@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0908: (2015-12-19 )
MAQKTLLIITDGIGYRKDSDHNAFFHAKKPTYDLMFKTLPYSLIDTHGLSVGLPKGQMGNSEVGHMCIGAGRVLYQDLVRISLSLQNDELKNNPAFLNTIQKSHVVHLMGLMSDGGVHSHIEHFIALALECEKSHKKVCLHLITDGRDVAPKSALTYLKQMQNICNENIQIATISGRFYAMDRDNRFERIELAYNSLMGLNHTPLSPSEYIQSQYDKNITDEFIIPACFKNYCGMQDDESFIFINFRNDRAREIVSALGQKEFNSFKRQAFKKLHIATMTPYDNSFPYPVLFPKESVQNTLAEVVSQHNLTQSHIAETEKYAHVTFFINGGVETPFKNENRVLIQSPKVTTYDLKPEMSAKGVTLAVLEQMRLGTDLIIVNFANGDMVGHTGNFEASIKAVEAVDACLGEILSLAKELDYAMLLTSDHGNCERMKDENQNPLTNHTAGSVYCFVLGNGVKSIKNGALNNIASSVLKLMGIKAPATMDEPLF
Atome Classification :
(20 SA)
--....-..-...10........20--.........30......-..40..-.......50...-...-..60........70........80........90........----100--.--.----..----.....110.......120.-....-..130.-..--....140.......150.......160-------......------.-----.--170....-.-..180.-.-.....190....-..-.200-.-......210.--....--..220.......-----230----..----.-----.....240.......250.......260......--.270......---...280....-.--.-..--290.-......300.......310.......320.......330.-..-..--..340......-.-350.......360.......370.----.-.-....380.....-..-------390-------------........400.......410.....----..420.......430.----------.----------...----------------------------------------------------------.----------.--440.-....---....450.......460-----.-----.--.-......470.......480...-....490---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MA
Q
K
-
T
L
-
L
I
I
TDGIGYRKDSD---HN
A
F
F
HAKKP
T
Y
D
L
M
F
K
-TL
P
-
Y
S
-
L
I
DTHGLSVGLP-KGQ-MGNSEVG
H
M
C
I
G
A
G
R
V
L
Y
Q
D
L
V
R
I
S
L
S
LQNDELKNN
P
A
F
L
N
T
----
I
----
Q
--
K
----
S
H
----
V
V
H
L
M
G
LMSDGG
V
H
S
H
I
E
H
-
F
I
A
L
-
A
L
E
C
EK-SH--
K
K
V
C
L
H
L
ITDGRDVA
P
K
S
A
L
T
Y
L
K
Q
M
--------
Q
N
I
C
NE------N-----
I
--
Q
I
A
T
IS
G
-
R
-
F
Y
A
MDR-D-NR
F
E
R
I
E
L
A
Y
N
S-LM-GLNH-T-PL
S
P
S
E
Y
I
Q
S
--
Q
YDK--NI
T
D
E
F
I
I
P
A
C
F
-----
K
N
-----YC----G-----MQDDE
S
F
I
F
I
N
FR
N
D
R
A
R
E
I
V
S
A
L
G
Q
K
E
F
N
S
F
K
R
--
Q
A
--
F
K
KL
H
I
---
A
T
MTP-YDNS-F--P-YP--VLF
P
-
K
E
S
V
Q
N
T
L
A
E
V
V
S
QHN
L
T
Q
S
H
I
A
ETE
K
Y
A
H
V
T
F
F
INGGVE-TP-FK--NE
N
R
V
L
I
QSP
K
-
V
-
T
T
Y
DLKPEMSAK
G
V
T
L
A
V
L
E
Q
MRL----G-T-
D
L
I
I
V
N
FANGDM-VG-------HT--------------GNF
E
A
S
I
K
A
V
E
A
V
D
A
C
L
G
E
I
L
S
L
A
K
E----L
D
Y
A
M
L
L
TSDHG
N
C
E
R
----------M----------KDE----------------------------------------------------------N----------Q--N--P-LTNH---TAG
S
V
Y
C
F
V
LGN
G
V
K
-------
S
-----
I
--K-NG
A
L
N
N
I
A
S
S
V
L
K
L
MGIKAPAT-MDEPLF----------
3
PsiBlast_PDB
98.43
44%
-110
- C4 -
4NWX
4
?
