@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2520: (2016-04-04 )
MYFQEARLIHVELPLIAPFKTSYGELNSKDFYIIELVNEEGIRGYGELEAFPLPDYTEETLSTAISIVKQHLLPILAQKEIRTPQEINQMFSWIQGNEMAKAAVELAVWDAFAKNEKLSLAKMIGAEKDSIAVGVSIGLQPDAETLVRLVSQYMDEGYERVKLKIAPKKDIQFVKAVREKFPNLSLMADANSAYNREDFWLLKELDHFNLEMIEQPFGAKDFVDHAWLQKKLKTRICLDENIRSLDDLKQAHMLGSCQAVNLKLARVGGMSEALKIAKYCSDNNLLVWCGGMLEAGIGRAHNIALAARAEFTFPGDISASNRYFNKDIVSPAFVLNQGKLTVPTGQGIGVALDLDVLQKYTKSTERILLNKGWS
Atome Classification :
(23 SA)
.........10........20........30........40....--..-..50........60........70........80........90........100.......110.......120.......130......--.140.......150.......160......---.170.......180..-......190......-.200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MYF
Q
E
A
R
L
I
H
V
EL
P
L
IAPFKTSYGELNSK
D
F
Y
I
I
E
L
VNEEGIRGY--GE-LEAFPLPD
Y
T
E
E
T
L
S
T
A
I
S
I
V
K
Q
H
L
L
P
I
L
A
Q
K
EIR
T
P
Q
E
I
N
Q
M
F
S
W
IQG
N
E
M
A
K
A
A
V
E
L
A
V
W
D
A
FAKNE
K
L
S
L
A
K
M
IGAEKD
S
I
A
V
G
V
S
IG--LQP
D
A
E
T
L
V
R
L
V
S
Q
Y
M
DEGY
E
R
V
K
L
K
IAPK---K
D
I
Q
F
V
K
A
V
R
E
KF-PN-
L
S
L
M
ADANSAYN
R
E
D
-
F
W
L
L
K
E
L
D
HF
N
L
E
M
I
EQPFGA
K
D
F
V
D
H
A
W
L
Q
K
K
L
K
T
R
I
C
L
D
E
N
I
R
S
L
D
D
L
K
Q
A
H
MLGS
C
Q
A
V
N
L
K
L
A
RVG
G
M
S
E
A
L
K
I
A
K
YCSDN
N
L
L
V
W
CG
G
M
L
E
A
GIGRA
H
N
I
A
L
A
A
R
A
E
F
TFPGDISASNRYFNKDIVS
P
A
F
V
LNQG
K
L
T
VPTGQG
I
G
V
A
L
D
L
D
V
L
Q
K
Y
T
K
S
T
E
R
I
L
LNKGWS
58
HHSearch
97.57
80%
-110
- C1 -
1WUF
1
?
A:
[20-389]
M
Y
F
Q
K
A
R
L
I
H
A
E
L
P
L
L
A
P
F
K
T
S
Y
G
E
L
K
S
K
D
F
Y
I
I
E
L
I
N
E
E
G
I
H
G
Y
--
G
E
-
L
E
A
F
P
L
P
D
Y
T
E
E
T
L
S
S
A
I
L
I
I
K
E
Q
L
L
P
L
L
A
Q
R
K
I
R
K
P
E
E
I
Q
E
L
F
S
W
I
Q
G
N
E
M
A
K
A
A
V
E
L
A
V
W
D
A
F
A
K
M
E
K
R
S
L
A
K
M
I
G
A
T
K
E
S
I
K
V
G
V
S
I
G
--
L
Q
Q
N
V
E
T
L
L
Q
L
V
N
Q
Y
V
D
Q
G
Y
E
R
V
K
L
K
I
A
P
N
---
K
D
I
Q
F
V
E
A
V
R
K
S
F
-
P
K
-
L
S
L
M
A
D
A
N
S
A
Y
N
R
E
D
-
F
L
L
L
K
E
L
D
Q
Y
D
L
E
M
I
E
Q
P
F
G
T
K
D
F
V
D
H
A
W
L
Q
K
Q
L
K
T
R
I
C
L
D
E
N
I
R
S
V
K
D
V
E
Q
A
H
S
I
G
S
C
R
A
I
N
L
K
L
A
R
V
G
G
M
S
S
A
L
K
I
A
E
Y
C
A
L
N
E
I
L
V
W
C
G
G
M
L
E
A
G
V
G
R
A
H
N
I
A
L
A
A
R
N
E
F
V
F
P
G
D
I
S
A
S
N
R
F
F
A
E
D
I
V
T
P
A
F
E
L
N
Q
G
R
L
K
V
P
T
N
E
G
I
G
V
T
L
D
L
K
V
L
K
K
Y
T
K
S
T
E
E
I
L
L
N
----
1
PsiBlast_PDB
97.57
80%
-110
- C1 -
1WUF
1
?
