@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_0910: (2015-12-19 )
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLEHVLLASFSHKPIITLSQRLCQLTGMDKCFYADNGSSCIEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLITPVPKNDSEIENSLNALKRLLDKHGEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLWCKQKNIHIIFDEIATGFGRTGSMFAYEQCGIKPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSEFIFSALQNALKPLIERQVVSDLRHLGMVFAFEVFLQTKERLSLAVFKKALKKGLLLRPLNNTIYLMPPYIITHEEIKKAIAGLVEAIDELKKAENK
Atome Classification :
(33 SA)
....--.....10........20........30........40.......---.50........60........70.......--.80........90........100.---.--.....110.......120.......130....-.-..140.......150......-.160----........170.......-180--------..--..----.----.-..190.......200.......210-.......220.......230.......240.......250.......260....--...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370......--.380---.--------......-.390........400.-......410.......420.......430.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
F
Q
--
E
N
L
A
A
L
D
L
E
Y
LWH
P
C
S
Q
M
Q
E
HQNF
P
I
I
P
I
KKA
Q
G
I
Y
L
Y
DFND
N
A
---
Y
M
D
L
I
S
S
W
W
V
N
L
FGH
N
N
A
Y
I
S
Q
Q
L
K
N
Q
I
D
N
--
L
E
H
V
L
L
A
SFSHK
P
I
I
T
L
S
Q
R
L
C
Q
LT---G--M
D
K
C
F
YADNG
S
S
C
I
E
I
A
L
K
M
S
Y
H
A
H
F
L
K
NQ
T
R
-
R
-
K
K
L
F
L
S
LSNSYHG
E
T
L
G
A
L
S
V-G
D
V
-----
K
L
YKDTY
T
P
L
L
L
K
N
LITP-VP---------K
N
--
D
S
----
E
----
I
-
E
N
S
L
N
A
L
K
R
L
L
D
KH
G
E
E
I
C
A
F
I
A
E
P
-
L
L
Q
CAGN
M
H
I
Y
S
A
K
Y
L
K
Q
A
V
L
W
C
KQK
N
I
H
I
I
F
D
E
I
A
T
GFGRTGS
M
F
A
Y
E
Q
CGIK--P
D
F
L
C
L
SKGISGG
Y
L
P
L
S
A
L
L
T
H
N
E
I
Y
N
Q
FYAPYEEN
K
A
F
L
HSHSYTGNA
L
A
C
ACANA
T
L
D
I
F
E
K
E
N
V
I
E
K
N
K
A
L
S
E
F
I
F
S
A
L
Q
N
A
L
K
P
L
I
E
R
Q
V
V
S
D
L
R
H
L
G
M
V
F
A
F
E
V
F
L
--
Q
T
K
----
E
--------
R
L
S
L
A
V
-
F
K
K
-
A
L
KKG
L
L
LRPLN-
N
T
I
Y
LMP
P
Y
II
T
H
E
E
I
K
K
A
I
A
G
L
V
E
A
I
D
E
L
K
KAENK
30
PsiBlast_CBE
91.48
34%
-121
- C1 -
1S08
1
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
N
T
F
G
A
M
S
V
-
C
D
P
------------------
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
----
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
21
PsiBlast_CBE
90.64
35%
-127
- C1 -
3DOD
2
BIOK_BACSU
B:
[11-448]
--------------
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
K
D
I
N
G
K
E
---
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
PK-
K
--
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
--
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
-
I
P
YVYRSESG-
D
P
--
D
E
----
C
----
R
-
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
----
L
H
A
L
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
SK
E
T
K
----
E
PYPADR--
R
I
G
Y
K
V
-
S
L
K
-
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
-
2
PsiBlast_PDB
89.81
35%
-126
- C1 -
3DRD
-
BIOK_BACSU
A:
[11-448]
--------------
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
K
D
I
N
G
K
E
---
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
PK-
K
--
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
--
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
-
I
P
YVYRSESG-
D
P
--
D
E
----
C
----
R
-
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
----
L
H
A
L
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
SK
E
T
K
----
E
PYPADR--
R
I
G
Y
K
V
-
S
L
K
-
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
-
28
PsiBlast_CBE
88.57
34%
-114
- C1 -
1MGV
7
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
A
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
1
PsiBlast_PDB
88.54
35%
-126
- C1 -
3DOD
2
BIOK_BACSU
A:
[11-448]
--------------
K
H
L
W
L
P
F
T
Q
M
K
D
Y
D
E
N
P
L
I
-
I
E
S
G
T
G
I
K
V
K
D
I
N
G
K
E
---
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
PK-
K
--
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
--
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
