@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0243: (2015-11-29 )
MFKELVKFIYSSSEGQLKALQSKANALTGEVTISDDVSDIADAWKKRLGLKTVQTALARKLAYASARHHYKDGKTMLEDISAGKTRRHANSYI
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------...--......10....---....20...-------.....30---...---......40...-----.....-50........60---.......--------..70---------------.....----...80.--.......90..----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
K
--
E
L
V
K
F
I
YSSSE
G
---
Q
L
K
A
L
Q
S
KA-------NALTG
E
----
V
T
I---SD
D
V
S
D
I
A
D
A
W
-----
K
KRLG-
L
K
T
V
Q
T
A
L
A
R
K
----
L
A
Y
A
S
A
R
--------HHYK---------------D
G
K
T
M
----
L
E
D
I
SA--GKTRRHANSYI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.35
30%
-45
- C6 -
4FWK
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.96
30%
-44
- C6 -
4FWL
-
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.92
30%
-43
- C6 -
4FWM
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.99
30%
-45
- C6 -
4FWQ
2
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.92
30%
-43
- C6 -
4FWP
2
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.80
30%
-40
- C6 -
1X3M
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.62
30%
-43
- C6 -
4FWS
2
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.56
30%
-40
- C6 -
2E1Y
-
TDCD_SALTY
A:
[259-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.23
30%
-42
- C6 -
2E1Z
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.16
30%
-40
- C6 -
4FWR
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.04
30%
-42
- C6 -
4FWN
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
74.45
30%
-41
- C6 -
1X3N
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.95
30%
-37
- C6 -
4FWO
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.61
30%
-38
- C6 -
2E20
1
TDCD_SALTY
A:
[272-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
R
V
V
N
K
E
-------
S
G
L
L
G
I
----
S
G
L
---
S
S
D
L
R
V
L
E
K
A
W
H
E
GH
E
R
A
R
L
A
-
I
K
T
F
V
H
R
I
A
R
H
----
I
A
G
H
A
A
S
--------
L
H
R
L
---------------
D
G
I
I
F
----
T
G
G
I
G
E
--
N
S
V
L
I
R
Q
L
V
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
72.57
29%
-19
* C5 *
3ZPJ
-
?
A:
[1-356]
----------------------------M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
A
K
V
YEIED
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
DGPMEW
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
LRD
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
EY
E
E
D
A
M
D
F
F
N
R
A
I
D
E
A
N
E
IES
P
I
E
K
G
M
V
L
S
T
L
A
Y
H
L
A
I
A
GY
P
D
N
A
L
E
I
F
N
I
A
F
D
T
I
I
G
AETS
Y
T
H
K
V
D
G
I
L
R
I
G
D
L
L
E
K
A
G
D
T
LPSNEA
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
HV
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
K
T
V
YDVGL
P
Q
I
R
A
A
L
L
K
GK
N
H
Y
A
L
A
I
I
K
K
K
YSG
V
M
R
L
I
G
E
L
E
V
A
L
W
M
K
R
V
NNME
Y
L
D
V
V
D
K
A
F
E
C
CESPRFT
D
V
N
V
Q
H
I
A
R
L
L
T
--
E
L
