@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : jhp_1409: (2015-12-23 )
MSFTRIPLKVFIKKYNPQEPKKETIENFEKEINSLLENVPRQDDEEFQKNEINKFLKNAYGYDCNTYEKVDSVIYVDKEVRVLIEVKALNNKTEFPKNRENPLSKAFCQMVLYFLEEIEKEKNNSLKHTIICNAHEFFLFDCKDLLSLKEDKRIKKFYKNYAKKEGTDSSKPKFYKDLEQFLQEDFQGELRYTHFNLSDDFKELPLIYQVLSQEVLLKQKRTLDANTLNKDFYEELLYILGLEEQNDKGKILIKPSRTKNSLSGALKEKYKNLDDEEVMALLIAWNNRILFLRLLESLLISFEHFEKERSFLTTGNFKDFNALNTLFFEVLAKKNSERLPEIKENKILGKIPYLNSSLFDKTPLELKGHEIKLLDNKKLEIYKNSVLKKHENYQKDKASLPLLEYFFKFLHLYKFTTTPKDIKDNTDTSESRLINPSVLGLVFEKLNGYKEGSFYTPSFITSYMCKESITTIVLDKFNQKYNIECDKLKELKNYLKNSYKEDKRKEYLQLLLTLRICDPAVGSGHFLVSALNEMVLIAYELGLIASLHRYSLTLENDEIIIHYTPTGEIFNYKKPLRENDPHHHIQKELFELKKSIIENCLFGVDINPNSCEITKLRLWIELLKYSYYIFEEGKNTNALETLPNIDINIKCANSLISRFNLNDDLKKIPNIKKKIQEYKDLVAQYKDPNPLYPLNKADLINKIQDLKNTFSLTLKDPKTKAELEKTIEKHIKKYNFFALDDKSLLDGLNYFIPSLFGTLKLSPKEEEEAFASYGRIRALRKKLDDALSGGEYQNAFEWRFEFPEVLDDEGDFLGFDCIIGNPPYIRQEQIKDLKPLLEKQYQDFYNSTADIYTYFFALSFHLLREKGFSAFITSNKYARAKYGAKLREWLLKKTTLVSYMELNALKVFESAAVDTSIIHFIKQPPLKESDFKYYEPTPDDKDDLKSTPYLSMKQNALSTESFIFANATLLDLRDKIESVGTPLKDWDIQINYGIKTGANEAFIIPTEKRDEILNACKTQEERERTERLIKPILRGKDIKRYSYEWAGEWLINTHNGYTSNLKSKIPPIDIEKYPATKAHLDAHYDTIATRCDQGDTPYHLRNCAYLEDFEKEKIVYPETSQGAYFIYENSGIFLEKTVFMIVSDAYNLKLLTALLNSKLITFYFKNFCGGCILGKSGYQYNKHALEKIPIPQITEKNQELADKITDCAEQILALKAKDPKANTQKLEKEIDALVYQLYHLTDEEIKTIEDGQ
Atome Classification :
(20 SA)
---.........10........20........30........40........50.---.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......------450.......460.......470.......480.......490.......500...---------....510..------.....520.......530.....-..540.......550.......560-....-.....570.......580.......590.-......600......---------.610.......620.......630.-......640.......650........660.......670.......680..-....-.690------------------.......700-------.........710........720.......730.......740-.------.....---...750.......760---..-..-....--.770--...---....780.-......790.......800----------------....---------....810.------.-.....820...-.....-------830.--------......840------.......850....-...860----..-------.....870.......-----880.-........890..-.-.....900-.-......910........920.......930......--.--940...---.----------.--..950...-...---.960......---.970...-..-..980.-......990...--....1000.....---------..1010......1020......1030...-...1040--------....--...1050.....---.1060.......1070-.....-----.1080------------.-.....1090......1100......1110-------......-1120----------.......1130......1140---.....-.1150......1160......1170.......1180......1190......1200......1210......1220......1230......-1240......1250-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MSFTR
