@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0506: (2016-03-16 )
MKALKLYGKRDLRYEEADMPTIEEPDDVILKVKTVGICGSDISRYSKLGPYVPGMVWGHEFSGEVIEVGSEVTDIEIGDRAAGCPALYCGECEYCKKGEFARCRKLTVIGARHPGAYAEYIKLPAENVVKIPNELDYEAAALVEPSAVVVHGFYHTKLQAGDDVVVVGSGNIGLLAIQWAKVFGARRVIAIDVDDKKLALAKEVGADVVINSLKEDPLEVVAAHTDGLNADLVVEAAGSPITSAQVFAYAKKGGGVVFLGIPYADVTIERFYFEKIVRSELTVWGSWNAISAPFPGKEWQTTIHFLANKQINIEPMITHRLSLAEGPEVFERIYERNEFFGKVLFFPE
Atome Classification :
(22 SA)
.........-10........20...-.....30........40.....----...50---..--...--....60........70........80.......--.90........100.......110..--.....120.......130.......140.......150........160.......170.......180.......190.......200......--.210.......220......---.--230.......240.......250.......260.......270.-.-.....280.......290.......300.......310.......320.......330...--....340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
A
L
KLYGK-RDLRYEEADMPTIEE-PD
D
V
I
L
K
V
K
T
VGIC
G
S
D
I
S
R
Y
S----KLGP----YV--PGM--VWGHEFSG
E
V
I
EVGS
E
V
T
D
I
E
IGDRAAGCP
A
L
Y--CGE
C
E
Y
CKKG
E
F
A
R
C
R
K
L
T
V
I
GARHP--G
A
Y
A
E
Y
IKL
P
A
E
N
V
VKIPNELDY
E
A
A
ALVEP
S
A
V
V
V
H
-
G
F
Y
H
T
KLQAGD
D
V
V
V
VGSG
N
I
G
L
L
A
I
Q
W
A
K
V
FGA
R
R
V
I
A
I
DVDD
K
K
L
A
L
A
K
EV
G
A
D
V
--
V
I
N
S
LKED
P
L
E
V
V
AAHTDGL---N--A
D
L
V
V
EAAGSPITS
A
Q
V
F
A
Y
AKKGG
G
V
V
F
L
GIPYA
D
V
T
I
E
R
F
Y
F
-
E
-
K
I
V
R
S
E
L
T
V
W
GSWNAISAPFPGK
E
W
Q
T
T
I
H
F
LAN
K
Q
INI
E
P
M
I
T
H
RLSLAE
G
P
E
V
F
E
R
I
Y
E
--
R
N
E
FF
G
K
V
LFFPE
15
PsiBlast_PDB
87.34
32%
-106
- C1 -
3PII
5
ADH3_GEOSE
A:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
P
L
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
23
PsiBlast_CBE
85.59
37%
-95
- C1 -
4UEJ
4
?
B:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
4
PsiBlast_PDB
85.42
37%
-97
- C1 -
4UEO
3
?
A:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
38
PsiBlast_CBE
84.78
32%
-107
- C1 -
3PII
5
ADH3_GEOSE
C:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
36
PsiBlast_CBE
84.72
32%
-106
- C1 -
1RJW
6
ADH3_GEOSE
B:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
14
PsiBlast_PDB
84.53
32%
-103
- C1 -
1RJW
4
ADH3_GEOSE
A:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
2
PsiBlast_PDB
84.36
37%
-95
- C1 -
4UEJ
4
?
A:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
1
PsiBlast_PDB
84.35
37%
-97
- C1 -
4A2C
3
GATD_ECOLI
A:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
37
PsiBlast_CBE
83.97
32%
-105
- C1 -
3PII
4
ADH3_GEOSE
D:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
9
PsiBlast_PDB
83.86
33%
-103
- C1 -
2DFV
3
TDH_PYRHO
A:
[20-344]
----------------
E
V
D
V
P
K
-
P
G
-
P
G
E
V
L
I
K
V
L
A
T
S
I
C
G
T
D
L
H
I
Y
E
WN
E
W
A
Q
S
R
----
I
K
--
P
P
Q
--
I
M
G
H
E
V
A
G
E
V
V
E
I
G
P
G
V
E
G
I
E
V
G
D
Y
V
S
V
E
T
H
I
V
--
C
G
K
C
Y
A
C
R
R
G
Q
Y
H
V
C
Q
N
T
K
I
F
G
V
D
T
D
--
G
V
F
A
E
Y
A
V
V
P
A
Q
N
I
W
K
N
P
K
S
I
P
P
E
Y
A
T
L
Q
E
P
L
G
N
A
V
D
-
T
V
L
A
G
P
I
-
S
G
K
S
V
L
I
T
G
A
G
P
L
G
L
L
G
I
A
V
A
K
A
S
G
A
Y
P
V
I
V
S
E
P
S
D
F
R
R
E
L
A
K
K
V
G
A
D
Y
--
V
I
N
P
F
E
E
D
V
V
K
E
V
M
D
I
T
D
G
N
---
G
--
V
D
V
F
L
E
F
S
G
A
P
K
A
L
E
Q
G
L
Q
A
V
T
P
A
G
R
V
S
L
L
G
L
Y
P
G
K
V
T
I
D
--
F
N
-
N
-
L
I
I
F
K
A
L
T
I
Y
G
----
I
T
G
R
H
L
W
E
T
W
Y
T
V
S
R
L
L
Q
S
G
K
L
N
L
D
P
I
I
T
H
K
Y
---
K
G
F
D
K
Y
E
E
A
F
E
L
M
R
A
G
K
T
G
K
V
V
F
---
35
PsiBlast_CBE
83.80
32%
-105
- C1 -
1RJW
5
ADH3_GEOSE
C:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
34
PsiBlast_CBE
83.40
32%
-105
- C1 -
1RJW
6
ADH3_GEOSE
D:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
L
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
22
PsiBlast_CBE
83.05
37%
-94
- C1 -
4UEK
4
?
B:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
24
PsiBlast_CBE
83.02
37%
-96
- C1 -
4A2C
3
GATD_ECOLI
B:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
5
PsiBlast_PDB
82.55
35%
-96
- C1 -
4EJ6
19
?
A:
[25-363]
-
K
A
V
R
L
E
S
V
-
G
N
I
S
V
R
N
V
G
I
P
E
-
P
G
-
P
D
D
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
H
L
L
H
----
G
E
F
P
----
S
T
--
P
P
V
--
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
S
--
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
G
I
H
R
D
--
G
G
F
A
E
Y
V
L
V
P
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
F
C
E
P
L
A
C
C
L
H
-
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
G
V
I
G
L
L
T
V
Q
L
A
R
L
A
G
A
T
T
V
I
L
S
T
R
Q
A
T
K
R
R
L
A
E
E
V
G
A
T
A
--
T
V
D
P
S
A
G
D
V
V
E
A
I
A
G
P
V
-
G
L
VPG
G
--
V
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
G
G
T
V
V
I
L
G
V
L
P
Q
G
E
K
V
E
I
E
P
F
-
D
-
I
L
F
R
-
E
L
R
V
L
G
S
F
---
I
N
P
F
---
V
H
R
R
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
S
L
D
E
A
P
D
V
I
S
N
P
A
A
--
A
G
E
V
--
K
V
L
V
I
P
S
3
PsiBlast_PDB
81.71
37%
-96
- C1 -
4UEK
4
?
A:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
39
PsiBlast_CBE
81.45
32%
-105
- C1 -
3PII
5
ADH3_GEOSE
B:
[10-337]
--------
K
-
E
P
L
K
I
K
E
V
E
K
P
T
I
S
Y
--
G
E
V
L
V
R
I
K
A
C
G
V
C
H
T
D
L
H
A
A
H
----
G
D
W
P
----
V
K
--
P
K
L
PL
I
P
G
H
E
G
V
G
I
V
E
E
V
G
P
G
V
T
H
L
K
V
G
D
R
V
-
G
I
P
W
L
Y
SA
C
G
H
C
D
Y
C
L
S
G
Q
E
T
L
C
E
H
Q
K
N
A
G
Y
S
V
D
--
G
G
Y
A
E
Y
C
R
A
A
A
D
Y
V
V
K
I
P
D
N
L
S
F
E
E
A
A
P
I
F
C
A
G
V
T
T
Y
K
A
L
K
V
T
G
A
K
P
G
E
W
V
A
I
Y
G
I
G
G
F
G
H
V
A
V
Q
Y
A
K
A
M
G
L
-
N
V
V
A
V
D
I
G
D
E
K
L
E
L
A
K
E
L
G
A
D
L
--
V
V
N
P
L
K
E
D
A
A
K
F
M
K
E
K
V
G
G
V
---
H
--
A
A
V
V
T
A
V
S
K
P
A
F
Q
S
A
--
Y
N
S
I
R
R
G
G
A
C
V
L
V
G
L
P
P
E
E
M
P
I
P
I
F
-----
D
T
V
L
N
G
I
K
I
I
G
S
I
V
G
T
R
-----
K
D
L
Q
E
A
L
Q
F
A
A
E
G
K
V
K
---
T
I
I
E
V
Q
P
L
E
K
I
N
E
V
F
D
R
M
L
---
K
G
Q
I
N
G
R
V
V
L
T
L
E
6
PsiBlast_PDB
81.42
35%
-97
- C1 -
4EJM
5
?
