@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0591: (2015-12-16 )
MIKKCLFPAAGYGTRFLPITKTIPKEMLPIVDKPLIQYAVEEAMEAGCEVMAIVTGRNKRSLEDYFDTSYEIEHQIQGTNKENALKSIRNIIEKCCFSYVRQKQMKGLGHAILTGEALIGNEPFAVILADDLCISHEYPSVLKQMTSLYQKYQCSIVAIEEVVLEEVSKYGVIRGEWLEERVYEIKDMVEKPSQEDAPSNLAVIGRYILTPDIFDILRETKPGKNNEIQITDALLTQAKRKRIIAYQFKGKRYDCGSVEGYIEASNAYYKKRL
Atome Classification :
(20 SA)
.........10........20........30........40.......-.50........-60........70........80.-.......90........100.......110.......120...--......130.......140.......150-.......160.......170--.......180--.........190.......200.......210.......220.......230.---......-240......--.--250.......260.......270.-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
K
K
CLFPAAGYG
T
R
F
L
P
I
T
K
TI
P
K
E
M
L
P
IV
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
AGC-
E
V
M
A
I
V
TGRNK-R
S
L
E
D
YFDTS
Y
E
I
E
H
Q
IQGT
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
GLG
H
A
ILTGEALIG--NE
P
--
F
A
V
I
L
AD
D
L
CIS
H
E
Y
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y-Q
C
S
I
V
A
I
E
E
V
V
L
E
E
V
S
KYGV--
I
R
G
E
W
L
E
E
----
R
V
Y
E
I
K
D
M
V
EKPSQEDAPS
N
L
A
V
I
G
R
Y
IL
T
P
D
I
F
D
I
L
R
ETKPGKNN
E
I
Q
I
T
D
A
---
L
L
T
Q
A
K-RK
R
I
I
A
Y
Q
F--K--GKRYDCGSV
E
G
Y
I
EASN
A
Y
Y
KKRL-------------------------------------------------
2
PsiBlast_PDB
98.88
97%
-126
- C2 -
3JUK
5
?
A:
[1-273]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
L
-------------------------------------------------
22
PsiBlast_CBE
98.79
97%
-125
- C2 -
3JUK
4
?
C:
[1-273]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
L
-------------------------------------------------
63
HHSearch
98.63
97%
-126
- C2 -
3JUK
5
?
A:
[1-272]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
L
-------------------------------------------------
21
PsiBlast_CBE
97.85
97%
-123
- C2 -
3JUK
4
?
D:
[1-272]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
--------
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
--------------------------------------------------
1
PsiBlast_PDB
97.66
97%
-124
- C2 -
3JUJ
-
?
A:
[1-273]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
E
I
E
H
Q
I
Q
G
T
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
L
-------------------------------------------------
23
PsiBlast_CBE
96.84
97%
-124
- C2 -
3JUK
4
?
B:
[1-272]
M
I
K
K
C
L
F
P
A
A
G
Y
G
T
R
F
L
P
I
T
K
T
I
P
K
E
M
L
P
I
V
D
K
P
L
I
Q
Y
A
V
E
E
A
M
E
A
G
C
-
E
V
M
A
I
V
T
G
R
N
K
-
R
S
L
E
D
Y
F
D
T
S
Y
---------
N
K
E
-
N
A
L
K
S
I
R
N
I
I
E
K
C
C
F
S
Y
V
R
Q
K
Q
M
K
G
L
G
H
A
I
L
T
G
E
A
L
I
G
--
N
E
P
--
F
A
V
I
L
A
D
D
L
C
I
S
H
D
H
P
S
V
L
K
Q
M
T
S
L
Y
Q
K
Y
-
Q
C
S
I
V
A
I
E
E
V
A
L
E
E
V
S
K
Y
G
V
--
I
R
G
E
W
L
E
E
----
G
V
Y
E
I
K
D
M
V
E
K
P
N
Q
E
D
A
P
S
N
L
A
V
I
G
R
Y
I
L
T
P
D
I
F
E
I
L
S
E
T
K
P
G
K
N
N
E
I
Q
I
T
D
A
---
L
R
T
Q
A
K
-
R
K
R
I
I
A
Y
Q
F
--
K
--
G
K
R
Y
D
C
G
S
V
E
G
Y
I
E
A
S
N
A
Y
Y
K
K
R
--------------------------------------------------
24
PsiBlast_CBE
77.52
44%
-128
- C2 -
2UX8
1
?
H:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
---------------------------
L
T
E
V
K
G
L
--------------
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
---------
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
27
PsiBlast_CBE
76.41
44%
-113
- C2 -
2UX8
1
?
E:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
--------
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
30
PsiBlast_CBE
76.24
44%
-108
- C2 -
2UX8
1
?
B:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
--------
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
29
PsiBlast_CBE
75.91
44%
-111
- C2 -
2UX8
1
?
C:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
25
PsiBlast_CBE
75.17
44%
-109
* C2 *
2UX8
1
?
G:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
G
A
G
G
E
I
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
26
PsiBlast_CBE
75.13
44%
-110
- C2 -
2UX8
1
?
F:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
K
------
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
28
PsiBlast_CBE
74.75
44%
-110
- C2 -
2UX8
1
?
D:
[14-281]
-
L
R
K
A
V
F
P
V
A
G
L
G
T
R
F
L
P
A
T
K
A
M
P
K
E
M
L
P
V
V
D
R
P
L
I
Q
Y
A
V
D
E
A
V
E
A
G
I
-
E
Q
M
I
F
V
T
G
R
G
K
-
S
A
L
E
D
H
F
D
I
A
Y
E
L
E
A
T
M
A
A
R
G
K
S
L
D
V
L
D
G
T
R
--
L
K
P
G
N
I
A
Y
V
R
Q
Q
E
P
M
G
L
G
H
A
V
W
C
A
R
D
I
V
G
--
D
E
P
--
F
A
V
L
L
P
D
D
F
M
F
G
Q
--
P
G
C
L
K
Q
M
V
D
A
Y
N
K
V
-
G
G
N
L
I
C
A
E
E
V
P
D
D
Q
T
H
R
Y
G
I
--
I
T
P
G
T
Q
D
G
----
V
L
T
E
V
K
G
L
V
E
K
P
A
P
G
T
A
P
S
N
L
S
V
I
G
R
Y
I
L
Q
P
E
V
M
R
I
L
E
N
Q
G
-------
Q
L
T
D
A
---
M
Q
R
M
I
G
-
D
Q
P
F
H
G
V
T
F
--
Q
--
G
T
R
Y
D
C
G
D
K
A
G
F
I
Q
A
N
L
A
V
A
L
S
R
P
-------------------------------------------------
67
HHSearch
71.71
39%
-104
- C2 -
2PA4
2
?
A:
[12-284]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
-
T
R
L
A
I
I
T
A
P
N
K
-
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
DD
E
D
V
--
V
A
V
M
L
P
D
D
L
V
L
P
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
-
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
--
F
E
I
E
A
--
D
TKDS
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
---
I
D
L
L
I
D
E
G
H
P
V
H
I
V
I
H
--
Q
--
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
-------------------------------------------------
33
PsiBlast_CBE
71.66
39%
-106
- C2 -
2PA4
2
?
B:
[12-276]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
-
T
R
L
A
I
I
T
A
P
N
K
-
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
-
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
----
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
------
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
-------------------------------------------------
3
PsiBlast_PDB
70.54
39%
-105
- C2 -
2PA4
2
?
A:
[12-276]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
-
T
R
L
A
I
I
T
A
P
N
K
-
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
-
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
F
E
I
E
A
D
T
K
D
S
----
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
------
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
-------------------------------------------------
31
PsiBlast_CBE
70.23
39%
-108
- C2 -
2PA4
2
?
D:
[12-276]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
-
T
R
L
A
I
I
T
A
P
N
K
-
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
----
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
DV
V
A
V
M
L
P
D
D
L
V
L
P
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
-
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
FE
I
E
A
D
T
K
D
S
----
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
IDL
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
------
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
-------------------------------------------------
32
PsiBlast_CBE
69.54
39%
-103
- C2 -
2PA4
2
?
