@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1836: (2016-03-29 )
MTKRILMLEDGNYFIGDAIGSEKETIGEVVFNTGMTGYQETITDPSYYGQIITFTYPLVGNYGVNRDDFESINPAVKGVVVREAAEFASNWRNQITLNEFLKEKGIPGIAGIDTRKLTKLIRKEGTLKGILAAETADKEELLHHLRSVRLPVDQVHEVSSAKAFASPGDGKRVVLVDYGVKSSILRELNKRNCYVTVVPYNTSAEEILAMHPDGVMLSNGPGDPKDVPEALEMIRGIQGKLPLFGICLGHQLFALANGADTFKLKFGHRGANHPVKELATGRVDFTAQNHGYAVEKDSLIGTDLKVTHIELNDETVEGLAHKEYPAYTVQYHPEANPGPSDVNYLFDEFMEMMNGKEEGELHA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60......--------..70........80........90........100.......110.....-..120.......-130.-......140.......150---........160....-----------...170-----........180---.--.--.-----..--....190--.........200-..-.----...--.210.......220-----...--...-.---.230....-..-.240-----........250.......260.....-----------------------------..270------.------.....--------------------------------.------.---------280-----.-------.-----....-...290.......---300-....---------.....310..----------...-----------------.--------.320....-...330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
K
R
I
L
M
LEDG
N
Y
F
I
GDAIGS
E
K
E
T
I
G
E
V
V
FNTGMTGYQETITDPSYY
G
Q
I
I
T
F
T
Y
PLVGNYGV
N
R
D
--------
D
F
E
SI
N
P
A
V
K
G
V
V
V
R
E
A
A
E
F
A
S
NWRNQI
T
L
N
E
F
L
K
EKGIPGIAGI
D
T
R
K
L
-
T
K
L
I
R
KEGTL
K
G
-
I
L
AA-ETA
D
K
E
E
L
L
H
H
L
R
S
VRL
P
----
V
D
Q
V
H
E
V
SSAKAFAS-----------PGDG
K
------
R
V
V
L
V
DYG
V
-----
K
--
S
--
S
-----
I
L
--
R
E
L
NK----R
N
C
Y
V
T
V
V
PYNT-
S
A
-
E
----
E
I
L
--
A
MHPD
G
V
M
LSNGP------G
D
P
--
K
D
V
-
P
---
E
A
L
E
M
I
R
G-IQ-GKL------P
L
F
G
I
C
L
G
H
Q
L
F
A
LANGA
D
T
F
K
L
K
FG-----------------------------HRGA-------N------H
P
V
K
E
--------------------------------L------A---------T-------G-------
R
-----
V
D
F
T
-AQNHG
Y
A
VEKDSL---I---GTD
L
---------
K
V
T
H
I
E
LND
E
----------
T
V
E
-----------------
G
--------LAHKEY
P
A
-
Y
T
V
Q
YHPEANPGP
S
D
V
N
Y
L
F
D
E
F
M
E
M
MNGKEEGELHA
1
PsiBlast_PDB
96.97
46%
-76
- C3 -
1JDB
2
CARA_ECOLI
C:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
TQGSWTLTGGL
P
Q
A
K
K
EDELPF
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
6
PsiBlast_PDB
95.87
46%
-74
- C3 -
1C30
2
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
E
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
2
PsiBlast_PDB
95.43
46%
-77
- C3 -
1BXR
2
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
Q
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
4
PsiBlast_PDB
95.22
46%
-78
- C3 -
1T36
1
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
E
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
D
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
8
PsiBlast_PDB
95.16
46%
-72
- C3 -
1KEE
2
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
E
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
-
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
5
PsiBlast_PDB
95.05
46%
-79
- C3 -
1M6V
2
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
Q
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
----
A
A
P
L
F
D
H
F
I
E
L
I
----------
3
PsiBlast_PDB
94.66
46%
-74
- C3 -
1CE8
1
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
Q
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
7
PsiBlast_PDB
94.35
46%
-73
- C3 -
1C3O
2
CARA_ECOLI
B:
[6-374]
----
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
-
D
N
P
D
A
A
L
A
L
E
K
A
R
A
--
F
P
GLNG
M
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
G
S
W
T
LTGGL
P
E
A
K
K
EDELP
F
H
V
V
A
Y
D
F
G
A
-----
K
--
R
--
N
-----
I
L
--
R
M
L
V
D
----
R
G
C
R
L
T
I
V
P
A
Q
T
-
S
A
-
E
----
D
V
L
--
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
D
P
--
A
P
C
-
D
---
Y
A
I
T
A
I
Q
K
F
L
E
-
T
D
I
------
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
F
G
-----------------------------
H
H
G
G
-------
N
------
H
P
V
K
D
--------------------------------
V
------
E
---------
K
-------
N
-------
V
-----
V
M
I
T
-
A
Q
N
H
G
F
A
V
D
E
A
T
L
-------
P
A
N
L
---------
R
V
T
H
K
S
L
F
D
G
----------
T
L
Q
-----------------
G
--------
I
H
R
T
D
K
P
A
-
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
----------
74
Fugue
58.25
46%
-84
- C3 -
1A9X
-
CARA_ECOLI
B:
[1-149]
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
T
G
S
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
A
--------
D
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
-
T
R
L
L
R
E
K
G
A
Q
N
G
-
C
I
I
A
G
D
N
P
D
A
A
L
A
L
E
K
A
R
A
F
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.21
24%
-85
- C3 -
3UOW
-
?
