@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0119: (2015-12-12 )
MKRILFFLAATTFLLRAETASATINTTVDPNVMFSESSTGNVKKDRKRVLKSMVDLEKERVKNFNQYSETKMSKGDLSAFGAFFKGSLEDCVEQKICYYEHRNGKVSFVVNDREKFYKHVLKDLGTELSLPLFNWLYKGSDFGALHEQFGDMYDGYIKYLISMVRVSQKEKARKVDAIVLKKMEEQAEKDTKAAFQKRSSGELESHTDSPEFISSSKTQNSSNPDLDPMTNANTLKETASKEPETSSKKEKKPKKKRRLSKKEKQQQALQQEFEKQISDSSKSEK
Atome Classification :
(20 SA)
-------------------------------.........10........20.......---.30........40.....------...50........60........70........80......--..90......--..100.......110.......-120....-...--130--.----........140.......150.......160.......170.......180--.......190....-----...200.......210--.......----.220......-.230.......240....-...250.......260-..----......270.......280...--------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------M
K
R
I
L
F
F
L
A
A
T
T
F
L
L
R
AETAS
A
T
I
NTTV---DP
N
V
M
FSESSTGN
V
K
K
D
R
------
K
R
V
L
K
S
M
V
D
L
E
K
E
R
V
KN
F
N
Q
Y
S
ETKMSKG
D
L
S
A
F
G
A
F
F
K
G
S
--
L
E
D
C
V
E
Q
K
I
C
--
Y
Y
EHRN
G
K
V
S
F
V
VN
D
R
E
K
F
Y
K
H
-
V
L
K
DLGT-ELS--
L
----
P
----
L
F
N
W
L
YKGSD
F
G
A
L
H
E
Q
F
G
D
M
Y
D
G
Y
I
K
Y
L
I
S
M
V
R
V
S
Q
K
E
K
A
R
K
V
D
A
I
V
L
K
K
--
M
E
E
Q
A
E
K
D
T
K
A
A
F
Q
-----KRSSGELESHTDS
P
E
---
F
ISSSKT----QNSSNPDLDP-MTN
A
N
T
L
K
E
T
ASKEPETS-
S
K
K
EKK
P
K
K
K
R
R
L
S
K
--
K
E
----
K
Q
Q
Q
A
L
Q
Q
E
F
E
K
Q
ISDSSKSEK--------------------------------------
20
PsiBlast_PDB
72.11
21%
20
- C4 -
1MH3
-
MALE_ECOLI
A:
[192-504]
-----------------------------------------------------------------------------------------
L
T
F
L
V
D
L
----
I
K
N
K
H
M
N
A
D
T
D
Y
S
I
A
E
----
A
A
F
N
K
G
E
--
T
A
M
T
I
N
G
P
W
A
--
W
S
N
I
D
T
S
K
V
N
Y
G
V
T
---------
V
L
P
T
F
K
G
-
Q
P
S
--
K
----
P
----
F
V
G
V
L
S
A
G
I
N
A
A
S
P
N
K
E
L
A
K
E
F
--
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
K
S
--
Y
E
E
E
L
A
K
D
P
R
I
A
A
T
-----
M
E
N
A
Q
K
G
E
I
M
P
N
I
P
Q
M
S
A
F
W
Y
A
V
R
T
A
V
I
N
A
A
S
G
R
Q
T
V
D
A
-
A
L
A
A
A
Q
T
A
A
A
A
A
I
S
P
Q
A
R
-
A
F
L
E
Q
V
F
R
R
K
Q
S
L
N
S
--
K
E
----
K
E
E
V
A
K
K
C
G
I
T
P
L
Q
V
R
V
W
F
I
N
K
--------------------------------------
45
Fugue
57.64
17%
31
- C3 -
1W3B
-
OGT1_HUMAN
B:
[1-388]
GPMELAHREYQAGDFEAAERHCMQLWRQEPD
N
T
G
V
L
L
L
L
S
S
I
H
F
Q
C
R
R
L
D
R
S
A
H
F
S
T
L
A
IKQ
N
P
L
L
A
E
A
Y
S
N
L
G
N
V
Y
K
E
R
GQLQEA
I
E
H
Y
R
H
A
L
R
L
K
P
D
F
I
D
G
Y
I
N
L
A
A
A
L