A:
[11-505]
----
K
K
P
T
A
-
L
I
I
L
D
G
F
A
N
R
E
S
E
H
---
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
-
K
Y
P
-
T
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
----
I
----
A
H
V
N
----
S
H
D
S
--
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
-
L
F
A
L
--
L
E
L
A
K
-
K
Q
GV
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
--------
E
A
K
F
N
E
L
-----
G
-----
I
G
-
Q
F
A
S
V
S
G
-
R
-
Y
Y
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
-
I
R
-
N
F
D
A
P
T
-
Y
A
T
A
K
E
G
V
E
A
--
S
Y
N
E
--
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
--
E
Q
--
V
K
D
L
F
Y
---
A
T
F
T
K
-
Y
N
D
N
-
I
--
D
-
A
A
--
I
V
F
E
-
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
-
E
E
-
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
-
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
----
G
-
D
L
D
L
I
I
L
N
F
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
----------
V
----------
L
T
D
----------------------------------------------------------
D
----------
D
--
Q
--
P
-
M
T
T
H
---
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
-----
R
--
E
-
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
-
M
T
G
E
S
L
----------
4
PsiBlast_PDB
97.84
44%
-109
- C4 -
4QAX
3
?
A:
[11-505]
----
K
K
P
T
A
-
L
I
I
L
D
G
F
A
N
R
E
S
E
H
---
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
-
K
Y
P
-
T
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
----
I
----
A
H
V
N
----
S
H
D
S
--
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
-
L
F
A
L
--
L
E
L
A
K
-
K
Q
GV
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
--------
E
A
K
F
N
E
L
-----
G
-----
I
G
-
Q
F
A
S
V
S
G
-
R
-
Y
Y
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
-
I
R
-
N
F
D
A
P
T
-
Y
A
T
A
K
E
G
V
E
A
--
S
Y
N
E
--
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
--
E
Q
--
V
K
D
L
F
Y
---
A
T
F
T
K
-
Y
N
D
N
-
I
--
D
-
A
A
--
I
V
F
E
-
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
-
E
E
-
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
-
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
----
G
-
D
L
D
L
I
I
L
N
F
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
----------
V
----------
L
T
D
----------------------------------------------------------
D
----------
D
--
Q
--
P
-
M
T
T
H
---
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
-----
R
--
E
-
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
-
M
T
G
E
S
L
----------
1
PsiBlast_PDB
97.39
44%
-109
- C4 -
4MY4
2
?
A:
[11-505]
----
K
K
P
T
A
-
L
I
I
L
D
G
F
A
N
R
E
S
E
H
---
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
-
K
Y
P
-
T
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
----
I
----
A
H
V
N
----
S
H
D
S
--
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
-
L
F
A
L
--
L
E
L
A
K
-
K
Q
GV
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
--------
E
A
K
F
N
E
L
-----
G
-----
I
G
-
Q
F
A
S
V
S
G
-
R
-
Y
Y
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
-
I
R
-
N
F
D
A
P
T
-
Y
A
T
A
K
E
G
V
E
A
--
S
Y
N
E
--
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
--
E
Q
--
V
K
D
L
F
Y
---
A
T
F
T
K
-
Y
N
D
N
-
I
--
D
-
A
A
--
I
V
F
E
-
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
-
E
E
-
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
-
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
----
G
-
D
L
D
L
I
I
L
N
F
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
----------
V
----------
L
T
D
----------------------------------------------------------
D
----------
D
--
Q
--
P
-
M
T
T
H
---
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
-----
R
--
E
-
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
-
M
T
G
E
S
L
----------
2
PsiBlast_PDB
97.29
44%
-110
- C4 -
4NWJ
3
?
