@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs2084: (2015-12-13 )
MAKIVVALGGNALGNSPEEQLRLVKHTAKSLVALIKKGHEIVVSHGNGPQVGAINLGMNFAAESGQGTNFPFPECGAMSQGYIGYHLQQSLLNELRQEGINKEVATIITQIEVDESDQAFSAPTKPIGTFYDKETSEKIAIEKGYTFVEDAGRGYRRVVASPEPKKIIEINSIKTLIENDTLVIAGGGGGIPVINKGGYEGIAAVIDKDKSSALLAGELAADQLIILTAVDYVYTQFGKENQKALTEVNENQMIDYVNQGEFAKGSMLPKVIACMSFLDHNPKGTALITSLNGLEDALDGKLGTRITK
Atome Classification :
(37 SA)
.........10.-...-----...-----.-----20........30........40........50........60-..-.....----.70........80........90........100.......110.......120.......130...-------....----------.140...---....150.......160.......---170.......180.......190..-.---..-.--.-200.......210.......220.......230--.......240.......250.......260.......270.......280.......290-....-...300.......-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
K
I
V
V
A
LGGNA-LGN-----
S
P
E
-----
E
-----
Q
L
R
L
V
K
H
T
A
K
S
L
V
A
L
I
KKG
H
E
I
V
V
SHGNGP
Q
V
G
A
I
N
LG
M
N
F
A-AE-SGQGT----NFPFPECGAMSQ
G
Y
I
G
Y
H
L
Q
Q
S
L
L
N
E
L
R
QEGI
N
K
E
V
A
T
I
I
T
Q
I
E
VDESDQAFSAPTKPI
G
T
FY-DKE-------TS
E
K
----------
I
A
IEKGY---
T
F
V
E
DAGR
G
Y
R
RVVASPEP
K
K
I
I
E
---I
N
S
I
K
T
L
IEND
T
L
V
I
AGGGGGI
P
V
I-N---KG-G--Y-
E
G
I
A
A
V
IDKDKSSA
L
L
A
GELAA
D
Q
L
I
I
L
T
A
V
D
Y
--
V
Y
T
QFGKE
N
Q
K
A
L
T
EVNE
N
Q
M
I
DYVNQGEFAKG
S
M
L
P
K
V
I
A
C
M
S
F
LDHNPKG
T
A
L
I
T
SLN-G
L
E
D
-
A
LDGK-LGTRITK-
1
PsiBlast_PDB
89.88
46%
-93
- C6 -
1E19
1
CPKA_PYRFU
A:
[4-312]
--
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
RGQKG
S
Y
E
-----
E
-----
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
------
A
G
Q
A
T
YG
I
P
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
-
D
E
E
-------
T
A
K
R
----------
L
A
R
E
K
G
W
---
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
V
I
L
E
---
D
G
-
E
--
I
-
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
--
A
A
L
Y
Y
G
T
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
G
E
-
R
A
I
I
A
H
L
E
-
K
A
V
E
-
A
L
E
G
K
-
T
G
T
Q
V
L
P
-
19
PsiBlast_CBE
89.85
46%
-93
- C6 -
1E19
1
CPKA_PYRFU
B:
[4-312]
--
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
RGQKG
S
Y
E
-----
E
-----
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
------
A
G
Q
A
T
YGIP
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
-
D
E
E
-------
T
A
K
R
----------
L
A
R
E
K
G
W
---
I
V
K
E
D
S
G
R
G
W
R
R
V
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
V
I
L
E
---
D
G
-
E
--
I
-
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
--
A
A
L
Y
Y
G
T
E
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
G
E
-
R
A
I
I
A
H
L
E
-
K
A
V
E
-
A
L
E
G
K
-
T
G
T
Q
V
L
P
-
4
PsiBlast_PDB
89.72
48%
-85
- C6 -
2WE5
2
ARCC1_ENTFA
A:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
21
PsiBlast_CBE
88.64
48%
-87
- C6 -
2WE5
1
ARCC1_ENTFA
B:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
20
PsiBlast_CBE
88.49
48%
-85
- C6 -
2WE5
1
ARCC1_ENTFA
C:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
23
PsiBlast_CBE
88.31
48%
-83
- C6 -
2WE4
3
ARCC1_ENTFA
C:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
24
PsiBlast_CBE
88.16
48%
-83
- C6 -
2WE4
5
ARCC1_ENTFA
B:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
3
PsiBlast_PDB
87.72
48%
-80
- C6 -
2WE4
4
ARCC1_ENTFA
A:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
22
PsiBlast_CBE
87.50
48%
-81
- C6 -
2WE4
4
ARCC1_ENTFA
D:
[4-310]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
T
K
-
9
PsiBlast_PDB
86.18
38%
-87
- C6 -
2E9Y
-
?