A:
[9-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
L
V
L
N
F
G
S
-----
Q
Y
F
H
--
L
-----
I
V
--
K
R
L
N
N
----
I
K
I
F
S
E
T
K
D
Y
G
V
-
E
L
-
K
----
D
I
K
--
D
M
N
I
K
G
V
I
L
S
G
G
P
YSVTEA
G
S
P
--
H
L
K
-
K
---
E
V
F
E
Y
F
---
L
E
-
K
K
I
------
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
-----------------------------
E
Y
G
C
T
D
V
N
I
L
R
N
------
D
N
I
N
N
--------------------------------
I
------
T
---------
Y
-------
C
-------
R
NFSS
A
M
D
L
Y
-
S
-
N
Y
K
L
M
N
--
C
C
L
FEN
I
---
K
S
D
I
---------
T
T
V
W
M
N
H
N
D
E
----------
V
T
K
IPENFYLV
S
S
S
ENCLIC
S
--------
I
Y
N
K
E
Y
N
I
-
Y
G
V
Q
Y
H
P
E
V
----------------------------
53
HHSearch
53.98
24%
-69
- C3 -
1QDL
-
TRPG_SULSO
B:
[2-195]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------
L
T
L
I
I
D
N
Y
D
-----
S
F
V
Y
--
N
-----
I
A
--
Q
I
V
G
E
----
L
G
S
Y
P
I
V
I
R
N
D
E
I
S
I
-
K
----
G
I
E
--
R
I
D
P
D
R
L
I
I
S
P
G
P
------
G
T
P
--
E
K
R
-
E
DIG
V
S
L
D
V
I
K
Y
--
L
G
K
R
T
------
P
I
L
G
V
C
L
G
H
Q
A
I
G
Y
A
F
G
A
K
I
R
R
A
R
K
V
-----------------------------
F
H
G
K
-------
I
------
S
N
I
I
L
--------------------------------
V
------
N
NSPLSLYY-
G
I------
A
-------
K
-----
E
F
K
A
-
T
R
Y
H
S
L
V
V
D
E
--
V
---
H
---
R
-
P
L
---------
I
V
D
A
I
S
A
E
D
N
----------
E
I
M
-----------------
A
--------
I
H
H
E
E
Y
P
I
-
Y
G
V
Q
F
H
P
E
S
V
G
T
S
-
L
G
Y
K
I
L
Y
N
F
L
N
R
V
----------
49
HHSearch
52.81
24%
-62
- C3 -
2A9V
3
GUAAA_THEAC
A:
[12-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
L
------
K
I
Y
V
V
D
N
G
G
QW---
T
--
H
--
R
-----
E
W
--
R
V
L
R
E
----
L
G
V
D
T
K
I
V
P
N
D
I
-
D
S
-
S
----
E
L
----
D
G
L
D
G
L
V
L
S
G
G
A
------
P
N
I
--
D
E
E
L
D
---
K
L
G
S
V
G
K
Y
-
I
D
D
H
N
Y
------
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
V
K
A
K
H
P
-----------------------------
E
F
G
K
--------------
T
K
V
S
V
--------------------------------
M
------
H
---------
S
ENIFGGL
P
-------
S
-----
E
I
T
V
-
W
E
N
H
N
D
E
I
I
--
N
L
---
P
---
D
-
D
F
---------
T
L
A
A
S
S
A
-
T
C
----------
Q
V
Q
-----------------
G
--------
F
Y
H
K
T
R
P
I
-
Y
A
T
Q
F
H
P
E
V
E
H
T
Q
-
Y
G
R
D
I
F
R
N
F
I
G
I
C
A
S
Y
R
E
I
Q
K
--
56
HHSearch
52.09
26%
-68
- C3 -
2YWB
-
GUAA_THET8
A:
[1-215]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
V
L
D
F
G
S
-----
Q
--
Y
T
R
L
-----
I
A
--
R
R
L
R
E
----
L
R
A
F
S
L
I
L
P
G
D
A
-
P
L
-
E
----
E
V
L
--
K
H
R
P
Q
A
L
I
L
S
G
G
P
------
R
S
V
--
F
D
P
-
D
----
A
P
R
P
D
P
R
-
L
F
S
S
G
L
------
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
E
R
A
--------------------------------
E
Y
G
K
-------
A
L
L
T
R
H
E
G
P
L
F
R
--------------------------------
G
------
L
-----------------
E
-------
G
-----
E
V
Q
V
-
W
M
S
H
Q
D
A
V
T
--
A
P
---
P
---
P
-
G
W
---------