I
P
L
K
V
F
I
K
KYNPQEP
K
K
E
T
I
E
N
F
E
K
E
I
N
S
L
L
E
NVPRQ
D
D
E
E
F
Q
K
N
E
I
---
N
K
F
L
K
N
AYGYDC
N
T
Y
E
K
VD
S
V
I
Y
VDK
E
V
R
V
L
I
E
V
K
ALNNKTEFPKNREN
P
L
S
K
A
F
C
Q
M
V
L
Y
F
L
E
E
I
E
K
EKNNSL
K
H
T
I
I
CNAH
E
F
F
L
F
D
C
K
D
L
L
S
L
K
E
D
K
R
I
K
K
F
Y
K
N
Y
A
KKEGTDSSK
P
K
F
Y
K
D
L
E
Q
F
L
Q
E
DFQG
E
L
R
Y
T
H
FNLS
D
D
F
K
E
L
P
L
I
Y
Q
V
L
S
Q
E
V
L
L
K
Q
KRTLDANTL
N
K
D
F
Y
E
E
L
L
Y
I
LGLEEQNDK
G
K
I
L
I
KPSRTK
N
S
L
S
G
A
L
K
E
K
YKNL
D
D
E
E
V
M
A
L
L
I
AWN
N
R
I
L
F
L
R
L
L
E
S
L
L
I
S
F
E
H
F
E
K
E
R
S
F
LTTGNFK
D
F
N
A
L
N
T
L
F
F
E
V
L
A
KKNSERLPEIKENKILGKIPYLNSSLFDKTPLELKG
H
E
I
K
L
LDNK
K
L
E
I
Y
K
N
S
V
L
K
K
H
ENY
Q
K
D
KASL
P
L
L
E
Y
F
F
K
F
L
H
L
Y
KFTTTPKDIKDNTDTSESRLI
N
P
S
V
L
G
L
V
F
E
K
LNGY------KEG
S
F
Y
T
P
S
F
I
T
S
Y
M
C
K
E
S
I
T
T
I
V
L
D
KFNQKYNI
E
C
D
K
L
K
E
L
K
N
Y
L
K
N
S
Y
K
E
D
K
R
K
---------
E
Y
L
Q
L
L
L
T
L
------RICDPAVGS
G
H
F
L
V
S
A
L
N
E
M
V
L
I
-
A
Y
E
L
G
L
I
A
S
L
H
R
Y
S
L
T
LEN
D
E
I
I
---
I
H
YT-PTGEIFNYKKPLRENDP
H
H
H
I
Q
K
E
L
F
E
L
K
-
K
S
I
I
E
NC
L
F
GVDINP---------NSC
E
I
T
K
L
R
L
W
I
E
L
L
K
Y
S
Y
Y
I
F
EEG-KNTNALETLPN
I
D
I
N
I
K
-
C
A
N
S
L
I
S
RFNL
N
D
D
L
K
KI
P
N
I
K
K
K
I
Q
E
Y
K
D
L
V
A
Q-YKDP-NPLY------------------PL
N
K
A
D
L
I
---------
N
K
I
Q
D
L
K
N
T
F
-
S
L
T
LKDPK
T
K
A
E
L
E
K
T
I
E
K
H
I
K
KYN
F
F
ALD---
D
------
K
S
L
L
D
---
G
L
N
Y
F
I
P
S
L
F
G
TLK-----LS-P
K
-
E
E
E
E
--
A
F
A
S
--
Y
G
R
---
I
R
A
L
R
K
K
L
-
D
D
ALSGGEYQ
N
A
F
E
W
RFE-----------------F
P
E
V---------LDDEG
D
F
L
------
G
-
F
D
C
IIG-NPPY-
I
R
Q
E
Q
-------
I
K
D
L
--------
K
P
L
L
E
K
Q
Y
Q
------
D
F
Y
NS
T
A
D
I
Y
T
Y
F
F
-
A
L
S
F
H
L
----
L
R
-------
E
KGF
S
A
F
ITSNKY
A
R
-----
A
--
K
-
Y
G
A
K
L
R
E
W
L
L
-
K
K
-
T
-
T
L
V
S
Y
M
E
L
-
N
-
A
L
K
V
F
E
S
-AAV
D
T
S
I
I
H
F
I
KQPPLKESD
F
K
YYEPTP--D--
D
K
D
D
LK---S----------T--PY
L
S
M
K
QN-ALS---TE
S
F
I
F
ANA
T
---
L
L
D
L
R
D
K
-
I
E
-
S
VGTPL-K
D
W
D
I
Q
I
N
Y
G
IK--TGAN
E
-
A
F
I
I
PT
E
---------
K
R
D
E
I
L
N
A
CK
T
Q
E
E
R
E
R
T
E
R
L
I
K
P
I
LRGK-DIK
R
Y
S
---------
Y
EWA--
G
E
W
L
I
NTHNGYT---SN-LKSKIPPIDIEKY-PAT
K
A
-----
H
L
D
A
H
------------
Y
-
D
T
I
A
T
RCDQGDTP
Y
H
LRN
C
A
Y
L
E
DFEKE
K
-------
I
VYPET-S-Q
G
----------
A
Y
F
I
YENS
G
I
F
L
E
K
T
V
F
M
I
VS---DAY
N
L
-
K
L
L
T
A
L
LNS
K
L
I
T
F
Y
F
K
NFCG
G
-
C
I
LGKSGYQY
N
K
H
A
L
E
KIPIPQITE
K
N
Q
E
L
A
D
K
I
T
D
C
A
E
Q
I
L
A
LKAKDPKA
N
T
Q
K
L
E
K
E
I
D
A
L
V
Y
Q
L
Y
H-L
T
D
E
E
I
KTIEDGQ------------
65
Fugue
86.25
12%
-18
- C2 -
3S1S
26
?