A:
[20-389]
M
Y
F
Q
K
A
R
L
I
H
A
E
L
P
L
L
A
P
F
K
T
S
Y
G
E
L
K
S
K
D
F
Y
I
I
E
L
I
N
E
E
G
I
H
G
Y
--
G
E
-
L
E
A
F
P
L
P
D
Y
T
E
E
T
L
S
S
A
I
L
I
I
K
E
Q
L
L
P
L
L
A
Q
R
K
I
R
K
P
E
E
I
Q
E
L
F
S
W
I
Q
G
N
E
M
A
K
A
A
V
E
L
A
V
W
D
A
F
A
K
M
E
K
R
S
L
A
K
M
I
G
A
T
K
E
S
I
K
V
G
V
S
I
G
--
L
Q
Q
N
V
E
T
L
L
Q
L
V
N
Q
Y
V
D
Q
G
Y
E
R
V
K
L
K
I
A
P
N
---
K
D
I
Q
F
V
E
A
V
R
K
S
F
-
P
K
-
L
S
L
M
A
D
A
N
S
A
Y
N
R
E
D
-
F
L
L
L
K
E
L
D
Q
Y
D
L
E
M
I
E
Q
P
F
G
T
K
D
F
V
D
H
A
W
L
Q
K
Q
L
K
T
R
I
C
L
D
E
N
I
R
S
V
K
D
V
E
Q
A
H
S
I
G
S
C
R
A
I
N
L
K
L
A
R
V
G
G
M
S
S
A
L
K
I
A
E
Y
C
A
L
N
E
I
L
V
W
C
G
G
M
L
E
A
G
V
G
R
A
H
N
I
A
L
A
A
R
N
E
F
V
F
P
G
D
I
S
A
S
N
R
F
F
A
E
D
I
V
T
P
A
F
E
L
N
Q
G
R
L
K
V
P
T
N
E
G
I
G
V
T
L
D
L
K
V
L
K
K
Y
T
K
S
T
E
E
I
L
L
N
----
21
PsiBlast_CBE
97.40
80%
-111
- C1 -
1WUF
1
?
B:
[20-389]
M
Y
F
Q
K
A
R
L
I
H
A
E
L
P
L
L
A
P
F
K
T
S
Y
G
E
L
K
S
K
D
F
Y
I
I
E
L
I
N
E
E
G
I
H
G
Y
--
G
E
-
L
E
A
F
P
L
P
D
Y
T
E
E
T
L
S
S
A
I
L
I
I
K
E
Q
L
L
P
L
L
A
Q
R
K
I
R
K
P
E
E
I
Q
E
L
F
S
W
I
Q
G
N
E
M
A
K
A
A
V
E
L
A
V
W
D
A
F
A
K
M
E
K
R
S
L
A
K
M
I
G
A
T
K
E
S
I
K
V
G
V
S
I
G
--
L
Q
Q
N
V
E
T
L
L
Q
L
V
N
Q
Y
V
D
Q
G
Y
E
R
V
K
L
K
I
A
P
N
---
K
D
I
Q
F
V
E
A
V
R
K
S
F
-
P
K
-
L
S
L
M
A
D
A
N
S
A
Y
N
R
E
D
-
F
L
L
L
K
E
L
D
Q
Y
D
L
E
M
I
E
Q
P
F
G
T
K
D
F
V
D
H
A
W
L
Q
K
Q
L
K
T
R
I
C
L
D
E
N
I
R
S
V
K
D
V
E
Q
A
H
S
I
G
S
C
R
A
I
N
L
K
L
A
R
V
G
G
M
S
S
A
L
K
I
A
E
Y
C
A
L
N
E
I
L
V
W
C
G
G
M
L
E
A
G
V
G
R
A
H
N
I
A
L
A
A
R
N
E
F
V
F
P
G
D
I
S
A
S
N
R
F
F
A
E
D
I
V
T
P
A
F
E
L
N
Q
G
R
L
K
V
P
T
N
E
G
I
G
V
T
L
D
L
K
V
L
K
K
Y
T
K
S
T
E
E
I
L
L
N
----
2
PsiBlast_PDB
86.65
51%
-110
- C1 -
1WUE
-
?
