@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2100: (2016-03-31 )
MWRLTGNSSLPIYLQIVDLIETKIMNGELLPEEKLPPERQLAEMFGVNRSTVVRALDELTARAVIIRKQGSGTTVNAEKWGLFAGQSTNWRHYLTQGGFTPAVPYIRQAGVMERANSDNVIDAASGELPLEMTPKMETPSLSWQSFIAEEQQEDEAGYKPLRETIQKQMKEAYGLQTRSEQIFITSGAQQALFLITQCLLKPGDAVAIESPSYFYSLSLFQSAGLRIFALPMDEDGVVISELRDLYHKHRVKMVFVNPTFQNPTGLVMSLKRRKELVKICAHLQIPIVEDDPFSELGALDNQIPAPLKRLDTDNVLYIGSLSKIMGSTTRIGWLIGPTAVIERLALARQEMDFGLSIFPQVLANSVLNTAGYKAHLLQLHHVLEQRRDDLIEAFEAILPSEVTFIKPKGGFHLWVKLPVEFRSVRDFDIFLANDLLVMPGFLFGVKEAVIRVTYARLEKKEARRVAEIIKQILVSKKCEEA
Atome Classification :
(20 SA)
.........10---........20........30........40........50........60........70.....------...80........90........100.......110....-----...120.......130.......140......----.----150.......160----.........170....-...180.......190.......200.......210.......220.......230.......240--......-----..-------.250.......260.......270.......280-.......290.......300.....---..310.--.-.-.....320.......330.......340.......350.......360.......370.--.-......380.......390.......400.........410.......420.......430.....------...440-..-...---.---.-------.---.-----450......----.----460---........470.......480
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
W
R
LTGNSSL
P
---
I
Y
L
Q
I
V
D
L
I
E
T
KIMNGELLPEEKLP
P
E
R
Q
L
A
E
M
FGV
N
R
S
T
V
V
R
A
L
D
E
LTA
R
A
V
I
I
R
KQGSG
T
T
V
N
------
A
E
K
W
G
LFAGQSTN
W
R
H
Y
LTQGGFT
P
A
V
P
Y
I
R
Q
AGVMERAN-----SD
N
V
I
DAASGELPLEMTPKMETPS
L
S
W
Q
S
F
I
A
----
E
----
E
Q
QEDEAG
Y
K
P
------
L
R
E
T
I
Q
K
Q
M
K
E
AYGLQ-TRS
E
Q
I
F
I
TSG
A
Q
Q
A
L
F
L
I
T
Q
C
LLKPG
D
A
V
A
IESP
S
Y
F
Y
S
L
S
L
F
QSAG
L
R
I
F
A
L
PMDED
G
V
V
I
S
----
E
L
R
D
L
Y
-----
H
K-------H
R
V
K
M
V
F
VNPTFQNP
T
G
L
V
M
S
L
K
R
R
K
E
L
V
K
I
C
A
H-LQIPIVEDDP
F
S
E
L
G
A
L
DNQIPA
P
L
---
K
RLD-T--D-
N
-
V
L
Y
IG
S
L
S
K
I
MGST
T
R
I
G
W
L
I
G
P
T
A
V
I
E
R
L
A
L
A
R
Q
E
M
D
F
G
L
S
I
F
P
Q
V
L
A
N
S
V
L
NTAG-
Y
--
K
-
A
H
L
L
Q
L
H
H
V
L
E
Q
R
R
D
D
L
I
E
A
F
E
A
ILPS--
E
V
T
F
I
KPKG
G
F
H
L
W
V
K
L
P
V
E
F
RSV
R
D
F
D
I
F
-LAND
L
L
------VM
P
G
---
F
L
-
F
G
V
---
K
---
E
-------
A
---
V
-----
I
R
V
T
Y
A
R
L
E
----
K
----
K
E
----
A
R
R
V
A
E
I
I
K
Q
I
L
V
S
KKCEEA
13
PsiBlast_PDB
85.97
29%
-105
- C3 -
2ZC0
4
?
