@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1138: (2016-03-21 )
MAENTKNENITNILTQKLIDTRTVLIYGEINQELAEDVSKQLLLLESISNDPITIFINSQGGHVEAGDTIHDMIKFIKPTVKVVGTGWVASAGITIYLAAEKENRFSLPNTRYMIHQPAGGVQGQSTEIEIEAKEIIRMRERINRLIAEATGQSYEQISKDTDRNFWLSVNEAKDYGIVNEIIENRDGLK
Atome Classification :
(40 SA)
.........10........20........30........40........50.---.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAENTKNE
N
I
T
N
I
L
T
Q
K
LIDT
R
T
V
L
I
Y
GE
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
SISND
P
---
I
T
I
F
I
NSQGGHVEA
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
GTG
W
V
ASA
G
I
T
I
Y
L
A
AEKENRFSLPNT
R
Y
M
I
HQPAGGVQGQS
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
ATG
Q
S
Y
E
Q
I
SKDTDR
N
F
W
L
S
VNEAKDY
G
I
V
N
E
I
I
ENRDGLK
23
PsiBlast_CBE
97.59
100%
-120
- C4 -
4RYF
1
?
E:
[10-187]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
---
24
PsiBlast_CBE
97.44
100%
-120
- C4 -
4RYF
1
?
D:
[10-188]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
G
--
22
PsiBlast_CBE
97.41
100%
-120
- C4 -
4RYF
1
?
F:
[10-187]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
---
26
PsiBlast_CBE
97.35
100%
-120
- C4 -
4RYF
2
?
B:
[10-187]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
---
21
PsiBlast_CBE
97.33
100%
-120
- C4 -
4RYF
1
?
G:
[10-187]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
---
1
PsiBlast_PDB
97.12
100%
-120
- C4 -
4RYF
1
?
A:
[10-188]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
G
--
25
PsiBlast_CBE
97.03
100%
-120
- C4 -
4RYF
2
?
C:
[10-187]
---------
I
T
N
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
G
V
Q
G
Q
S
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
N
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
---
2
PsiBlast_PDB
94.08
99%
-122
- C4 -
4JCR
-
?
A:
[13-190]
------------
I
L
T
Q
K
L
I
D
T
R
T
V
L
I
Y
G
E
I
N
Q
E
L
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
N
D
P
---
I
T
I
F
I
N
S
Q
G
G
H
V
E
A
G
D
T
I
H
D
M
I
K
F
I
K
P
T
V
K
V
V
G
T
G
W
V
A
S
A
G
I
T
I
Y
L
A
A
E
K
E
N
R
F
S
L
P
N
T
R
Y
M
I
H
Q
P
A
G
-------
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
E
A
T
G
Q
S
Y
E
Q
I
S
K
D
T
D
R
D
F
W
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
E
N
R
D
G
L
K
103
PsiBlast_CBE
80.64
42%
-121
- C4 -
3TT7
1
CLPP_BACSU
F:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
121
PsiBlast_CBE
80.17
42%
-120
- C4 -
3KTK
2
CLPP_BACSU
B:
[22-189]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
6
PsiBlast_PDB
80.03
42%
-119
- C4 -
2ZL4
1
CLPP_HELPY
A:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
E
K
D
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
111
PsiBlast_CBE
79.90
42%
-122
- C4 -
3KTK
1
CLPP_BACSU
L:
[22-189]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
69
PsiBlast_CBE
79.80
43%
-124
- C4 -
2FZS
2
CLPP_ECOLI
F:
[22-193]
----------------
R
L
L
K
E
R
V
I
F
L
T
G
Q
V
E
D
H
M
A
N
L
I
V
A
Q
M
L
F
L
E
A
E
N
P
E
K
D--
I
Y
L
Y
I
N
S
P
G
G
V
I
T
A
G
M
S
I
Y
D
T
M
Q
F
I
K
P
D
V
S
T
I
C
M
G
Q
A
A
S
M
G
A
F
L
L
T
A
G
A
K
G
K
R
F
C
L
P
N
S
R
V
M
I
H
Q
P
L
G
G
Y
Q
G
Q
A
T
D
I
E
I
H
A
R
E
I
L
K
V
K
G
R
M
N
E
L
M
A
L
H
T
G
Q
S
L
E
Q
I
E
R
D
T
E
R
D
R
F
L
S
A
P
E
A
V
E
Y
G
L
V
D
S
I
L
T
H
R
N
---
104
PsiBlast_CBE
79.78
42%
-118
- C4 -
3TT7
1
CLPP_BACSU
E:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
116
PsiBlast_CBE
79.75
42%
-120
- C4 -
3KTK
2
CLPP_BACSU
G:
[22-189]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
49
PsiBlast_CBE
79.75
42%
-118
- C4 -
2ZL4
1
CLPP_HELPY
B:
[A-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
45
PsiBlast_CBE
79.68
42%
-119
- C4 -
2ZL4
2
CLPP_HELPY
F:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
71
PsiBlast_CBE
79.54
43%
-121
- C4 -
2FZS
1
CLPP_ECOLI
D:
[22-193]