---------
G
---
N
L
R
R
A
L
K
F
A
-------
K
--------------------
E
I
Q
N
I
H
-----
K
R
S
E
A
-
L
K
A
I
A
L
E
L
V
R
-----------
R
--------
K
K
F
E
---------------
E
V
K
K
I
----
I
E
S
I
P
D
--
P
K
I
R
E
E
A
L
N
E
I
GTIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
65.24
14%
-71
- C4 -
4P0P
1
EME1_HUMAN
B:
[62-389]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKAQRPE
E
C
L
K
H
I
I
V
V
L
D
P
V
L
L
Q
MEG
G
G
Q
L
L
G
A
L
Q
T
M
E
C
R
C
V
I
E
A
Q
AVPC
S
V
T
W
R
R
R
A
G
PSEDRED
W
V
E
E
P
T
V
L
V
L
L
R
A
E
A
F
V
S
M
I
D
N
G
KT
L
Q
G
F
V
T
D
I
T
A
K
T
AGKA
L
S
L
V
I
V
D
QEKCFVS
R
V
D
A
E
E
A
L
V
D
L
Q
L
HTE
A
Q
A
Q
I
V
QS
W
K
E
L
A
D
--
F
T
C
A
F
T
K
A
V
A
E
A
---
P
F
K
K
L
R
D
E
T
TFSFCLE
S
D
W
A
G
G
----
V
K
V
---
D
L
A
G
R
G
L
A
L
V
W
-----
R
R
Q
I
Q
Q
L
N
R
V
S
L
E
M
A
S
A
----
V
V
N
A
-------------
Y
P
---------------
S
P
Q
L
L
----
V
Q
A
Y
Q
Q
--
C
F
S
D
K
E
R
Q
N
L
L
AD
I
Q
V
R
RTSRRIG
P
E
L
S
R
R
I
Y
L
Q
M
TTLQPHLSL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
60.41
22%
-1
- C5 -
4A0G
6
BIODA_ARATH
A:
[27-831]
P
F
H
L
P
LN
H
P
T
Y
L
I
W
S
ANTSLG
K
T
L
V
S
T
G
I
A
A
S
F
L
L
QQPSSSA
T
K
L
L
Y
L
KPIQTGFPSDS
D
S
R
F
V
F
S
K
L
D
S
L
S
L
R
R
Q
I
P
I
S
I
S
N
S
V
LHSS
L
P
A
A
K
S
L
GLN
V
E
V
S
ESG
M
C
S
L
N
F
R
D
E
K
T
V
T
G
A
P
E
L
L
C
K
T
L
Y
A
W
E
AAIS
P
H
L
A
A
E
R
E
N
A
T
V
E
D
S
V
V
L
Q
M
I
E
K
C
L
K
E
E
MD
L
L
C
L
V
E
T
A
G
GVASPGPSGTL
Q
C
D
L
Y
RPFR
L
P
G
I
L
VGDGRLG
G
I
S
G
T
I
A
A
Y
E
S
L
K
L
R
GYDIA
A
V
V
F
E
D
HGLV
N
E
V
P
L
T
S
Y
L
RNK
V
P
V
L
V
L
P
P
VPKDPSDDL
I
E
W
F
V
E
S
D
G
V
F
K
A
L
K
E
T
M
V
L
A
N
L
E
R
L
E
R
L
N
G
M
A
K
L
A
G
E
VFWWPFTQHKL
V
H
Q
--
E
T
V
T
V
I
D
S
R
C
G
E
---
N
F
S
I
Y
K
A
S
D
-------
N
S
---------
S
L
---
S
Q
Q
F
D
A
C
A
S
W
W
-----
T
Q
G
P
D
--
P
T
F
Q
A
E
L
A
R
E
----
M
G
Y
T
A
A
R
FGHVMFPE
N
V
Y
E
---------------
P
A
L
K
C
----
A
E
L
L
L
D
--
G
V
G
K
G
W
A
S
R
V
Y
F
S
D
N
G
S
T
A
I
E
I
A
L
K
M
A
F
R
K
F
C
V
D
H
NFI
V
V
K
V
I
A
L
RGSYHGDT
L
G
A
M
E
A
QAPSPYTGFLQQPWYTGRGL
F
L
D
P
P
T
V
F
L
S
NG
S
W
N
I
S
L
P
ESFSEIAPEYGTFTS
R
D
E
I
F
DKSRDAS
T
L
A
R
I
Y
S
A
Y
L
S
K
H
LAHVG
A
L
I
I
EPVIHGAGGMHMVD
P
L
F
Q
R
V
L
V
N
E
C
R
N
R
K
I
P
V
I
F
DEVFTGFWRLGVETTTELLGCKPD
I
A
C
F
A
KLLTGGM
V
P
L
A
V
T
L
A
T
D
A
V
F
D
S
F
SGDSKLKALLHGHSYSAH
A
M
G
C
A
T
A
A
K
A
I
Q
W
F
K
DPETNHNITSQGKTLRELWD
E
E
L
V
Q
Q
I
S
S
HSAVQ
R
V
V
V
I
GT
L
F
A
L
E
L
KS
L
Y
A
K
S
L
L
I
M
L
R
E
D
G
I
F
T
R
P
LGN
V
I
Y
L
M
C
G
PCTS
P
E
I
C
R
R
L
L
T
K
L
Y
K
R
L
G
E
F
NRT
30
Fugue
56.70
18%
-2
- C5 -
2LQO
-
Y3198_MYCTU
A:
[1-88]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
T
--
A
A
L
T
I
Y
T
T
S
W
C
G
Y
C
L
R
L
K
T
A
L
T
A
N
-------
R
I
A
Y
D
E
----
V
D
I
---
E
H
N
R
A
A
A
E
F
V
G
-----
S
V
N
G
G
-
N
R
T
V
----------------
P
T
--------
V
K
F
A
---------------
D
G
S
T
L
T
NPS
A
D
E
V
K
A
--
K
L
V
K
I
A
G
L
E
H
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
56.44
14%
-42
- C5 -
2KPO
-
?
