.......210...-....220.......230..--.-----....240..--.--....250-.-.-.....260.......270.......280.......290.......300----.......310.......320........330........340.......350...----------------------.-------------...360..--...--..-370..---..-.---..380.......390...-....400.......410.......420.--........430.......-440.......-----450.-.------.....460..-.....470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSNKNK
S
Y
D
Y
V
I
IGGGS
A
G
S
V
L
G
N
RLSEDKDK
E
V
L
V
L
EAG----RSD
Y
F
W
D
L
F
I
QM
P
A
A
L-MFPSGN
K
F
Y
D
W
----
I
YSTDEEPHM--GG
R
K
-
V
AHARGKVLGGSSSI
N
G
M
I
Y
QRGNPMDYEGWAEPEGME
T
W
D
F
A
H
C
L
P
Y
F
K
K
L
E
K
T
--YGAAP--------
Y
D
KFRGHDG
P
I
K
L
KRGPA---T
N
P
L
F
Q
S
F
F
D
A
G
V
E--A----GYHKTPDVNG
F
R
--QEGFGP
F
D
S
Q
-
V
HR---GRRMSA
S
R
A
Y
L
H
P
A
M
K-RKN
L
T
V
E
T
R
A
F
V
T
E
I
H
YEG--
R
-----
R
AT
G
V
T
Y
KK--N--
G
K
L
H
T
ID-A-N-
E
V
I
LSGGAFNT
P
Q
L
L
Q
L
SGIG
D
S
E
F
L
K
SKGIEPRVHLPGVGE
N
F
E
D
H
L
----
E
V
Y
I
Q
H
KCKEPVSLQPSL-DIKRMPFI
G
L
-
Q
W
I
FTRTGAAASNHFEGG
G
F
V
RSNN----------------------E-------------VDY
P
N
L
M
F
--
H
F
L
--
P
I
-
A
V
R
YD---GQ-
K
---
A
A
V
AH
G
Y
Q
V
H
V
G
P
MYSNS-RG
S
L
K
IKSKDPFEKP
S
I
R
F
N
YLS
T
E
--
E
--
D
K
K
E
W
V
E
A
I
R
V
A
R
N
I
L
S
Q
-KAMDPFNGGE-----ISPG-P------EVQ
T
D
E
E
I
L
D
-
W
V
R
RDGETALHPSCSAKMGPASDP
M
A
V
VDP
L
T
M
K
V
HGME
N
L
R
V
VDASAMPRTTNGNI
H
A
P
V
L
M
L
A
E
K
A
A
D
I
IRGRKPLE
P
Q
Y
I
D
Y
Y
K
HGVHDENEG
A
I
E
V
KPYAK
27
PsiBlast_CBE
91.37
33%
-55
- C3 -
3NNE
2
CHOX_ARTGO
C:
[10-528]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
-------------------------------
3
PsiBlast_PDB
91.20
33%
-53
- C3 -
2JBV
4
CHOX_ARTGO
A:
[10-527]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
--------------------------------
26
PsiBlast_CBE
90.65
33%
-51
- C3 -
3NNE
2
CHOX_ARTGO
D:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
23
PsiBlast_CBE
90.46
33%
-52
- C3 -
3NNE
2
CHOX_ARTGO
G:
[10-529]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
------------------------------
30
PsiBlast_CBE
90.43
33%
-51
- C3 -
2JBV
4
CHOX_ARTGO
B:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
25
PsiBlast_CBE
90.41
33%
-53
- C3 -
3NNE
2
CHOX_ARTGO
E:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
2
PsiBlast_PDB
90.40
33%
-52
- C3 -
3NNE
2
CHOX_ARTGO
A:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HG
Y
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
21
PsiBlast_CBE
90.16
33%
-51
- C3 -
3LJP
1
CHOX_ARTGO
B:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
A
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
4
PsiBlast_PDB
90.07
33%
-50
- C3 -
4MJW
7
CHOX_ARTGO
A:
[10-532]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HG
Y