A:
[6-875]
LNN
C
V
F
S
Y
L
P
-------
S
Y
G
D
D
E
V
S
V
Y
H
P
I
C
E
A
A
L
N
Q
A
L
V
N
T
G
L
D
S
T
Y
E
V
V
H
H
E
L
---
V
G
S
I
E
A
D
F
V
I
K
N
K
Q
----------
T
K
K
Y
L
L
I
V
E
V
K
---------
R
T
K
S
Q
V
S
S
T
R
Y
R
L
Q
A
Q
S
Y
V
R
E
A
N
I
K
V
E
Q
H
Y
Y
C
L
T
N
L
E
I
I
D
F
F
K
H
D
-----
P
N
K
P
V
V
S
Q
Q
I
I
E
P
S
P
I
V
V
G
N
F
S
D
T
V
S
E
F
Y
N
R
L
V
E
A
F
Q
N
I
I
D
I
S
V
N
----
D
A
G
T
Y
K
S
S
T
A
N
L
V
D
I
L
E
N
R
K
D
N
S
T
S
W
H
Q
A
L
V
V
A
G
Y
E
Y
I
R
G
V
L
R
G
Q
N
V
E
V
P
T
R
D
A
I
Y
F
K
S
R
-------
P
G
R
L
L
E
E
G
R
K
I
D
------------------------------------------------
F
N
V
L
F
S
E
P
E
P
N
T
N
D
N
------------------------------------------
D
I
W
N
V
N
L
L
S
S
L
N
D
L
G
R
R
I
L
T
G
D
E
L
A
E
L
I
H
D
I
A
---------------------------------
T
R
G
R
G
------
H
E
G
V
V
P
T
D
-----
I
E
L
G
K
V
L
S
I
I
S
Q
H
I
L
G
R
P
L
T
--------------------------------------
E
D
E
------
V
I
S
D
P
A
A
G
S
G
N
L
L
A
T
V
S
A
G
F
N
N
V
M
P
R
Q
-----------------------------------------------------------------
I
W
A
N
D
I
E
T
---------
L
F
L
E
L
L
S
I
R
L
G
L
L
F
P
Q
-----------------
L
V
S
S
N
N
A
P
T
I
-
T
G
E
D
V
C
S
L
N
P
E
D
F
A
N
V
S
V
V
-------------------
V
M
N
P
P
Y
------------------
V
S
G
V
T
D
P
A
---------
I
K
R
K
F
A
H
K
I
I
-
Q
L
T
G
N
R
P
Q
T
L
-------------
F
G
Q
I
G
V
E
---
A
------
L
F
L
E
L
---
V
T
E
L
V
Q
D
G
--
T
V
I
S
-----
A
I
M
P
K
---
Q
Y
--
L
T
A
Q
--
G
N
E
---
S
K
A
F
R
E
F
L
-
V
G
N
F
----------------------------------------------------------
G
-
L
E
H
I
F
L
-
Y
P
R
E
-
G
----------------------------------------
L
F
E
E
V
I
K
D
T
V
V
F
-
V
G
R
K
G
------
S
-------
S
V
E
E
I
E
V
L
D
S
F
T
P
L
E
-----
Q
----
V
D
L
H
N
L
K
R
A
L
-
S
N
-
S
-
S
N
E
Q
I
I
Q
P
M
G
M
E
L
R
K
E
K
R
-
E
E
L
E
N
R
V
T
V
G
W
----------------------------------------------------
R
-
H
I
T
---
S
N
G
R
V
A
E
E
W
I
---
T
N
N
L
E
S
H
-
C
I
-
R
L
V
A
S
---
D
Y
D
L
R
R
G
R
V
G
N
--
K
G
A
S
D
-
L
L
F
I
N
S
-----------
K
K
K
L
W
D
L
L
D
E
S
V
P
R
D
W
L
Y
P
A
L
R
K
V
N
E
I
N
-
T
P
I
F
N
E
---------
D
A
T
P
--
V
R
F
L
C
P
P
N
S
A
Y
Q
---
D
G
-
T
---------
G
E
S
-
I
I
L
D
K
-----
I
L
D
V
Y
------------
V
-
D
F
Q
V
Y
K
S
K
Q
K
K
F
E
K
S
K
E
E
L
K
E
I
L
Y
K
E
S
D
F
YSSEH
T
V
F
I
P
R
A
L
-
R
-
R
S
----------
A
R
A
F
I
N
E
Q
K
V
F
C
S
T
N
A
L
E
V
F
G
---
G
N
S
E
E
M
W
L
L
L
S
W
L
S
S
V
F
A
Q
L
Q
F
E
----
A
M
A
K
D
Q
E
G
E
R
K
L
E
K
K
S
I
Q
N
L
Y
I
P
N
L
G
D
I
D
D
V
L
K
Q
D
L
I
E
E
V
R
E
I
H
F
F
D
L
C
R
P
R
--
V
R
K
L
D
L
L
W
A
K
V
F
W
S
G
N
E
M
S
K
T
K
E
A
A
E
L
L
E
D
L
V
F
E
R
YPEGSQ--
63
Fugue
74.41
19%
1
- C3 -
2ADM
1
MTTA_THEAQ
A:
[21-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-----
E
T
-
P
P
-
E
V
V
D
--
F
M
V
S
--
L
A
E
---
A
P
R
G
G
R
V
L
-
E
P
A
C
A
H
G
P
F
L
R
A
F
R
E
A
H
G
TG
Y
R
F
V
G
V
E
IDPKALDL
P
P
W
A
---------
E
G
I
L
A
D
F
L
LWEPGE
A
-
F
D
L
I
L
G
-
N
P
P
Y
-
G
I
V
G
V
-------
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
