@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0162: (2015-12-13 )
MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAERFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVRKSYLDAGGDLKGSKGVPFEFLQESIKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI
Atome Classification :
(25 SA)
---.........10........20........30........40........50.....--...60......-...70........80...-----------.....90........100.......110.......120.......130.......140.......150.......160......-.170.......180.......-190.......200-.......210.....-..220.......230.......240.......250.......260.......270...-....280.......290.......300.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MLVKG
N
E
I
L
L
K
AHKEGYGVG
A
F
N
F
V
N
F
E
M
L
N
A
I
F
EAGNEENS
P
L
F
I
QASEG
A
I
K
Y
M--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
RYPHI
P
V
A
L
H
LDHG-----------T
T
F
E
S
C
E
K
A
V
K
AGF
T
S
V
M
I
DAS
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
HNAG
V
S
V
E
A
E
L
G
R
L
MGIEDNISVDEK
D
A
V
L
V
N
P
K
E
A
E
R
F
V
K
E
SQ-V
D
Y
LAPAIGTSHG
A
F
K
FKGEP-KL
D
F
E
R
L
Q
E
V
K
R
L-TNI
P
L
V
L
HGASAI
P
D
-
D
V
R
K
S
Y
L
DAGGDLKGSKGV
P
F
E
F
L
Q
E
S
I
KGGINKVNTDT
D
L
R
I
A
F
I
A
E
V
R
K
V
A
NED
K
S
-
Q
F
D
L
R
K
FF
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
LLGSANKI-
22
PsiBlast_CBE
99.33
99%
-98
- C5 -
3N9R
14
?
Z:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
4
PsiBlast_PDB
99.30
99%
-99
- C5 -
3N9R
4
?
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
26
PsiBlast_CBE
99.02
99%
-98
- C5 -
3N9R
4
?
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
24
PsiBlast_CBE
98.96
99%
-100
- C5 -
3N9R
4
?
P:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
23
PsiBlast_CBE
98.65
99%
-97
- C5 -
3N9R
2
?
U:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
1
PsiBlast_PDB
98.59
99%
-100
- C5 -
3C4U
2
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
3
PsiBlast_PDB
98.47
99%
-94
- C5 -
3C56
3
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
2
PsiBlast_PDB
98.42
99%
-96
- C5 -
3C52
4
ALF_HELPY
A:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-----------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
28
PsiBlast_CBE
98.35
99%
-99
- C5 -
3C4U
2
ALF_HELPY
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
25
PsiBlast_CBE
98.14
99%
-96
- C5 -
3N9R
4
?
K:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
21
PsiBlast_CBE
98.13
99%
-94
- C5 -
3N9S
5
?
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
------------
A
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
27
PsiBlast_CBE
98.07
99%
-95
- C5 -
3C56
3
ALF_HELPY
B:
[1-307]
---
M
L
V
K
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
--
G
I
D
M
-
A
V
G
M
V
K
-
I
M
C
E
R
Y
P
H
I
P
V
A
L
H
L
D
H
G
-----------
T
T
F
E
S
C
E
K
A
V
K
A
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
-------------
V
L
V
N
P
K
E
A
E
Q
F
V
K
E
S
Q
-
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
K
G
E
P
-
K
L
D
F
E
R
L
Q
E
V
K
R
L
-
T
N
I
P
L
V
L
H
G
A
S
A
I
P
D
-
N
V
R
K
S
Y
L
D
A
G
G
D
L
K
G
S
K
G
V
P
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
D
K
S
-
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
7
PsiBlast_PDB
79.28
50%
-77
- C5 -
2FJK
1
ALF_THECA
A:
[2-304]
----
L
V
T
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
R
A
L
-
T
R
M
V
V
A
-
L
A
Q
E
--
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
K
A
L
R
E
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
-
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
-
F
I
D
H
P
R
L
A
R
I
A
K
L
-
V
P
A
P
L
V
L
H
G
A
S
A
V
P
Q
-
E
L
V
E
R
F
R
A
A
G
G
E
I
G
E
A
S
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
L
G
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
10
PsiBlast_PDB
79.11
42%
-93
- C5 -
2ISW
2
?
A:
[3-304]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
-
L
K
K
L
C
E
-
A
A
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
-
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
---
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
-
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
9
PsiBlast_PDB
79.00
42%
-95
- C5 -
2ISV
2
?
A:
[3-304]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
-
L
K
K
L
C
E
-
A
A
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
-----------------
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
-
V
D
A
L
A
V
A
I
G
T
S
H
G
A
--------
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
-
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
50
HHSearch
78.85
42%
-89
- C5 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
-
M
I
Y
L
K
K
L
C
E
-
A
A
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
-
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
K
S
---
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
-
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
49
HHSearch
78.84
51%
-79
- C5 -
1RVG
8
?