V
A
A
G
D
M
E
G
A
V
Q
A
Y
V
S
A
--
L
Q
Y
--
N
P
D
L
Y
--
C
V
R
S
D
L
G
N
L
L
K
A
L
G
R
L
E
E
A
K
A
C
-
Y
L
K
A
I
E
T
-
Q
P
---------------
N
F
A
V
A
W
S
N
L
G
C
V
F
N
A
Q
G
E
I
W
L
A
I
H
H
F
E
K
A
V
T
L
D
P
N
F
L
D
A
Y
I
N
L
G
N
V
L
K
E
AR
I
F
D
R
A
V
A
A
Y
L
R
A
L
S
LSPNH
A
V
V
H
G
N
L
A
C
V
Y
Y
E
Q
G
---
L
I
D
L
A
I
D
----
T
Y
R
R
A
I
E
L
Q
P
H
F
P
D
A
Y
C
N
L
A
N
A
L
K
E
K
G
S
V
-
A
E
A
E
D
C
Y
N
T
A
L
R
L
C
P
--
T
H
ADSY
R
K
A
L
E
V
F
P
E
F
A
A
A
H
S
N
L
A
S
V
L
Q
QQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD
48
Fugue
52.07
9%
26
- C2 -
1AQU
2
ST1E1_MOUSE
A:
[9-296]
-----------------------------E
Y
Y
E
V
F
G
E
F
R
G
V
L
M
D
K
R
F
T
K
Y
W
E
D
V
E
M
F
L
A
---
R
P
D
D
L
V
I
A
T
Y
P
K
S
G
T
T
W
I
------
S
E
V
V
Y
M
I
Y
K
E
G
D
A
I
F
N
R
I
P
Y
L
E
C
R
N
E
D
L
I
N
G
I
K
Q
L
K
E
K
E
S
P
R
I
V
K
T
H
L
P
P
K
L
L
PA
S
F
W
E
K
N
C
K
M
I
Y
L
C
R
N
A
K
D
V
A
V
S
-
Y
Y
Y
F
L
L
M
-
I
T
S
--
Y
----
P
----------
N
P
K
S
F
S
E
F
V
E
K
F
M
Q
G
Q
V
P
Y
G
S
W
Y
D
H
V
K
A
W
W
E
K
S
K
N
S
R
V
L
F
M
F
Y
E
D
--
M
K
E
D
I
R
R
E
V
V
K
L
I
E
-----
F
-----
L
E
R
K
P
S
A
E
L
---
V
D
R
I
I
Q
H
----
T
S
F
Q
E
M
K
N
N
P
-
S
T
N
Y
T
M
M
P
E
E
M
M
N
Q
K
V
S
P
-
F
M
R
K
G
I
I
G
D
W
K
N
-
H
F
--
P
E
----
A
L
R
E
R
F
D
E
H
Y
K
Q
Q
M
K
D
C
T
V
K
F
R
ME------------------------------------
15
PsiBlast_PDB
47.79
26%
-68
- C4 -
1QGH
1
DPS_LISIN
A:
[8-53]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
E
F
L
N
H
-
Q
V
A
N
L
N
V
F
T
V
K
--
I
----
H
----
Q
I
H
W
Y
M
R
G
H
N
F
F
T
L
H
E
K
M
D
D
L
Y
S
E
F
G
E
Q
M
D
E
V
A
E
R
L
L
A
I
G
G
S
P
F
S
T
L
K
E
F
L
--
E
N
A
S
V
E
E
A
P
Y
T
K
P
K
-----
T
M
D
Q
L
M
E
D
L
V
G
T
L
E
L
---
L
R
D
E
Y
K
Q
----
G
I
E
L
T
D
K
E
G
D
-
D
V
T
N
D
M
L
I
A
F
K
A
S
I
D
K
H
I
-
W
M
F
K
A
F
L
G
K
A
P
L
E
----------------------------------------------------------------------
16
PsiBlast_PDB
47.04
26%
-66
- C4 -
2IY4
1
DPS_LISMO
A:
[8-53]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
E
F
L
N
H
-
Q
V
A
N
L
N
V
F
T
V
K
--
I
----
H
----
Q
I
H
W
Y
M
R
G
H
N
F
F
T
L
H
E
K
M
D
D
L
Y
S
E
F
G
E
Q
M
D
E
V
A
E
R
L
L
A
I
G
G
S
P
F
S
T
L
K
E
F
L
--
E
N
A
S
V
E
E
A
P
Y
T
K
P
K
-----
T
M
D
Q
L
M
E
D
L
V
G
T
L
E
L
---
L
R
D
E
Y
Q
Q
----
G
I
E
L
T
D
K
E
G
D
-
N
V
T
N
D
M
L
I
A
F
K
A
S
I
D
K
H
I
-
W
M
F
K
A
F
L
G
K
A
P
L
E
----------------------------------------------------------------------
37
HHSearch
46.42
18%
-49
- C4 -
2YJK
1
?