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
A
G
---------------------------
24
PsiBlast_CBE
89.90
33%
-54
- C3 -
3NNE
2
CHOX_ARTGO
F:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
1
PsiBlast_PDB
89.82
33%
-50
- C3 -
3LJP
1
CHOX_ARTGO
A:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
H
GY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
A
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
29
PsiBlast_CBE
89.73
33%
-51
- C3 -
4MJW
7
CHOX_ARTGO
B:
[10-531]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
A
----------------------------
28
PsiBlast_CBE
89.73
33%
-52
- C3 -
3NNE
2
CHOX_ARTGO
B:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
81
HHSearch
89.15
34%
-49
* C3 *
2JBV
4
CHOX_ARTGO
A:
[9-527]
--
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
-
V
P
E
V
L
Q
L
D
R
W
-
M
-
E
L
L
E
S
G
Y
D
W
----
D
Y
P
I
E
P
Q
E
N
G
---
N
S
F
-
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
-
K
F
N
T
G
T
TV
V
N
G
A
N
F
F
Q
I
N
R
R
A
D
---
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
SA
F
--
G
H
T
H
R
L
T
-
A
-
R
N
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
---
T
----------
Q
W
W
E
--
I
G
I
F
T
----------
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
SV
P
F
-
D
M
N
T
L
---
R
H
G
Y
---
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
EG
H
--
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
E
L
-
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
--------------------------------
22
PsiBlast_CBE
88.58
33%
-51
- C3 -
3NNE
2
CHOX_ARTGO
H:
[10-530]
---
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
----
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
L
E
S
G
---
Y
D
W
----
D
Y
P
I
--
E
P
Q
E
--
N
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
T
N
--
E
D
A
G
P
--------
D
A
P
H
H
G
D
S
G
P
V
H
L
M
N
V
P
P
---
K
D
P
T
G
V
A
L
L
D
A
C
E
Q
--
A
----
G
I
P
R
A
K
F
N
T
G
T
T
--
V
V
N
G
A
N
F
-
F
Q
-
I
N
R
RAD
G
T
R
S
S
S
S
V
S
Y
I
H
P
I
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D-
R
-----
R
C
T
G
V
D
I
V
D
--
S
AF
G
H
T
H
R
L
T
-
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
Q
P
M
V
A
E
S
T
-------------
Q
W
------------
W
E
I
G
I
F
T
P
T
E
D
----------------------
G
-------------
L
D
R
P
D
L
M
M
--
H
Y
G
--
S
V
-
P
F
D
M
N
---
T
L
-
R
HGY
P
T
T
E
N
G
F
S
L
T
P
N
V
T
H
A
R
S
-
R
G
T
V
R
L
R
S
R
D
F
R
D
K
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
-
P
A
M
A
E
W
T
G
R
E
-----
L
S
P
G
-
V
------
E
A
Q
T
D
E
E
L
Q
D
-
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
M
S
P
L
D
P
-
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-----------------------------
78
HHSearch
86.64
31%
-42
- C3 -
3FIM
1
?
