@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1196: (2015-12-21 )
MDISIFREYDIRGIYPTTLDENTAFSIGVELGKIMREYDKSVFVGHDARVHGRFLFEVLSAGLQSSGLKVYDLGLIPTPVAYFAAFNEIDNIQCPNSIMITGSHNPKEYNGFKITLNQNPFYGKDIQALKNTLLNAKHEIKPLKETPEKVNALEAYHRYLIKDFKHLKNLKYKIALDFGNGVGALGLEPILKALNIDFSSLYSDPDGDFPNHHPDPSEAKNLKDLEKHMRENAILIGFAFDGDADRIAMLSSHHIYAGDELAILFAKRLHAQGITPFVIGEVKCSQVMYNAINTFGKTLMYKTGHSNLKIKLKETNAHFAAEMSGHIFFKERYFGYDDALYACLRALELLLEQSPSDLENTIKNLPYSYTTPEEKIAVSEEEKFEIIRNLQEALKNPPSHFPTIKEIISIDGVRVVFEHGFGLIRASNTTPYLVSRFEGKDETTALEYKRALLGLLEKL
Atome Classification :
(20 SA)
----.........10........20........30.-....-.-.---.40---........50........60........70........80......----..----90........100.......110....-...120.......130..------...-..140.........150.......160..---...-..170.......180.......190.......200.......210.......220.......230.......240.......250.-.-...-...260.......270.......280.......290.-..-.-...300.......310.......320.......330.......340.......350..-.....360.......370.......380.......390.......400.......410.......420.......430.......440....----...450.......--------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----M
D
I
S
I
F
R
EYDIRGIYPTTLDENT
A
F
S
I
G
V
E
L
G
-
K
I
M
R
-
E
-Y---DK
S
---
V
F
VGHDAR
V
H
G
R
F
L
F
E
V
L
S
A
G
L
Q
SSG
L
K
V
Y
D
LGLIP
T
P
V
A
Y
F
A
A
F
N----EI----DNIQCP
N
S
I
M
I
TGSHNPKEYN
G
F
K
I
T
L-NQNPFYG
K
D
I
Q
A
L
K
N
T
L
L------NAK-HEI--K
P
L
KET
P
E
K
V
N
A
L
E
A
Y
H
R
Y
L
I
K
D
F
---
K
H
L
-KNL
K
Y
K
I
A
L
DFGNGVGAL
G
L
E
P
I
L
K
A
LN
I
D
F
S
S
LYSDPDGDFPNHHP
D
P
S
E
A
K
N
L
K
D
L
E
K
H
M
REN
A
I
L
I
G
F
AFDGDAD
R
I
A
M
LS-S-H-HIY-AG
D
E
L
A
I
L
F
A
K
R
L
H
AQGIT
P
F
V
I
GE
V
K
C
S
Q
V
M
Y
N
A
I
N
-
T
F
-
G
-
K
T
L
M
YKTGHS
N
L
K
I
K
L
KETN
A
H
F
A
AEMS
G
H
I
F
F
K
ERYFGY
D
D
A
L
Y
A
C
L
R
A
L
E
L
L
L
EQS-P
S
D
L
E
N
T
I
K
NLPYSYTT
P
E
E
KIAV
S
E
E
E
K
F
E
I
I
R
N
L
Q
E
A
LKNPPSH
F
P
T
I
K
E
I
I
SID
G
V
R
V
V
FEHGF
G
L
I
RASNTT
P
Y
L
V
SRFEGKDE
T
T
A
L
----
E
Y
K
R
A
L
L
G
L
L
EKL--------
76
Fugue
98.28
39%
-92
- C2 -
1K2Y
2
ALGC_PSEAE
X:
[5-463]
KAPT
L
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
-
S
E
S
L
-
A
-
R
G--
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
------------
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
------
K
---
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
--
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
-
N
-
T
G
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
-
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
------
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
DSSLPVPF
55
HHSearch
97.55
40%
-88
- C2 -
1P5D
2
ALGC_PSEAE
X:
[10-455]
-----
P
A
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
-
S
E
S
L
A
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
------------
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
------
K
N
D
-
L
----
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
--
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
-
N
T
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
G
G
-
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
-
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
-----
W
G
E
G
-
N
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
56
HHSearch
97.53
38%
-92
- C2 -
3UW2
10
?