A:
[25-362]
-
K
A
V
R
L
E
S
V
-
G
N
I
S
V
R
N
V
G
I
P
E
-
P
G
-
P
D
D
L
L
V
K
V
E
A
C
G
I
C
G
T
D
R
H
L
L
H
----
G
E
F
P
----
S
T
--
P
P
V
--
T
L
G
H
E
F
C
G
I
V
V
E
A
G
S
A
V
R
D
I
A
P
G
A
R
I
T
G
D
P
N
I
S
--
C
G
R
C
P
Q
C
Q
A
G
R
V
N
L
C
R
N
L
R
A
I
G
I
H
R
D
--
G
G
F
A
E
Y
V
L
V
P
R
K
Q
A
F
E
I
P
L
T
L
D
P
V
H
G
A
F
C
E
P
L
A
C
C
L
H
-
G
V
D
L
S
G
I
K
A
G
S
T
V
A
I
L
G
G
G
V
I
G
L
L
T
V
Q
L
A
R
L
A
G
A
T
T
V
I
L
S
T
R
Q
A
T
K
R
R
L
A
E
E
V
G
A
T
A
--
T
V
D
P
S
A
G
D
V
V
E
A
I
A
G
P
V
-
G
L
VPG
G
--
V
D
V
V
I
E
C
A
G
V
A
E
T
V
K
Q
S
T
R
L
A
K
A
G
G
T
V
V
I
L
G
V
L
P
Q
G
E
K
V
E
I
E
P
F
-
D
-
I
L
F
R
-
E
L
R
V
L
G
S
F
---
I
N
P
F
---
V
H
R
R
A
A
D
L
V
A
T
G
A
I
E
I
D
R
M
I
S
R
R
I
S
L
D
E
A
P
D
V
I
S
N
P
A
A
--
A
G
E
V
--
K
V
L
V
I
P
-
19
PsiBlast_PDB
81.13
28%
-107
- C1 -
1E3J
4
?
A:
[10-347]
-----
L
Y
K
Q
-
N
D
L
R
L
E
Q
R
P
I
P
E
P
K
E
--
D
E
V
L
L
Q
M
A
Y
V
G
I
C
G
S
D
V
H
Y
Y
E
HG--
R
I
A
D
----
F
I
VK
D
P
M
--
V
I
G
H
E
A
S
G
T
V
V
K
V
G
K
N
V
K
H
L
K
K
G
D
R
V
A
V
E
P
G
V
P
--
C
R
R
C
Q
F
C
K
E
G
K
Y
N
L
C
P
D
L
T
F
C
-
A
T
P
P
D
D
G
N
L
A
R
Y
Y
V
H
A
A
D
F
C
H
K
L
P
D
N
V
S
L
E
E
G
A
L
L
E
P
L
S
V
G
V
H
-
A
C
R
R
A
G
V
Q
L
G
T
T
V
L
V
I
G
A
G
P
I
G
L
V
S
V
L
A
A
K
A
Y
G
A
-
F
V
V
C
T
A
R
S
P
R
R
L
E
V
A
K
N
C
G
A
D
V
TL
V
V
D
P
A
K
E
E
E
S
S
I
I
E
R
I
R
S
A
I
---
G
DL
P
N
V
T
I
D
C
S
G
N
E
K
C
I
T
I
G
I
N
I
T
R
T
G
G
T
L
M
L
V
G
M
G
S
Q
M
V
T
V
P
---
L
-
V
-
N
A
C
A
R
E
I
D
I
K
S
V
F
R
Y
C
N
------
D
Y
P
I
A
L
E
M
V
A
S
G
R
C
N
V
K
Q
L
V
T
H
S
F
K
L
E
Q
T
V
D
A
F
E
A
A
R
K
--
K
A
D
N
T
I
K
V
M
I
---
21
PsiBlast_CBE
80.69
37%
-95
- C1 -
4UEO
3
?