-------
T
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
--
K
T
S
V
Y
Y
L
-
G
---
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
I
R
F
A
A
R
S
-
P
E
F
K
K
H
P
A
V
R
K
E
--
P
G
P
G
L
-
V
P
V
L
T
G
R
NLKPGWVDY
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
F
Y
A
T
P
H
L
V
V
A
-
H
T
K
G
T
R
V
V
A
A
W
DERA
Y
P
W
R
--
E
E
F
H
L
L
P
K
E
G
V
R
L
D
P
S
T
-
L
V
Q
W
L
N
S
E
A
M
Q
K
H
-
V
R
T
L
Y
RDFVP
H
L
T
L
R
------------
M
L
E
R
L
P
V
R
R
E
Y
G
F
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
72.07
10%
-26
- C1 -
1W36
-
RECC_ECOLI
C:
[1-1121]
---------
M
L
R
V
Y
H
S
---------
N
R
L
D
V
L
E
A
L
M
E
F
I
V
E
R
E
R
L
D
D
--
P
F
E
P
E
M
I
LVQ
S
T
G
M
A
Q
W
L
Q
M
T
L
S
Q
K
F
G
I
A
A
N
I
D
F
P
L
P
A
S
F
I
W
D
M
F
V
R
V
L
P
---
E
I
P
K
E
S
A
F
N
K
Q
S
M
S
W
K
L
M
T
L
L
P
Q
L
L
E
R
E
D
------
F
T
L
L
R
H
Y
L
T
D
D
S
D
K
R
K
L
F
Q
L
S
S
K
A
A
D
L
F
D
Q
Y
L
------
V
Y
R
P
D
W
L
A
Q
W
E
T
----------
G
H
L
V
E
G
L
G
E
A
Q
A
W
Q
A
P
L
W
K
A
L
V
E
Y
T
H
Q
L
G
Q
P
R
W
H
R
A
N
L
Y
Q
R
F
I
E
T
L
E
S
A
T
T
C
P
P
G
L
P
S
R
V
F
I
C
G
I
S
A
L
P
----------------
P
V
Y
L
Q
A
L
Q
A
L
G
K
H
I
E
I
H
L
L
F
T
N
P
C
R
Y
Y
W
G
D
I
K
D
P
A
Y
L
A
K
L
L
T
R
Q
----
R
R
H
S
F
E
D
R
E
L
P
L
F
R
D
S
E
N
A
G
Q
L
F
N
S
D
G
E
Q
D
V
G
N
P
L
L
A
S
W
G
K
L
G
R
D
Y
I
Y
L
L
S
D
L
E
S
S
Q
E
L
D
A
--------
F
V
D
V
T
P
D
N
L
L
H
N
I
Q
S
D
I
L
E
L
E
N
R
A
V
A
G
V
N
I
E
E
F
S
R
S
D
N
K
R
P
L
D
P
L
D
S
S
I
T
F
H
V
C
H
S
P
------
Q
R
E
V
E
V
L
H
D
R
L
L
A
M
L
E
E
D
P
T
L
T
------
P
R
D
I
I
V
M
V
A
D
I
D
S
Y
S
P
F
I
Q
A
V
F
G
S
A
P
A
D
---------
R
Y
L
P
Y
----------
A
I
S
D
R
R
A
R
Q
S
H
P
V
L
E
A
F
I
S
L
L
S
L
-
P
D
S
R
F
V
S
E
D
V
L
A
L
---
L
D
V
P
V
L
A
---
A
R
F
D
I
T
E
E
G
L
R
Y
L
R
Q
W
V
N
E
S
G
I
R
W
G
I
D
D
D
N
V
R
E
L
--------------
E
L
---------
P
A
T
G
Q
H
T
W
R
F
G
L
T
R
M
L
L
G
Y
A
M
E
S
A
Q
-
G
E
W
Q
S
V
L
P
Y
D
E
S
S
----------------
G
L
I
A
E
L
V
G
H
L
A
S
L
L
M
Q
L
N
I
W
R
R
G
-
L
A
Q
E
-
R
P
L
E
------------------
E
W
L
--
P
V
C
---------
R
D
M
--
L
N
A
F
F
-
L
P
D
A
E
T
E
A
A
M
T
L
I
E
Q
Q
W
Q
A
I
I
A
E
G
L
G
A
Q
Y
G
---
D
------
A
V
P
L
S
---
L
L
R
D
E
L
A
Q
R
L
D
Q
E
R
-----
I
S
-
Q
R
-
F
L
A
G
PV
N
I
C
T
--
L
M
P
---
M
R
S
I
P
-----------------------------------------------------------
F
------
K
-
V
V
C
L
L
G
M
N
D
G
V
-
Y
P
R
Q
L
-------
A
P
L
G
--------
F
D
L
M
S
Q
K
P
K
------
R
G
D
R
S
R
R
D
D
D
R
Y
L
F
-
L
E
A
L
I
S
----
A
Q
-------
Q
K
L
Y
I
S
Y
I
G
R
S
I
Q
D
N
SERFP
S
--
V
-
L
V
Q
E
L
I
D
Y
I
G
-
Q
S
-
H
-
Y
L
P
G
D
E
A
L
-
N
-
C
D
E
S
E
A
R
-
V
K
A
H
L
T
C
L
H
--
T
R
M
P
F
D
P
Q
N
Y
Q
P
G
E
R
Q
S
--
Y
--
A
R
E
W
L
P
---
A
----------
A
--
S
-
Q
A
G
K
A
H
-
S
E
F
---
V
Q
P
L
P
F
T
L
P
E
---
T
V
P
L
E
T
L
-
Q
R
-
F
W
A
H
P
V
-
R
A
F
-
F
Q
M
R
L
Q
V
N
--
F
R
T
E
D
-
S
E
I
P
D
T
E
---------
P
-----
F
I
L
E
G
L
S
R
Y
Q
I
N
Q
Q
L
L
N
A
L
V
E
Q
D
-
D
A
E
R
L
F
---------
R
R
F
R
--
A
A
G
D
L
P
Y
G
A
F
G
E
---
I