A:
[1001-1362]
M
N
I
Q
S
I
E
T
Y
Q
V
R
L
P
L
K
T
P
F
V
T
S
Y
G
R
L
E
E
K
A
F
D
L
F
V
I
T
D
E
Q
G
N
Q
G
F
--
G
E
-
L
V
A
F
E
Q
P
D
Y
V
Q
E
T
L
V
T
E
R
F
I
I
Q
Q
H
L
I
P
L
L
L
T
E
A
I
E
Q
P
Q
E
V
S
T
I
F
E
E
V
K
G
H
W
M
G
K
A
A
L
E
T
A
I
W
D
L
Y
A
K
R
Q
Q
K
S
L
T
E
F
F
G
P
T
R
R
K
I
P
V
G
I
S
L
G
--
I
Q
E
D
L
P
Q
L
L
K
Q
V
Q
L
A
V
E
K
G
Y
Q
R
V
K
L
K
I
R
P
G
---
Y
D
V
E
P
V
A
L
I
R
Q
H
F
-
P
N
-
L
P
L
M
V
D
A
N
S
A
Y
T
L
A
D
-
L
P
Q
L
Q
R
L
D
H
Y
Q
L
A
M
I
E
Q
P
F
A
A
D
D
F
L
D
H
A
Q
L
Q
R
E
L
K
T
R
I
C
L
D
E
N
I
R
S
L
K
D
C
Q
V
A
L
A
L
G
S
C
R
S
I
N
L
K
I
P
R
V
G
G
I
H
E
A
L
K
I
A
A
F
C
Q
E
N
D
L
L
V
W
L
G
G
M
F
E
S
G
V
G
R
A
L
N
L
Q
F
A
S
Q
P
T
F
S
F
P
G
D
I
S
A
T
E
R
Y
F
Y
E
D
I
I
T
E
P
F
I
L
E
Q
G
T
M
T
V
P
Q
G
L
G
I
G
V
T
L
S
Q
T
N
L
L
K
Y
S
Q
------------
63
HHSearch
86.60
51%
-108
- C1 -
1WUE
-
?
A:
[1001-1365]
M
N
I
Q
S
I
E
T
Y
Q
V
R
L
P
L
K
T
P
F
V
T
S
Y
G
R
L
E
E
K
A
F
D
L
F
V
I
T
D
E
Q
G
N
Q
G
F
--
G
E
-
L
V
A
F
E
Q
P
D
Y
V
Q
E
T
L
V
T
E
R
F
I
I
Q
Q
H
L
I
P
L
L
L
T
E
A
I
E
Q
P
Q
E
V
S
T
I
F
E
E
V
K
G
H
W
M
G
K
A
A
L
E
T
A
I
W
D
L
Y
A
K
R
Q
Q
K
S
L
T
E
F
F
G
P
T
R
R
K
I
P
V
G
I
S
L
G
--
I
Q
E
D
L
P
Q
L
L
K
Q
V
Q
L
A
V
E
K
G
Y
Q
R
V
K
L
K
I
R
P
G
---
Y
D
V
E
P
V
A
L
I
R
Q
H
F
-
P
N
-
L
P
L
M
V
D
A
N
S
A
Y
T
L
A
D
-
L
P
Q
L
Q
R
L
D
H
Y
Q
L
A
M
I
E
Q
P
F
A
A
D
D
F
L
D
H
A
Q
L
Q
R
E
L
K
T
R
I
C
L
D
E
N
I
R
S
L
K
D
C
Q
V
A
L
A
L
G
S
C
R
S
I
N
L
K
I
P
R
V
G
G
I
H
E
A
L
K
I
A
A
F
C
Q
E
N
D
L
L
V
W
L
G
G
M
F
E
S
G
V
G
R
A
L
N
L
Q
F
A
S
Q
P
T
F
S
F
P
G
D
I
S
A
T
E
R
Y
F
Y
E
D
I
I
T
E
P
F
I
L
E
Q
G
T
M
T
V
P
Q
G
L
G
I
G
V
T
L
S
Q
T
N
L
L
K
Y
S
Q
Y
Q
K
---------
61
HHSearch
82.45
40%
-105
- C1 -
2ZC8
-
?
