@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs1108: (2015-12-05 )
MNYAQLIKHYGQLLEACGEEVENFIYVLKDLKQWSTTDYLLNQNSSVSDTDQQLMENIFQQLKKHRSPQYITGKAYFRDLIFFVDERVLIPRPETEELVDLILSENKVEDCSVLDIGTGSGAIAISLKKERPSWDVLASDISVSALDLAKENANNCDAEVTFIESDVFSNISGKFDIIVSNPPYISYNDKDEVGKNVLASEPHSALFADEEGLAIYRKIIENSREYLQPRGKLYFEIGYKQGDDLRSLLKRYFPNNRCRVLKDIFGKDRMVVLDNE
Atome Classification :
(20 SA)
.........10.......-.20........30........40........50........60........70......--..80........90..---......100..--.-.-------..-.110........120.......130.-----.......140.......150..--...--..-160.----......170-----.---.----..---....180.......190.......200.......210.......220.......230.--...-....240---.-......--..250....-...260.......270....--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
Y
A
Q
L
I
K
H
Y
G
Q
L
L
E
A
C
G
-
E
E
V
E
N
F
I
Y
V
L
K
D
L
K
Q
WSTT
D
Y
L
LNQNSSVS
D
T
D
Q
Q
L
M
E
N
I
F
Q
Q
L
K
K
HRSPQYI
T
G
K
A
Y
F
--
R
D
L
I
F
F
VDERVLIPRP---
E
T
E
E
L
V
D
L
I
L
S--E-N-------KV-ED
C
-
S
V
L
D
IGTGS
G
A
I
A
I
S
L
KKER-P-----S
W
D
V
L
ASDIS
V
S
A
L
D
L
A
KENAN--NCD--
A
E
-
V
T
F
I----
E
S
D
V
F
SNI------S---G----
K
F
---
D
I
I
VSNP
P
Y
I
SYN
D
K
D
E
VG
K
N
V
LASEPHSALFADEE
G
L
A
I
Y
R
K
I
I
EN
S
R
E
Y
LQPR-
G
K
--
L
Y
F
-
E
I
GYK-----Q-
G
D
D
L
R
S
--
L
L
K
R
YFPN
N
-
R
C
R
V
L
K
D
IFGKD
R
M
V
V
LDNE--
2
PsiBlast_PDB
93.95
32%
-71
- C1 -
2B3T
1
PRMC_ECOLI
A:
[1-262]
M
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
P
I
A
H
L
T
G
V
R
E
F
--
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
P
---
D
T
E
C
L
V
E
Q
A
L
A
--
R
-
L
-------
P
E
-
Q
P
C
-
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
-
P
-----
D
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
--
H
L
A
--
I
K
N
I
H
I
L
----
Q
S
D
W
F
S
A
L
------
A
---
G
Q
---
Q
F
---
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
-
H
L
Q
Q
G
D
V
R
F
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
V
S
G
-
G
F
--
L
L
L
-
E
H
G
W
Q
-----
Q
-
G
E
A
V
R
Q
A
F
I
L
A
G
Y
H
D
V
E
-
T
C
R
D
Y
G
D
N
E
R
V
T
L
G
R
Y
Y
-----
61
HHSearch
93.45
30%
-66
- C1 -
2B3T
1
PRMC_ECOLI
A:
[1-275]
M
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
P
I
A
H
L
T
G
V
R
E
F
--
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
P
---
D
T
E
C
L
V
E
Q
A
L
A
--
R
-
L
-------
P
E
-
Q
P
C
-
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
-
P
-----
D
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
--
H
L
A
I-
K
N
-
I
H
I
L
----
Q
S
D
W
F
S
A
L
------
A
G
--
Q
----
Q
F