B:
[2-566]
------
D
F
D
Y
V
V
V
G
A
G
N
A
G
N
V
V
A
A
R
L
T
E
D
P
D
V
S
V
L
V
L
E
A
G
----
V
S
D
E
N
-
V
L
G
A
E
A
P
L
L
A
-
P
G
L
V
P
N
S
I
F
D
W
----
N
Y
T
T
T
A
Q
A
G
Y
--
N
G
R
S
-
I
A
Y
P
R
G
R
M
L
G
G
S
S
S
V
H
Y
M
V
M
M
R
G
S
T
E
D
F
D
R
Y
A
A
V
T
G
D
E
G
W
N
W
D
N
I
Q
Q
F
V
R
K
N
E
M
V
--
V
P
P
A
D
NHNTSGEF
I
P
A
V
H
G
T
N
G
S
V
S
I
S
L
P
G
F
---
P
T
P
L
D
D
R
V
L
A
T
T
Q
E
QS
E
----
E
F
F
F
N
P
D
M
G
T
G
H
--
P
L
G
I
S
W
S
I
A
S
-
V
G
N
---
G
Q
R
S
S
S
S
T
A
Y
L
R
P
A
Q
S
-
R
P
N
L
S
V
L
I
N
A
Q
V
T
K
L
V
N
S
G
--
T
TNGLP
A
F
R
C
V
E
Y
A
E
QE
G
--
A
P
T
T
T
V
C
-
A
K
K
-
E
V
V
L
S
A
G
S
V
G
T
P
I
L
L
Q
L
S
G
I
G
D
E
N
D
L
S
S
V
G
I
D
T
I
V
N
N
P
S
V
G
R
N
L
S
D
H
L
----
L
L
P
A
A
F
F
V
N
S
N
Q
T
F
D
N
I
F
-
R
D
S
S
E
F
N
V
D
L
D
Q
W
T
N
T
R
T
G
P
L
T
A
L
I
A
N
H
L
A
W
L
R
L
P
S
----------------------
N
SSIFQTFPDPAAG
P
N
S
A
H
W
E
T
--
I
F
S
--
N
Q
-
W
F
H
P
A
---
I
P
-
R
---
P
D
T
G
S
F
M
S
V
T
N
A
L
I
S
P
V
A
-
R
G
D
I
K
L
A
T
S
N
P
F
D
K
P
L
I
N
P
Q
Y
L
S
T
E
--
F
--
D
I
F
T
M
I
Q
A
V
K
S
N
L
R
F
L
S
G
-
Q
A
W
A
D
F
V
I
R
P
-----
F
D
P
R
L
R
------
D
P
T
D
D
A
A
I
E
S
-
Y
I
R
D
N
A
N
T
I
F
H
P
V
G
T
A
S
M
S
P
R
G
A
S
W
G
V
V
D
P
D
L
-
K
V
K
G
V
D
G
L
R
I
V
D
G
S
I
L
P
F
A
P
N
A
H
T
Q
G
P
I
Y
L
V
G
K
Q
G
A
D
L
I
K
A
D
Q
-----------------------------
79
HHSearch
86.19
27%
-46
- C3 -
3Q9T
4
?
A:
[2-575]
--
T
D
G
S
H
F
D
F
V
I
V
G
G
G
T
A
G
N
T
V
A
G
R
L
A
E
N
P
N
V
T
V
L
I
V
E
A
G
----
I
G
N
P
E
D
I
P
E
I
T
T
P
S
S
A
-
M
-
D
L
R
N
S
K
Y
D
W
----
A
Y
K
T
T
M
V
R
R
D
D
Y
E
R
I
E
-
K
P
N
T
R
G
K
T
L
G
G
S
S
S
L
N
Y
F
T
W
V
P
G
H
K
A
T
F
D
Q
W
E
E
F
-
G
G
K
E
W
T
W
D
P
L
V
P
Y
L
R
K
S
A
T
Y
--
H
D
D
P
R
LYSP----
E
L
E
K
I
G
G
G
G
P
I
P
I
S
H
A
E
L
IDE
M
A
P
F
R
E
N
L
T
K
A
W
K
S
--
M
----
G
Q
P
L
I
E
N
I
Y
D
G
E
--
M
D
G
L
T
H
C
C
D
T
-
I
Y
R
---
G
Q
R
S
G
S
---
F
L
F
-
V
K
N
-
K
P
N
I
T
I
V
P
E
V
H
S
K
R
L
I
I
N
E
AD
R
-----
T
C
K
G
V
T
V
V
T
A-
A
--
G
N
E
L
N
F
F
A
D
-
R
-
E
V
I
L
S
Q
G
V
F
E
T
P
K
L
L
M
L
S
G
I
G
P
T
R
E
L
S
R