----------------
R
L
L
K
E
R
V
I
F
L
T
G
Q
V
E
D
H
M
A
N
L
I
V
A
Q
M
L
F
L
E
A
E
N
P
E
K
D
--
I
Y
L
Y
I
N
S
P
G
G
V
I
T
A
G
M
S
I
Y
D
T
M
Q
F
I
K
P
D
V
S
T
I
C
M
G
Q
A
A
S
M
G
A
F
L
L
T
A
G
A
K
G
K
R
F
C
L
P
N
S
R
V
M
I
H
Q
P
L
G
G
Y
Q
G
Q
A
T
D
I
E
I
H
A
R
E
I
L
K
V
K
G
R
M
N
E
L
M
A
L
H
T
G
Q
S
L
E
Q
I
E
R
D
T
E
R
D
R
F
L
S
A
P
E
A
V
E
Y
G
L
V
D
S
I
L
T
H
R
N
---
110
PsiBlast_CBE
79.48
42%
-118
- C4 -
3KTK
3
CLPP_BACSU
M:
[22-189]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
48
PsiBlast_CBE
79.48
42%
-117
- C4 -
2ZL4
1
CLPP_HELPY
C:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
107
PsiBlast_CBE
79.42
42%
-118
- C4 -
3TT7
1
CLPP_BACSU
B:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
102
PsiBlast_CBE
79.31
42%
-120
- C4 -
3TT7
1
CLPP_BACSU
G:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
42
PsiBlast_CBE
79.04
42%
-120
- C4 -
2ZL4
1
CLPP_HELPY
I:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
106
PsiBlast_CBE
79.03
42%
-120
- C4 -
3TT7
1
CLPP_BACSU
C:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
105
PsiBlast_CBE
79.00
42%
-117
- C4 -
3TT7
1
CLPP_BACSU
D:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
EKE
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
43
PsiBlast_CBE
78.95
42%
-121
- C4 -
2ZL4
2
CLPP_HELPY
H:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
41
PsiBlast_CBE
78.88
42%
-119
- C4 -
2ZL4
1
CLPP_HELPY
J:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
35
PsiBlast_CBE
78.73
42%
-121
- C4 -
2ZL2
2
CLPP_HELPY
C:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
108
PsiBlast_CBE
78.72
42%
-118
- C4 -
3TT7
1
CLPP_BACSU
A:
[23-190]
----------------
R
L
L
K
D
R
I
I
M
L
G
S
A
I
D
D
N
V
A
N
S
I
V
S
Q
L
L
F
L
A
A
--
E
D
P
E
K
E
I
S
L
Y
I
N
S
P
G
G
S
I
T
A
G
M
A
I
Y
D
T
M
Q
F
I
K
P
K
V
S
T
I
C
I
G
M
A
A
S
M
G
A
F
L
L
A
A
G
E
K
G
K
R
Y
A
L
P
N
S
E
V
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
T
E
I
E
I
A
A
K
R
I
L
L
L
R
D
K
L
N
K
V
L
A
E
R
T
G
Q
P
L
E
V
I
E
R
D
T
D
R
D
N
F
K
S
A
E
E
A
L
E
Y
G
L
I
D
K
I
L
-------
40
PsiBlast_CBE
78.48
42%
-117
- C4 -
2ZL4
1
CLPP_HELPY
K:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
32
PsiBlast_CBE
78.40
42%
-122
- C4 -
2ZL2
1
CLPP_HELPY
F:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
30
PsiBlast_CBE
78.32
42%
-120
- C4 -
2ZL2
1
CLPP_HELPY
H:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
4
PsiBlast_PDB
78.32
42%
-117
- C4 -
2ZL2
1
CLPP_HELPY
A:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
E
K
D
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
46
PsiBlast_CBE
77.96
42%
-113
- C4 -
2ZL4
1
CLPP_HELPY
E:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
44
PsiBlast_CBE
77.70
42%
-114
- C4 -
2ZL4
1
CLPP_HELPY
G:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
A
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
29
PsiBlast_CBE
77.59
42%
-115
- C4 -
2ZL2
1
CLPP_HELPY
K:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
27
PsiBlast_CBE
77.33
42%
-121
- C4 -
2ZL2
2
CLPP_HELPY
N:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
31
PsiBlast_CBE
76.97
42%
-119
- C4 -
2ZL2
1
CLPP_HELPY
G:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
28
PsiBlast_CBE
76.73
42%
-118
- C4 -
2ZL2
2
CLPP_HELPY
M:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------
33
PsiBlast_CBE
76.49
42%
-117
- C4 -
2ZL2
1
CLPP_HELPY
E:
[20-192]
------------
D
I
Y
S
R
L
L
K
D
R
I
V
L
L
S
G
E
I
N
D
S
V
A
S
S
I
V
A
Q
L
L
F
L
E
A
--
E
D
P
EKD
I
G
L
Y
I
N
S
P
G
G
V
I
T
S
G
L
S
I
Y
D
T
M
N
F
I
R
P
D
V
S
T
I
C
I
G
Q
A
A
S
M
G
A
F
L
L
S
C
G
A
K
G
K
R
F
S
L
P
H
S
R
I
M
I
H
Q
P
L
G
G
A
Q
G
Q
A
S
D
I
E
I
I
S
N
E
I
L
R
L
K
G
L
M
N
S
I
L
A
Q
N
S
G
Q
S
L
E
Q
I
A
K
D
T
D
R
D
F
Y
M
S
A
K
E
A
K
E
Y
G
L
I
D
K
V
L
Q
------