B:
[12-346]
------------
V
R
V
A
E
S
V
I
P
E
I
K
H
-
Q
D
E
V
R
V
K
I
A
S
S
G
L
C
G
S
D
L
P
R
I
F
----
K
N
G
A
----
H
Y
--
Y
P
I
--
T
L
G
H
E
F
S
G
Y
I
D
A
V
G
S
G
V
D
D
L
H
P
G
D
A
V
A
C
V
P
L
L
P
--
C
F
T
C
P
E
C
L
K
G
F
Y
S
Q
C
A
K
Y
D
F
I
G
S
R
R
D
--
G
G
F
A
E
Y
I
V
V
K
R
K
N
V
F
A
L
P
T
D
M
P
I
E
D
G
A
F
I
E
P
I
T
V
G
L
H
-
A
F
H
L
A
Q
G
C
E
N
K
N
V
I
I
I
G
A
G
T
I
G
L
L
A
I
Q
C
A
V
A
L
G
A
K
S
V
T
A
I
D
I
S
S
E
K
L
A
L
A
K
S
F
G
A
M
Q
--
T
F
N
S
S
E
M
S
A
P
Q
M
Q
S
V
L
R
E
L
R
---
F
--
N
Q
L
I
L
E
T
A
G
V
P
Q
T
V
E
L
A
V
E
I
A
G
P
H
A
Q
L
A
L
V
G
T
L
H
Q
D
L
H
L
T
S
A
T
F
-
G
-
K
I
L
R
K
E
L
T
V
I
G
S
W
M
N
Y
S
S
P
W
P
G
Q
E
W
E
T
A
S
R
L
L
T
E
R
K
L
S
L
E
P
L
I
A
H
R
G
S
F
E
S
F
A
Q
A
V
R
D
I
-
A
--
R
N
A
M
P
G
K
V
L
L
I
P
-
75
HHSearch
73.34
30%
-90
- C1 -
2DQ4
3
TDH_THET8
A:
[1-342]
M
R
A
L
A
K
L
A
P
E
E
G
L
T
L
V
D
R
P
V
P
E
P
G
--
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
----
W
D
A
W
A
R
G
R
I
R
--
P
P
L
--
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
--
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
D
R
D
--
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
I
L
E
P
F
G
N
A
V
H
-
T
V
Y
A
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
--
L
V
N
P
L
E
E
D
L
L
E
V
V
R
R
V
T
-
G
S
---
G
--
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
G
E
A
R
I
L
G
I
P
S
D
P
---
I
R
F
D
L
A
G
-
E
L
V
M
R
G
I
T
A
F
G
I
A
G
R
R
----
L
W
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
G
L
L
A
S
--
G
Q
--
A
V
K
V
I
L
D
P
K
17
PsiBlast_PDB
64.77
30%
-96
- C1 -
2DQ4
3
TDH_THET8
A:
[17-326]
------------------
D
R
P
V
P
E
P
G
P
G
E
I
L
V
R
V
E
A
A
S
I
C
G
T
D
L
H
I
W
K
WD
A
W
A
R
G
R
----
I
R
--
P
P
L
--
V
T
G
H
E
F
S
G
V
V
E
A
V
G
P
G
V
R
R
P
Q
V
G
D
H
V
S
L
E
S
H
I
V
--
C
H
A
C
P
A
C
R
T
G
N
Y
H
V
C
L
N
T
Q
I
L
G
V
D
R
D
--
G
G
F
A
E
Y
V
V
V
P
A
E
N
A
W
V
N
P
K
D
L
P
F
E
V
A
A
I
L
E
P
F
G
N
A
V
H
-
T
V
Y
A
G
S
G
V
S
G
K
S
V
L
I
T
G
A
G
P
I
G
L
M
A
A
M
V
V
R
A
S
G
A
G
P
I
L
V
S
D
P
N
P
Y
R
L
A
F
A
R
P
Y
-
A
D
R
--
L
V
N
P
L
E
E
D
L
L
E
V
V
R
R
V
T
-
G
S
---
G
--
V
E
V
L
L
E
F
S
G
N
E
A
A
I
H
Q
G
L
M
A
L
I
P
G
G
E
A
R
I
L
G
I
P
S
D
P
I
---
R
F
D
L
-
A
G
E
L
V
M
R
G
I
T
A
F
G
----
I
A
G
R
R
L
W
Q
T
W
M
Q
G
T
A
L
V
Y
S
G
R
V
D
L
S
P
L
L
T
H
R
L
P
L
S
R
Y
R
E
A
F
--------------------