R
V
V
A
E
T
E
-
E
N
----------
P
V
A
-----------------
A
--------
I
A
S
P
D
G
R
A
-
Y
G
V
Q
F
H
P
E
V
A
H
T
P
-
K
G
M
Q
I
L
E
N
F
L
E
L
A
G
V
--------
61
HHSearch
50.43
22%
-77
- C3 -
2VXO
-
GUAA_HUMAN
A:
[29-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
------
A
V
V
I
L
D
A
G
---------
Y
--
G
K
V
---
I
D
--
R
R
V
R
E
----
L
F
V
Q
S
E
I
F
P
L
E
T
-
P
A
-
F
----
A
I
K
--
E
Q
G
F
R
A
I
I
I
S
G
G
P
--------------------
A
P
W
F
D
P
A
-
I
F
T
I
G
K
------
P
V
L
G
I
C
Y
G
M
Q
M
M
N
K
V
F
G
G
T
V
H
K
------------------------------------
V
--------------
F
N
I
S
V
--------------------------------
D
------
N
TCSLFR---
G
L------
Q
-------
K
-----
E
E
V
V
-
L
L
T
H
G
D
S
V
D
--
K
V
---
A
---
D
-
G
F
---------
K
V
V
A
R
S
G
--
N
----------
I
V
A
-----------------
G
--------
I
A
N
E
S
K
K
L
-
Y
G
A
Q
F
H
P
E
V
G
L
T
E
-
N
G
K
V
I
L
K
N
F
L
Y
D
I
A
G
C
S
------
58
HHSearch
50.18
23%
-57
* C3 *
3UOW
-
?
A:
[7-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
------
K
I
L
V
L
N
F
G
S
-----
Q
--
Y
F
H
L
-----
I
V
--
K
R
L
N
N
----
I
K
I
F
S
E
T
K
D
Y
G
V
-
E
L
-
K
----
D
I
K
--
D
M
N
I
K
G
V
I
L
S
G
G
P
------
Y
S
V
--
T
E
A
-
G
SPH
L
K
K
E
V
F
E
Y
-
F
L
E
K
K
I
------
P
I
F
G
I
C
Y
G
M
Q
E
I
A
V
Q
M
N
G
E
V
K
K
S
K
T
S
-----------------------------
E
Y
G
C
-------
T
------
D
-
V
N
I
L
R
NDNINNITYCRNFSS
A
M
D
L
Y
S
N
Y
K
L
M
NCCL
F
------
E
---------
N
IK-----
S
-------
D
-----
I
T
T
V
-
W
M
N
H
N
D
E
V
T
--
K
I
---
P
---
E
-
N
F
---------
Y
L
V
S
S
S
E
-
N
C
----------
L
I
C
-----------------
S
--------
I
Y
N
K
E
Y
N
I
-
Y
G
V
Q
Y
H
P
E
V
Y
E
S
L
-
D
G
E
L
M
F
Y
N
F
A
Y
N
I
C
K
C
K
------
18
PsiBlast_PDB
49.71
26%
-71
- C3 -
2A9V
3
GUAAA_THEAC
A:
[15-182]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
Y
V
V
D
N
G
G
-----
Q
--
W
--
T
H
R
E
W
R
V
L
--
R
E
L
G
V
----
D
---
T
K
I
V
P
N
D
I
-
D
S
-
S
----
E
L
D
--
G
L
--
D
G
L
V
L
S
G
G
A
-----------
P
N
I
-
D
---
E
E
L
D
K
L
-
G
-
S
V
-
G
K
Y
I
D
D
H
N
Y
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
V
K
------------------------------------
A
-------
K
------
H
P
--
E
--------------------------------
F
------
G
---------
K
-------
T
-------
K
-----
V
S
V
M
H
S
E
N
I
F
G
G
L
P
S
E
I
T
---
V
---
W
E
N
H
---------
N
D
E
I
I
N
L
P
D
D
FTLAASSATC
Q
V
Q
-----------------
G
--------
F
Y
H
K
T
R
P
I
-
Y
A
T
Q
F
H
P
E
V
----------------------------
62
HHSearch
49.64
21%
-77
- C3 -
3TQI
-
GUAA_COXBU
A:
[6-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
H
------
R
I
L
I
L
D
F
G
S
-----
Q
--
Y
A
Q
L
-----
I
A
--
R
R
V
R
E
----
I
G
V
Y
C
E
L
M
P
C
D
I
-
D
E
-
E
----
T
I
R
--
D
F
N
P
H
G
I
I
L
S
G
G
P
------
E
----------------
A
P
A
F
-
I
F
E
I
G
C
------
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
----------------------------------
E
F
G
H