A:
[10-505]
---
A
K
K
P
T
A
-
L
I
I
L
D
G
F
A
N
R
E
S
E
H
---
G
N
A
V
K
L
A
N
K
P
N
F
D
R
Y
Y
N
-
K
Y
P
-
T
T
-
Q
I
E
A
S
G
L
D
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
M
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
K
S
I
E
D
G
D
F
F
E
N
D
V
L
N
N
A
----
I
----
A
H
V
N
----
S
H
D
S
--
A
L
H
I
F
G
L
L
S
D
G
G
V
H
S
H
Y
K
H
-
L
F
A
L
--
L
E
L
A
K
-
K
Q
GV
E
K
V
Y
V
H
A
F
L
D
G
R
D
V
D
Q
K
S
A
L
K
Y
I
E
E
T
--------
E
A
K
F
N
E
L
-----
G
-----
I
G
-
Q
F
A
S
V
S
G
-
R
-
Y
Y
A
M
D
R
-
D
-
K
R
W
E
R
E
E
K
A
Y
N
A
-
I
R
-
N
F
D
A
P
T
-
Y
A
T
A
K
E
G
V
E
A
--
S
Y
N
E
--
G
L
T
D
E
F
V
V
P
F
I
V
-----
E
N
-----
Q
N
D---
G
-----
V
N
D
G
D
A
V
I
F
Y
N
F
R
P
D
R
A
A
Q
L
S
E
I
F
A
N
R
A
F
E
G
F
K
V
--
E
Q
--
V
K
D
L
F
Y
---
A
T
F
T
K
-
Y
N
D
N
-
I
--
D
-
A
A
--
I
V
F
E
-
K
V
D
L
N
N
T
I
G
E
I
A
Q
N
N
N
L
T
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
Y
F
M
S
G
G
R
N
-
E
E
-
F
K
--
G
E
R
R
R
L
I
D
S
P
K
-
V
-
A
T
Y
D
L
K
P
E
M
S
A
Y
E
V
K
D
A
L
L
E
E
L
N
K
----
G
-
D
L
D
L
I
I
L
N
F
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
M
L
E
P
T
I
K
A
I
E
A
V
D
E
C
L
G
E
V
V
D
K
I
L
D
----
M
D
G
Y
A
I
I
T
A
D
H
G
N
S
D
Q
----------
V
----------
L
T
D
----------------------------------------------------------
D
----------
D
--
Q
--
P
-
M
T
T
H
---
T
T
N
P
V
P
V
I
V
T
K
E
G
V
T
-------
L
-----
R
--
E
-
T
G
R
L
G
D
L
A
P
T
L
L
D
L
L
N
V
E
Q
P
E
D
-
M
T
G
E
S
L
----------
42
Fugue
95.47
43%
-97
- C4 -
1EJJ
3
GPMI_GEOSE
A:
[3-510]
---
K
K
P
-
V
A
-
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
----
N
--
H
----
V
K
Q
H
G
T
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
-
L
R
L
A
A
K
-
E
G
V-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
Y
G----
V
-----
G
--
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
Y
G
E
G
P
-
T
-
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
GP
K
H
--
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
-
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
-----
R
--
D
-
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
IV--------
21
HHSearch
94.50
43%
-98
- C4 -
1O98
9
GPMI_GEOSE
A:
[3-508]
---
K
K
P
-
V
A
-
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
----
N
--
H
V
K
Q
H
G
T
----
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
-
L
R
L
A
A
K
-
E
G
V-
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
Y
G----
V
-----
G
--
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
-
Y
G
E
G
-
P
T
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
GRPV
A
T----
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
--
G
P
KH
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
K
Y
-
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------------
L
--
R
D
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
----------
7
PsiBlast_PDB
94.29
42%
-97
- C4 -
1O98
9
GPMI_GEOSE
A:
[2-503]
---
S
K
K
-
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
N
H
V
K
Q
--
H
----
G
T
----
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
L
R
L
A
A
K
E
-
G
V
--
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
------
Y
-----
G
V
G
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
Y
G
E
G
P
-
T
-
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
GP
K
H
--
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
-
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
-----
R
--
D
-
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
----------
5
PsiBlast_PDB
93.36
42%
-97
- C4 -
1EJJ
3
GPMI_GEOSE
A:
[3-503]
----
K
K
-
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
N
H
V
K
Q
--
H
----
G
T
----
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
L
R
L
A
A
K
E
-
G
V
--
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
------
Y
-----
G
VG
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
Y
G
E
G
P
-
T
-
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