F
-
W
E
T
Q
C
Q
E
M
Q
Q
L
A
D
-
R
V
I
A
C
-----
R
Q
P
G
Q
------------
S
-
M
E
I
D
L
A
C
N
----
G
V
Q
I
T
G
--
W
L
P
Q
V
Q
P
D
G
-------
L
L
R
W
R
P
-
S
-
L
L
SVAQGMQLWL
E
H
L
V
Y
C
A
S
G
G
N
G
E
S
R
L
F
L
R
K
D
---
G
E
W
R
F
-
P
P
L
A
A
E
Q
A
L
H
Y
L
S
Q
L
I
E
G
Y
R
E
G
---
M
S
A
P
L
L
V
L
P
E
S
G
G
A
W
L
K
T
C
Y
D
A
Q
N
D
A
M
L
D
D
D
S
T
L
-
Q
K
A
R
T
K
F
L
Q
A
Y
E
G
N
M
M
V
R
G
E
G
D
D
I
W
Y
Q
R
L
W
R
Q
-
L
T
P
E
T
M
E
A
I
V
E
Q
S
QRFLLPLFRFNQ
42
HHSearch
70.51
18%
-45
- C3 -
2IH2
5
MTTA_THEAQ
A:
[98-412]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
F
D
L
I
L
G
-
N
P
P
Y
-
G
I
V
G
E
-------
A
S
K
Y
P
I
H
V
F
K
A
V
K
D
L
Y
K
K
A
F
S
-------
T
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
-
K
T
-
S
V
Y
Y
L
-
G
---
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
--
S
L
W
D
T
Q
E
S
E
--
S
--
G
F
T
P
----------------
I
--
L
W
A
E
Y
-----
P
H
---
W
E
G
E
I
I
R
F
E
T
-----
E
E
T
R
K
-
L
E
-
I
S
G
M
P
L
-
G
D
L
-
F
H
I
R
F
A
A
R
--
S
P
E
F
K
-
K
H
---
P
-------------
A
V
---------
R
K
E
P
G
P
G
L
V
P
V
L
T
G
R
-
N
L
K
P
G
W
---------
V
D
Y
E
--
K
N
H
S
G
L
------------------------------------
W
M
P
K
-------------------
E
R
-----------
A
K
E
L
R
D
F
Y
A
T
P
H
-------
L
V
V
A
H
T
K
G
-
T
R
----------
V
V
A
A
W
D
E
R
A
Y
P
W
R
-
E
E
F
H
L
L
P
K
E
G
V
R
L
D
P
-
S
S
L
V
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
------
F
V
P
H
L
T
L
R
M
L
E
R
L
P
V
R
R
E
Y
G
F
H
T
-------------------------------------------------------------------
66
Fugue
70.43
16%
-10
* C2 *
3UFB
-
?
A:
[12-495]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
P
M
-
T
T
A
Q
Q
L
G
A
I
V
K
S
S
R
Q
I
M
R
K
D
K
G
L
NGD
L
D
R
L
-
P
M
L
T
W
I
M
F
L
K
F
L
D
D
L
E
Q
M
R
E
T
E
A
V
L
E
G
K
S
F
Q
P
A
I
E
A
P
Y
R
W
R
D
W
A
A
---------
I
E
G
G
I
T
G
-
D
E
L
I
A
F
I
N
N
D
E
A
M
R
P
D
G
T
R
G
I
G
L
F
A
Y
L
R
S
L
Q
G
D
-----
N
G
G
D
R
R
D
V
I
A
T
V
F
K
G
M
Q
N
R
M
I
N
G
Y
L
L
R
D
V
V
D
K
-
I
N
G
I
-
H
----------------------
F
N
S
S
E
E
M
---------
H
T
L
S
R
L
Y
E
T
M
-
L
R
E
M
R
D
A
A
G
D
S
G
-
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
M
D
PQL
G
------
E
S
V
L
D
PAC
G
T
G
G
F
L
V
E
A
F
E
H
L
E
-----
R
Q
-
C
K
T
V
E
D
R
--
E
V
L
Q
--
E
S
S
---
I
F
G
G
E
A
K
S
-
L
P
Y
L
L
V
--
Q
M
N
L
L
L
H
G
L
E
-----------------
Y
P
R
I
DPENSLRFP
L
R
E
M
G
D
K
D
------
R
-
V
D
V
I
L
T
-
N
P
P
F
-
G
G
E
E
E
--------
K
G
I
--------
L
G
N
F
P
E
D
M
Q
------
T
--
A
E
T
A
M
L
F
L
Q
L
I
-
M
R
K
L
K
R
PGHG
S
D
-------
N
G
G
R
A
A
V
V
V
P
N
G
T
L
F
-----
S
--
D
G
I
S
A
R
I
K
E
E
L
L
-
K
N
-
F
-
N
L
H
T
I
V
R
L
-
P
-
E
G
V
F
A
P
Y
-
T
D
I
A
G
N
L
L
F
F
D
R
S
G
P
T
D
D
I
W
Y
Y
Q
I
T
V
P
E
--
G
--
R
K
K
Y
T
K
---
T
----------
K
--
P
M
E
S
H
E
F
D
-
E
C
L
---
N
W
W
S
N
R
I
V
N
Q
---
N
A
W
K
E
S
A
-
S
E
-
I
I
K
Y
S
E
-
S
G
Q
L
I
D
V
N
L
D
R
K
--
N
P
N
S
L
-
E
V
L
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
69.53
23%
-68
- C3 -
3UFB
-
?
