@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0010: (2015-12-11 )
MILKSSIDRLLQTIDIVEVISSYVDLRKSGSNYMACCPFHEERSASFSVNQVKGFYYCFGCGASGDSIKFVMAFEKLSFVEALEKLAHRFNIALEYDKGVYYDHKEDYHLLEMVSSLYQEELFNAPFFLNYLQKRGLSMESIKAFKLGLCTNKIDYGIENKGLNKDKLIELGVLGKSDKEDKTYLRFLDRIMFPIYSPSAQVVGFGGRTLKEKAAKYINSPQNKLFDKSSLLYGYHLAKEHIYKQKQVIVTEGYLDVILLHQAGFKNAIATLGTALTPSHLPLLKKGDPEILLSYDGDKAGRNAAYKASLMLAKEQRKGGVILFENNLDPADMIANHQIETLKNWLSRPIAFIEFVLRHMAGSYLLDDPLEKDKALKEMLGFLKNFSLLLQNEYKPLIATLLQAPLHVLGIREPVSFQPFYPKTEKPNRPQKFAHVSSMPSLEFLEKLVIRYLLEDRSLLDLAVGYIHSGVFLHKKQEFDALCQEKLDDPKLVALLLDANLPLKKGGFEKELRLLILRYFERQLKEIPKSPLSFSEKMIFLKRARQAIMKLKQGELVAI
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100....---...110.......120.--.---.....130----.......140.......150--....---..---..160---.......170.....-..180....--...190.......200.......210-.......220.......230.......240.......250.......260.......270.......280.......290.......300......---.310..---.....---320.......330.......340......-.350.......360....-...370.......380....-...390.....-..400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.....-..540.......550.......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
L
K
S
S
I
D
R
L
L
Q
T
I
D
I
V
E
V
I
S
S
Y
V
D
L
R
KSGSN
Y
M
A
CCPFHEERSASFSVNQ
V
K
G
F
Y
Y
C
F
GCGASGD
S
I
K
F
V
M
A
F
E
K
L
S
F
V
E
A
L
E
K
L
A
H
RF
N
I
A
L
E
YDKGVYYDHKE---
D
Y
H
L
L
E
M
V
S
S
L
Y
Q
E
E
LF--N---
A
P
F
F
L
N
Y
L
----
Q
KRGL
S
M
E
S
I
K
A
F
K
LGLCT---NKID---YG---IENKG---L
N
K
D
K
L
I
E
LGVLGKS-DKE
D
K
T
Y
L
R
--
F
L
D
R
I
M
F
PIYSPSA
Q
V
V
GFGG
R
T
L
K
E
-
K
A
A
K
Y
INS
P
Q
N
KLFDKSS
L
L
Y
G
Y
H
L
A
K
E
H
I
Y
KQ
K
Q
V
I
V
TEG
Y
L
D
V
I
L
L
HQAG
F
K
N
A
I
A
T
L
GTALTPSHLPLLKKGDP
E
I
L
L
S
YDGDKAGRNA
A
Y
K
A
---
S
L
M
L
A
K---EQRKG---
G
V
I
L
F
ENNL
D
P
A
D
M
I
A
NH
Q
I
E
T
L
K
N
W
L
SR-
P
I
A
F
I
E
F
V
L
R
HMAGSYLL-DDPL
E
K
D
K
A
L
K
E
M
L
G
F
L
K
N
F
-
S
L
L
L
QNEY
K
P
L
-
I
A
T
L
L
QA
P
L
H
VLGIREPVSFQPFYPKTEKPNR
P
Q
K
F
A
HVSSMP
S
L
E
F
L
E
K
L
V
I
R
Y
L
LEDR
S
L
L
D
L
A
V
G
Y
I
HS
G
V
F
L
HK
K
Q
E
F
D
A
L
C
Q
EKLD
D
P
K
L
V
A
L
L
LDANLPLKKG
G
F
E
K
E
L
R
L
L
I
L
R
Y
F
E
R
Q
L
K
EIPKSPL
S
F
S
E
K
-
M
I
F
L
K
R
A
R
Q
A
I
M
K
LKQG
E
L
V
AI--
2
PsiBlast_PDB
94.09
34%
-96
- C3 -
2AU3
1
DNAG_AQUAE
A:
[3-379]
--
M
S
S
D
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
R
Y
G
K
K
L
D
L
E
K
-
I
S
K
D
E
K
V
----
Y
V
A
L
D
R
V
C
D
F
Y
R
E
S
L
L
--
K
---
N
R
E
A
S
E
Y
V
----
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
---
S
S
E
A
---
L
------
V
K
V
---
L
K
E
N
D
L
L
E
A
Y
L
E
T
K
N
L
L
S
P
T
K
G
V
Y
R
D
L
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
E
D
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
I
K
E
E
G
F
A
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
M
K
S
A
---
I
P
L
L
L
S
---
A
G
V
E
V
---
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
R
L
I
N
S
-
S
G
E
L
F
E
T
L
I
K
T
A
R
------
E
N
L
E
E
K
T
R
E
F
R
Y
Y
L
G
F
I
S
D
G
-
V
R
R
F
A
L
A
S
E
F
H
-
T
K
Y
K
V
P
M
E
I
L
L
M
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
93.98
32%
-98
- C3 -
2AU3
1
