@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SA2423: (2016-04-04 )
MKKRIDYLSNKQNKYSIRRFTVGTTSVIVGATILFGIGNHQAQASEQSNDTTQSSKNNASADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQPTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTISNAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTFMAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDILTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYSSPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEESSGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGDITKTYVVLVEGHYDNTGKNLKTQVIQENVDPVTNRDYSIFGWNNENVVRYGGGSADGDSAVNPKDPTPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSRVTPPNNEQKAPSNPKGEVNHSNKVSKQHKTDALPETGDKSENTNATLFGAMMALLGSLLLFRKRKQDHKEKA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220....-.------.------.-----.230.......240---.........250.......260----........270.......280....-...290........----300.......310.......320......-------.330....-.-..-340.......350.......360.......370.......380.......390.......400.......--.410.......420.-.....-.430-......---...440.......450.......460.....----..-----------470.......----480--.-.---.......490....-...---500.......510.......520.......530.....-..540.....-...550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
R
I
D
Y
L
SNKQN
K
Y
S
I
R
R
F
TVGT
T
S
V
I
V
G
A
T
I
L
F
GIGNHQAQASEQSNDTTQSSKNNASADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQPTAIKNQ
A
T
A
A
KMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTISNAQGTSKP
S
V
R
T
R
A
V
R
S
L
A
VAEPVVNAADAKGTNVN
D
K
V
TA-SN
F
K
-
L
------
E
------
K
-----
T
TFDPNQSG
N
T
F
-----
M
A
A
N
F
T
V
T
D
KVKSG
D
Y
F
T
A
KL-----PDSLTGNG
D
V
D
YSNSNNT
M
P
I
A
D
IK-STNG
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
DYVNNKENINGQFSL
P
L
F-------TDRAKAPK-S-GT-YDAN
I
N
I
A
D
E
MFNN
K
I
T
Y
NYSSPIAGIDKPNGANIS
S
Q
I
I
G
V
DTASGQN
T
Y
K
Q
T
V
F
VN
P
K
Q
-
R
VLGN
T
W
V
--
Y
I
KGY
Q
D
K
I
E
ESSG
K
-
V
SATD-
T
K
---
L
R
I
F
EV---NDTSKLSDSYYADPNDS
N
L
K
E
V
T
D
Q
F
KN
R
I
Y
----
Y
E-----------HP
N
V
A
S
I
K
FG----D----I-
T
---
K
T
Y
V
V
L
V
EGHYDNT-GK
N
---
L
K
T
Q
V
I
Q
ENVDPVTNR
D
Y
S
I
F
GWNNE
N
V
V
R
YGGGSADG-DSAV-NPKDP-TPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSRVTPPNNEQKAPSNPKGEVNHSNKV
S
K
QHKTDALPETGDKSENT
N
A
T
L
F
G
A
M
M
A
L
L
G
S
L
L
L
F
R
K
R
K
Q
DHKEKA
1
PsiBlast_PDB
90.97
99%
-63
- C6 -
3AU0
2
CLFB_STAAN
A:
[1-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
V
N
V
A
D
A
K
G
T
N
V
N
D
K
V
T
A
-
S
N
F
K
-
L
------
E
------
K
-----
T
T
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
T
V
T
D
K
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
L
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
N
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
E
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
D
Q
F
K
N
R
I
Y
----
Y
E
-----------
H
P
N
V
A
S
I
K
F
G
----
D
----
I
-
T
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