A:
[20-403]
---------------------------------------------------------------------------------------------------------------------
A
D
V
M
K
K
A
S
E
L
Q
K
K
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
I
A
K
E
V
L
-----------
E
K
E
P
K
S
V
M
Y
T
P
ANGI
P
E
L
R
E
E
L
A
A
F
L
K
K
Y
D
H
L
E
-
V
S
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
L
L
E
E
K
I
K
E
L
K
-----
A
K
G------
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
-
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
D
I
-
V
P
L
---
K
A
L
D
-
N
--
E
-
G
R
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
R
-
G
-
Y
FE
K
-
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
N
---
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
------
F
A
N
E
L
M
E
REG
V
V
V
V
P
G
---
K
P
-
F
Y
T
---
D
---
E
-------
S
GKN
A
-----
I
R
L
N
F
S
R
P
S
----
K
----
E
E
I
P
I
G
I
K
K
L
A
K
L
Y
K
E
----------
59
HHSearch
85.60
30%
-98
- C3 -
3AOW
4
?
A:
[75-447]
----------------------------------------------------------------------------------------------------------------------------------
T
S
D
I
I
S
L
A
G
G
L
P
N
P
K
T
F
P
K
E
I
I
R
D
-
I
L
V
E
I
M
E
KY
A
D
K
A
---
L
Q
Y
G
T
T
K
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
S
-
Q
-
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
----
I
L
E
E
K
L
-----
K
E
L
K
S
Q
G--
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
-
P
E
K
K
I
---
K
A
L
D
-
N
--
E
G
R
-
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
-
G
G
Y
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
RDV
K
-------
N
---
T
-----
M
R
L
N
F
T
Y
V
D
----
E
----
D
K
----
I
M
E
G
I
K
R
L
A
E
T
I
K
E
E
L
K
---
4
PsiBlast_PDB
84.92
33%
-113
- C3 -
3AV7
5
?
A:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
5
PsiBlast_PDB
84.91
33%
-113
- C3 -
3WX9
7
?
A:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
21
PsiBlast_CBE
84.72
33%
-111
- C3 -
3WX9
6
?
C:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
ILEE
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KNTMR
L
N
F
T
Y
V
D
E
D
----
K
IM--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
79
Fugue
84.43
25%
-94
- C3 -
4MGR
3
GABR_BACSU
A:
[2-469]
D
I
T
I
T
L
D
R
S
E
Q
ADY
I
Y
Q
Q
I
Y
Q
K
L
K
K
E
I
L
S
R
N
L
L
P
H
S
K
V
P
S
K
R
E
L
A
E
N
L
K
V
S
V
N
S
V
N
S
A
Y
Q
Q
L
L
A
E
G
Y
L
Y
A
I
E
R
K
G
F
F
V
E
ELDMFS
A
E
E
H
P
P
F
A
L
P
D
D
L
K
E
I
H
I
D
Q
S
D
W
I
S
----------
F
S
H
M
S
-----
S
D
T
------
D
H
F
P
I
K
S
W
F
R
C
E
Q
K
A
A
S
R
-
S
Y
R
T
----
L
----
G
D
M
S
H
P
Q
G
I
Y
E
------
V
R
A
A
I
T
R
L
I
S
L
T
R
G
V
K
-
C
R
P
E
Q
M
I
I
G
A
G
T
Q
V
L
M
Q
L
L
T
E
L
L
P
K
E
A
-
V
Y
A
M
E
E
P
G
Y
R
R
M
Y
Q
L
L
K
N
A
G
K
Q
V
K
T
I
M
L
D
E
K
G
M
S
I
A
----
E
I
T
R
Q
----------------
Q
P
D
V
L
V
T
T
P
S
H
Q
F
P
S
G
T
I
M
P
V
S
R
R
I
Q
L
L
N
W
A
A
E
E
P
R
R
Y
I
I
E
D
D
Y
D
S
E
F
T
Y
D
V
D
S
I
P
A
-
L
---
Q
S
L
D
-
R
F-
Q
-
N
-
V
I
Y
M
G
T
F
S
K
S
L
L
P
G
L
R
I
S
Y
M
V
L
P
P
E
L
L
R
A
Y
K
Q
R
G
Y
D
L
Q
T
-
C
S
S
L
T
Q
L
T
L
Q
E
F
I
E
S
G
E
-
Y
--
Q
-
K
H
I
K
K
M
K
Q
H
Y
K
E
K
R
E
R
L
I
T
A
L
E
A
E
F
S
G
--
E
V
T
V
K
G
A
N
A
G
L
H
F
V
T
E
F
D
T
R
-
R
T
E
Q
D
I
L
S
H
-
A
A
G
L
Q
L
------
E
I
F
G
---
M
S
R
F
N
L
---
K
---
E
NKRQTGR
P
---
A
-----
L
I
I
G
F
A
R
L
K
----
E
----
E
D
----
I
Q
E
G
V
Q
R
L
F
K
A
V
Y
-------
24
PsiBlast_CBE
84.21
33%
-111
- C3 -
3AOW
4
?
C:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
ILEE
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KNTMR
L
N
F
T
Y
V
D
E
D
----
K
IM--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
6
PsiBlast_PDB
84.10
33%
-112
- C3 -
1X0M
-
?
A:
[99-426]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
60
HHSearch
84.06
28%
-94
- C3 -
2ZC0
4
?
A:
[33-405]
----------------------------------------------------------------------------------------------------------------------------------
G
V
K
L
I
S
L
A
A
G
D
P
D
P
E
L
I
P
R
A
V
L
G
E
-
I
A
K
E
V
L
E
K
E
P-
K
S---
V
M
Y
T
P
A
N
G
I
P
E
------
L
R
E
E
L
A
A
F
L
K
K
Y
D
H
L
E
-
V
S
P
E
N
I
V
I
T
I
G
G
T
G
A
L
D
L
L
G
R
V
L
I
D
P
G
D
V
V
I
T
E
N
P
S
Y
I
N
T
L
L
A
F
E
Q
L
G
A
K
I
E
G
V
P
V
D
N
D
G
M
R
V
D
----
L
L
E
E
K
I
-----
K
E
L
K
A
K
G--
Q
K
V
K
L
I
Y
T
I
P
T
G
Q
N
P
M
G
V
T
M
S
M
E
R
R
K
A
L
L
E
I
A
S
K
-
Y
D
L
L
I
I
E
D
T
A
Y
N
F
M
R
Y
E
G
G
-
D
I
V
P
L
---
K
A
L
D
-
N
--
E
G
R
-
V
I
V
A
G
T
L
S
K
V
L
G
T
G
F
R
I
G
W
I
I
A
E
G
E
I
L
K
K
V
L
M
Q
K
Q
P
I
D
F
C
A
P
A
I
S
Q
Y
I
A
L
E
Y
L
K
-
R
G
Y
F
--
E
K
Y
H
L
E
G
A
L
L
G
Y
K
E
K
R
D
I
M
L
K
A
L
E
N
H
L
P
N
---
A
E
F
T
K
P
I
A
G
M
F
V
M
F
F
L
P
E
G
A
D
G
I
S
F
A
N
E
L
M
E
R
E
G
V
V
------
V
V
P
G
---
K
P
-
F
Y
T
---
D
ESG
K
-------
N
---
A
-----
I
R
L
N
F
S
R
P
S
----
K
----
E
E
----
I
P
I
G
I
K
K
L
A
K
L
Y
K
E
K
F
----
2
PsiBlast_PDB
83.98
33%
-109
- C3 -
3AOW
4
?
A:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
3
PsiBlast_PDB
83.91
33%
-111
- C3 -
3ATH
3
?
A:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
23
PsiBlast_CBE
83.69
33%
-112
- C3 -
3ATH
3
?
C:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
ILEE
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KNTMR
L
N
F
T
Y
V
D
E
D
----
K
IM--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
1
PsiBlast_PDB
83.55
33%
-110
- C3 -
3AOV
1
?
A:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
I
L
E
E
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KN
T
M
R
L
N
F
T
Y
V
D
E
D
----
K
I
M
--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
25
PsiBlast_CBE
83.29
33%
-110
- C3 -
3AOV
2
?
C:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
ILEE
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KNTMR
L
N
F
T
Y
V
D
E
D
----
K
IM--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
22
PsiBlast_CBE
83.26
33%
-112
- C3 -
3AV7
4
?