--------------
A
Q
L
R
V
--------------------------------
L
NPAFLF
D
---------
G
IE-----
D
QVSPQG
E
P
-----
L
L
D
V
-
W
M
S
H
G
D
I
V
S
--
E
L
---
P
---
P
-
G
F
---------
E
A
T
A
C
T
D
-
N
S
----------
P
L
A
-----------------
A
--------
M
A
D
F
K
R
R
F
-
F
G
L
Q
F
H
P
E
V
T
H
T
P
-
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
------
60
HHSearch
48.91
20%
-57
- C3 -
1GPM
1
GUAA_ECOLI
A:
[6-227]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
H
------
R
I
L
I
L
D
F
G
S
-----
Q
--
Y
T
Q
L
-----
V
A
--
R
R
V
R
E
----
L
G
V
Y
C
E
L
W
A
W
D
V
-
T
E
-
A
----
Q
I
R
--
D
F
N
P
S
G
I
I
L
S
G
G
P
------
E
S
T
--
T
E
E
-
N
----
S
P
R
A
P
Q
Y
-
V
F
E
A
G
V
------
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
E
A
S
N
E
R
-----------------------------
E
F
G
Y
--------------
A
Q
V
E
V
--------------------------------
V
------
N
DSALVRGIE
D
ALTADG-
K
-------
P
-----
L
L
D
V
-
W
M
S
H
G
D
K
V
T
--
A
I
---
P
---
S
-
D
F
---------
I
T
V
A
S
T
E
-
S
C
----------
P
F
A
-----------------
I
--------
M
A
N
E
E
K
R
F
-
Y
G
V
Q
F
H
P
E
V
T
H
T
R
-
Q
G
M
R
M
L
E
R
F
V
R
D
I
C
Q
C
E
------
15
PsiBlast_PDB
48.44
24%
-73
- C3 -
1GPM
1
GUAA_ECOLI
A:
[9-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
L
I
L
D
F
G
S
-----
Q
--
Y
--
T
-----
Q
L
V
A
R
R
V
R
E
----
L
G
V
Y
C
E
L
W
A
W
D
V
-
T
E
-
A
----
Q
I
R
--
D
F
N
P
S
G
I
I
L
S
G
G
P
------
E
S
T
TE
E
N
S
-
P
---
R
A
P
Q
Y
V
---
F
E
-
A
G
V
------
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
--------
G
-----------------------------
H
V
E
A
-------
S
------
N
E
-
R
E
--------------------------------
F
------
G
---------
Y
-------
A
-------
Q
-----
V
E
V
V
-
N
D
S
A
L
V
R
G
I
E
D
A
L
---
T
AD-
G
K
P
L
L
D
V
W
M
S
H
G
D
K
V
T
A
I
P
S
D
F
I
----------
T
V
A
-----------------
S
TESCPFA
I
M
A
N
E
E
K
R
F
-
Y
G
V
Q
F
H
P
E
V
T
---------------------------
47
HHSearch
47.23
17%
-49
- C3 -
3NVA
-
PYRG_SULSO
A:
[180-534]
--------------------------------------------------------
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
-
I
L
S
R
-
L
K
L
E
D
R
Q
--
V
D
L
T
D
W
-------
I
S
F
V
N
N
I
K
G
I
N
---------------
S
K
K
T
I
------
N
I
A
L
V
G
K
Y
T
KLKDS
Y
--
I
--
S
-----
I
K
--
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
-
T
D
L
E
SDTK
N
L
N
EI
L
G
N
V
N
G
I
I
V
L
P
G
F
------
G
S
R
--
G
A
E
-
G
----
K
I
K
A
I
K
Y
-
A
R
E
H
N
I
------
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
NSTEINPNTKDPV
I
T
L
L
D
EQKNVTQLG
G
T
M
R
L
G
-------
A
------
Q
K
I
I
L
--------------------------------
K
------
E
---------
G
T
I
A
Y
Q
L
Y
G
K------
K
-----
V
V
Y
E
-
R
H
R
H
R
Y
E
V
N
P
K
Y
V
---
D
I
L
E
D
A
G
L
---------
V
V
S
G
I
S
-
E
N
G
----------
L
V
E
-----------------
I
--------
I
E
L
P
S
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
--------