GP
K
H
--
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
-
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
-----
R
--
D
-
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
----------
6
PsiBlast_PDB
93.24
42%
-96
- C4 -
1EQJ
3
GPMI_GEOSE
A:
[3-503]
----
K
K
-
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
N
H
V
K
Q
--
H
----
G
T
----
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
L
R
L
A
A
K
E
-
G
V
--
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
------
Y
-----
G
VG
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
Y
G
E
G
P
-
T
-
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
----
G
RPVAT
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
GP
K
H
--
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
-
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
-----
R
--
D
-
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
----------
8
PsiBlast_PDB
93.04
42%
-97
- C4 -
1O99
8
GPMI_GEOSE
A:
[2-503]
---
S
K
K
-
P
V
A
L
I
I
L
D
G
F
A
L
R
D
E
T
Y
---
G
N
A
V
A
Q
A
N
K
P
N
F
D
R
Y
W
N
-
E
Y
P
-
H
T
-
T
L
K
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
A
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
I
N
I
A
I
R
E
G
E
F
D
R
N
E
T
F
L
A
A
----
M
N
H
V
K
Q
--
H
----
G
T
----
S
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
I
H
H
-
L
Y
A
L
L
R
L
A
A
K
E
-
G
V
--
K
R
V
Y
I
H
G
F
L
D
G
R
D
V
G
P
Q
T
A
P
Q
Y
I
K
E
L
--------
Q
E
K
I
K
E
------
Y
-----
G
VG
E
I
A
T
L
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
A
Y
R
A
-
M
V
Y
G
E
G
P
-
T
-
Y
R
D
P
L
E
C
I
E
D
--
S
Y
K
H
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
R
-----
E
D
----
G
RPV
A
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
P
D
R
A
I
Q
I
S
N
T
F
T
N
E
D
F
R
E
F
D
R
GP
K
H
--
P
K
H
L
F
F
---
V
C
L
T
H
-
F
S
E
T
-
V
--
A
-
G
Y
--
V
A
F
K
-
P
T
N
L
D
N
T
I
G
E
V
L
S
Q
H
G
L
R
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
M
S
G
G
R
E
-
E
E
-
F
P
--
G
E
D
R
I
L
I
N
S
P
K
-
V
-
P
T
Y
D
L
K
P
E
M
S
A
Y
E
V
T
D
A
L
L
K
E
I
E
A
----
D
-
K
Y
D
A
I
I
L
N
Y
A
N
P
D
M
-
V
G
-------
H
S
--------------
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
D
E
----------
V
----------
L
T
P
----------------------------------------------------------
D
----------
G
--
K
--
P
-
Q
T
A
H
---
T
T
N
P
V
P
V
I
V
T
K
K
G
I
K
-------
L
-----
R
--
D
-
G
G
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
E
-
M
T
G
K
S
L
----------
9
PsiBlast_PDB
92.76
42%
-101
- C4 -
2IFY
2
GPMI_BACAN
A:
[2-501]
----
K
P
-
T
A
-
L
I
I
L
D
G
F
G
L
R
E
E
T
Y
---
G
N
A
V
A
Q
A
K
K
P
N
F
D
G
Y
W
N
-
K
F
P
-
H
T
-
T
L
T
A
C
G
E
A
V
G
L
P
-
E
G
Q
-
M
G
N
S
E
V
G
H
L
N
I
G
A
G
R
I
V
Y
Q
S
L
T
R
V
N
V
A
I
R
E
G
E
F
D
K
N
E
T
F
Q
S
A
----
I
K
S
V
K
E
--
K
----
G
T
----
A
L
H
L
F
G
L
L
S
D
G
G
V
H
S
H
M
N
H
-
M
F
A
L
L
R
L
A
A
K
E
-
G
V
--
E
K
V
Y
I
H
A
F
L
D
G
R
D
V
G
P
K
T
A
Q
S
Y
I
D
A
T
--------
N
E
V
I
K
E
------
T
-----
G
V
G
Q
F
A
T
I
S
G
-
R
-
Y
Y
S
M
D
R
-
D
-
K
R
W
D
R
V
E
K
C
Y
R
A
-
M
V
N
G
E
G
P
-
T
-
Y
K
S
A
E
E
C
V
E
D
--
S
Y
A
N
--
G
I
Y
D
E
F
V
L
P
S
V
I
-----
V
N
EDNTP
V
A
----
T
-----
I
N
D
D
D
A
V
I
F
Y
N
F
R
P
D
R
A
I
Q
I
A
R
V
F
T
N
G
D
F
R
E
F
D
R
--
G
E
---
K
V
P
H
I
PEF
V
C
M
T
H
-
F
S
E
T
-
V
--
D
-
G
Y
--
V
A
F
K
-
P
M
N
L
D
N
T
L
G
E
V
V
A
Q
A
G
L
K
Q
L
R
I
A
E
T
E
K
Y
P
H
V
T
F
F
F
S
G
G
R
E
-
A
E
-
F
P
--
G
E
E
R
I
L
I
N
S
P
K
-
V
-
A
T
Y
D
L
K
P
E
M
S
I
Y
E
V
T
D
A
L
V
N
E
I
E
N
----
D
-
K
H
D
V
I
I
L
N
F
A
N
C
D
M
-
V
G
-------
H
S
--------------
G
M
M
E
P
T
I
K
A
V
E
A
T
D
E
C
L
G
K
V
V
E
A
I
L
A
----
K
D
G
V
A
L
I
T
A
D
H
G
N
A
D
E
----------
E
----------
L
T
S
----------------------------------------------------------
E
----------
G
--
E
--
P
-
M
T
A
H
---
T
T
N
P
V
P
F
I
V
T
K
N
D
V
E
-------
L
-----
R
--
E
-
D
G
I
L
G
D
I
A
P
T
M
L
T
L
L
G
V
E
Q
P
K
E
-
M
T
G
K
T
I
----------
22
HHSearch
81.37
30%
-85
- C4 -
3IGZ
4
?