A:
[155-416]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
L
R
D
V
V
D
K
I
N
G
I
H
F
N
S
---------------
S
E
E
M
H
T
L
S
R
L
Y
E
T
M
L
R
E
M
R
D
AAG
D
S
G
E
F
Y
T
P
R
P
V
V
R
F
M
V
E
V
-----
M
D
P
Q
--------------------------------------------
L
G
E
------
S
V
L
D
P
A
C
G
T
G
G
F
L
V
E
A
F
E
H
L
E
R
Q
-
C
K
T
V
-----------------------------------------------------
E
D
R
-
E
V
L
Q
E
S
S
I
F
G
G
E
A
K
S
---------
L
P
Y
L
L
V
Q
M
N
L
L
L
H
G
L
E
Y
----------------------
P
R
I
D
-
P
E
N
S
L
R
F
P
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------
M
---------
G
----
D
K
D
------
R
-
V
D
V
I
L
T
-
N
P
P
F
-
G
G
E
E
E
-------
K
G
I
-------------
L
G
N
F
P
-------
E
D
M
Q
T
A
E
T
A
M
L
F
L
-
Q
L
I
M
R
K
----
L
K
RPGHGSD
N
G
G
R
A
A
V
V
V
P
N
G
T
L
F
-----
S
D-
G
-
I
S
A
R
I
K
E
E
L
L
-
K
N
-
F
-
N
L
H
T
I
V
R
L
-
P
-
E
-
G
V
F
A
P
Y
T
D
I
A
G
N
L
L
F
F
D
R
S
G
P
T
D
D
I
W
Y
Y
Q
I
T
V
P
E
--
G
--
R
K
K
Y
T
K
---
T
----------
K
--
P
M
E
S
H
E
F
D
-
E
C
L
---
N
W
W
S
N
R
I
V
N
Q
---
N
A
W
K
E
S
A
-
S
E
-
I
I
K
Y
S
E
-
S
G
Q
L
I
D
V
N
L
D
R
K
--
N
P
N
S
L
-
E
V
L
E
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
69.01
16%
-57
- C2 -
3S1S
12
?
A:
[399-853]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
V
S
V
V
V
M
-
N
P
P
Y
-
V
S
G
V
T
-------
D
P
A
I
K
-------
R
K
F
A
H
K
I
I
Q
L
TGNRP
Q
T
L
F
G
Q
I
G
V
E
A
L
F
L
-
E
L
V
T
E
L
----
V
Q
-------
D
G
T
V
I
S
A
I
M
P
K
Q
Y
L
T
-----
A
QG
N
-
E
S
K
A
F
R
E
F
L
V
-
G
N
-
F
-
G
L
E
H
I
F
L
Y
-
P
-
R
E
G
L
F
E
E
-
V
I
K
D
T
V
V
F
V
G
R
K
G
S
S
V
E
--
E
I
E
V
L
D
S
F
T
PL
E
QV
D
L
H
N
L
K
R
A
L
S
N
SSNE
Q
I
I
Q
P
M
G
M
E
L
R
K
E
K
R
E
-
E
L
E
N
R
V
T
V
G
W
R
H
I
T
S
N
G
R
V
A
E
E
W
I
T
N
N
L
E
-
S
H
C
I
R
L
V
A
S
D
-
Y
D
L
R
R
G
R
V
GN
K
G
A
S
D
L
L
F
I
N
S
K
K
---------
K
L
W
D
L
L
-------
D
E
S
V
P
R
D
W
L
Y
P
A
L
R
K
V
N
E
I
N
T
P
I
---------
F
N
E
D
AT
P
V
R
F
L
C
P
P
N
S
A
Y
---
Q
D
-
G
----
T
G
E
S
I
I
L
D
-
K
I
L
D
V
-----
Y
V
D
F
Q
V
Y
K
SKQKKFEKS
K
-
E
E
L
K
E
I
L
Y
K
-------
E
S
D
F
----
Y
S
S
E
H
T
------
V
F
I
P
R
A
-
L
R
R
S
----------
A
R
A
F
I
N
E
Q
K
V
F
C
S
T
N
A
L
E
V
F
G
G--
N
S
E
E
M
-
W
L
L
L
S
W
L
S
S
V
F
A
Q
L
Q
F
E
A
M
A
K
---
D
Q
-
E
G
E
R
K
L
E
K
K
S
I
Q
N
L
Y
I
P
N
L
G
D
I
D
D
V
L
K
Q
D
L
I
E
E
V
R
E
I
H
F
F
D
L
------
C
R
P
R
V
R
K
L
D
L
L
W
A
K
V
F
W
-
S
G
N
E
M
S
K
T
K
E
A
A
E
------------
64
Fugue
59.70
12%
15
- C2 -
2AR0
7
T1MK_ECOLI
A:
[6-529]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
L
V
A
K
L
W
K
L
C
D
N
L
R
D
G
G
-
V
S
Y
Q
N
Y
V
N
E
L
A
S
L
L
F
L
K
M
C
K
E
T
G
Q
E
A
E
Y
L
P
E
G
Y
R
W
D
D
L
K
S
R
I
G
Q
E
Q
L
Q
F
Y
R
K
M
L
V
H
L
-
G
E
D
D
------------------
K
K
L
V
Q
A
V
F
HNVSTTITE
P
K
Q
I
T
A
L
V
S
N
M
D
S
L
D
W
Q
Y
F
T
P
R
P
L
I
K
T
I
I
H
L
L
K
P
Q
P
R
E
V
V
Q
---
D
PAAGTA
G
F
L
I
E
---
A
D
R
Y
V
K
S
Q
T
N
D
L
D
D
-----
L
D
-
G
D
-
T
Q
D
F
--
Q
I
H
R
A
F
I
G
L
E
LV
P
G
T
R
R
L
A
L
M
N
C
L
L
H
D
I
E
G
N
L
D
H
G
G
A
I
R
-----------------
L
G
N
T
---------
L
G
S
D
G
E
N
L
------
P
K
A
H
I
V
A
T
-
N
P
P
F
-
G
S