V
D
P
V
T
N
R
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
-
D
S
A
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.45
99%
-65
- C6 -
3ASW
1
CLFB_STAAN
A:
[9-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
N
V
N
D
K
V
T
A
-
S
N
F
K
-
L
------
E
------
K
-----
T
T
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
T
V
T
D
K
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
L
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
N
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
E
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
D
Q
F
K
N
R
I
Y
----
Y
E
-----------
H
P
N
V
A
S
I
K
F
G
----
D
----
I
-
T
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
V
D
P
V
T
N
R
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.01
99%
-65
- C6 -
3AT0
1
CLFB_STAAN
A:
[9-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
N
V
N
D
K
V
T
A
-
S
N
F
K
-
L
------
E
------
K
-----
T
T
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
T
V
T
D
K
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
L
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
N
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
N
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
E
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
D
Q
F
K
N
R
I
Y
----
Y
E
-----------
H
P
N
V
A
S
I
K
F
G
----
D
----
I
-
T
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
V
D
P
V
T
N
R
D
Y
S
I
F
G
W
N
N
E
N
V
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.67
93%
-59
- C6 -
4F20
3
CLFB_STAAR
A:
[31-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
T
N
V
N
D
K
V
T
A
-
S
D
F
K
-
L
------
E
------
K
-----
T
A
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
K
V
T
G
Q
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
V
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
D
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
G
E
F
K
D
K
I
S
----
Y
K
-----------
Y
D
N
V
A
S
I
N
F
G
----
D
----
I
-
N
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
I
D
P
A
T
G
K
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
-
D
S
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.08
93%
-62
- C6 -
4F24
5
CLFB_STAAR
A:
[22-355]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
P
V
V
N
A
A
D
A
K
G
T
N
V
N
D
K
V
T
A
-
S
D
F
K
-
L
------
E
------
K
-----
T
A
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
K
V
T
G
Q
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
V
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
D
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
G
E
F
K
D
K
I
S
----
Y
K
-----------
Y
D
N
V
A
S
I
N
F
G
----
D
----
I
-
N
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
I
D
P
A
T
G
K
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.95
92%
-60
- C6 -
4F27
3
CLFB_STAAR
A:
[30-360]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
K
G
T
N
V
N