B:
[14-549]
---
R
R
T
-
V
L
-
I
V
V
M
D
G
L
G
I
G
P
E
D
D
---
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
-
D
N
R
-
H
F
R
C
V
R
A
H
G
T
A
V
G
L
P
-
T
D
A
D
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
----
H
----
G
--
A
FSKE
G
S
----
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
-
I
Y
S
I
-
I
E
H
A
V
K
-
D
G
A-
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
--------
E
A
V
L
A
K
V-----
R
QNGCD
A
--
A
I
A
S
G
G
G
R
M
-
F
V
T
M
D
R
-
Y
D
A
D
W
S
I
V
E
R
G
W
R
A
-
Q
V
-
L
G
D
A
-
R
H
F
H
S
A
K
E
A
I
T
T
--
F
R
E
E
DP
K
V
T
D
Q
Y
Y
P
P
F
I
V
-----
V
D
-----
E
Q
DKPL
G
T----
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
--
V
R
--
V
P
K
V
R
Y
---
A
G
M
M
R
-
Y
D
G
D
-
L
GI
P
-
N
N
--
F
L
V
P
-
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
-
G
K
-
I
D
EK
H
E
T
F
K
E
V
P
S
D
R
-
V
--
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
S
----
G
M
Y
-
N
V
V
R
I
N
F
P
N
G
D
M
-
V
G
-------
H
T
--------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
----------
M
----------
A
Q
R
----------------------------------------------------------
D
KKGKPMKDGN
G
NV
L
--
P
-
L
T
S
H
---
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
-------
P
RVAMR
T
D-
L
P
A
A
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
-
Y
E
P
S
L
I
----------
11
PsiBlast_PDB
80.14
29%
-90
- C4 -
3IGY
4
?
B:
[15-541]
----
R
T
-
V
L
-
I
V
V
M
D
G
L
G
I
G
P
E
D
D
---
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
-
F
R
-
C
V
R
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
HGAF
S
----
K
--
E
----
G
S
----
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
-
I
Y
S
I
-
I
E
H
A
V
K
D
G
A
--
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
EAVLAKVR
Q
N
G
C
D
-------------
A
--
A
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
-
G
D
A
R
-
H
-
F
H
S
A
K
E
A
I
T
T
FR
E
E
D
P
--
K
V
T
D
Q
Y
Y
P
P
F
I
V
VDEQD
K
P
-----
L
G
----
T
-----
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
--
V
R
--
V
P
K
V
R
Y
---
A
G
M
M
R
-
Y
D
G
D
-
L
--
G
-
I
P
NN
F
L
V
P
-
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
-
G
K
-
I
D
--
E
K
H
E
T
F
K
E
V
P
S
D
R
-
V
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
S
----
G
-
M
Y
N
V
V
R
I
N
F
P
N
G
D
M
-
V
G
-------
H
T
--------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
MAQRDKKGKP
M
----------
K
D
G
----------------------------------------------------------
N
----------
G
--
N
VL
P
-
L
T
S
H
---
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
PRVAMRT
D
-----
L
--
P
-
A
A
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
-
Y
E
P
S
L
I
----------
12
PsiBlast_PDB
79.80
29%
-90
- C4 -
3IGZ
4
?