A
A
G
------------------------
T
N
I
T
------
R
T
F
V
H
P
T
S
N
K
Q
L
C
F
M
Q
H
I
I
E
T
----
L
H
-------
P
G
G
R
A
A
V
V
V
P
D
N
V
L
F
-----
E
--
G
-
G
K
G
T
D
I
R
R
D
L
M
D
K
-
C
-
H
L
H
T
I
L
R
L
-
P
-
T
-
G
I
F
Y
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
---------
A
N
P
N
--
Q
--
D
K
N
C
T
D
---
D
----------
V
--
W
V
Y
D
L
R
T
N
M
P
S
F
---
G
K
R
T
P
F
T
D
E
H
---
L
Q
P
F
E
R
V
-
Y
G
-
E
D
P
-------
H
G
L
S
P
R
T
E
G
--
E
W
S
F
N
-
A
E
E
T
E
V
A
---------
D
S
E
E
N
K
N
T
-
D
Q
H
L
A
T
S
R
W
R
K
F
S
R
E
W
I
R
T
A
-
K
S
D
S
L
D
---------
I
S
W
L
--
K
D
K
D
P
E
P
D
V
L
A
A
---
E
A
M
G
E
L
V
Q
A
L
S
E
L
D
A
L
M
R
E
L
G
A
-----
S
D
E
A
D
------------
L
-
Q
R
Q
L
L
E
E
A
F
G
G
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
56.58
28%
-25
- C3 -
1G38
3
MTTA_THEAQ
A:
[68-190]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
F
L
LWEPGE
A
-
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYPIHV
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
G
K
-
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.14
28%
-10
- C3 -
2IBT
5
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
54.07
28%
-6
- C3 -
2ADM
1
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
--V------
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
T
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
54.01
28%
-11
- C3 -
2JG3
6
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
S
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.93
28%
-11
- C3 -
2IH2
5
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.83
28%
-9
- C3 -
2NP6
3
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYPIHV
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
53.70
28%
-13
- C3 -
2IH5
4
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
52.96
28%
-5
- C3 -
2NP7
5
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
52.91
28%
-7
- C3 -
2IH4
4
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYPIHV
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.87
28%
-9
- C3 -
2IBS
3
MTTA_THEAQ
A:
[99-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
I
L
G
-
N
P
P
Y
G
I
V
G
E
A
SKYP
I
H
V
F
K
A
V
--------
K
D
L
Y
K
K
A
F
S
------
T
-
W
K
G
K
Y
N
L
Y
G
A
F
L
-
E
K
A
V
R
L
----
L
K
-------
P
G
G
V
L
V
F
V
V
P
A
T
W
L
V
-----
L
--
E
-
D
F
A
L
L
R
E
F
L
A
-
R
E
-
G
K
T
S
V
Y
Y
L
G
------
E
V
F
P
Q
-
K
K
V
S
A
V
V
I
R
F
Q
K
S
G
K
G
L
S
L
W
D
T
Q
E
S
E
S
G
--
F
--
T
P
I
L
W
A
---
E
----------
Y
--
P
H
W
E
G
E
I
I
-
R
F
E
---
T
E
E
T
R
K
L
E
I
S
---
G
M
P
L
G
D
L
-
F
H
-
I
R
F
A
A
R
-
S
P
E
F
K
K
H
P
A
V
R
K
--
E
P
G
P
G
-
L
V
P
V
L
T
G
---------
R
N
L
K
P
G
W
V
D
Y
E
K
N
H
S
G
L
W
M
P
K
E
R
A
K
E
L
R
D
-
F
Y
A
T
P
H
---------
L
V
V
A
--
H
T
K
G
T
R
V
V
A
A
W
D
---
E
R
-
A
Y
P
W
R
E
E
F
H
L
L
P
K
-
E
G
V
R
L
-----
D
P
S
S
L
------------
V
-
Q
W
L
N
S
E
A
M
Q
K
H
V
R
T
L
Y
R
D
F
V
P
H
L
T
L
R
M
L
E
-------
R
L
P
V
R
R
-
E
-
Y
G
----------
F
H
T
-------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
51.61
15%
23
- C2 -
3KHK
1
?