H
G
I
N
T
I
V
D
S
R
H
V
G
Q
N
L
M
D
H
P
----
G
V
P
F
V
L
R
V
K
D
G
F
G
M
D
D
V
L
L
R
H
G
P
K
R
D
A
V
V
S
A
Y
N
K
N
R
S
G
P
V
G
S
G
L
L
E
L
V
G
F
P
R
I
D
K
Y
L
E
K
D
A
E
Y
R
K
A
K
A
A
N
GGKDPFS
P
-------------
L
G
Q
P
H
F
E
L
--
D
F
V
--
C
M
-
F
G
T
A
F
QWH
F
P
-
T
---
P
K
T
G
D
H
L
T
V
V
V
D
L
V
R
P
I
S
D
P
G
E
V
T
L
N
S
A
D
P
F
Q
Q
P
N
I
N
L
N
F
F
A
N
D
--
L
--
D
I
I
A
M
R
E
G
I
R
F
S
Y
D
L
L
F
K
G
E
G
F
K
D
L
V
E
S
E
-----
Y
P
W
E
-
M
------
P
L
D
S
D
K
E
M
H
R
-
A
V
L
D
R
C
Q
T
A
F
H
P
T
G
T
A
R
L
S
K
N
I
-
D
Q
G
V
V
D
P
K
L
-
K
V
H
G
I
K
K
L
R
V
A
D
A
S
V
I
P
I
I
P
D
C
R
I
Q
N
S
V
Y
A
V
G
E
K
C
A
D
M
I
K
A
E
H
K
D
---------------------------
31
PsiBlast_CBE
85.85
31%
-42
- C3 -
4UDQ
2
HMFO_METS6
B:
[6-527]
-------
F
D
Y
V
I
V
G
G
G
T
A
G
S
V
L
A
N
R
L
S
A
R
P
E
N
R
V
L
L
I
E
A
G
IDTP
E
N
N
I
P
P
E
I
H
D
G
L
R
P
W
L
-
P
R
L
S
G
D
K
F
F
-
W
PNLT
I
H
R
A
A
E
H
P
G
I
--
T
R
E
P
-
Q
F
Y
E
Q
G
R
L
L
G
G
G
S
S
V
N
M
V
V
S
N
R
G
L
P
R
D
Y
D
E
W
-
Q
A
L
G
A
D
G
W
D
W
Q
G
V
L
P
Y
F
I
K
T
E
R
D
AD
Y
G
D
-----------
D
P
L
H
G
N
A
G
P
I
P
I
G
R
V
D
S
---
R
H
--
W
S
D
F
T
V
A
A
T
Q
--
A
LEAA
G
L
P
N
I
H
D
Q
N
A
R
F
--
D
D
G
Y
F
P
P
A
F
T
-
L
K
G
---
E
E
R
F
S
A
A
R
G
Y
L
D
A
S
V
R
V
R
P
N
L
S
L
W
T
E
S
R
V
L
K
L
L
T
T
G
--
N
-----
A
I
T
G
V
S
V
L
R
--
G
--
R
E
T
L
Q
V
Q
-
A
-
R
-
E
V
I
L
T
A
G
A
L
Q
S
P
A
I
L
L
R
T
G
I
G
P
A
A
D
L
H
A
L
G
I
P
V
L
A
D
R
P
G
V
G
R
N
L
W
E
H
S
----
S
I
G
V
V
A
P
L
T
E
Q
A
R
A
D
A
S
-------------------
T
G
K
A
G
S
R
H
Q
L
G
---
I
R
A
S
S
----------------------
G
-------------
V
D
P
A
T
P
S
D
--
L
F
L
--
H
I
G
A
D
P
V
S
---
G
L
-
A
---
S
A
V
---
F
W
V
N
----
K
P
S
S
-
T
G
W
L
K
L
K
D
A
D
P
F
S
Y
P
D
V
D
F
N
L
L
S
D
P
--
R
--
D
L
G
R
L
K
A
G
L
R
L
I
T
H
Y
F
A
A
-
P
S
L
A
K
Y
G
L
A
L
ALSRF
A
A
P
Q
-
P
GGPLLN
D
L
L
Q
D
E
A
A
L
E
R
Y
L
R
T
N
V
G
G
V
W
H
A
S
G
T
A
R
I
G
R
A
D
D
S
Q
A
V
V
D
K
-
A
G
R
V
Y
G
V
T
G
L
R
V
A
D
A
S
I
M
P
T
V
P
T
A
N
T
N
L
P
T
L
M
L
A
E
K
I
A
D
A
I
---------------------------------
32
PsiBlast_CBE
