@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0906: (2016-03-19 )
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNNVDWIKGYAEFVDEKTLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFFALKELPKKVAVVGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMTLHKHAIPQKVEKNPDGSLTLSLEDGRTETVDTLIWAIGRKPVIKGLQIEKSGVELLESGHIAVDKFQNTNVAGIYAVGDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTERVIGLHGIGYGVDEMIQGFAVAINMGATKADFDNTVAIHPTGSEEFVTMK
Atome Classification :
(71 SA)
--------------------------------------------------------------------------------------------------.........10......-..20.....-...30.---.---------.-------..---------.------..40........50........60........--70.-----.-.---.-..---.---.80........90........100.-....-...110....-------..--.120...--.-----.---------.---------.-----.-----.130.......140...---.-...150........160.....---------..170.......180...---..-.---.190.......200.......210.......220.......230.--------...--------...240.---.--..----.---.------.--250---..------.......260.......270......-.280.-......290.......300-----.-.-.----..-..310.......320..--.....330.......340.......350.......360...-....370..--.....380-..----.----.-..--..390..-.-..-.-.400.......410.......420.......430.......440.......-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------MEK
H
Y
D
Y
I
A
I
GGGSG
G
I
-
A
S
I
N
R
A
A
MH-G
A
K
C
A
L---I---------E-------PK---------F------LG
G
T
C
V
NVGCV
P
K
K
V
M
W
Y
G
A
Q
I
K
E
A
M
D
L
Y
ADA--Y
G
Y
-----
Q
-V---D-AS---F---
N
F
Q
K
L
V
E
N
R
E
A
Y
I
E
R
I
R
G
S
YKNG-L-DNN
N
-
V
D
W
I
K
G
Y
A
E
F
-------VD--EK--
T
L
R
--V-----N---------
G
---------
E
-----
L
-----
V
T
A
D
H
I
L
I
ATGGEPALP---S-IPGA-EFGITS
D
G
F
F
A
L
K
EL
P
K
---------
K
V
A
V
VGA
G
Y
I
A
V
E
L
A
G
V
L
---
Q
Q
-L---GSET
H
L
F
V
R
KHAPLRNF
D
P
L
L
T
D
T
L
T
E
I
I
E
QSDM
T
L
H
K
HAI
P
Q
K
V
--------EKN--------PDG
S
L
T
L
---
S
--LE----D---G------R--T-----
E
T
------
V
D
T
L
I
W
AIGRKPVIKG
L
Q
I
E
K
S
G
V
E
L
-
L
ESG
H
-
I
A
V
D
KFQNTN
V
A
G
I
Y
A
V
GD-----V-T-G----H
Y
-
E
L
T
P
V
A
IAA
G
R
R
L
S
E
R
L
--FNNKKDAHLNYENI
P
T
V
V
FSHPAIGTVGLT
E
P
E
A
I
E
K
YGKE-
N
I
K
V
Y
TSS
F
--
T
S
M
Y
T
A
I
--TD----H----R-EP--
C
R
M
K
L
I
C-E-GK-T-
E
R
V
I
G
LHGIGY
G
V
D
E
M
I
Q
G
F
A
V
A
I
NMGATKADFD
N
T
V
A
I
HPTGSE
E
F
V
TMK-----------
1
PsiBlast_PDB
97.88
69%
-99
- C2 -
1GER
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
2
PsiBlast_PDB
95.32
69%
-97
- C2 -
1GET
3
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
22
PsiBlast_CBE
94.94
69%
-95
- C2 -
1GER
2
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
23
PsiBlast_CBE
94.30
67%
-96
- C2 -
1GEU
3
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
24
PsiBlast_CBE
94.27
67%
-97
- C2 -
1GES
2
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
101
HHSearch
93.76
68%
-98
- C2 -
1GES
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
T--
I
-
N
K
---
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
3
PsiBlast_PDB
93.45
67%
-98
- C2 -
1GES
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
21
PsiBlast_CBE
93.40
69%
-96
- C2 -
1GET
3
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
4
PsiBlast_PDB
92.73
67%
-97
- C2 -
1GEU
3
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
10
PsiBlast_PDB
92.06
54%
-102
- C2 -
1BWC
3
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
20
PsiBlast_PDB
91.26
54%
-97
- C2 -
3DK8
8
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
19
PsiBlast_PDB
91.15
54%
-100
- C2 -
3DK4
5
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
26
PsiBlast_CBE
90.59
54%
-95
- C2 -
3SQP
6
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
27
PsiBlast_CBE
90.58
54%
-96
- C2 -
3DK9
4
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
30
PsiBlast_CBE
90.45
54%
-99
- C2 -
1XAN
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
25
PsiBlast_CBE
90.44
54%
-95
- C2 -
3SQP
6
GSHR_HUMAN
B:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
HES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
MTMIPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
14
PsiBlast_PDB
90.06
54%
-98
- C2 -
1GRE
4
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------