C:
[119-446]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
E
T
L
M
K
W
L
G
K
R
Y
G
I
--
S
Q
D
N
D
I
M
I
T
S
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
I
V
V
V
E
A
P
T
Y
L
A
A
L
Q
A
F
N
F
Y
E
P
Q
Y
I
Q
I
P
L
D
D
E
G
M
K
V
E
ILEE
K
L
K
E
L
K
-----
S
Q
G------
K
K
V
K
V
V
Y
T
V
P
T
F
Q
N
P
A
G
V
T
M
N
E
D
R
R
K
Y
L
L
E
L
A
S
E
-
Y
D
F
I
V
V
E
D
D
P
Y
G
E
L
R
Y
S
G
N
P
-
E
K
K
I
---
K
A
L
D
-
N
--
E
-
G
R
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
M
V
G
D
P
G
I
I
R
K
M
E
I
A
K
Q
S
T
D
L
C
T
N
V
F
G
Q
V
V
A
W
R
Y
V
D
G
G
Y
-
L
--
E
-
K
H
I
P
E
I
R
K
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
F
M
P
E
--
G
V
K
W
T
K
P
E
G
G
M
F
I
W
V
T
L
P
D
G
I
D
S
K
K
M
L
E
R
A
-
I
K
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
Y
A
---
H
---
R
-------
D
---
V
KNTMR
L
N
F
T
Y
V
D
E
D
----
K
IM--
E
G
----
I
K
R
L
A
E
T
I
K
E
E
L
--------
7
PsiBlast_PDB
81.36
30%
-111
- C3 -
1WST
1
?
A:
[84-410]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
T
P
------
L
R
L
A
L
A
R
W
M
E
K
R
Y
D
I
P
-
M
S
K
V
E
I
M
T
V
A
G
S
Q
Q
A
L
D
L
I
G
R
V
F
L
N
P
G
D
P
I
V
V
E
A
P
T
Y
L
A
A
I
Q
A
F
K
Y
Y
D
P
E
F
I
S
I
P
L
D
D
K
G
M
R
V
D
----
L
L
E
E
K
L
E
E
L
R
K
Q
G
-------
K
R
V
K
I
V
Y
T
V
S
T
F
Q
N
P
A
G
V
T
M
S
V
D
R
R
K
K
L
L
E
L
A
N
E
-
Y
D
F
L
I
V
E
D
G
P
Y
S
E
L
R
Y
S
G
E
P
T
P
-
P
I
---
K
H
F
D
-
D
Y-
G
-
R
-
V
I
Y
L
G
T
F
S
K
I
L
A
P
G
F
R
I
G
W
V
A
A
H
P
H
L
I
R
K
M
E
I
A
K
Q
S
I
D
L
C
T
N
T
F
G
Q
A
I
A
W
K
Y
V
E
N
G
Y
-
L
--
D
-
E
H
I
P
K
I
I
E
F
Y
K
P
R
R
D
A
M
L
E
A
L
E
E
Y
M
P
E
--
G
V
E
W
T
K
P
E
G
G
M
F
V
R
V
T
L
P
E
G
I
D
T
K
L
M
M
E
R
A
-
V
A
K
G
V
A
------
Y
V
P
G
---
E
A
-
F
F
V
HRD
K
---
K
-------
N
---
T
-----
M
R
L
N
F
T
Y
V
P
E
E
T
I
R
----
E
G
----
V
R
R
L
A
E
T
I
K
E
----------
9
PsiBlast_PDB
79.30
28%
-118
- C3 -
2ZP7
3
LYSN_THET2
C:
[75-395]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
A
P
------
L
R
A
F
V
------
A
E
W
I
G
-
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D
L
D
----
A
L
E
E
V
L
-----
K
R
-------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
-
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
R
L
P
S
L
F
ELA
R
E
A
G
-
Y
--
P
-
G
-
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
E
-
G
-
F
--
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
--
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
-
L
E
E
N
V
A
------
F
V
P
G
GPF
F
A
-
N
G
G
---
G
---
E
-------
N
---
T
-----
L
R
L
S
Y
A
T
L
D
----
R
EGIA
E
G
----
V
R
R
L
G
R
A
L
K
G
L
L
A
-------