A:
[1-305]
---
M
L
V
T
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
G
--
G
-
R
A
-
L
T
L
M
A
V
-
E
L
A
K
-
E
A
R
V
P
V
A
V
H
L
D
H
G
-----------
S
S
Y
E
S
V
L
R
A
L
R
A
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
------
K
D
A
L
L
T
N
P
E
E
A
R
I
F
M
E
R
T
G
-
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
K
G
R
P
-
F
I
D
H
A
R
L
E
R
I
A
R
L
-
V
P
A
P
L
V
L
H
G
A
S
A
V
P
P
-
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
E
D
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
A
L
N
K
N
P
K
-
E
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
13
PsiBlast_PDB
78.08
38%
-97
- C5 -
1GVF
11
KBAY_ECOLI
A:
[3-284]
----
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
L
E
E
-
I
Y
A
L
C
S
-
A
Y
S
T
T
Y
-
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
-
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
K
T
P
-
K
I
D
F
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
A
S
D
V
P
D
----------------------
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
8
PsiBlast_PDB
77.89
42%
-95
- C5 -
3GAK
4
?
A:
[7-304]
--------
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
-
L
K
K
L
C
E
-
A
A
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
G
V
S
V
E
A
E
L
G
------------------
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
-
V
D
A
L
A
V
A
I
---------------
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
-
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
36
PsiBlast_CBE
77.53
42%
-90
- C5 -
2ISV
2
?
B:
[3-304]
----
L
C
T
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
--
D
M
I
Y
-
L
K
K
L
C
E
-
A
A
L
E
K
H
P
D
I
P
I
C
I
H
L
D
H
G
-----------
D
T
L
E
S
V
K
M
A
I
D
L
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
------------
Q
N
T
V
Q
L
T
E
P
Q
D
A
K
K
F
V
E
L
T
G
-
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
----I
R
L
A
I
D
R
V
K
T
I
S
D
L
-
T
G
I
P
L
V
M
H
G
S
S
S
V
P
K
-
D
V
K
D
M
I
N
K
Y
G
G
K
M
P
D
A
V
G
V
P
I
E
S
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
-
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
38
PsiBlast_CBE
77.52
38%
-96
- C5 -
1GVF
12
KBAY_ECOLI
B:
[3-284]
----
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
L
E
E
-
I
Y
A
L
C
S
-
A
Y
S
T
T
Y
-
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
--------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
-
V
D
S
L
A
V
A
I
G
T
A
H
G
L
--
Y
S
K
T
P
-
K
I
D
F
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
A
S
D
V
P
D
----------------------
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
51
HHSearch
77.10
41%
-93
* C5 *
1GVF
11
KBAY_ECOLI
A:
[2-284]
---
S
I
I
S
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
--
A
-
L
E
E
I
Y
A
L
C
S
-
A
Y
S
T
-
T
Y
N
M
P
L
A
L
H
L
D
H
H
-----------
E
S
L
D
D
I
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------
S
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
G
-
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
K
--
T
P
-
K
I
D
F
Q
R
L
A
E
I
R
E
V
-
V
D
V
P
L
V
L
H
G
A
S
D
V
P
----------------------
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
Q
-
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
41
Fugue
75.71
42%
-91
- C5 -
1GVF
11
KBAY_ECOLI
A:
[2-285]
SII
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
--
H
I
A
L
E
E
-
I
Y
A
L
C
S
-
A
Y
S
T
T
-
Y
N
M
P
L
A
L
H
L
D
H
H
ES
L
D
D
I
R
R
K
V
H
A
-----------
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
S
-----------
A
F
L
T
D
P
Q
E
A
K
R
F
V
E
L
T
-G
V
D
S
L
A
V
A
I
G
T
A
H
G
--
L
Y
S
K
T
P
-
K
I
D
F
Q
R
L
A
E
I
R
E
V
V-
D
V
P
L
V
L
H
G
A
S
----------------------
D
V
P
D
E
F
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
-Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
11
PsiBlast_PDB
74.37
44%
-83
- C5 -
4TO8
2
?
A:
[3-284]
----
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S-
G
F
Y
T
-
I
V
K
M
V
E
G
L
M
H
D
L
N
I
T
I
P
V
A
I
H
L
D
H
G
-----------
S
S
F
E
K
C
K
E
A
I
D
A
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
A
D
--
G
I
I
Y
A
D
P
K
E
C
Q
E
L
V
E
K
T
G
-
I
D
A
L
A
P
A
L
G
S
V
H
G
-------
P
-
K
L
G
F
K
E
M
E
E
I
G
L
S
-
T
G
L
P
L
V
L
H
G
G
T
G
I
P
T
K
D
I
Q
K
A
-------------
I
P
F
---------
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
L
N
N
D
K
E
-
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
-
37
PsiBlast_CBE
74.15
44%
-82
- C5 -
4TO8
2
?
B:
[3-284]
----
L
V
S
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
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-----------
S
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