85.71
31%
-43
- C3 -
4UDR
2
HMFO_METS6
B:
[6-527]
-------
F
D
Y
V
I
V
G
G
G
T
A
G
S
V
L
A
N
R
L
S
A
R
P
E
N
R
V
L
L
I
E
A
G
IDTP
E
N
N
I
P
P
E
I
H
D
G
L
R
P
W
L
-
P
R
L
S
G
D
K
F
F
-
W
PNLT
I
H
R
A
A
E
H
P
G
I
--
T
R
E
P
-
Q
F
Y
E
Q
G
R
L
L
G
G
G
S
S
V
N
M
V
V
S
N
R
G
L
P
R
D
Y
D
E
W
-
Q
A
L
G
A
D
G
W
D
W
Q
G
V
L
P
Y
F
I
K
T
E
R
D
AD
Y
G
D
-----------
D
P
L
H
G
N
A
G
P
I
P
I
G
R
V
D
S
---
R
H
--
W
S
D
F
T
V
A
A
T
Q
--
A
LEAA
G
L
P
N
I
H
D
Q
N
A
R
F
--
D
D
G
Y
F
P
P
A
F
T
-
L
K
G
---
E
E
R
F
S
A
A
R
G
Y
L
D
A
S
V
R
V
R
P
N
L
S
L
W
T
E
S
R
V
L
K
L
L
T
T
G
--
N
-----
A
I
T
G
V
S
V
L
R
--
G
--
R
E
T
L
Q
V
Q
-
A
-
R
-
E
V
I
L
T
A
G
A
L
Q
S
P
A
I
L
L
R
T
G
I
G
P
A
A
D
L
H
A
L
G
I
P
V
L
A
D
R
P
G
V
G
R
N
L
W
E
H
S
----
S
I
G
V
V
A
P
L
T
E
Q
A
R
A
D
A
S
-------------------
T
G
K
A
G
S
R
H
Q
L
G
---
I
R
A
S
S
----------------------
G
-------------
V
D
P
A
T
P
S
D
--
L
F
L
--
H
I
G
A
D
P
V
S
---
G
L
-
A
---
S
A
V
---
F
W
V
N
----
K
P
S
S
-
T
G
W
L
K
L
K
D
A
D
P
F
S
Y
P
D
V
D
F
N
L
L
S
D
P
--
R
--
D
L
G
R
L
K
A
G
L
R
L
I
T
H
Y
F
A
A
-
P
S
L
A
K
Y
G
L
A
L
ALSRF
A
A
P
Q
-
P
GGPLLN
D
L
L
Q
D
E
A
A
L
E
R
Y
L
R
T
N
V
G
G
V
W
A
A
S
G
T
A
R
I
G
R
A
D
D
S
Q
A
V
V
D
K
-
A
G
R
V
Y
G
V
T
G
L
R
V
A
D
A
S
I
M
P
T
V
P
T
A
N
T
N
L
P
T
L
M
L
A
E
K
I
A
D
A
I
---------------------------------
12
PsiBlast_PDB
85.21
31%
-43
- C3 -
4UDR
2
HMFO_METS6
A:
[6-527]
-------
F
D
Y
V
I
V
G
G
G
T
A
G
S
V
L
A
N
R
L
S
A
R
P
E
N
R
V
L
L
I
E
A
G
IDTP
E
N
N
I
P
P
E
I
H
D
G
L
R
P
W
L
-
P
R
L
S
G
D
K
F
F
-
W
PNL
T
I
H
R
A
A
E
H
P
G
I
--
T
R
E
P
-
Q
F
Y
E
Q
G
R
L
L
G
G
G
S
S
V
N
M
V
V
S
N
R
G
L
P
R
D
Y
D
E
W
-
Q
A
L
G
A
D
G
W
D
W
Q
G
V
L
P
Y
F
I
K
T
E
R
D
AD
Y
G
D
-----------
D
P
L
H
G
N
A
G
P
I
P
I
G
R
V
D
S
---
R
H
--
W
S
D
F
T
V
A
A
T
Q
--
A
L
E
A
A
G
L
P
N
I
H
D
Q
N
A
R
F
--
D
D
G
Y
F
P
P
A
F
T
-
L
K
G
---
E
E
R
F
S
A
A
R
G
Y
L
D
A
S
V
R
V
R
P
N
L
S
L
W
T
E
S
R
V
L
K
L
L
T
T
G
--
N
-----
A
I
T
G
V
S
V
L
R
--
G
--
R
E
T
L
Q
V
Q
-
A
-
R
-
E
V
I
L
T
A
G
A
L
Q
S
P
A
I
L
L
R
T