DNAG_AQUAE
A:
[3-405]
--
M
S
S
D
I
D
E
L
R
R
E
I
D
I
V
D
V
I
S
E
Y
L
N
L
E
K
V
G
S
N
Y
R
T
N
C
P
F
H
P
D
D
T
P
S
F
Y
V
S
P
S
K
Q
I
F
K
C
F
G
C
G
V
G
G
D
A
I
K
F
V
S
L
Y
E
D
I
S
Y
F
E
A
A
L
E
L
A
K
R
Y
G
K
K
L
D
L
E
K
I
S
--
K
D
E
K
---
V
Y
V
A
L
D
R
V
C
D
F
Y
R
E
S
L
L
--
K
---
N
R
E
A
S
E
Y
V
----
K
S
R
G
I
D
P
K
V
A
R
K
F
D
L
G
Y
A
P
---
S
S
E
A
L
V
-
K
V
---
L
K
E
N
D
---
L
L
E
A
Y
L
E
T
K
N
L
L
S
P
T
-
K
--
G
V
Y
R
D
L
--
F
L
R
R
V
V
I
P
I
K
D
P
R
G
R
V
I
G
F
G
G
R
R
I
V
E
D
K
S
P
K
Y
I
N
S
P
D
S
R
V
F
K
K
G
E
N
L
F
G
L
Y
E
A
K
E
Y
I
K
E
E
G
F
A
I
L
V
E
G
Y
F
D
L
L
R
L
F
S
E
G
I
R
N
V
V
A
P
L
G
T
A
L
T
Q
N
Q
A
N
L
L
S
K
F
T
K
K
V
Y
I
L
Y
D
G
D
D
A
G
R
K
A
M
K
S
A
---
I
P
L
L
L
S
---
A
G
V
E
V
---
Y
P
V
Y
L
P
E
G
Y
D
P
D
E
F
I
K
E
F
G
K
E
E
L
R
R
L
I
N
S
-
S
G
E
L
F
E
T
L
I
K
T
A
R
E
N
L
E
---------
E
K
T
R
E
F
R
Y
Y
L
G
F
I
S
D
G
V
R
R
F
A
L
A
S
E
-
F
H
T
K
Y
K
V
P
M
E
I
L
L
M
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
80.96
29%
-92
* C3 *
1DD9
1
DNAG_ECOLI
A:
[20-330]
---------------------------------------------------------------------------------------------------------
T
---
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
--
Q
PV-
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
---
P
G
W
D
N
V
L
K
R
---
F
G
G
N
P
---
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-----
R
S
Y
D
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
---
L
E
T
A
L
P
YMT
D
G
R
Q
L
---
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
T
L
R
I
Y
L
R
Q
E
-
L
G
N
K
L
G
I
L
D
D
S
Q
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
79.11
28%
-88
- C3 -
1DD9
1
DNAG_ECOLI
A:
[20-333]
---------------------------------------------------------------------------------------------------------
T
---
L
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
QP
V
---
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
PGW
D
N
V
L
---
K
R
---
F
G
G
N
P
---
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-
R
S
Y
D
----
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
S
T
-
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
---
L
E
T
A
L
P
---
Y
M
T
D
G
R
Q
L
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
P
G
E
T
L
R
I
Y
L
R
Q
E
-
L
G
N
K
L
G
I
L
D
D
S
Q
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.64
32%
-89
- C3 -
3B39
1
DNAG_ECOLI
A:
[10-278]
--------------------------------------------------------------------------------------------------------------
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
--
Q
PV-
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
---
P
G
W
D
---
N
V
---
L
K
R
F
G
GN
P
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-
D
---
R
S
Y
D
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
---
D
G
R
Q
L
---
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
-
P
G
E
T
L
R
I
Y
L
R
Q
-
E
L
G
N
K
L
G
I
L
D
D
S
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
77.46
27%
-97
- C3 -
4EDK
7
DNAG_STAAU
A:
[1-321]
---------------------------------------------------------------------------------------------------