---
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
H
L
Q
Q
G
D
V
-
R
F
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
V
S
G
-
G
F
--
L
L
L
-
E
H
G
W
Q
-----
Q
-
G
E
A
V
R
Q
--
A
F
I
L
A
G
Y
-
H
-
D
V
E
T
C
R
D
Y
G
D
N
E
R
V
T
L
G
R
Y
Y
--
62
HHSearch
90.68
31%
-87
- C1 -
1NV8
2
PRMC_THEMA
A:
[14-282]
R
K
I
W
S
L
I
R
D
C
S
G
K
L
E
G
V
T
E
T
S
V
L
E
V
L
L
I
V
S
R
V
L
G
I
R
K
E
D
L
F
L
K
-
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
-
I
-------
R
K
Y
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
--
S
-----
D
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
VS
D
R
-
F
F
V
R
----
K
G
E
F
L
E
P
F
------
K
EKF
A
----
S
I
---
E
M
I
L
S
N
P
P
Y
V
K
S
S
A
--
H
L
P
K
D
V
L
-
F
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
----
G
R
Y
D
T
S
G
K
I
--
V
L
M
-
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
S
D
-------
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
1
PsiBlast_PDB
88.40
32%
-58
- C1 -
1T43
1
PRMC_ECOLI
A:
[2-262]
-
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
P
I
A
H
L
T
G
V
R
E
F
--
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
P
---
D
T
E
C
L
V
E
Q
A
L
A
--
R
-
L
-------
P
E
-
Q
P
C
-
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
-
P
-----
D
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
--
H
L
A
--
I
K
N
I
H
I
L
----
Q
S
D
W
F
S
A
L
------
A
---
G
Q---
Q
F
---
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
-
H
L
Q
Q
G
D
V
R
F
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
V
S
G
-
G
F
--
L
L
L
-
E
H
G
W
Q
-----
Q
-
G
E
A
V
R
Q
A
F
I
L
A
G
Y
H
D
V
E
-
T
C
R
D
Y
G
D
N
E
R
V
T
L
G
R
Y
------
52
Fugue
88.25
30%
-82
- C1 -
1NV9
1
PRMC_THEMA
A:
[15-284]
-
K
I
W
S
L
I
R
D
C
S
G
K
L
E
G
V
T
-
E
T
S
V
L
E
V
L
L
I
V
S
R
V
L
G
I
R
K
E
D
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
-
I
-------
R
K
-
Y
G
I
K
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
--
S
-----
D
A
I
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
R
H
G
V
S
--
D
R
-
F
F
V
R
----
K
G
E
F
L
E
P
F
------
K
---
E
KFA-
S
I
---
E
M
I
L
S
N
P
P
Y
V
K
S
S
A
L
---------
F
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
---
Y
D
T
S
G
-
K
I
--
V
L
M
-
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
S
D
T
-------
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
SS
51
Fugue
87.02
30%
-55
- C1 -
1T43
1
PRMC_ECOLI
A:
[2-275]
-
E
Y
Q
H
W
L
R
E
A
I
S
Q
L
Q
A
S
E
-
S
P
R
R
D
A
E
I
L
L
E
H
V
T
G
R
G
R
T
F
I
L
A
F
G
E
T
Q
L
T
D
E
Q
C
Q