A:
[23-477]
----
I
S
Q
S
I
F
K
A
Y
D
I
R
G
V
I
G
K
T
L
D
A
D
V
A
R
S
I
G
R
A
F
G
-
S
E
V
R
-
A
Q
G
---
G
D
A
---
V
V
V
A
R
D
G
R
L
S
G
P
E
L
V
G
A
L
A
D
G
L
R
A
A
G
V
D
V
V
D
V
G
M
V
P
T
P
V
G
Y
F
A
A
S
V
PLAL
S
G
----
G
E
R
R
V
D
S
C
I
V
V
T
G
S
H
N
P
P
D
Y
N
G
F
K
M
V
L
-
R
G
A
A
I
Y
G
D
Q
I
Q
G
L
Y
K
R
I
V
------
D
A
R
-
F
----
E
T
G
S
G
S
Y
E
Q
Y
D
V
A
D
Q
Y
V
E
R
I
V
G
D
I
---
K
L
T
-
R
P
--
L
K
L
V
V
D
A
G
N
G
V
A
G
P
L
A
T
R
L
F
K
A
L
G
C
E
L
V
E
L
F
T
D
I
D
G
N
F
P
N
H
H
P
D
P
A
H
P
E
N
L
Q
D
V
I
A
K
L
K
A
T
D
A
E
I
G
F
A
F
D
G
D
G
D
R
L
G
V
V
T
-
K
D
G
-
Q
I
I
-
Y
P
D
R
Q
L
M
L
F
A
E
E
V
L
S
R
N
P
G
A
Q
I
I
Y
D
V
K
C
T
R
N
-
L
A
R
W
V
R
E
K
G
G
-
E
P
L
M
W
K
T
G
H
S
L
V
K
A
K
L
R
E
T
G
A
P
L
A
G
E
M
S
G
H
V
F
F
K
D
R
W
Y
G
F
D
D
G
L
Y
T
G
A
R
L
L
E
I
L
A
-
R
V
--
A
D
P
S
A
L
L
N
G
L
P
N
A
V
S
T
P
E
L
Q
L
------
N
V
K
L
I
D
K
L
R
A
D
A
K
-----
F
D
G
A
D
E
V
V
T
I
D
G
L
R
V
E
Y
P
D
G
F
G
L
A
R
S
S
N
T
T
P
V
V
V
L
R
F
E
A
T
S
D
A
A
L
A
----
R
I
Q
D
D
F
R
R
A
L
K
A
A
--------
15
PsiBlast_PDB
96.55
38%
-90
- C2 -
3UW2
10
?
A:
[26-474]
-------
S
I
F
K
A
Y
D
I
R
G
V
I
G
K
T
L
D
A
D
V
A
R
S
I
G
R
A
F
G
-
S
E
V
R
A
Q
-
G
---
G
D
A
---
V
V
V
A
R
D
G
R
L
S
G
P
E
L
V
G
A
L
A
D
G
L
R
A
A
G
V
D
V
V
D
V
G
M
V
P
T
P
V
G
Y
F
A
A
S
V
----
P
L
ALSG
G
E
R
R
V
D
S
C
I
V
V
T
G
S
H
N
P
P
D
Y
N
G
F
K
M
V
L
-
R
G
A
A
I
Y
G
D
Q
I
Q
G
L
Y
K
R
I
V
------
D
A
R
-
F
E
T
--
G
--
S
G
S
Y
E
Q
Y
D
V
A
D
Q
Y
V
E
R
I
V
G
D
I
---
K
L
T
-
R
P
L
K
--
L
V
V
D
A
G
N
G
V
A
G
P
L
A
T
R
L
F
K
A
L
G
C
E
L
V
E
L
F
T
D
I
D
G
N
F
P
N
H
H
P
D
P
A
H
P
E
N
L
Q
D
V
I
A
K
L
K
A
T
D
A
E
I
G
F
A
F
D
G
D
G
D
R
L
G
V
V
T
-
K
-
D
G
Q
I
I
-
Y
P
D
R
Q
L
M
L
F
A
E
E
V
L
S
R
N
P
G
A
Q
I
I
Y
D
V
K
C
T
R
N
L
A
R
W
V
R
E
K
G
-
G
-
E
P
L
M
W
K
T
G
H
S
L
V
K
A
K
L
R
E
T
G
A
P
L
A
G
E
M
S
G
H
V
F
F
K
D
R
W
Y
G
F
D
D
G
L
Y
T
G
A
R
L
L
E
I
L
A
R
V
A
D
P
S
A
L
L
N
---
G
L
P
N
A
V
S
T
P
E
L
Q
L
------
N
V
K
L
I
D
K
L
R
A
D
A
K
-----
F
D
G
A
D
E
V
V
T
I
D
G
L
R
V
E
Y
P
D
G
F
G
L
A
R
S
S
N
T
T
P
V
V
V
L
R
F
E
A
T
S
D
A
A
L
A
R
I
Q
D
D
F
R
R
A
L
K
A
A
K
P
G
A
--------
1
PsiBlast_PDB
95.52
40%
-88
- C2 -
4MRQ
13
ALGC_PSEAE
A:
[4-430]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
11
PsiBlast_PDB
95.19
39%
-87
- C2 -
4IL8
3
ALGC_PSEAE
A:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
G
G
-
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
A
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
9
PsiBlast_PDB
94.92
39%
-89
- C2 -
2FKF
2
ALGC_PSEAE
A:
[11-437]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
6
PsiBlast_PDB
94.80
39%
-85
- C2 -
1PCM
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
12
PsiBlast_PDB
94.71
39%
-87
- C2 -
3BKQ
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
G
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
13
PsiBlast_PDB
94.67
39%
-89
- C2 -
3C04
1
ALGC_PSEAE
A:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
G
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
4
PsiBlast_PDB
94.61
39%
-84
- C2 -
1P5G
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
14
PsiBlast_PDB
94.57
39%
-87
- C2 -
1K35
1
ALGC_PSEAE
A:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
--
P
M
K
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
G
G
-
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
10
PsiBlast_PDB
94.18
39%
-86
- C2 -
2FKM
2
ALGC_PSEAE
X:
[11-437]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
D