G
I
G
P
A
A
D
L
H
A
L
G
I
P
V
L
A
D
R
P
G
V
G
R
N
L
W
E
H
S
----
S
I
G
V
V
A
P
L
T
E
Q
A
R
A
D
A
S
-------------------
T
G
K
A
G
S
R
H
Q
L
G
---
I
R
A
S
S
----------------------
G
-------------
V
D
P
A
T
P
S
D
--
L
F
L
--
H
I
G
A
D
P
V
S
---
G
L
-
A
---
S
A
V
---
F
W
V
N
----
K
P
S
S
-
T
G
W
L
K
L
K
D
A
D
P
F
S
Y
P
D
V
D
F
N
L
L
S
D
P
--
R
--
D
L
G
R
L
K
A
G
L
R
L
I
T
H
Y
F
A
A
-
P
S
L
A
K
Y
G
L
A
L
A
L
S
RF
A
A
P
Q
-
P
GGPL
L
N
D
L
L
Q
D
E
A
A
L
E
R
Y
L
R
T
N
V
G
G
V
W
A
A
S
G
T
A
R
I
G
R
A
D
D
S
Q
A
V
V
D
K
-
A
G
R
V
Y
G
V
T
G
L
R
V
A
D
A
S
I
M
P
T
V
P
T
A
N
T
N
L
P
T
L
M
L
A
E
K
I
A
D
A
I
---------------------------------
6
PsiBlast_PDB
81.90
31%
-40
- C3 -
3T37
1
?
A:
[17-517]
------
N
C
D
I
V
I
V
G
G
G
S
A
G
S
L
L
A
A
R
L
S
E
D
P
D
S
R
V
L
L
I
E
A
G
----
E
E
P
T
--
D
P
D
I
W
N
P
A
A
W
-
P
A
L
Q
G
-
R
S
Y
D
W
----
D
Y
R
T
E
A
Q
A
G
T
--
A
G
R
A
-
H
H
W
A
R
G
R
L
I
G
G
S
S
C
L
H
A
M
G
Y
M
R
G
H
P
S
D
F
Q
A
W
V
D
A
S
G
D
R
R
W
G
W
D
E
L
L
P
V
F
Q
A
I
E
D
H
--
P
L
G
G
D
--------
G
I
H
G
K
G
G
P
L
P
I
H
L
---
P
A
DE-
V
S
P
L
A
R
A
F
I
E
A
G
A
S
--
L
----
G
L
P
R
L
E
G
H
N
S
G
E
--
M
I
G
V
T
P
N
S
L
N
-
I
R
D
---
G
R
R
V
T
A
A
D
A
W
L
T
K
A
V
R
G
R
K
N
L
T
I
L
T
G
S
R
V
R
R
L
K
L
E
G
--
N
-----
Q
V
R
S
L
E
V
V
G
--
R
--
Q
G
S
A
E
V
F
-
A
-
D
-
Q
I
V
L
C
A
G
A
L
E
S
P
A
L
L
M
R
S
G
I
G
P
H
D
V
L
D
A
A
G
V
G
C
L
I
D
M
P
D
I
G
R
N
L
Q
D
H
L
L
G
AG
N
L
Y
A
A
R
K
P
V
P
P
S
R
L
Q
----------------------------
H
S
E
S
M
A
Y
M
R
A
D
S
FT--------------------
A
-------------
A
G
Q
P
E
I
V
V
G
C
G
V
A
--
P
I
--
V
S
E
S
---
F
P
-
A
---
P
A
A
G
S
A
Y
S
L
L
F
G
I
T
H
P
T
S
-
R
G
S
V
R
I
S
G
P
E
L
G
D
R
L
I
I
D
P
A
Y
L
Q
T
G
--
R
--
D
R
E
R
F
R
R
A
L
E
A
S
R
T
I
G
H
R
-
D
E
L
A
G
W
R
E
R
E
-----
L
L
P
G
-
T
------
P
-
N
S
A
A
E
M
D
D
-
F
I
A
R
S
V
I
T
H
H
H
P
C
G
T
C
R
M
G
--
K
D
P
D
A
V
V
D
A
-
N
L
R
L
K
A
L
D
N
L
F
V
V
D
A
S
I
M
P
N
L
T
A
G
P
I
H
A
A
V
L
A
I
A
E
T
F
A
------------------------------------
7
PsiBlast_PDB
79.57
31%
-34
- C3 -
4HA6
9
?