61
HHSearch
78.61
27%
-97
- C3 -
2ZYJ
2
LYSN_THET2
A:
[31-396]
----------------------------------------------------------------------------------------------------------------------------------
R
P
G
I
L
S
F
A
G
G
L
P
A
P
E
L
F
P
K
E
E
A
A
E
-
A
A
A
R
I
L
R
E
K
G
E
V
A
---
L
Q
Y
S
P
T
E
G
Y
A
P
------
L
R
A
F
V
A
E
W
I
G
-------
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D
L
D
----
A
L
E
E
V
L
-----
K
R
-------
E
R
P
R
F
L
Y
L
I
P
S
F
Q
N
P
T
G
G
L
T
P
L
P
A
R
K
R
L
L
Q
M
V
M
E
-
R
G
L
V
V
V
E
D
D
A
Y
R
E
L
Y
F
G
E
A
-
R
L
P
S
L
---
F
E
L
A
R
E
A
G
Y
P
G
-
V
I
Y
L
G
S
F
S
K
V
L
S
P
G
L
R
V
A
F
A
V
A
H
P
E
A
L
Q
K
L
V
Q
A
K
Q
G
A
D
L
H
T
P
M
L
N
Q
M
L
V
H
E
L
L
K
-
E
G
-
F
--
S
-
E
R
L
E
R
V
R
R
V
Y
R
E
K
A
Q
A
M
L
H
A
L
D
R
E
V
P
K
--
E
V
R
Y
T
R
P
K
G
G
M
F
V
W
M
E
L
P
K
G
L
S
A
E
G
L
F
R
R
A
-
L
E
E
N
V
A
------
F
V
P
G
---
G
P
-
F
F
A
---
N
GGG
E
-------
N
---
T
-----
L
R
L
S
Y
A
T
L
D
----
R
----
E
G
----
I
A
E
G
V
R
R
L
G
R
A
L
K
G
L
L
A
L
--
58
HHSearch
77.68
24%
-98
* C3 *
1VP4
16
?
A:
[42-421]
----------------------------------------------------------------------------------------------------------------------------------
D
K
D
A
I
S
F
G
G
G
V
P
D
P
E
T
F
P
R
K
E
L
A
E
-
I
A
K
E
I
I
E
K---
E
YHYT
L
Q
Y
S
T
T
E
G
D
P
V
------
L
K
Q
Q
I
L
K
L
L
E
R
M
Y
G
I
T
G
L
D
E
D
N
L
I
F
T
V
G
S
Q
Q
A
L
D
L
I
G
K
L
F
L
D
D
E
S
Y
C
V
L
D
D
P
A
Y
L
G
A
I
N
A
F
R
Q
Y
L
A
N
F
V
V
V
P
L
E
D
D
G
M
D
L
N
----
V
L
E
R
K
L
-----
S
E
F
D
K
N
GKI
K
Q
V
K
F
I
Y
V
V
S
N
F
H
N
P
A
G
V
T
T
S
L
E
K
R
K
A
L
V
E
I
A
E
K
-
Y
D
L
F
I
V
E
D
D
P
Y
G
A
L
R
Y
E
G
E
-
T
V
D
P
I
---
F
K
I
G
-
G
--
P
E
R
-
V
V
L
L
N
T
F
S
K
V
L
A
P
G
L
R
I
G
M
V
A
G
S
K
E
F
I
R
K
I
V
Q
A
K
Q
S
A
D
L
C
S
P
A
I
T
H
R
L
A
A
R
Y
L
E
-
R
Y
D
L
--
L
-
E
Q
L
K
P
T
I
E
L
Y
R
R
K
R
T
V
M
L
N
A
L
E
E
Y
F
S
D
IP
G
V
K
W
V
K
S
E
G
G
L
F
I
W
L
T
L
P
E
G
F
D
T
W
E
M
F
E
Y
A
-
K
R
K
K
V
F
------
Y
V
P
G
---
R
V
-
F
K
V
---
Y
DEP
S
-------
P
---
S
-----
M
R
L
S
F
C
L
P
P
----
D
----
E
K
----
I
V
E
G
I
K
R
L
R
E
V
V
L
E
Y
G
K
E
--
12
PsiBlast_PDB
77.49
28%
-114
- C3 -
2ZYJ
2
LYSN_THET2
A:
[75-395]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
A
P
------
L
R
A
F
V
------
A
E
W
I
G
-
V
R
P
E
E
V
L
I
T
T
G
S
Q
Q
A
L
D
L
V
G
K
V
F
L
D
E
G
S
P
V
L
L
E
A
P
S
Y
M
G
A
I
Q
A
F
R
L
Q
G
P
R
F
L
T
V
P
A
G
E
E
G
P
D
L
D
----
A
L
E
E
V
L
-----
K
R
-------
E
R
P
R
F
L
Y
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-------
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-------