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
5
PsiBlast_PDB
94.12
39%
-85
- C2 -
1PCJ
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
2
PsiBlast_PDB
94.10
39%
-89
- C2 -
1K2Y
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
3
PsiBlast_PDB
94.09
39%
-85
- C2 -
1P5D
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
7
PsiBlast_PDB
94.02
39%
-87
- C2 -
2H4L
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
8
PsiBlast_PDB
93.87
39%
-84
- C2 -
2H5A
2
ALGC_PSEAE
X:
[12-438]
-------
S
I
F
R
A
Y
D
I
R
G
V
V
G
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
-
R
-
G
---
E
P
C
---
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
------------
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
-
A
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
-
N
D
L
--
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
---
A
M
A
-
K
P
M
K
--
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
K
P
E
N
L
K
D
L
I
A
K
V
K
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
-
G
-
T
I
I
-
Y
P
D
R
L
L
M
L
F
A
K
D
V
V
S
R
N
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
-
G
Y
-
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
-
I
L
S
Q
D
-
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
I
N
I
T
V
T
E
D
S
K
F
A
I
I
E
A
L
Q
R
D
A
Q
W
G
E
G
N
------
I
T
T
L
D
G
V
R
V
D
Y
P
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
----
R
I
K
T
V
F
R
N
Q
L
K
A
V
--------
16
PsiBlast_PDB
84.23
27%
-76
- C2 -
1WQA
1
?
A:
[4-452]
--------
L
F
G
T
F
G
V
R
G
I
A
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
-
T
L
L
K
-
R
-
E
---
G
R
K
K
P
L
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
------------
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
-
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
K
EDFD
R
A
K
W
Y
E
I
--
G
E
V
R
R
E
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
--
D
V
---
E
A
I
-
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
E
-
E
N
L
K
E
F
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
-
E
-
N
-
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
-
K
H
-
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
V
L
G
R
D
G
A
M
T
V
A
-
K
V
V
E
I
F
A
-
K
S
-
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
Q
I
K
T
K
R
H
V
--
E
G
D
R
H
A
I
V
N
K
V
A
E
M
A
R
E
R
G
Y
T
V
D
T
------
T
D
G
A
K
I
I
F
E
D
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
----
E
Y
L
N
L
G
I
E
L
L
E
K
A
--------
54
HHSearch
83.70
26%
-84
* C2 *
1WQA
1
?
A:
[2-452]
------
G
K
L
F
G
T
F
G
V
R
G
I
A
N
E
K
I
T
P
E
F
A
M
K
I
G
M
A
F
G
-
T
L
L
K
-
R
-
E
GRK
K
P
L
---
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
------------
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
E
A
I
V
E
E
L
F
F
------
K
E
D
-
F
D
R
AK
W
Y
E
I
G
E
V
R
R
E
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
V
E
A
I
K
K
R
K
--
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
-
E
E
N
L
K
E
F
M
E
I
V
K
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
-
E
N
G
-
R
F
I
-
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
G
G
L
L
V
T
T
V
A
T
S
N
L
-
L
D
D
I
A
K
K
H
G
A
-
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
-
K
S
-
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
T
K
R
H
V
E
G
-
D
R
H
A
I
V
N
K
V
A
E
M
A
R
-----
E
R
G
Y
-
T
V
D
T
T
D
G
A
K
I
I
F
E
D
G
W
V
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
----
E
Y
L
N
L
G
I
E
L
L
E
K
A
--------