-
I
P
YVYRSESG-
D
P
--
D
E
----
C
----
R
-
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
-
M
V
Q
G
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
----
L
H
A
L
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
SK
E
T
K
----
E
PYPADR--
R
I
G
Y
K
V
-
S
L
K
-
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
-
32
PsiBlast_CBE
88.18
34%
-116
- C1 -
1S06
1
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
K
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
29
PsiBlast_CBE
87.98
34%
-115
- C1 -
1S0A
1
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
F
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
26
PsiBlast_CBE
87.83
34%
-116
- C1 -
1MLY
4
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
23
PsiBlast_CBE
87.62
34%
-115
- C1 -
1QJ5
3
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
-
25
PsiBlast_CBE
86.86
34%
-115
- C1 -
1MLZ
4
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
5
PsiBlast_PDB
86.70
34%
-114
- C1 -
1S07
4
BIOA_ECOLI
A:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
-
27
PsiBlast_CBE
86.46
34%
-115
- C1 -
1S07
4
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
A
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
31
PsiBlast_CBE
86.26
34%
-113
- C1 -
1S09
1
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
F
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
24
PsiBlast_CBE
86.14
34%
-116
- C1 -
1QJ3
5
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DN----------
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM------
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
--
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
3
PsiBlast_PDB
84.96
35%
-110
- C1 -
1DTY
5
BIOA_ECOLI
A:
[7-423]
----------
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
--
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
A
R
-
D
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
--
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
-
4
PsiBlast_PDB
84.86
34%
-114
- C1 -
1MGV
5
BIOA_ECOLI
A:
[7-423]
----------
A
F
D
Q
R
H
I
L
H
P
Y
T
S
M
T
S
--
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
R
-
Q
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
--
N
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
A
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
--
22
PsiBlast_CBE
83.59
35%
-111
- C1 -
1DTY
5
BIOA_ECOLI
B:
[7-423]
----------
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
--
S
P
L
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
--
M
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
---
P
QP
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
A
R
-
D
-
R
--
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
-
C
D
P
DNSMH
S
L
W
K
G
-
Y
L
P
---
E
N
L
F
A
P
-
A
P
---------
Q
S
RM
D
G
----
E
----
W
D
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
--
G
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
----
V
Q
L
R
E
Q
L
A
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
----
H
--------
P
V
N
M
A
A
-
L
Q
K
F
F
V
E
Q
G
V
W
I
R
P
F
G
-
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
-
34
HHSearch
81.88
34%
-119
- C1 -
3DOD
2
BIOK_BACSU
A:
[3-446]
------
H
D
L
I
E
K
S
K
K
H
L
W
L
P
F
T
Q
M
K
D
-
Y
D
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
D
I
N
G
K
E
---
Y
Y
D
G
F
S
S
V
W
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
--
I
A
H
S
T
L
L
G
M
T
N
V
P
A
T
Q
L
A
E
T
L
I
D
I
S
---
P
KK
L
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
P
--
E
-
K
Q
K
F
I
A
M
K
-----------------------------------
S
Y
K
A
P
-
I
P
---------
Y
V
--
Y
R
SESG
D
P
D
E
C
R
-
D
Q
C
L
R
E
L
A
Q
L
L
E
E
H
H
E
E
I
A
A
L
S
I
E
S
M
V
Q
G
A
S
G
M
I
-
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
H
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
D
D
Y
E
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