A:
[1-110]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
L
L
Y
V
L
I
I
S
N
D
K
K
---
L
I
E
E
A
R
K
M
A
-------
E
K
A
N
L
E
----
L
R
T
V
KT
E
D
E
L
K
K
Y
L
E
E
F
-----
R
K
E
S
Q
-
N
I
K
V
L
I
L
V
S
N
D
----
E
E
L
D
K
A
K
--------
E
L
A
Q
K
M
E
I
D
V
R
T
R
K
V
TS
P
D
E
A
K
R
W
----
I
K
E
F
S
E
E
G
G
S
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
55.59
23%
-14
- C5 -
4PQG
2
?
A:
[6-511]
-------------------------------------------------HH
H
M
T
I
Y
N
I
N
LGIGWASS
G
V
E
Y
A
Q
A
Y
R
A
G
V
F
R
K
L
N
L
S
S
K
F
I
F
TDMILADN
I
Q
H
L
T
A
N
I
GFDDNQVIWLYNHFTDIKIAPTSVT
V
D
D
V
L
A
Y
F
GGEES
H
R
E
K
N
GK
V
L
R
V
F
F
FDQD
K
F
V
T
C
Y
L
VDENKDLVQ
H
A
E
Y
V
F
KGNLI
R
K
D
Y
F
S
YTRY
C
S
E
Y
F
A
P
K
DN
V
A
V
L
Y
Q
R
T
F
Y
N
EDGTPV
Y
D
I
L
M
N
QGKEEVYHFKD
K
I
F
Y
G
K
Q
A
F
V
R
A
F
M
K
S
L
NLNKS
D
L
V
I
L
DRETGI
G
Q
V
V
F
E
E
A
Q
T
A
H
L
A
V
V
V
H
A
EHYSENATNED
Y
I
L
W
NNYY
D
Y
Q
F
T
N
A
D
K
V
D
F
F
I
V
S
T
D
R
---
Q
N
E
V
L
Q
E
Q
F
-------
A
K
Y
T
Q
H
Q
P
K
I
V
T
I
P
VG
S
I
D
S
L
T
D
S
S
Q
G
-----
R
K
P
F
S
-
L
I
T
A
S
R
L
A
K
E
K
H
I
D
W
L
V
K
A
V
I
E
--------
A
H
K
E
---------------
L
P
E
L
T
----
F
D
I
Y
G
S
--
G
G
E
D
S
L
L
R
E
I
I
A
N
H
QAEDYIQLKGHAELSQIYSQYE
V
Y
L
T
ASTSEGFG
L
T
L
M
E
A
I
G
S
G
L
P
L
I
G
F
DVPY
G
N
Q
T
F
IEDGQN
G
Y
L
I
PSSSDHV
E
D
Q
I
K
Q
A
Y
A
A
K
I
C
Q
L
Y
Q
E
NR
L
E
A
M
R
A
Y
S
Y
Q
I
A
E
G
F
L
T
K
E
I
L
E
K
W
K
K
T
V
E
E
V
L
HD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------