S
N
A
D
D
L
Q
---
M
I
E
M
H
E
L
I
Q
E
F
Y
Y
Y
A
L
T
--
K
TVE
G
E
Q
A
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
DSS
H
F
C
H
---
D
F
---
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
D
K
K
S
F
A
H
Y
K
V
S
I
L
-
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
K
S
S
I
L
Q
Q
K
A
I
N
D
-
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.28
32%
-89
- C3 -
1DD9
1
DNAG_ECOLI
A:
[22-290]
--------------------------------------------------------------------------------------------------------------
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
--
Q
PV-
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
---
P
G
W
D
---
N
V
---
L
K
R
F
G
GN
P
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-----
R
S
Y
D
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
-
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
---
D
G
R
Q
L
---
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
-
P
G
E
T
L
R
I
Y
L
R
Q
-
E
L
G
N
K
L
G
I
L
D
D
S
Q
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
75.67
32%
-91
- C3 -
3B39
1
DNAG_ECOLI
B:
[10-278]
--------------------------------------------------------------------------------------------------------------
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
--
Q
PV-
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
---
P
G
W
D
---
N
V
---
L
K
R
F
G
GN
P
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-
D
-
Q
G
R
S
Y
D
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
C
A
L
E
T
A
L
P
Y
M
T
---
D
G
R
Q
L
---
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
-
P
G
E
T
L
R
I
Y
L
R
Q
-
E
L
G
N
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.53
32%
-91
- C3 -
1DDE
4
DNAG_ECOLI
A:
[22-290]
--------------------------------------------------------------------------------------------------------------
Y
Q
L
M
D
G
L
N
T
F
Y
Q
Q
S
L
Q
--
Q
PV-
A
T
S
A
R
Q
Y
L
----
E
K
R
G
L
S
H
E
V
I
A
R
F
A
I
G
F
A
P
---
P
G
W
D
---
N
V
---
L
K
R
F
G
GN
P
E
N
R
Q
S
L
I
D
A
G
M
L
V
T
N
-----
R
S
Y
D
R
--
F
R
E
R
V
M
F
P
I
R
D
K
R
G
R
V
I
G
F
G
G
R
V
L
G
N
-
D
T
P
K
Y
L
N
S
P
E
T
D
I
F
H
K
G
R
Q
L
Y
G
L
Y
E
A
Q
Q
D
N
A
E
P
N
R
L
L
V
V
E
G
Y
M
D
V
V
A
L
A
Q
Y
G
I
N
Y
A
V
A
S
L
G
T
S
T
T
A
D
H
I
Q
L
L
F
R
A
T
N
N
V
I
C
C
Y
D
G
D
R
A
G
R
D
A
A
W
R
A
L
E
T
A
L
P
Y
M
T
---
D
G
R
Q
L
---
R
F
M
F
L
P
D
G
E
D
P
D
T
L
V
R
K
E
G
K
E
A
F
E
A
R
M
E
Q
-
A
M
P
L
S
A
F
L
F
N
S
L
M
P
Q
V
D
L
-
S
T
P
D
G
R
A
R
L
S
T
L
A
L
P
L
I
S
Q
V
-
P
G
E
T
L
R
I
Y
L
R
Q
-
E
L
G
N
K
L
G
I
L
D
D
S
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.99
93%
-121
- C3 -
4EHS
3
DNAG_HELPY
A:
[26-147]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
P
S
L
E
F
L
E
K
L
V
I
R
Y
L
L
E
D
R
S
L
L
D
L
A
V
G
Y
I
H
S
G
V
F
L
H
K
K
Q
E
F
D
A
L
C
Q
E
K
L
D
D
P
K
L
V
A
L
L
L
D
A
N
L
P
L
K
K
G
G
F
E
K
E
L
R
L
L
I
L
R
Y
F
E
R
Q
L
K
E
I
P
K
S
S
L
P
F
S
E
K
-
M
I
C
L
K
K
A
R
Q
A
I
M
K
L
K
Q
G
E
L
V
A
I
--
21
PsiBlast_CBE
69.71
93%
-122
- C3 -
4EHS
4
B:
[27-147]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