A:
[17-69]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
A
A
A
A
Q
F
-
L
T
P
V
V
H
K
-
M
Q
A
--
L
----
V
V
N
G
K
Q
A
H
W
N
V
R
G
S
N
F
I
A
I
H
E
L
L
D
S
V
V
A
H
A
Q
D
Y
A
D
T
A
A
E
R
I
V
A
L
G
L
P
I
D
S
R
V
S
T
M
A
--
E
K
T
S
T
A
V
P
A
G
F
A
Q
W
-----
Q
D
E
I
K
A
I
V
S
D
I
D
A
A
L
---
V
D
L
Q
A
A
I
----
D
G
L
D
E
V
D
L
T
S
-
Q
D
V
A
I
E
I
K
R
G
V
D
K
D
R
W
F
L
-
L
A
H
L
A
E
-----------------------------------------------------------------------------
17
PsiBlast_PDB
45.78
26%
-61
- C4 -
2BK6
-
DPS_LISIN
A:
[8-53]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
K
E
F
L
N
H
-
Q
V
A
N
L
N
V
F
T
V
K
--
I
----
H
----
Q
I
G
W
Y
M
R
G
H
N
F
F
T
L
H
E
K
M
D
D
L
Y
S
E
F
G
E
Q
M
D
E
V
A
E
R
L
L
A
I
G
G
S
P
F
S
T
L
K
E
F
L
--
E
N
A
S
V
E
E
A
P
Y
T
K
P
K
-----
T
M
D
Q
L
M
E
D
L
V
G
T
L
E
L
---
L
R
D
E
Y
K
Q
----
G
I
E
L
T
D
K
E
G
D
-
D
V
T
N
D
M
L
I
A
F
K
A
S
I
D
K
H
I
-
W
M
F
K
A
F
L
G
K
A
P
L
E
----------------------------------------------------------------------
35
HHSearch
45.26
26%
-35
- C4 -
2C2J
-
DPS2_DEIRA
A:
[42-95]
---------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
D
L
K
K
S
V
Q
A
-
L
Q
N
T
L
T
E
-
L
Q
A
--
L
----
Q
L
Q
T
K
Q
A
H
W
N
V
S
G
T
L
W
Y
T
L
H
E
L
L
Q
D
H
Y
E
G
I
S
K
F
A
D
D
V
A
E
R
Q
L
S
V
G
A
S
S
D
G
R
A
I
T
I
V
--
A
A
S
R
L
P
E
I
P
G
G
F
L
D
-----
D
A
Q
V
I
Q
F
F
T
Y
Q
Y
E
T
V
---
G
Q
R
I
H
Q
R
----
V
G
D
V
E
K
V
D
P
T
-
T
A
N
L
L
Q
E
V
E
H
I
I
E
K
Y
Q
W
Q
-
M
R
A
F
L
Q
N
T
P
T
D
P
N
T
G
--
F
D
----
I
N
N
G
K
P
V
P
----------------------------------------------------
47
Fugue
43.59
9%
37
- C1 -
3C2B
2
?
A:
[14-216]
------------------------------S
P
R
Q
N
A
V
L
D
Q
A
L
R
L
L
V
E
G
G
E
K
A
L
--------------------------------------
T
T
S
G
L
A
R
A
A
----------
N
C
S
K
E
S
L
Y
K
W
F
---------------------------------
G
D
R
D
G
L
L
A
A
M
I
T
F
Q
Q
S
K
-
V
R
T
--
F
----
E
----
K
A
G
---
D
R
V
S
A
P
Q
L
A
D
H
L
E
V
F
A
H
D
L
L
D
V
L
-------
A
G
D
V
S
L
A
L
N
R
L
A
I
G
Q
--
A
S
R
K
L
G
D
L
L
L
E
R
-----------
G
R
R
Q
I
D
R
R
A
R
G
---
L
I
E
A
G
R
R
----
S
G
Y
L
R
F
D
-
D
A
-
E
E
A
Y
R
S
F
Y
G
L
I
V
S
D
L
H
V
R
M
L
L
G
E
A
P
D
K
D
-----
F
--
S
A
----
R
A
K
K
A
V
V
A
F
L
T
L
Y
G
T
E
K
V
H
S
E
L
G
G------------------------------------
14
PsiBlast_PDB
43.59
27%
80
- C4 -
4ZUZ
-
?