Q
L
D
A
L
L
T
R
R
R
D
G
E
P
I
A
H
L
T
G
V
R
E
F
--
W
S
L
P
L
F
V
S
P
A
T
L
I
P
R
P
---
D
T
E
C
L
V
E
Q
A
L
A
--
R
-
L
-------
P
E
-
Q
P
C
-
R
I
L
D
L
G
T
G
T
G
A
I
A
L
A
L
A
S
E
R
-
P
-----
D
C
E
I
I
A
V
D
R
M
P
D
A
V
S
L
A
Q
R
N
A
Q
--
H
L
A
--
I
K
N
I
H
I
L
----
Q
S
D
W
F
S
A
L
A-----
G
---
Q
----
Q
F
---
A
M
I
V
S
N
P
P
Y
I
D
E
Q
D
P
H
L
Q
Q
G
D
V
R
F
-
E
P
L
T
A
L
V
A
A
D
S
G
M
A
D
I
V
H
I
I
E
Q
S
R
N
A
L
V
S
G
-
G
F
--
L
L
L
-
E
H
G
W
Q
-----
Q
-
G
E
A
V
R
Q
--
A
F
I
L
A
-
G
Y
H
-
D
V
E
T
C
R
D
Y
G
D
N
E
R
V
T
L
G
R
Y
---
22
PsiBlast_CBE
84.12
33%
-72
- C1 -
1SG9
2
PRMC_THEMA
B:
[51-279]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
VR--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
H
L
P
K
D
V
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
4
PsiBlast_PDB
83.66
33%
-72
- C1 -
1NV8
2
PRMC_THEMA
A:
[53-281]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
V
R
--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
H
L
P
K
D
V
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
21
PsiBlast_CBE
83.42
33%
-72
- C1 -
1SG9
2
PRMC_THEMA
C:
[51-279]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
VR--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
H
L
P
K
D
V
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
6
PsiBlast_PDB
83.17
33%
-71
- C1 -
1SG9
2
PRMC_THEMA
A:
[51-279]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
V
R
--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
H
L
P
K
D
V
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
7
PsiBlast_PDB
83.08
33%
-72
- C1 -
1VQ1
1
PRMC_THEMA
A:
[63-291]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
V
R
--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
H
L
-----
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
5
PsiBlast_PDB
82.16
33%
-76
- C1 -
1NV9
1
PRMC_THEMA
A:
[53-281]
----------------------------------------
L
F
L
K
D
L
G
V
S
P
T
E
E
K
R
I
L
E
L
V
E
K
R
A
S
G
Y
P
L
H
Y
I
L
G
E
K
E
F
--
M
G
L
S
F
L
V
E
E
G
V
F
V
P
R
P
---
E
T
E
E
L
V
E
L
A
L
E
--
L
I
R
-------
K
Y
-
G
I
K
-
T
V
A
D
I
G
T
G
S
G
A
I
G
V
S
V
A
K
F
S
-
D
-----
A
I
-
V
F
A
T
D
V
S
S
K
A
V
E
I
A
R
K
N
A
E
--
R
H
G
--
V
S
-
D
R
F
F
V
R
--
K
G
E
F
L
E
P
F
------
K
---
E
----
K
F
ASI
E
M
I
L
S
N
P
P
Y
V
--
K
S
S
A
------
L
F
-
E
P
P
E
A
L
F
G
G
E
D
G
L
D
F
Y
R
E
F
F
G
R
----
Y
D
T
S
-
G
K
--
I
V
L
M
E
I
G
E
D
-----
Q
-
V
E
E
L
K
K
--
I
V
------
S
-
D
T
V
F
L
K
D
S
A
G
K
Y
R
F
L
L
L
N
R
R
--
3
PsiBlast_PDB
77.25
33%
-93
- C1 -
4DZR
3
?
A:
[1-205]
------------------------------------------------------------------------------------
F
E
V
G
P
D
C
L
I
P
R
P
---
D
T
E
V
L
V
E
E
A
I
R
F
L
K
-
R
-------
M
P
-
S
G
T
-
R
V
I
D
V
G
T
G
S
G
C
I
A
V
S
I
A
L
A
C
-
P
-----
G
V
S
V
T
A
V
D
L
S
------------------------
W
A
----
A
A
D
G
I
E
W
L
I
E
R
A
E
R
G
---
R
----
P
W
---
H
A
I
V
S
N
P
P
Y
I
P
------------------------
D
G
L
Q
F
Y
R
R
M
A
A
L
P
-
P
Y
V
L
A
R
-
G
R
A
G
V
F
L
-
E
V
G
H
N
-----
Q
-
A
D
E
V
A
R
--
L
F
A
P
W
R
E
R
G
F
R
V
R
K
V
K
D
L
R
G
I
D
R
V
I
A
V
T
R
E
--
59
Fugue
57.07
18%
-43
- C1 -
1UFK
-
PRMA_THET8
A:
[1-254]
M
W
V
Y
R
L
K
G
T
L
E
A
L
D
P
I
L
P
-
G
L
F
D
G
G
A
R
G
L
W
E
R
E
G
E
V
W
A
F
F
P
A
P
V
D
L
P
Y
E
G
V
W
E
E
V
G
D
E
D
W
L
E
A
W
R
R
D
L
K
P
A
L
A
P
P
F
V
V
L
A
P
W
H
T
W
E
G
A
E
I
P
L
V
I
E
P
GHH
E
T
T
R
L
A
L
K
A
L
A
--
R
-
H
-------
L
R
-
P
G
D
-
K
V
L
D
L
G
T
G
S
G
V
L
A
I
A
A
E
K
---
L
-----
G
G
K
A
L
G
V
D
I
D
P
M
V
L
P
Q
A
E
A
N
A
K
--
R
N
G
--
V
R
-
P
R
F
L
----
E
G
S
L
E
A
A
L
------
P
F--
G
----
P
F
---
D
L
L
V
A
N
L
Y
-----------------------------
A
E
L
H
A
A
L
A
P
R
Y
R
E
A
L
V
P
G
-
G
R
--
A
L
L
-
T
-
G
I
L
-------
K
D
R
A
P
L
--
V
R
E
A
M
A
G
A
G
-
F
R
P
L
E
E
A
A
E
G
E
W
V
L
L
A
Y
G
R
---
74
HHSearch
56.21
25%
-48
- C1 -
2NXC
-
PRMA_THET8
A:
[108-236]
-----------------------------------------------------------------------------------------------------
R
L
A
L
K
A
L
A
R
--
H
-
L
-------
R
--
P
G
D
-
K
V
L
D
L
G
T
G
S
G
V
L
A
I
A
A
E
K
L
--------
G
G
K
A
L
G
V
D
I
D
P
M
V
L
P
Q
A
E
A
N
A
K
--
R
N
G
--
V
R
-
P
R
F
L
----
E
G
S
L
E
A
A
L
------
P
F--
G
----
P
F
---
D
L
L
V
A
N
L
Y
A
E
--------------
L
---------------
H
A
A
L
A
P
R
Y
R
E
A
L
V
P
G
-
G
R
--
A
L
L
-
T
G
I
L
K
D----
R
-
A
P
L
V
R
E
--
A
M
A
G
A
G
F
R
P
-
L
E
E
A
A
E
G
E
W
V
L
L
A
Y
G
R
------
53
Fugue
54.71
17%
-38
- C1 -
2H00
2
MET16_HUMAN
A:
[5-254]
-----------------------------------------
V
S
L
N
F
K
D
P
E
A
V
R
A
L
T
C
T
L
L
R
E
D
F
-----------------
G
L
S
I
D
I
P
L
E
R
L
I
P
T
V
---
P
L
R
L
N
Y
I
H
W
V
E
--
D
-
L
I
G
H
Q
D
SD
K
S
-
T
L
R
-
R
G
I
D
I
G
T
G
A
S
C
I
Y
P
L
L
G
A
T
L
-
N
-----
G
W
Y
F
L
A
T
E
V
D
D
M
C
F
N
Y
A
K
K
N
V
E
Q
N
N
L
S
--
D
L
-
I
K
V
V
K
V
P
Q
K
T
L
L
M
D
A
L
------
K
---
E
ESEI
I
Y
---
D
F
C
M
C
N
P
P
F
F
G
I
T
E
----------------
I
M
A
E
G
G
E
L
E
F
V
K
R
I
I
H
D
S
L
Q
L
K
K
R
L
-
R
W
--
Y
S
C
-
M
L
G
K
K
-----
C
S
L
A
P
L
K
E
--
E
L
R
I
Q
G
V
P
K
-
V
T
Y
T
E
F
C
Q
G
R
T
M
R
W
A
L
A
W
S
F
YD
76
HHSearch
53.63
19%
-61
- C1 -
2F8L
6
?