D
K
V
T
A
-
S
D
F
K
-
L
------
E
------
K
-----
T
A
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
K
V
T
G
Q
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
V
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
D
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
G
E
F
K
D
K
I
S
----
Y
K
-----------
Y
D
N
V
A
S
I
N
F
G
----
D
----
I
-
N
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
I
D
P
A
T
G
K
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
G
G
S
A
D
G
-
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.26
93%
-58
- C6 -
4F1Z
2
CLFB_STAAR
A:
[31-352]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
G
T
N
V
N
D
K
V
T
A
-
S
D
F
K
-
L
------
E
------
K
-----
T
A
F
D
P
N
Q
S
G
N
T
F
-----
M
A
A
N
F
K
V
T
G
Q
V
K
S
G
D
Y
F
T
A
K
L
-----
P
D
S
V
T
G
N
G
D
V
D
Y
S
N
S
N
N
T
M
P
I
A
D
I
K
-
S
T
N
G
D
-
V
V
A
K
A
T
Y
D
----
I
L
T
K
T
Y
T
F
V
F
T
D
Y
V
N
D
K
E
N
I
N
G
Q
F
S
L
P
L
F
-------
T
D
R
A
K
A
P
K
-
S
-
G
T
-
Y
D
A
N
I
N
I
A
D
E
M
F
D
N
K
I
T
Y
N
Y
S
S
P
I
A
G
I
D
K
P
N
G
A
N
I
S
S
Q
I
I
G
V
D
T
A
S
G
Q
N
T
Y
K
Q
T
V
F
V
N
P
K
Q
-
R
V
L
G
N
T
W
V
--
Y
I
K
G
Y
Q
D
K
I
E
E
S
S
G
K
-
V
S
A
T
D
-
T
K
---
L
R
I
F
E
V
---
N
D
T
S
K
L
S
D
S
Y
Y
A
D
P
N
D
S
N
L
K
E
V
T
G
E
F
K
D
K
I
S
----
Y
K
-----------
Y
D
N
V
A
S
I
N
F
G
----
D
----
I
-
N
---
K
T
Y
V
V
L
V
E
G
H
Y
D
N
T
-
G
K
N
---
L
K
T
Q
V
I
Q
E
N
I
D
P
A
T
G
K
D
Y
S
I
F
G
W
N
N
E
N
V
V
R
Y
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.60
26%
-42
- C6 -
1N67
3
CLFA_STAAE
A:
[28-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
-
V
T
V
G
-
I
------
D
S
-----
G
-----
T
T
V
Y
P
H
Q
A
G
Y
V
K
-----
L
N
Y
G
F
S
V
P
N
S
A
V
K
G
D
T
F
K
I
T
V
-----
P
K
E
L
N
L
N
G
---
V
T
S
T
A
K
V
P
P
I
M
A
------
G
D
Q
V
L
A
N
G
V
I
D
SDG
N
V
I
-----
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
-------
I
D
P
E
N
V
K
K
-
T
-
G
N
-
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
----
Y
G
K
F
Y
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
N
--
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
P
V
-----
L
T
G
N
L
K
P
N
T
D
S
N
A
L
-
I
D
Q
Q
N
-
T
S
---
I
K
V
Y
K
V
---
D
N
A
A
D
L
S
E
S
Y
F
V
N
P
--
E
N
F
E
D
V
T
N
S
V
--
N
I
T
----
F
P
-----------
N
P
N
Q
Y
K
V
E
F
N
TPDD
Q
----
I
-
T
---
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
-
S
K
G
DL
A
L
R
S
T
L
Y
G
Y
N
----
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
K
P
V
-
V
P
E
Q
P
D
E
P
G
---
E
I
E
P
I
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
61.78
26%
-36
* C6 *
1N67
3
CLFA_STAAE
A:
[28-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
-
V
T
V
G
-
I
------
D
------
S
G
----
T
T
V
Y
P
H
Q
A
G
Y
V
K
-----
L
N
Y
G
F
S
V
P
N
S
A
V
K
G
D
T
F
K
I
T
V
-----
P
K
E
L
N
L
N
G
------
V
T
S
T
A
K
V
P
P
I
M
-
A
-
G
D
Q
-
V
L
A
N
G
V
I
D
-----
S
D
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
-------
I
D
P
E
N
V
K
K
-
T
-
G
N
-