B:
[15-541]
----
R
T
-
V
L
-
I
V
V
M
D
G
L
G
I
G
P
E
D
D
---
Y
D
A
V
H
M
A
S
T
P
F
M
D
A
H
R
R
D
N
R
H
-
F
R
-
C
V
R
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
A
L
Q
G
A
S
L
V
D
D
A
I
K
S
G
E
I
Y
T
G
E
G
Y
R
Y
L
HGAF
S
----
K
--
E
----
G
S
----
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
-
I
Y
S
I
-
I
E
H
A
V
K
D
G
A
--
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
G
S
S
F
R
F
T
D
E
L
EAVLAKVR
Q
N
G
C
D
-------------
A
--
A
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
D
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
-
G
D
A
R
-
H
-
F
H
S
A
K
E
A
I
T
T
FR
E
E
D
P
--
K
V
T
D
Q
Y
Y
P
P
F
I
V
VDEQD
K
P
-----
L
G
----
T
-----
I
E
D
G
D
A
V
L
C
V
N
F
R
G
D
R
V
I
E
M
T
R
A
F
E
D
E
D
F
N
K
F
D
R
--
V
R
--
V
P
K
V
R
Y
---
A
G
M
M
R
-
Y
D
G
D
-
L
--
G
-
I
P
NN
F
L
V
P
-
P
P
K
L
T
R
V
S
E
E
Y
L
C
G
S
G
L
N
I
F
A
C
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
-
G
K
-
I
D
--
E
K
H
E
T
F
K
E
V
P
S
D
R
-
V
Q
F
N
E
K
P
R
M
Q
S
A
A
I
T
E
A
A
I
E
A
L
K
S
----
G
-
M
Y
N
V
V
R
I
N
F
P
N
G
D
M
-
V
G
-------
H
T
--------------
G
D
L
K
A
T
I
T
G
V
E
A
V
D
E
S
L
A
K
L
K
D
A
V
D
S
----
V
N
G
V
Y
I
V
T
A
D
H
G
N
S
D
D
MAQRDKKGKP
M
----------
K
D
G
----------------------------------------------------------
N
----------
G
--
N
VL
P
-
L
T
S
H
---
T
L
S
P
V
P
V
F
I
G
G
A
G
L
D
PRVAMRT
D
-----
L
--
P
-
A
A
G
L
A
N
V
T
A
T
F
I
N
L
L
G
F
E
A
P
E
D
-
Y
E
P
S
L
I
----------
10
PsiBlast_PDB
78.62
29%
-90
- C4 -
3NVL
3
?
A:
[34-567]
----
R
K
-
L
V
-
L
V
V
L
D
G
V
G
I
G
P
R
D
E
---
Y
D
A
V
H
V
A
K
T
P
L
M
D
A
L
F
N
-
D
P
K
H
F
R
-
S
I
C
A
H
G
T
A
V
G
L
P
T
D
A
D
-
M
G
N
S
E
V
G
H
N
A
L
G
A
G
R
V
V
L
Q
G
A
S
L
V
D
D
A
L
E
S
G
E
I
F
T
S
E
G
Y
R
Y
L
H
G
A
F
S
----
Q
--
P
----
G
R
----
T
L
H
L
I
G
L
L
S
D
G
G
V
H
S
R
D
N
Q
V
Y
Q
I
L
-
K
H
A
G
A
N
-
G
A
--
K
R
I
R
V
H
A
L
Y
D
G
R
D
V
P
D
K
T
S
F
K
F
T
D
E
L
--------
E
E
V
L
A
K
L
R
E
G
GC
D
-----
A
--
R
I
A
S
G
G
G
-
R
M
F
V
T
M
D
R
Y
E
-
A
D
W
S
I
V
E
R
G
W
R
A
Q
V
L
-
G
E
G
R
-
A
-
F
K
S
A
R
E
A
L
T
K
F
R
E
E
D
A
--
N
I
S
D
Q
Y
Y
P
P
F
V
I
-----
A
G
-----
D
D
----
G
RPIGT
I
E
D
G
D
A
V
L
C
F
N
F
R
G
D
R
V
I
E
M
S
R
A
F
E
E
E
E
F
D
K
F
N
R
--
V
R
--
L
P
K
V
R
Y
---
A
G
M
M
R
-
Y
D
G
D
-
L
--
G
-
I
P
NN
F
L
V
P
-
P
P
K
L
T
R
T
S
E
E
Y
L
I
G
S
G
C
N
I
F
A
L
S
E
T
Q
K
F
G
H
V
T
Y
F
W
N
G
N
R
S
-
G
K
-
L
S
--
E
E
R
E
T
F
C
E
I
P
S
D
R
-
V
Q
F
N
Q
K
P
L
M
K
S
K
E
I
T
D
A
A
V
D
A
I
K
S
----
G
-
K
Y
D
M
I
R
I
N
Y
P
N
G
D
M
-
V
G
-------
H
T
--------------
G
D
L
K
A
T
I
T
S
L
E
A
V
D
Q
S
L
Q
R
L
K
E
A
V
D
S
----
V
N
G
V
F
L
I
T
A
D
H
G
N
S
D
D
----------
M
V
Q
R
D
KKG
K
P
V
R
D
A
----------------------------------------------------------
E
----------
G
--
N
L
M
P
-
L
T
S
H
---
T
L
A
P
V
P
V
F
I
G
G
A
G
L
D
PR
V
Q
M
R
T
D
-----
L
--
P
-
R
A
G
L
A
N
V
T
A
T
F
I
N
L
M
G
F
E
A
P
S
D
-
Y
E
P
S
L
I
----------
38
HHSearch
41.99
15%
-78
- C4 -
1K7H
6
?