A:
[1-365]
M
R
I
E
A
A
E
L
R
I
L
E
L
P
L
K
F
R
F
E
T
S
F
G
V
Q
T
K
R
T
I
L
L
L
R
L
F
-
G
E
G
L
E
G
L
--
G
E
-
G
V
M
E
R
L
P
L
Y
R
E
E
T
V
A
G
A
R
Y
L
L
E
E
V
F
L
P
R
V
L
G
R
D
L
P
N
P
E
A
L
R
E
A
L
A
P
F
R
G
N
P
M
A
K
A
V
L
E
M
A
F
F
D
L
W
A
K
A
L
G
R
P
L
W
Q
V
L
G
G
V
R
Q
A
V
E
V
G
V
S
L
G
--
I
Q
P
S
V
E
D
T
L
R
V
V
E
R
H
L
E
E
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
Y
E
V
L
K
A
V
R
E
A
F
-
P
E
-
A
T
L
T
A
D
A
N
S
A
Y
S
L
A
N
-
L
A
Q
L
K
R
L
D
E
L
R
L
D
Y
I
E
Q
P
L
A
Y
D
D
L
L
D
H
A
K
L
Q
R
E
L
S
T
P
I
C
L
D
E
S
L
T
G
A
E
K
A
R
K
A
I
E
L
G
A
G
R
V
F
N
V
K
P
A
R
L
G
G
H
G
E
S
L
R
V
H
A
L
A
E
S
A
G
I
P
L
W
M
G
G
M
L
E
A
G
V
G
R
A
H
N
L
H
L
A
T
L
P
G
F
T
K
P
G
D
V
S
S
A
S
R
Y
W
E
E
D
I
V
E
E
A
L
E
A
K
D
G
L
M
P
V
P
E
G
V
G
I
G
V
H
L
K
L
P
F
V
E
R
V
T
L
W
Q
R
Y
--------
44
PsiBlast_CBE
81.62
40%
-102
- C1 -
4A6G
2
?
C:
[1-362]
M
K
L
S
G
V
E
L
R
R
V
Q
M
P
L
V
A
P
F
R
T
S
F
G
T
Q
S
V
R
E
L
L
L
L
R
A
V
T
P
A
G
-
E
G
W
--
G
E
-
C
V
T
M
A
G
P
L
Y
S
S
E
Y
N
D
G
A
E
H
V
L
R
H
Y
L
I
P
A
L
L
A
A
E
D
I
T
A
A
K
V
T
P
L
L
A
K
F
K
G
H
R
M
A
K
G
A
L
E
M
A
V
L
D
A
E
L
R
A
H
E
R
S
F
A
A
E
L
G
S
V
R
D
S
V
P
C
G
V
S
V
G
--
I
M
D
T
I
P
Q
L
L
D
V
V
G
G
Y
L
D
E
G
Y
V
R
I
K
L
K
I
E
P
G
---
W
D
V
E
P
V
R
A
V
R
E
R
F
G
D
D
-
V
L
L
Q
V
D
A
N
T
A
Y
T
L
G
D
-
A
P
Q
L
A
R
L
D
P
F
G
L
L
L
I
E
Q
P
L
E
E
E
D
V
L
G
H
A
E
L
A
R
R
I
Q
T
P
I
C
L
D
E
S
I
V
S
A
R
A
A
A
D
A
I
K
L
G
A
V
Q
I
V
N
I
K
P
G
R
V
G
G
Y
L
E
A
R
R
V
H
D
V
C
A
A
H
G
I
P
V
W
C
G
D
M
I
E
T
G
L
G
R
A
A
N
V
A
L
A
S
L
P
N
F
T
L
P
G
D
T
S
A
S
D
R
Y
Y
K
T
D
I
T
E
P
-
F
V
L
S
G
G
H
L
P
V
P
T
G
P
G
L
G
V
A
P
I
P
E
L
L
D
E
V
T
T
A
-----------
23
PsiBlast_CBE
81.45
38%
-107
- C1 -
1XS2
1
?
C:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
AE
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
5
PsiBlast_PDB
81.41
38%
-109
- C1 -
1XS2
1
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
6
PsiBlast_PDB
81.40
38%
-106
- C1 -
2GGJ
-
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
C
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
8
PsiBlast_PDB
81.39
38%
-109
- C1 -
2GGG
-
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
C
G
A
L
C
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
15
PsiBlast_PDB
81.36
40%
-101
- C1 -
4A6G
2
?
A:
[1-362]
M
K
L
S
G
V
E
L
R
R
V
Q
M
P
L
V
A
P
F
R
T
S
F
G
T
Q
S
V
R
E
L
L
L
L
R
A
V
T
P
A
G
-
E
G
W
--
G
E
-
C
V
T
M
A
G
P
L
Y
S
S
E
Y
N
D
G
A
E
H
V
L
R
H
Y
L
I
P
A
L
L
A
A
E
D
I
T
A
A
K
V
T
P
L
L
A
K
F
K
G
H
R
M
A
K
G
A
L
E
M
A
V
L
D
A
E
L
R
A
H
E
R
S
F
A
A
E
L
G
S
V
R
D
S
V
P
C
G
V
S
V
G
--
I
M
D
T
I
P
Q
L
L
D
V
V
G
G
Y
L
D
E
G
Y
V
R
I
K
L
K
I
E
P
G
---
W
D
V
E
P
V
R
A
V
R
E
R
F
G
D
D
-
V
L
L
Q
V
D
A
N
T
A
Y
T
L
G
D
-
A
P
Q
L
A
R
L
D
P
F
G
L
L
L
I
E
Q
P
L
E
E
E
D
V
L
G
H
A
E
L
A
R
R
I
Q
T
P
I
C
L
D
E
S
I
V
S
A
R
A
A
A
D
A
I
K
L
G
A
V
Q
I
V
N
I
K
P
G
R
V
G
G
Y
L
E
A
R
R
V
H
D
V
C
A
A
H
G
I
P
V
W
C
G
D
M
I
E
T
G
L
G
R
A
A
N
V
A
L
A
S
L
P
N
F
T
L
P
G
D
T
S
A
S
D
R
Y
Y
K
T
D
I
T
E
P
-
F
V
L
S
G
G
H
L
P
V
P
T
G
P
G
L
G
V
A
P
I
P
E
L
L
D
E
V
T
T
A
-----------
16
PsiBlast_PDB
81.28
39%
-106
- C1 -
2ZC8
-
?
A:
[1-360]
M
R
I
E
A
A
E
L
R
I
L
E
L
P
L
K
F
R
F
E
T
S
F
G
V
Q
T
K
R
T
I
L
L
L
R
L
F
G
E
G
L
E
G
L
G
--
E
G
V
M
E
R
L
P
L
--
Y
R
E
E
T
V
A
G
A
R
Y
L
L
E
E
V
F
L
P
R
V
L
G
R
D
L
P
N
P
E
A
L
R
E
A
L
A
P
F
R
G
N
P
M
A
K
A
V
L
E
M
A
F
F
D
L
W
A
K
A
L
G
R
P
L
W
Q
V
L
G
G
V
R
Q
A
V
E
V
G
V
S
L
G
--
I
Q
P
S
V
E
D
T
L
R
V
V
E
R
H
L
E
E
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
Y
E
V
L
K
A
V
R
E
A
F
-
P
E
-
A
T
L
T
A
D
A
N
S
A
Y
S
L
A
N
-
L
A
Q
L
K
R
L
D
E
L
R
L
D
Y
I
E
Q
P
L
A
Y
D
D
L
L
D
H
A
K
L
Q
R
E
L
S
T
P
I
C
L
D
E
S
L
T
G
A
E
K
A
R
K
A
I
E
L
G
A
G
R
V
F
N
V
K
P
A
R
L
G
G
H
G
E
S
L
R
V
H
A
L
A
E
S
A
G
I
P
L
W
M
G
G
M
L
E
A
G
V
G
R
A
H
N
L
H
L
A
T
L
P
G
F
T
K
P
G
D
V
S
S
A
S
R
Y
W
E
E
D
I
V
E
E
A
L
E
A
K
D
G
L
M
P
V
P
E
G
V
G
I
G
V
H
L
K
L
P
F
V
E
R
V
T
-------------
7
PsiBlast_PDB
81.24
38%
-107
- C1 -
2FKP
-
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
C
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
C
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
30
PsiBlast_CBE
81.18
38%
-110
- C1 -
2GGH
1
?
B:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
C
G
A
L
C
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
9
PsiBlast_PDB
81.18
38%
-108
- C1 -
2GGH
1
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
C
G
A
L
C
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
24
PsiBlast_CBE
81.08
38%
-108
- C1 -
1XS2
1
?
B:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
AE
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
3
PsiBlast_PDB
81.06
38%
-105
- C1 -
1R0M
-
?
A:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
27
PsiBlast_CBE
81.04
38%
-110
- C1 -
1XPY
1
?
B:
[10-371]
--
I
E
A
A
E
I
V
V
A
R
L
P
L
K
----------
T
H
K
V
V
P
L
L
-
I
L
H
G
E
G
V
Q
G
V
A
E
G
T
-
M
E
A
R
P
M
--
Y
R
E
E
T
I
A
G
A
L
D
L
L
R
G
T
F
L
P
A
I
L
G
Q
T
F
A
N
P
E
A
V
S
D
A
L
G
S
Y
R
G
N
R
M
A
R
A
M
V
E
M
A
A
W
D
L
W
A
R
T
L
G
V
P
L
G
T
L
L
G
G
H
K
E
Q
V
E
V
G
V
S
L
G
--
I
Q
A
D
E
Q
A
T
V
D
L
V
R
R
H
V
E
Q
G
Y
R
R
I
K
L
K
I
K
P
G
---
W
D
V
Q
P
V
R
A
T
R
E
A
F
-
P
D
-
I
R
L
T
V
D
A
N
S
A
Y
T
L
A
D
-
A
G
R
L
R
Q
L
D
E
Y
D
L
T
Y
I
E
Q
P
L
A
W
D
D
L
V
D
H
A
E
L
A
R
R
I
R
T
P
L
C
L
D
E
S
V
A
S
A
S
D
A
R
K
A
L
A
L
G
A
G
G
V
I
N
L
K
V
A
R
V
G
G
H
A
E
S
R
R
V
H
D
V
A
Q
S
F
G
A
P
V
W
C
G
G
M
L
E
S
G
I
G
R
A
H
N
I
H
L
S
T
L
S
N
F
R
L
P
G
D
T
S
S
A
S
R
Y
W
E
R
D
L
I
Q
E
P
L
E
A
V
D
G
L
M
P
V
P
Q
G
P
G
T
G
V
T
L
D
R
E
F
L
A
T
V
T
E
A
Q
E
---------
40
PsiBlast_CBE
80.85
40%
-100
- C1 -
1SJA
2
?