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
----
G
K
F
Y
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
N
--
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-
D
N
V
I
A
--
P
--
V
L
T
G
N
L
K
P
N
T
D
S
N
A
L
-
I
D
Q
Q
N
-
T
S
---
I
K
V
Y
K
V
---
D
N
A
A
D
L
S
E
S
Y
F
V
N
--
P
E
N
F
E
D
V
T
N
S
V
--
N
I
T
----
F
P
-----------
N
P
N
Q
Y
K
V
E
F
N
TPDD
Q
----
I
-
T
---
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
-
S
K
G
DL
A
L
R
S
T
L
Y
G
Y
N
----
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
-
I
D
K
P
V
V
P
E
Q
P
-
D
E
P
G
E
I
E
P
I
P
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
60.19
29%
-86
- C6 -
1R17
1
SDRG_STAEP
A:
[53-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
-----
Y
D
V
T
F
E
V
D
D
K
V
K
S
G
D
T
M
T
V
N
I
DKNTV
P
S
D
L
T
-----------
D
S
F
A
I
P
K
I
K
-
D
N
S
G
E
-
I
I
A
T
G
T
Y
D
----
N
T
N
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
E
N
I
K
A
H
L
K
L
T
S
Y
-------
I
D
K
S
K
V
P
N
-
N
-
N
T
K
L
D
V
E
Y
K
T
A
L
S
S
V
N
K
T
I
T
V
E
Y
Q
K
P
----
N
E
N
R
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
N
--
H
T
V
E
Q
T
I
Y
I
N
P
L
R
-
Y
S
A
K
E
T
N
V
--
N
I
S
G
N
G
D
E
-----
G
S
-
T
I
I
D
D
S
T
I
---
I
K
V
Y
K
V
---
G
D
N
Q
N
L
P
D
S
------------------
N
R
I
Y
DYSE
Y
E
DVTNDDY
A
Q
L
G
N
N
N
D
V
N
I
N
F
G
----
N
----
I
-
D
---
S
P
Y
I
I
K
V
I
S
K
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.14
29%
-84
- C6 -
2RAL
-
SDRG_STAEP
A:
[308-546]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
-----
Y
D
V
T
F
E
V
D
D
K
V
K
S
G
D
T
M
T
V
N
I
D
KNTV
P
S
D
L
T
-----------
D
S
F
A
I
P
K
I
K
-
D
N
S
G
E
-
I
I
A
T
G
T
Y
D
----
N
T
N
K
Q
I
T
Y
T
F
T
D
Y
V
D
K
Y
C
N
I
K
A
H
L
K
L
T
S
Y
-------
I
D
K
S
K
V
P
N
-
N
-
N
T
K
L
D
V
E
Y
K
T
A
L
S
S
V
N
K
T
I
T
V
E
Y
Q
K
P
----
N
E
N
R
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
N
--
H
T
V
E
Q
T
I
Y
I
N
P
L
R
-
Y
S
A
K
E
T
N
V
--
N
I
S
G
N
G
D
E
-----
G
S
-
T
I
I
D
D
S
T
I
---
I
K
V
Y
K
V
---
G
D
N
Q
N
L
P
D
S
------------------
N
R
I
Y
DYSE
Y
E
DVTNDDY
A
Q
L
G
N
N
N
D
V
N
I
N
F
G
----
N
----
I
-
D
---
S
P
Y
I
I
K
V
I
S
K
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.96
28%
-63
- C6 -
4JE0
-
?
A:
[38-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
Q
I
K
V
D
D
K
V
K
S
G
D
Y
F
T
I
K
Y
-----
S
D
T
V
Q
V
Y
G
----
L
N
P
E
D
I
K
N
I
G
D
I
K
D
P
N
N
G
E
-
T
I
A
T
A
K
H
D
----
T
A
N
N
L
I
T
Y
T
F
T
D
Y
V
D
R
F
N
S
V
Q
M
G
I
N
Y
S
I
Y
-------
M
D
A
D
T
I
P
V
-
S
-
K
N
D
V
E
F
N
V
T
I
G
N
D
T
T
K
T
T
A
N
I
Q
Y
P
D
Y
V
S
R
D
N
N
S
I
G
S
A
F
T
E
T
V
S
H
A
G
N
A
E
D
P
G
Y
Y
K
Q
T
V
Y
V
N
P
S
E
-
K
S
L
T
N
A
K
L
--
K
V
E
A
Y
H
K
D
Y
P
D
N
V
G
Q
-
I
N
K
D
V
-
T
K
---
I
K
I
Y
Q
A
---
P
K
D
Y
V
L
N
K
G
Y
--
D
V
N
T
N
Q
L
I
D
V
T
E
Q
F
K
D
K
I
T
----
Y
G
-----------
A
N
D
S
V
N
V
D
F
G
----
S
----
I
-
N
---
N
S
Y
V
V
M
V
D
T
K
F
E
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.78
28%
-61
- C6 -
4JDZ
-
?