A:
[130-276]
-----------------------------------------------------------------------------------------------------------------------------
K
N
V
-
S
I
L
D
P
A
C
G
T
A
N
L
L
T
T
V
I
N
Q
L
-
E
LKGDV
D
V
H
A
S
G
V
D
V
D
D
L
L
I
S
L
A
L
V
G
A
D
--
L
Q
R
--
Q
K
-
M
T
L
L
----
H
Q
D
G
L
A
N
L
------
L
V--
D
----
P
V
---
D
V
V
I
S
D
L
P
V
G
Y
Y
P
D
D
E
N
A
K
----
T
F
E
L
C
----
R
E
E
G
H
S
F
A
H
F
L
F
I
E
Q
G
M
R
Y
T
K
P
G
-
G
Y
--
L
F
F
-
L
V
P
D
A
MFGT
S
D
-
F
A
K
V
D
K
--
F
I
K
K
N
G
H
I
E
-
G
I
I
K
L
P
E
T
L
F
K
S
Q
A
R
K
S
I
L
I
--
72
HHSearch
53.30
25%
-56
- C1 -
3TMA
-
?
A:
[186-320]
-----------------------------------------------------------------------------------------------
S
---
L
T
P
V
L
A
Q
A
L
L
R
--
L
-
A
-------
D
A
R
P
G
M
-
R
V
L
D
P
F
T
G
S
G
T
I
A
L
E
A
A
S
T
L
G
P
-----
T
S
P
V
Y
A
G
D
L
D
E
K
R
L
G
L
A
R
E
A
A
L
--
A
S
G
L-
S
W
-
I
R
F
L
----
R
A
D
A
R
H
L
P
------
R
FF-
P
----
E
V
---
D
R
I
L
A
N
P
P
H
G
L
-------------
K
---------
E
G
L
F
H
L
Y
W
D
F
L
R
G
A
L
A
L
L
P
P
G
-
G
R
--
V
A
L
-
L
T
L
R
P
-----
A
-
L
L
K
R
A
L
--
P
P
G
F
A
L
R
H
A
-
R
V
V
E
Q
G
G
V
Y
P
R
V
F
V
L
E
K
L
----
73
HHSearch
52.96
22%
-63
- C1 -
3TM4
1
?
A:
[205-344]
------------------------------------------------------------------------------------------------------
S
I
A
N
A
M
I
E
--
L
-
A
-------
E
L
-
D
G
G
-
S
V
L
D
P
M
C
G
S
G
T
I
L
I
E
L
A
L
R
R
-
Y
-----
S
G
E
I
I
G
I
E
K
Y
R
K
H
L
I
G
A
E
M
N
A
L
--
A
A
G
VL
D
K
-
I
K
F
I
----
Q
G
D
A
T
Q
L
S
------
Q
YV-
D
----
S
V
---
D
F
A
I
S
N
L
P
Y
G
------
S
-------
M
-----------
I
P
D
L
Y
M
K
F
F
N
E
L
A
K
V
L
E
K
R
-
G
V
--
F
I
T
-
T
E
----------
K
K
A
I
E
E
--
A
I
A
E
N
G
F
E
I
-
I
H
H
R
V
I
G
H
G
G
L
M
V
H
L
Y
V
V
K
L
--
65
HHSearch
52.77
22%
-44
- C1 -
3Q87
1
?
B:
[2-158]
-----------------------------------------------------------------------------------------
D
W
Y
E
P
G
E
---
D
T
Y
T
L
M
D
A
L
E
R
--
E
-
G
-------
L
--
E
M
K
-
I
V
L
D
L
G
T
S
T
G
V
I
T
E
Q
L
R
K
R
---------
N
T
V
V
S
T
D
L
N
I
R
A
L
E
S
H
R
G
-------------
G
N
L
V
----
R
A
D
L
L
C
S
I
------
N
Q--
E
----
S
V
---
D
V
V
V
F
N
P
P
Y
V
P
D
T
D
D
P
-----
I
I
G
G
G
------------
Y
L
G
R
E
V
I
D
R
F
V
D
A
V
T
V
G
-
M
L
--
Y
L
L
-
V
I
E
A
N
-----
R
-
P
K
E
V
L
A
--
R
L
E
E
R
G
Y
G
T
-
R
I
L
K
V
R
K
I
L
G
E
T
V
Y
I
I
K
G
E
K
--