A:
[284-472]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
L
P
E
M
T
K
V
A
I
E
M
L
T
K
D---
E
N
G
-
F
F
L
L
V
E
G
G
R
I
D
H
-
M
H
-------
H
A
--------------
N
Q
I
R
Q
S
L
A
E
T
L
D
M
E
E
A
V
S
M
A
L
S
M
T
D
P
----
E
E
T
I
I
L
V
T
A
D
H
G
H
T
L
T
----------
I
----------
T
G
Y
ADRNTDILDFAGISDLDD
R
R
Y
T
ILDYGSGPG
Y
H
I
T
EDGKR
Y
E
P
T
E
E
D
L
K
DINFRYASA
A
----------
P
--
K
--
H
-
S
A
T
H
---
D
G
T
D
V
G
I
W
V
N
G
P
F
A
H
-------
L
-----
F
--
T
G
V
Y
E
E
N
Y
I
P
H
A
L
A
Y
A
A
C
V
G
T
G
R
T
-
F
C
D
-------------
44
Fugue
40.13
16%
-34
- C4 -
2ZKT
3
APGM_PYRHO
A:
[1-412]
M
V
L
K
R
K
-
G
L
-
L
I
I
L
D
G
L
G
D
R
P
I
K
E
LNG
L
T
P
L
E
Y
A
N
T
P
N
M
D
K
L
A
E
-
I
--------
G
I
L
G
Q
Q
D
P
I
K
-
P
G
Q
-
P
A
G
S
D
T
A
H
L
S
I
--------------
F
G
Y
D
P
Y
E
T
Y
R
G
---------------------------------------------------
R
G
-
F
F
E
A
L
G
-
V
G
--
L
D
L
------
S
K
D
D
L
A
F
R
V
N
F
A
T
L
E
E
E
--------
A
H
--------------------------------------------------------------------------------------------------------------------------------
E
R
A
I
Q
E
E
V
D
I
G
V
D
F
I
F
K
G
L
V
L
--
K
G
--
M
S
K
-
V
G
---
D
N
D
L
I
-
R
G
A
G
-
T
--
Y
-
P
N
--
I
P
M
K
-
F
T
E
Q
W
K
V
K
A
A
G
V
I
A
V
A
L
V
K
G
V
A
R
A
V
G
F
D
V
Y
T
P
E
G
A
T
G
E
Y
N
-
T
N
-
E
M
--
A
K
A
K
K
A
V
E
L
L
K
-
D
-
Y
-------------------------------
D
F
V
F
L
H
F
K
P
T
D
A
-
A
G
-------
H
D
--------------
N
K
P
K
L
K
A
E
L
I
E
R
A
D
R
M
I
G
Y
I
L
D
H
V
D
L
----
E
E
V
V
I
A
I
T
G
D
H
S
T
P
C
E
----------
V
----------
M
N
---------------------------------------------------------------------------------
H
---
S
G
D
P
V
P
L
L
I
A
G
G
G
V
R
-------
T
-----
D
--
D
-
T
K
R
F
G
E
R
E
A
M
K
G
G
L
G
R
I
R
G
H
D
I
-
V
P
I
M
M
D
L
M
NR
S
E
K
F
G
A
23
HHSearch
38.44
13%
-62
- C4 -
2W8D
3
LTAS2_BACSU
A:
[51-335]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
G
K
E
V
T
P
F
L
N
-----
K
L
-----------------
A
H
D
N
E
T
F
Y
F
D
N
F
F
H
----
Q
T
G
Q
--------------
G
K
--
T
S
D
A
E
F
---
M
M
E
N
S
L
Y
P
L
A
-
Q
--
G
S
V
F
--
V
N
K
--
A
Q
N
T
L
Q
S
V
P
A
I
L
K
S
K
N
Y
T
S
A
T
F
-----
H