B:
[34-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
Q
I
K
V
D
D
K
V
K
S
G
D
Y
F
T
I
K
Y
-----
S
D
T
V
Q
V
Y
G
----
L
N
P
E
D
I
K
N
I
G
D
I
K
D
P
N
N
G
E
-
T
I
A
T
A
K
H
D
----
T
A
N
N
L
I
T
Y
T
F
T
D
Y
V
D
R
F
N
S
V
Q
M
G
I
N
Y
S
I
Y
-------
M
D
A
D
T
I
P
V
-
S
-
K
N
D
V
E
F
N
V
T
I
G
N
D
T
T
K
T
T
A
N
I
Q
Y
P
D
Y
V
S
R
D
N
N
S
I
G
S
A
F
T
E
T
V
S
H
A
G
N
A
E
D
P
G
Y
Y
K
Q
T
V
Y
V
N
P
S
E
-
K
S
L
T
N
A
K
L
--
K
V
E
A
Y
H
K
D
Y
P
D
N
V
G
Q
-
I
N
K
D
V
-
T
K
---
I
K
I
Y
Q
A
---
P
K
D
Y
V
L
N
K
G
Y
--
D
V
N
T
N
Q
L
I
D
V
T
E
Q
F
K
D
K
I
T
----
Y
G
-----------
A
N
D
S
V
N
V
D
F
G
----
S
----
I
-
N
---
N
S
Y
V
V
M
V
D
T
K
F
E
Y
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.09
26%
-61
- C6 -
2VR3
1
CLFA_STAA8
A:
[31-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
V
Y
P
H
Q
A
G
Y
V
K
-----
L
N
Y
G
F
S
V
P
N
S
A
V
K
G
D
T
F
K
I
T
V
-----
P
K
E
L
N
L
N
G
------
V
T
S
T
A
K
V
P
P
I
M
-
A
-----
V
L
A
N
G
V
I
D
SDG
N
V
I
-----
Y
T
F
T
D
Y
V
N
T
K
C
D
V
K
A
T
L
T
M
P
A
Y
-------
I
D
P
E
N
V
K
K
-
T
-
G
N
-
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
----
Y
G
K
F
Y
N
L
S
I
K
G
T
I
D
Q
I
D
K
T
N
--
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
D
N
V
I
A
P
V
-----
L
T
G
N
L
K
P
N
T
D
S
N
A
L
-
I
D
Q
Q
N
-
T
S
---
I
K
V
Y
K
V
---
D
N
A
A
D
L
S
E
S
Y
F
V
N
P
-----
E
D
V
T
N
S
V
--
N
I
T
----
F
P
-----------
N
P
N
Q
Y
K
V
E
F
-PDD-
Q
----
I
-
T
---
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
-
S
K
G
DL
A
L
R
S
T
L
Y
G
Y
N
----
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
I
D
C
P
V
-
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
57.66
24%
-68
- C6 -
3IRP
2
X:
[3-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
G
R
N
V
N
H
L
V
F
A
-
N
T
S
Y
E
I
------
L
------
G
GGKKY
N
Q
V
F
M
T
M
D
G
K
L
K
-----
I
K
I
D
Y
T
V
D
D
S
V
V
E
G
D
Y
F
T
V
D
F
-----
G
K
Y
I
H
P
G
T
S
R
K
------
P
Y
R
V
N
N
I
H
-
D
A
N
G
R
-
T
I
A
I
G
S
Y
D
----
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
L
L
S
W
-------
P
F
K
E
L
V
T
T
D
K
-
Q
S
-
V
P
V
G
I
T
V
A
G
E
D
Y
T
Q
N
V
I
F
N