A:
[732-840]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
T
K
L
D
E
I
I
S
L
E
--
M
E
E
Q
F
Q
K
I
Q
D
P
A
V
Q
-----
Q
I
V
R
-
D
L
P
S
H
C
H
N
D
E
---
A
I
E
F
F
K
T
-----------
L
N
P
-
E
E
A
A
K
V
A
S
Y
L
S
L
E
Y
R
E
I
N
-
K
S
T
D
K
K
T
L
L
E
Q
D
I
P
R
L
F
K
E
----
V
N
T
Q
L
L
S
K
L
K
E
E
K
A
I
D
E
Q
V
H
E
K
--------------------------------------
28
HHSearch
41.36
22%
-32
- C4 -
1O9R
1
DPS_AGRFC
A:
[13-61]
----------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
K
S
T
V
I
G
I
-
L
N
E
S
L
A
S
-
V
I
D
--
L
A
L
V
T
K
----
Q
A
H
W
N
L
K
G
P
Q
F
I
A
V
H
E
L
L
D
T
F
R
T
Q
L
D
N
H
G
D
T
I
A
E
R
V
V
Q
L
G
G
T
A
L
G
S
L
Q
A
V
S
--
S
T
T
K
L
K
A
Y
P
T
D
I
Y
K
-----
I
H
D
H
L
D
A
L
I
E
R
Y
G
E
V
---
A
N
M
I
R
K
A
----
I
D
D
S
D
E
A
G
D
P
-
T
T
A
D
I
F
T
A
A
S
R
D
L
D
K
S
L
W
-
F
L
E
A
H
V
Q
E
K
S
-------------------------------------------------------------------------
27
HHSearch
40.88
22%
-33
- C4 -
3KWO
8
DPS_CAMJE
A:
[2-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
M
S
V
T
K
Q
-
L
L
Q
M
Q
A
D
-
A
H
H
--
L
W
V
K
F
H
----
N
Y
H
W
N
V
K
G
L
Q
F
F
S
I
H
E
Y
T
E
K
A
Y
E
E
M
A
E
L
F
D
S
C
A
E
R
V
L
Q
L
G
E
K
A
I
T
C
Q
K
V
L
M
--
E
N
A
K
S
P
K
V
A
K
D
C
F
T
-----
P
L
E
V
I
E
L
I
K
Q
D
Y
E
Y
L
---
L
A
E
F
K
K
L
----
N
E
A
A
E
K
E
S
D
T
-
T
T
A
A
F
A
Q
E
N
I
A
K
Y
E
K
S
L
W
-
M
I
G
A
T
L
Q
G
A
C
-------------------------------------------------------------------------
29
HHSearch
40.71
20%
-35
- C4 -
2YW6
-
DPS_MYCSM
A:
[12-60]
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
A
S
D
V
A
D
L
-
L
Q
K
Q
L
S
T
-
Y
N
D
--
L
----
H
L
T
L
K
H
V
H
W
N
V
V
G
P
N
F
I
G
V
H
E
M
I
D
P
Q
V
E
L
V
R
G
Y
A
D
E
V
A
E
R
I
A
T
L
G
K
S
P
K
G
T
P
G
A
I
I
--
K
D
R
T
W
D
D
Y
S
V
E
R
D
T
-----
V
Q
A
H
L
A
A
L
D
L
V
Y
N
G
V
---
I
E
D
T
R
K
S
----
I
E
K
L
E
D
L
D
L
V
-
S
Q
D
L
L
I
A
H
A
G
E
L
E
K
F
Q
W
F
-
V
R
A
H
L
E
S
----------------------------------------------------------------------------
1
PsiBlast_PDB
39.64
37%
-12
- C4 -
4ABN
1
TTC5_MOUSE
A:
[125-167]
----------------------------------------------------------------------------------------
L
L
S
K
A
V
K
L
E
P
E
L
V
E
A
W
N
Q
L
G
E
V
Y
W
K
K
G
D
V
T
S
A
H
T
C
F
S
G
A
--
L
T
H
C
K
N
K
V
S
L
--
Q
N
L
S
M
V
L
R
Q
L
Q
T
D
S
G
D
E
H
S
R
H
V
-
M
D
S
V
R
Q
A
-
K
L
A
--
V
----
Q
----
M
D
V
L
D
G
R
S
W
Y
I
L
G
N
A
Y
L
S
L
Y
F
N
T
G
Q
N
P
K
I
S
Q
Q
A
L
S
A
Y
A
Q
A
E
K
V
D
R
K
A
S
S
N
P
--
D
L
H
L
N
R
A
T
L
H
K
Y
E
E
-----
S
Y
G
E
A
L
E
G
F
S
Q
A