C:
[12-276]
-
V
K
T
V
V
V
P
A
A
G
L
G
T
R
F
L
P
A
T
K
T
V
P
K
E
L
L
P
V
V
D
T
P
G
I
E
L
I
A
A
E
A
A
E
L
G
A
-
T
R
L
A
I
I
T
A
P
N
K
-
A
G
V
L
A
H
F
E
R
S
S
E
L
E
E
T
L
M
E
R
G
K
T
-
D
Q
V
E
I
I
R
R
A
A
D
L
I
K
A
V
P
V
T
Q
D
K
P
L
G
L
G
H
A
V
G
L
A
E
S
V
L
D
--
D
D
E
D
V
V
A
V
M
L
P
D
D
L
V
L
P
T
---
G
V
M
E
R
M
A
Q
V
R
A
E
F
-
G
G
S
V
L
C
A
V
E
V
S
E
A
D
V
S
K
Y
G
I
FE
I
E
A
D
T
K
D
S
----
D
V
K
K
V
K
G
M
V
E
K
P
A
I
E
D
A
P
S
R
L
A
A
T
G
R
Y
L
L
D
R
K
I
F
D
A
L
R
R
I
T
P
G
A
G
G
E
L
Q
L
T
D
A
I
D
L
L
I
D
E
G
H
-
P
V
H
I
V
I
H
Q
------
G
K
R
H
D
L
G
N
P
G
G
Y
I
P
A
C
V
D
F
G
L
S
H
P
-------------------------------------------------
53
Fugue
62.35
28%
-98
- C2 -
1FXO
2
?
A:
[2-293]
-
K
R
K
G
I
I
L
A
G
G
S
G
T
R
L
H
P
A
T
L
A
I
S
K
Q
L
L
P
V
Y
D
K
P
M
I
Y
Y
P
L
S
T
L
M
L
A
G
I
R
E
I
L
I
I
S
T
P
Q
D
T
-
P
R
F
Q
Q
L
L
G
D
G
S
N
W
G
----------------------
L
D
L
Q
Y
A
V
Q
P
S
P
D
G
L
A
Q
A
F
L
I
G
E
S
F
I
G
--
N
D
L
--
S
A
L
V
L
G
D
N
L
Y
Y
G
H
D
F
H
E
L
L
G
S
A
S
Q
--
R
Q
T
-
G
A
S
V
F
A
Y
H
---
V
L
D
P
E
R
Y
G
V
--
V
E
F
D
--------
Q
G
G
K
A
I
S
L
E
E
K
P
L
E
P
--
K
S
N
Y
A
V
T
G
L
Y
F
Y
D
Q
Q
V
V
D
I
A
R
D
L
K
P
S
P
R
G
E
L
E
I
T
D
V
---
N
R
A
Y
L
E
-
R
G
Q
L
S
V
E
I
M
--
G
RG
Y
A
W
L
D
T
G
T
H
D
S
L
L
E
A
G
Q
F
I
A
T
L
E
N
R
Q
GLKVAC
P
E
E
I
A
Y
R
Q
KWID
A
A
Q
L
E
K
L
A
A
P
L
AKN
G
Y
G
Q
Y
L
K
R
L
L
T
ETVY
62
HHSearch
60.63
24%
-108
- C2 -
1LVW
8
?
A:
[2-243]
A
H
M
K
G
I
V
L
A
G
G
S
G
T
R
L
Y
P
I
T
R
A
V
S
K
Q
L
L
P
I
Y
D
K
P
M
I
Y
Y
P
L
S
V
L
M
L
A
G
I
-
R
D
I
L
I
I
S
T
P
R
D
L
P
L
Y
R
D
L
L
G
D
G
S
----------------------
Q
F
G
V
R
F
S
Y
R
V
Q
E
E
P
R
G
I
A
D
A
F
I
V
G
K
D
F
I
G
--
D
S
K
--
V
A
L
V
L
G
D
N
V
F
Y
G
----
H
R
F
S
E
I
L
R
R
A
A
S
L
E
D
G
A
V
I
F
G
Y
--
Y
V
R
D
P
R
P
F
G
V
--
V
E
F
D
S
--------
E
G
R
V
I
S
I
E
E
K
P
S
--
R
P
K
S
N
Y
V
V
P
G
L
Y
F
Y
D
N
Q
V
V
E
I
A
R
R
I
E
P
S
D
R
G
E
L
E
I
T
S
V
---
N
E
E
Y
L
R
-
M
G
K
L
R
V
E
L
M
GR
G
--
M
A
W
L
D
T
G
T
H
D
G
L
L
E
A
S
S
F
I
E
T
I
Q
K
-------------------------------------------------