A:
[7-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
F
L
N
D
L
D
N
Q
L
W
R
A
A
D
K
L
R
S
N
L
D
A
A
N
Y
K
H
V
-
V
L
G
L
I
F
L
K
Y
V
S
D
A
F
E
E
R
Q
Q
E
L
T
E
L
-----
F
Q
K
D
D
D
D
N
I
Y
Y
L
P
R
E
D
Y
D
S
D
E
A
Y
Q
Q
A
I
A
E
E
L
E
I
G
D
Y
Y
T
E
K
N
V
F
W
V
P
K
T
A
--------
R
W
N
K
L
R
D
V
I
T
L
P
T
S
V
S
W
L
I
D
N
A
F
D
D
I
E
K
A
N
------
P
K
L
K
G
-----------------
I
L
N
R
I
S
Q
Y
Q
L
D
A
D
K
L
I
G
L
I
N
E
F
S
K
--
D
I
L
G
H
V
Y
E
Y
F
L
G
Q
F
A
L
A
E
G
K
QGGQYYTP
K
S
I
V
T
L
I
V
E
M
L
EPYK
G
R
V
Y
D
P
A
M
G
S
G
G
F
F
V
S
S
D
K
F
I
E
K
H
-
A
N
V
K
H
Y
N
A
S
E
Q
K
K
Q
I
S
V
Y
G
Q
E
------
S
N
P
-
T
T
W
K
L
A
A
M
N
M
V
I
R
G
I
D
F
N
F
G
K
K
N
A
D
S
F
L
D
-
D
Q
H
P
D
L
R
A
D
F
V
M
T
N
P
PFNMKDWWH
E
K
L
A
D
D
P
R
W
T
I
N
T
N
K
R
I
L
T
P
P
T
G
N
A
-
N
F
A
W
M
L
H
M
L
Y
H
L
A
P
T
G
S
-
M
A
-
L
L
L
A
N
G
S
M
S
S
N
T
N
N
E
G
E
I
R
K
T
L
V
E
Q
D
L
V
E
C
M
-
V
A
L
P
-
G
Q
L
F
TNTQ
I
P
A
C
I
W
F
L
T
KDKNA
K
N
G
K
R
D
R
R
---------
G
Q
V
L
F
I
D
A
R
K
-
L
G
Y
M
K
D
R
V
L
R
D
F
K
D
E
D
I
Q
K
L
A
D
T
F
H
N
W
Q
Q
E
---
W
------
S
E
E
N
N
---
Q
A
G
F
C
F
S
A
D
L
A
L
I
R
K
N
DFV
L
T
-
P
G
-
R
Y
V
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
50.67
18%
6
- C3 -
2AR0
-
T1MK_ECOLI
A:
[261-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
A
H
I
V
A
T
-
N
P
P
F
-
G
S
A
A
G
-------
T
N
I
-------------
T
R
T
F
V
---------
H
P
T
S
N
K
Q
L
C
F
M
-
Q
H
I
I
E
T
----
L
H
-------
P
G
G
R
A
A
V
V
V
P
D
N
V
L
F
E----
G
--
G
-
K
G
T
D
I
R
R
D
L
M
-
D
K
-
C
-
H
L
H
T
I
L
R
L
-
P
-
T
-
G
I
F
Y
A
-
Q
G
V
K
T
N
V
L
F
F
T
K
G
T
V
A
N
P
N
Q
D
K
N
C
T
D
D
V
--
W
--
V
Y
D
L
R
T
---
N
----------
M
--
P
S
F
G
K
R
T
P
-
F
T
D
---
E
H
L
Q
P
F
E
R
V
Y
---
G
E
D
P
H
G
L
-
S
P
-
R
T
E
G
E
W
-
S
F
N
A
E
E
T
E
V
A
D
S
--
E
E
N
K
N
-
T
D
Q
H
L
A
T
---------
S
R
W
R
K
F
S
R
E
W
I
R
T
A
K
S
D
S
L
D
I
S
W
L
K
D
K
D
P
-
E
P
D
V
L
A
---------
A
E
A
M
--
G
E
L
V
Q
A
L
S
E
L
D
A
---
L
M
-
R
E
L
G
A
S
D
E
A
D
L
Q
R
-
Q
L
L
E
E
-----
A
F
G
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------