A
A
L
---
D
P
A
W
P
E
P
----
Q
Q
R
E
Q
Q
L
L
E
F
-
L
S
R
L
T
S
L
L
E
S
K
G
K
T
K
P
K
K
-
L
Q
S
M
L
G
S
L
R
P
A
H
L
G
P
--
Y
Q
----
S
A
Q
K
M
T
L
E
L
K
P
L
S
T
L
Q
P
G
V
N
S
G
--------------------------------------
21
PsiBlast_CBE
38.85
48%
-13
- C4 -
2CHP
1
MRGA_BACSU
D:
[31-55]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
H
----
R
F
H
W
Y
V
K
G
P
H
F
F
T
L
H
E
K
F
E
E
L
Y
D
H
A
A
E
T
V
D
T
I
A
E
R
L
L
A
I
G
G
Q
P
V
A
T
V
K
E
Y
T
--
E
H
A
S
I
T
D
G
G
N
E
T
S
A
-----
S
E
M
V
Q
A
L
V
N
D
Y
K
Q
I
S
---
S
E
S
K
F
V
I
----
G
L
A
E
E
N
Q
D
N
A
-
T
A
D
L
F
V
G
L
I
E
E
V
E
K
Q
V
W
M
-
L
S
S
Y
L
G
-----------------------------------------------------------------------------
22
PsiBlast_CBE
38.51
48%
0
- C4 -
2CHP
1
MRGA_BACSU
B:
[31-55]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
H
----
R
F
H
W
Y
V
K
G
P
H
F
F
T
L
H
E
K
F
E
E
L
Y
D
H
A
A
E
T
V
D
T
I
A
E
R
L
L
A
I
G
G
Q
P
V
A
T
V
K
E
Y
T
--
E
H
A
S
I
T
D
G
G
N
E
T
S
A
-----
S
E
M
V
Q
A
L
V
N
D
Y
K
Q
I
S
---
S
E
S
K
F
V
I
----
G
L
A
E
E
N
Q
D
N
A
-
T
A
D
L
F
V
G
L
I
E
E
V
E
K
Q
V
W
M
-
L
S
S
Y
L
G
-----------------------------------------------------------------------------
39
Fugue
38.28
16%
123
- C4 -
3CL3
-
NEMO_HUMAN
D:
[193-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
H
S
-
V
Q
V
D
Q
L
R
M
Q
G
Q
S
V
E
A
A
L
R
-
M
E
R
Q
A
A
S
E
E
K
R
K
L
A
Q
--
L
Q
----
V
A
Y
H
Q
L
F
Q
E
Y
D
N
H
I
K
S
S
V
V
G
----------------------------------------
46
Fugue
38.22
16%
141
- C4 -
4PKY
2
TACC3_MOUSE
B:
[2-50]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
V
L
A
L
Q
A
S
L
R
-
K
A
Q
M
Q
N
H
S
L
E
M
T
L
E
Q
--
K
T
----
K
E
I
D
E
L
T
R
I
C
D
D
L
I
S
K
M
E
K
I
----------------------------------------
2
PsiBlast_PDB
37.91
48%
-10
- C4 -
2CHP
1
MRGA_BACSU
A:
[31-55]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
----
H
----
R
F
H
W
Y
V
K
G
P
H
F
F
T
L
H
E
K
F
E
E
L
Y
D
H
A
A
E
T
V
D
T
I
A
E
R
L
L
A
I
G
G
Q
P
V
A
T
V
K
E
Y
T
--
E
H
A
S
I
T
D
G
G
N
E
T
S
A
-----
S
E
M
V
Q
A
L
V
N
D
Y
K
Q
I
S
---
S
E
S
K
F
V
I
----
G
L
A
E
E
N
Q
D
N
A
-
T
A
D
L
F
V
G
L
I
E
E
V
E
K
Q
V
W
M
-
L
S
S
Y
L
G
-----------------------------------------------------------------------------
31
HHSearch
37.39
21%
-53
- C4 -
1YZ7
-
IF2A_PYRAB
A:
[104-143]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
L
K
L
-
A
A
E
K
L
G
K
-
D
F
E
T
A
W
----
R
----
E
V
W
V
--------
P
L
E
E
E
W
G
E
V
Y
A
A
F
E
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------