A:
[3-501]
--------
D
I
V
I
V
G
G
G
S
A
G
S
L
L
A
A
R
L
S
E
D
P
D
S
R
V
L
L
I
E
A
G
----
E
E
P
T
--
D
P
D
I
W
N
P
A
A
W
-
P
A
L
Q
G
-
R
S
Y
D
W
----
D
Y
R
T
E
A
Q
A
G
T
--
A
G
R
A
-
H
H
W
A
R
G
R
L
I
G
G
S
S
C
L
H
A
M
G
Y
M
R
G
H
P
S
D
F
Q
A
W
V
D
A
S
G
D
R
R
W
G
W
D
E
L
L
P
V
F
Q
A
I
E
D
H
--
P
L
G
G
D
--------
G
I
H
G
K
G
G
P
L
P
I
H
L
---
P
A
DE-
V
S
P
L
A
R
A
F
I
E
A
G
A
S
--
L
----
G
L
P
R
L
E
G
H
N
S
G
E
--
M
I
G
V
T
P
N
S
L
N
-
I
R
D
---
G
R
R
V
T
A
A
D
A
W
L
T
K
A
V
R
G
R
K
N
L
T
I
L
T
G
S
R
V
R
R
L
K
L
E
G
--
N
-----
Q
V
R
S
L
E
V
V
G
--
R
--
Q
G
S
A
E
V
F
-
A
-
D
-
Q
I
V
L
C
A
G
A
L
E
S
P
A
L
L
M
R
S
G
I
G
P
H
D
V
L
D
A
A
G
V
G
C
L
I
D
M
P
D
I
G
R
N
L
Q
D
H
L
LGA
G
N
L
Y
A
A
R
K
P
V
P
P
S
R
L
Q
H
S
E
-
S
M
A
Y
M
R
A
D
S
F
-------
T
A
A
G
Q
P
E
I
V
V
G
C
G
V
A
P
I
V
S
----------------------
E
--------------
S
F
P
-------------------------
A
---
P
A
A
G
S
A
Y
S
L
L
F
G
I
T
H
P
T
S
-
R
G
S
V
R
I
S
G
P
E
L
G
D
R
L
I
I
D
P
A
Y
L
Q
T
G
--
R
--
D
R
E
R
F
R
R
A
L
E
A
S
R
T
I
G
H
R
-
D
E
L
A
G
W
R
E
R
E
-----
L
L
P
G
-
T
------
P
-
N
S
A
A
E
M
D
D
-
F
I
A
R
S
V
I
T
H
H
H
P
C
G
T
C
R
M
G
--
K
D
P
D
A
V
V
D
A
-
N
L
R
L
K
A
L
D
N
L
F
V
V
D
A
S
I
M
P
N
L
T
A
G
P
I
H
A
A
V
L
A
I
A
E
T
F
A
------------------------------------