D:
[1-362]
M
K
L
S
G
V
E
L
R
R
V
Q
M
P
L
V
A
P
F
R
T
S
F
G
T
Q
S
V
R
E
L
L
L
L
R
A
V
T
P
A
G
-
E
G
W
--
G
E
-
C
V
T
M
A
G
P
L
Y
S
S
E
Y
N
D
G
A
E
H
V
L
R
H
Y
L
I
P
A
L
L
A
A
E
D
I
T
A
A
K
V
T
P
L
L
A
K
F
K
G
H
R
M
A
K
G
A
L
E
M
A
V
L
D
A
E
L
R
A
H
E
R
S
F
A
A
E
L
G
S
V
R
D
S
V
P
C
G
V
S
V
G
--
I
M
D
T
I
P
Q
L
L
D
V
V
G
G
Y
L
D
E
G
Y
V
R
I
K
L
K
I
E
P
G
---
W
D
V
E
P
V
R
A
V
R
E
R
F
G
D
D
-
V
L
L
Q
V
D
A
N
T
A
Y
T
L
G
D
-
A
P
Q
L
A
R
L
D
P
F
G
L
L
L
I
E
Q
P
L
E
E
E
D
V
L
G
H
A
E
L
A
R
R
I
Q
T
P
I
C
L
D
E
S
I
V
S
A
R
A
A
A
D
A
I
K
L
G
A
V
Q
I
V
N
I
K
P
G
R
V
G
G
Y
L
E
A
R
R
V
H
D
V
C
A
A
H
G
I
P
V
W
C
G
G
M
I
E
T
G
L
G
R
A
A
N
V
A
L
A
S
L
P
N
F
T
L
P
G
D
T
S
A
S
D
R
F
Y
K
T
D
I
T
E
P
-
F
V
L
S
G
G
H
L
P
V
P
T
G
P
G
L
G
V
A
P
I
P
E
L
L
D
E
V
T
T
A
-----------
53
PsiBlast_CBE
36.87
32%
-81
- C1 -
2PP0
1
TAGAD_SALTY
B:
[131-314]
------------------------------------------------------------------------------------------------------
A
I
S
P
I
D
I
A
L
W
D
M
K
A
K
R
A
G
L
P
L
A
K
L
L
G
A
H
R
D
S
V
Q
C
Y
N
T
S
G
GF
L
H
T
P
L
D
Q
V
L
K
N
V
V
I
S
R
E
N
G
I
G
G
I
K
L
K
V
G
Q
P
NCA
E
D
I
R
R
L
T
A
V
R
E
A
L
-
G
D
E
F
P
L
M
V
D
A
N
Q
Q
W
D
R
E
T
A
I
R
M
G
R
K
M
E
Q
F
N
L
I
W
I
E
E
P
L
D
A
Y
D
I
E
G
H
A
Q
L
A
A
A
L
D
T
P
I
A
T
G
E
M
L
T
S
F
R
E
H
E
Q
L
I
L
G
N
A
S
D
F
V
Q
P
D
A
P
R
V
G
G
I
S
P
F
L
K
I
--------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
36.63
32%
-82
- C1 -
2PP0
1
TAGAD_SALTY
C:
[131-314]
------------------------------------------------------------------------------------------------------
A
I
S
P
I
D
I
A
L
W
D
M
K
A
K
R
A
G
L
P
L
A
K
L
L
G
A
H
R
D
S
V
Q
C
Y
N
T
S
G
GF
L
H
T
P
L
D
Q
V
L
K
N
V
V
I
S
R
E
N
G
I
G
G
I
K
L
K
V
G
Q
P
NCA
E
D
I
R
R
L
T
A
V
R
E
A
L
-
G
D
E
F
P
L
M
V
D
A
N
Q
Q
W
D
R
E
T
A
I
R
M
G
R
K
M
E
Q
F
N
L
I
W
I
E
E
P
L
D
A
Y
D
I
E
G
H
A
Q
L
A
A
A
L
D
T
P
I
A
T
G
E
M
L
T
S
F
R
E
H
E
Q
L
I
L
G
N
A
S
D
F
V
Q
P
D
A
P
R
V
G
G
I
S
P
F
L
K
I
--------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
36.45
32%
-80
- C1 -
2PP0
1
TAGAD_SALTY
A:
[131-314]
------------------------------------------------------------------------------------------------------
A
I
S
P
I
D
I
A
L
W
D
M
K
A
K
R
A
G
L
P
L
A
K
L
L
G
A
H
R
D
S
V
Q
C
Y
N
T
S
G
GF
L
H
T
P
L
D
Q
V
L
K
N
V
V
I
S
R
E
N
G
I
G
G
I
K
L
K
V
G
Q
P
N
C
A
E
D
I
R
R
L
T
A
V
R
E
A
L
-
G
D
E
F
P
L
M
V
D
A
N
Q
Q
W
D
R
E
T
A
I
R
M
G
R
K
M
E
Q
F
N
L
I
W
I
E
E
P
L
D
A
Y
D
I
E
G
H
A
Q
L
A
A
A
L
D
T
P
I
A
T
G
E
M
L
T
S
F
R
E
H
E
Q
L
I
L
G
N
A
S
D
F
V
Q
P
D
A
P
R
V
G
G
I
S
P
F
L
K
I
--------------------------------------------------------------------------------------------------