E
F
L
E
K
L
V
I
R
Y
L
L
E
D
R
S
L
L
D
L
A
V
G
Y
I
H
S
G
V
F
L
H
K
K
Q
E
F
D
A
L
C
Q
E
K
L
D
D
P
K
L
V
A
L
L
L
D
A
N
L
P
L
K
K
G
G
F
E
K
E
L
R
L
L
I
L
R
Y
F
E
R
Q
L
K
E
I
P
K
S
S
L
P
F
S
E
K
-
M
I
C
L
K
K
A
R
Q
A
I
M
K
L
K
Q
G
E
L
V
A
I
--
53
Fugue
68.22
90%
-111
- C3 -
4EHS
3
DNAG_HELPY
A:
[26-149]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
P
S
L
E
F
L
E
K
L
V
I
R
Y
L
L
E
D
R
S
L
L
D
L
A
V
G
Y
I
H
S
G
V
F
L
H
K
K
Q
E
F
D
A
L
C
Q
E
K
L
D
D
P
K
L
V
A
L
L
L
D
A
N
L
P
L
K
K
G
G
F
E
K
E
L
R
L
L
I
L
R
Y
F
E
R
Q
L
K
E
I
P
K
S
S
L
P
F
S
E
K
M
I
C
L
K
K
A
R
Q
A
I
M
-
K
L
K
Q
G
E
L
V
A
I
L
E
7
PsiBlast_PDB
67.84
32%
-91
- C3 -
4E2K
1
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
--
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.81
32%
-86
- C3 -
4EDT
3
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.75
32%
-88
- C3 -
4EDV
4
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.69
32%
-87
- C3 -
4EE1
4
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.55
32%
-86
- C3 -
4EDR
6
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.46
32%
-86
- C3 -
4EDK
6
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.42
32%
-86
- C3 -
4EDG
5
DNAG_STAAU
A:
[33-253]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
Y
L
----
Q
E
R
G
F
T
D
A
L
I
K
E
R
G
I
G
F
A
P
---
D
S
S
H
---
F
C
H
D
F
L
Q
K
K
G
---
Y
D
I
E
L
A
Y
E
A
G
L
L
S
R
N
-
E
E
N
F
S
Y
Y
D
R
--
F
R
N
R
I
M
F
P
L
K
N
A
Q
G
R
I
V
G
Y
S
G
R
T
Y
T
G
-
Q
E
P
K
Y
L
N
S
P
E
T
P
I
F
Q
K
R
K
L
L
Y
N
L
D
K
A
R
K
S
I
R
K
L
D
E
I
V
L
L
E
G
F
M
D
V
I
K
S
D
T
A
G
L
K
N
V
V
A
T
M
G
T
Q
L
S
D
E
H
I
T
F
I
R
K
L
T
S
N
I
T
L
M
F
D
G
D
F
A
G
S
E
A
T
L
K
T
---
G
Q
H
L
L
Q
---
Q
G
L
N
V
---
F
V
I
Q
L
P
S
G
M
D
P
D
E
Y
I
G
K
Y
G
N
D
A
F
T
T
F
V
K
N
-
D
K
K
S
F
A
H
Y
K
V
S
I
L
K
D
E
I
A
-
H
N
D
L
S
Y
E
R
Y
L
K
E
L
S
H
D
I
S
L
M
-
K
S
S
I
L
Q
Q
K
A
I
N
-
D
V
A
P
F
F
N
V
S
P
E
Q
L
A
N
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
59.61
19%
-76
- C2 -
4WW4
1
?
A:
[3-458]
--------------
Q
I
S
E
V
R
G
N
T
R
D
H
R
T
A
A
H
T
H
I
K
G
L
G
L
N
S
S
G
I
A
E
---
K
Q
A
A
G
F
V
---
G
Q
C
A
A
R
E
A
C
G
V
V
V
D
L
I
K
A
----------
H
K
M
A
-----
G
R
G
V
L
L
A
G
G
P
GTG
K
T
A
L
A
L
A
I
S
Q
E
L
G
T
K
I
P
--
F
---
C
P
I
T
G
S
E
I
YSTE
V
K
K
T
E
V
L
M
E
N
F
R
R
A
I
G
L
R
V
---
R
E
T
K
---
D
V
---
Y
E
--
G
---
E
V
S
T
L
L
I
G
L
K
S
A
R
G
Q
-
K
L
D
Q
K
E
R
V
Q
--
V
G
D
V
I
Y
I
E
T
N
T
G
A
C
R
S
D
A
Y
A
-
T
E
F
D
L
-
E
A
E
E
Y
V
P
I
P
K
G
E
V
---------------
H
K
K
K
E
I
V
Q
D
V
T
L
H
D
L
D
V
A
N
A
R
----
P
D
I
I
S
M
M
G
Q
L
M
K
P
K
M
T
E
I
T
D
K
L
R
M
E
I
N
K
V
V
Q
K
Y
I
N
Q
G
V
A
E
L
I
P
--------------------
G
V
L
F
I
D
E
----
A
H
M
L
D
I
E
C
F
T
Y
L
N
K
A
L
E
S
-
P
I
A
P
I
V
V
L
A
S
N
R
G
I
A
T
I
R
G
A
D
D
L
K
A
A
H
G
I
--
P
P
D
F
L
Q
R
L
-
L
I
I
P
T
H
P
Y
E
P
D
E
I
R
R
I
V
R
I
R
A
Q
T
E
G
V
Q
--------------------------------
L
T
D
A
A
V
D
R
V
A
E
H
G
V
R
I
S
L
R
Y
C
L
---------------------------
Q
L
L
A
P
A
S
I
L
A
R
V
N
G
R
----------------
T
Q
V
D
V
Q
D
I
A
E
A
E
E
-
L
-
F
L
D
A
R
R
S
A
N
I
L
T
S
T
G
G
L
H
----