G
N
T
Q
T
F
W
N
R
N
E
M
-
Y
K
A
E
G
--
I
D
K
F
F
D
S
A
Y
Y
D
-
M
N
E
E
N
T
K
N
Y
G
M
K
D
K
P
F
F
K
E
S
M
P
L
L
E
S
L---
P
Q
P
-
F
Y
T
K
F
I
T
L
S
N
H
F
-
P
F
-------
G
M
DEGDT
D
F
P
A
G
DFG
D
S
V
V
D
N
Y
F
Q
S
A
H
Y
L
D
Q
S
I
E
Q
F
F
N
D
L
K
K
D
G
L
Y
D
K
S
I
I
V
M
Y
G
D
H
Y
G
I
S
E
----------
N
----------
H
N
K
----------------------------------------------------------
A
M
A
K
V
L-----
G
--
K
--
D
E
I
T
D
Y
D
N
A
Q
L
Q
R
V
P
L
F
I
H
A
A
G
V
K
-------
G
-----
E
KV
H
K
Y
A
G
D
V
D
V
A
P
T
I
L
H
L
L
G
V
D
T
K
D
Y
L
M
S
G
S
D
I
----------
28
HHSearch
36.79
15%
-52
- C4 -
3LXQ
1
?
A:
[107-367]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
L
T
P
N
L
D
-----
E
L
-----------------
M
Q
--
E
G
W
Q
F
T
Q
M
Y
A
T
----
G
T
R
--
S
V
---------------
R
-
G
I
E
---
A
V
T
T
G
-
F
P
P
S
P
S
--
R
-
A
V
--
V
K
L
S
K
S
Q
T
G
F
F
T
I
A
D
L
L
K
E
Q
G
Y
H
T
Q
F
I
Y
G
G
E
-----
A
N
F
D
N
M
K
T
F
F
F
G
-
N
G
--
F
D
Q
I
V
E
E
K
N
Y
T
-
N
-
P
G
F
V
G
S
W
G
V
S
D
E
D
L
Y
N
K
A
D
E
E
F
E
R
L
S
K
G
D
K
P
-
F
F
S
L
V
F
T
S
S
N
H
S
-
P
Y
E
Y
P
E
GKI
E
Q
YD------------
S
E
H
M
T
R
N
N
A
V
K
Y
S
D
Y
A
L
G
T
F
F
D
K
A
K
K
SSYW
D
D
T
I
F
I
V
I
A
D
H
D
A
R
V
F
---------------------------------------------------------------------------------------------
G
--
A
--
N
-
L
V
P
V
---
K
H
F
H
I
P
A
L
I
I
G
K
D
I
Q
-------
P
-----
R
KD
D
R
I
A
N
N
I
D
M
P
P
T
L
L
S
L
I
G
V
D
A
K
T
P
-
M
I
G
R
D
L
----------
26
HHSearch
34.72
20%
-50
- C4 -
3M7V
2
DEOB_STRMU
A:
[230-400]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
A
P
T
V
L
N
K
L
A
D
A
G
V
S
T
Y
A
V
G
K
I
N
D
-----
I
F
N
G
S
G
I
T
----------
N
--------------
D
M
G
H
N
K
S
N
S
H
G
V
D
T
L
I
K
T
M
G
L
SA--
F
T
K
-
G
F
S
F
T
N
L
V
D
F
D
A
L
Y
G
-------
H
R
--------------
R
N
A
H
G
Y
R
D
C
L
H
E
F
D
E
R
L
P
E
I
I
A
A
M
K
-----
V
D
D
L
L
L
I
T
A
D
H
G
N
D
P
T
------------------------------------------------------------------------------------------------
Y
--
A
-
G
T
D
H
---
T
R
E
Y
V
P
L
L
A
Y
S
P
S
F
T
-------
G
-----
N
G
V
L
P
V
G
H
Y
A
D
I
S
A
T
I
A
D
N
F
G
V
D
T
A
M
---
I
G
E
S
F
----------