Y
G
N
R
T
V
----
P
V
I
S
D
I
N
Y
-
L
-------
T
K
D
F
A
E
F
T
T
Y
I
N
Q
N
R
-
A
F
N
T
G
S
K
V
--
R
L
S
G
Q
-------
G
F
K
F
T
S
P
D
---
E
---
I
E
V
Y
K
V
---
L
N
N
S
Q
F
R
D
S
F
S
P
D
--
Y
A
N
L
T
Q
V
R
-
N
P
K
I
I
I
N
-----------------
S
D
G
S
A
T
V
D
L
G
----
D
----
I
-
G
T--
L
G
Y
I
I
R
S
K
P
N
T
L
P
D
-
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.12
29%
-88
- C6 -
1R19
-
SDRG_STAEP
A:
[308-552]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
I
-----
Y
D
V
T
F
E
V
D
D
K
V
K
S
--
T
M
T
V
N
I
D
KNTV
P
S
D
L
T
-----------
D
S
F
-
I
P
K
I
K
----
G
E
-
I
I
A
T
G
T
Y
D
----
N
T
N
K
Q
I
T
Y
T
-
T
D
Y
V
D
---
N
I
K
A
H
L
K
L
T
S
Y
-------
I
D
K
S
K
V
P
N
-
N
-
N
T
K
L
D
V
E
Y
K
T
A
L
S
S
V
N
K
T
I
T
V
E
Y
Q
K
P
----
N
E
N
R
T
A
N
L
Q
S
M
F
T
N
I
D
T
K
N
--
H
T
V
E
Q
T
I
Y
I
N
P
L
R
-
Y
S
A
K
E
T
N
V
--
N
I
S
G
N
G
D
E
-----
G
S
-
T
I
I
D
D
S
T
I
---
I
K
V
Y
K
V
---
G
D
N
Q
N
L
P
D
S
------------------
N
R
I
Y
DYSE
Y
E
DVTNDDYAQLG--
N
D
V
N
I
N
F
G
----
N
----
I
-
D
---
S
P
Y
I
I
K
V
I
S
K
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
56.97
26%
-19
- C6 -
1N67
3
CLFA_STAAE
A:
[28-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
D
I
T
N
Q
L
T
N
-
V
T
V
G
-
I
------
D
------
S
G
----
T
T
V
Y
P
H
Q
A
G
Y
V
K
-----
L
N
Y
G
F
S
V
P
N
S
A
V
K
G
D
T
F
K
I
T
V
-----
P
K
E
L
N
L
N
G
V
T
S
T
-------
A
K
V
P
P
I
-
M
A
G
D
Q
-
V
L
A
N
G
V
I
D
----
S
D
-
G
N
V
I
Y
T
F
T
D
Y
V
N
T
K
D
D
V
K
A
T
L
T
M
P
A
Y
-------
I
D
P
E
N
V
K
K
-
T
-
G
N
-
V
T
L
A
T
G
I
G
S
T
T
A
N
K
T
V
L
V
D
Y
E
K
Y
G
K
F
Y
---
N
L
S
I
K
G
-
T
I
D
Q
I
D
--
K
T
N
N
T
Y
R
Q
T
I
Y
V
N
P
S
G
-
D
N
V
I
A
P
V
L
T
G
N
L
K
P
N
T
--
D
S
N
A
L
I
D
-
Q
Q
N
T
---
S
---
I
K
V
Y
K
V
---
D
N
A
A
D
L
S
E
S
Y
F
V
N
P
--
E
N
F
E
D
V
T
N
S
V
N
I
T
F
P
-----------------
N
P
N
Q
Y
K
V
E
F
N
----
T
PDDQ
I
-
T
---
T
P
Y
I
V
V
V
N
G
H
I
D
P
N
S
K
G
D
---
L
A
L
R
-
S
T
L
Y
G
Y
N
-
S
N
I
I
W
R
S
M
S
W
D
N
E
V
A
F
N
N
G
S
G
S
G
D
G
-
I
D
K
P
--
V
V
P
E
-
Q
P
D
E
P
G
E
I
E
P
I
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
55.94
27%
-44
- C6 -
4MBR
-
?