E
K
S
K
K
L
H
F
L
L
Q
D
-
L
H
A
---
L
P
H
V
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
--
S
K
E
----
T
KEPYPADR
R
I
G
Y
K
V
-
S
L
K
-
M
R
E
L
G
M
L
T
R
P
L
G
-
D
V
I
A
F
L
P
P
L
A
S
T
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
T
S
L
E
D
-
57
Fugue
81.37
34%
-114
- C1 -
1DTY
5
BIOA_ECOLI
A:
[1-429]
----MT
T
D
D
L
A
F
D
E
R
H
I
W
H
P
Y
T
S
M
T
S
P
L
--
P
V
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
D
G
R
R
---
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
-
S
Q
I
D
A
M-
S
H
V
M
F
G
E
I
T
H
A
P
A
I
E
L
C
R
-
K
L
V
A
M
T
PQ
P
--
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
-
G
E
---A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
-----
N
S
M
H
S
L
W
K
G
Y
L
P
E
N
L
F
A
P
-
A
P
QSRMDGEWD-----------------
E
R
D
M
V
G
F
A
R
L
M
A
A
H
R
H
E
I
A
A
V
I
I
E
P
-
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
A
E
--IA
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
D
G
--
E
A
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
I
E
V
Q
L
R
E
Q
L
A
P
A
R
D
---
A
-
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
E
T
T
------HPVN-----------
M
A
A
L
-
Q
K
F
-
F
V
E
Q
G
V
W
I
R
P
F
-G
K
L
I
Y
L
M
P
P
Y
I
I
L
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
T
F
F
C
Q
-
12
PsiBlast_PDB
80.31
30%
-115
- C1 -
4CXQ
8
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
-
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
10
PsiBlast_PDB
79.82
30%
-114
- C1 -
4MQQ
7
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
16
PsiBlast_PDB
79.39
30%
-114
- C1 -
4WYE
7
?
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
---
8
PsiBlast_PDB
79.37
30%
-116
- C1 -
3TFU
3
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H--------------
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
------
17
PsiBlast_PDB
78.85
30%
-114
- C1 -
4WYF
3
?
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
19
PsiBlast_PDB
78.28
30%
-113
- C1 -
4XEW
4
?
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
14
PsiBlast_PDB
78.02
30%
-116
- C1 -
4W1X
7
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
---
11
PsiBlast_PDB
77.50
30%
-114
- C1 -
4MQR
4
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
6
PsiBlast_PDB
76.65
30%
-116
- C1 -
4W1V
5
BIOA_MYCTU
A:
[5-422]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
18
PsiBlast_PDB
76.63
30%
-112
- C1 -
4WYG
10
?
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
L
---
9
PsiBlast_PDB
76.63
30%
-117
- C1 -
4MQP
4
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
7
PsiBlast_PDB
76.43
30%
-116
- C1 -
3TFT
3
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
-----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
------
15
PsiBlast_PDB
75.84
30%
-113
- C1 -
4WYC
7
?
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
-
E
A
V
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----
13
PsiBlast_PDB
75.65
30%
-114
- C1 -
4CXR
6
BIOA_MYCTU
A:
[31-448]
------
E
Q
I
I
A
V
D
G
A
H
L
W
H
P
Y
S
S
I
G
R
----
S
P
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
--
M
N
H
V
M
F
G
G
L
T
H
E
P
A
A
R
L
A
K
L
L
V
D
I
T
PA-
G
--
L
D
T
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
-
Y
W
R
G
R
G
L
P
-
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
-
C
D
P
H----
G
G
M
H
S
L
W
T
D
V
L
A
A
Q
V
F
A
P
Q
V
P
---------
R
D
--
Y
D
----
P
----
A
-
Y
S
A
--
A
F
E
A
Q
L
A
Q
H
A
G
E
L
A
A
V
V
V
E
P
-
V
V
Q
G
A
G
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
H
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
I
S
A
--
G
A
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
E
L
A
A
G
L
T
A
G
L
D
T
A
R
A
----
L
P
A
V
T
D
V
R
V
C
G
A
I
G
V
I
E
C
------
D
----
R
--------
P
V
D
L
A
V
A
T
P
A
-
A
L
D
R
G
V
W
L
R
P
F
R
-
N
L
V
Y
A
M
P
P
Y
I
C
T
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
V
G
S
----