A:
[18-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
Q
D
V
T
D
K
L
Q
N
-
L
D
I
K
-
L
SGGVQA
K
------
A
-----
G
V
I
N
M
D
K
S
E
S
M
H
-----
M
S
L
K
F
T
I
-
D
S
V
N
R
G
D
T
F
E
I
K
L
-----
S
D
N
I
D
T
N
G
A
S
N
Y
S
------
I
V
E
P
I
K
-
S
P
T
G
E
-
V
Y
A
T
G
I
Y
D
----
S
Q
K
K
S
I
V
Y
S
F
T
D
F
A
A
S
K
N
N
I
N
G
I
L
D
I
P
L
W
-------
P
D
D
T
T
V
Q
N
-
T
-
K
E
D
V
L
F
S
V
K
I
K
D
Q
E
A
T
I
K
E
T
V
K
Y
D
P
P
V
R
-
I
D
F
A
G
G
V
S
V
D
S
R
I
T
N
I
D
D
V
G
K
K
M
T
Y
I
S
Q
I
N
V
D
G
K
S
-
L
Y
N
Y
N
--------
G
L
Y
T
R
I
Y
N
Y
S
-
K
-
E
S
T
A
D
-
L
K
N
S
T
I
K
I
Y
K
T
T
SD
N
I
V
E
S
M
V
Q
D
Y
------
S
S
M
E
D
V
T
S
K
F
A
N
S
------
Y
P
-----------
E
K
G
W
Y
D
I
Y
W
G
----
Q
----
F
-
I
ASN
E
T
Y
V
I
V
V
E
T
P
F
T
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
54.02
16%
15
- C6 -
3IRP
7
UAFA_STAS1
X:
[2-419]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
S
G
R
N
V
N
H
L
V
F
A
-
N
T
S
Y
-
E
------
I
LGGGKK
Y
-----
N
Q
V
F
M
T
M
D
G
K
L
K
-----
I
K
I
D
Y
T
V
D
D
S
V
V
E
G
D
Y
F
T
V
D
F
-----
G
K
Y
------
I
H
P
G
T
S
R
K
P
Y
R
V
N
N
I
H
-
D
A
N
G
R
-
T
I
A
I
G
S
Y
D
----
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
L
L
S
W
-------
P
F
K
E
L
V
T
T
-
D
K
Q
S
-
V
P
V
G
I
T
V
A
G
E
D
Y
T
Q
N
V
I
F
N
Y
G
N
R
------------
T
V
P
V
I
S
D
I
N
Y
L
T
K
D
F
A
E
F
T
T
Y
I
N
Q
N
R
-
A
F
N
T
G
S
K
V
--
R
L
S
G
Q
G
F
K
F
T
---------
S
P
-
D
E
---
I
E
V
Y
K
V
---
L
N
N
S
Q
F
R
D
S
F
S
P
D
-----
Y
A
N
L
T
Q
V
R
N
P
K
I
I
----
I
N
-----------
S
D
G
S
A
T
V
D
L
G
----
D
----
I
G
T
---
L
G
Y
I
I
R
S
K
P
N
T
L
P
D
-
F
S
G
---
I
G
V
L
K
S
E
Y
T
F
T
N
N
K
N
Q
R
D
T
R
A
H
A
S
S
I
Q
F
V
R
A
E
L
A
G
F
G
G
-
F
G
G
Y
-
V
W
F
D
K
-
N
N
D
G
V
Q
N
D
S
N
A
A
A
A
G
I
T
V
N
L
L
D
P
T
G
I
R
L
A
T
T
T
T
D
I
T
G
H
Y
N
F
D
N
L
T
N
G
N
Y
L
V
E
F
V
M
P
E
G
Y
I
P
T
Q
A
N
S
T
V
D
D
K
D
S
D
V
V
F
E
N
G
R
Y
I
A
H
V
T
I
K
D
A
D
N
M
T
I
D
A
G
L
V
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
48.44
28%
-78
- C6 -
3IS1
1
X:
[19-196]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
S
G
R
N
V
N
H
L
V
F
A
N
T
S
Y
E
-
I
------
L
------
G
-----
G
G
K
K
Y
N
Q
V
F
M
T
M
DGKLK
I
K
I
D
Y
T
V
D
D
S
V
V
E
G
D
Y
F
T
V
D
F
-----
G
K
Y
------
I
H
P
G
T
S
R
K
P
Y
R
V
N
N
I
H
-
D
A
N
G
R
-
T
I
A
I
G
S
Y
D
----
S
A
T
N
T
A
K
Y
T
F
T
N
Y
V
D
I
Y
N
N
V
R
G
S
F
S
L
L
S
W
PFKELVT
T
D
K
Q
S
V
P
---------
V
G
I
T
V
A
G
E
D
Y
T
Q
N
V
I
F
N
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------