A:
[8-311]
----
V
I
A
L
G
G
N
A
-
I
A
G
PGMDV
S
V
E
-----
S
-----
Q
T
A
A
V
K
R
A
S
S
I
I
A
D
V
L
A
D
G
W
R
S
V
I
T
H
G
N
G
P
Q
V
G
--
Y
L
S
E
A
F
E
-
A
L
-
P
P
E
R
P
----
R
Q
P
L
Y
I
A
T
A
M
T
Q
A
W
I
G
L
L
L
K
H
S
L
E
E
E
L
R
R
R
G
L
N
V
L
V
P
V
V
I
S
R
V
L
V
D
V
S
D
P
S
F
N
N
P
S
K
P
V
G
P
I
Y
-
G
R
E
-------
E
A
E
E
----------
L
S
R
R
Y
G
W
---
V
F
K
R
D
P
R
G
G
F
R
R
V
V
P
S
P
R
P
V
S
I
V
D
---
R
D
L
I
A
E
A
S
A
E
S
P
A
V
V
A
L
G
G
G
G
V
P
V
V
-
E
---
R
P
-
G
G
V
L
-
E
P
V
E
A
V
V
D
K
D
L
A
S
S
L
L
A
T
Q
L
N
A
D
L
L
V
I
L
T
D
V
P
G
--
V
A
V
N
Y
G
R
E
G
E
R
W
L
R
R
A
A
A
S
E
L
K
K
Y
L
R
E
G
H
F
P
P
G
S
M
G
P
K
V
E
A
A
I
S
F
V
E
R
T
G
K
-
P
A
V
I
G
S
L
E
-
E
A
R
Q
-
V
L
S
L
Q
-
A
G
T
V
V
M
L
-
46
Fugue
85.86
46%
-80
- C6 -
1B7B
1
ARCC1_ENTFC
A:
[2-308]
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
NDA--
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
--
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
-
T
E
A
-------
E
A
K
E
----------
A
M
-
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
-
L
----
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
-
M
S
G
D
E
-
I
V
G
T
V
V
--
27
PsiBlast_CBE
85.77
48%
-77
- C6 -
1B7B
1
ARCC1_ENTFC
B:
[4-308]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
---
26
PsiBlast_CBE
85.75
48%
-79
- C6 -
1B7B
1
ARCC1_ENTFC
C:
[4-308]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
---
25
PsiBlast_CBE
85.53
48%
-78
- C6 -
1B7B
1
ARCC1_ENTFC
D:
[4-308]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
---
55
HHSearch
85.34
44%
-89
- C6 -
1E19
1
CPKA_PYRFU
A:
[2-314]
G
K
R
V
V
I
A
L
G
G
N
A
-
L
Q
Q
-----
R
G
Q
KGS
Y
E
E
-----
M
M
D
N
V
R
K
T
A
R
Q
I
A
E
I
I
A
R
G
Y
E
V
V
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
A
G
-
Q
A
-
T
Y
G
I
P
----
A
Q
P
M
D
V
A
G
A
M
S
Q
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
P
A
F
Q
N
P
T
K
P
V
G
P
F
Y
-
D
E
E
-------
T
A
K
R
L
A
R
E
KG
W
I
V
K
E
D
S
G
R
G
W
---
R
R
V
----------
V
P
S
P
D
P
K
G
H
V
E
---
A
E
T
I
K
K
L
V
E
R
G
V
I
V
I
A
S
G
G
G
G
V
P
V
I
-
L
E
--
D
G
-
E
--
I
-
K
G
V
E
A
V
I
D
K
D
L
A
G
E
K
L
A
E
E
V
N
A
D
I
F
M
I
L
T
D
V
N
G
A
A
L
Y
Y
G
T
E
K
--
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
G
H
F
K
A
G
S
M
G
P
K
V
L
A
A
I
R
F
I
E
W
G
G
-
E
R
A
I
I
A
H
L
E
-
K
A
V
E
-
A
L
E
G
K
-
T
G
T
Q
V
L
P
-
45
Fugue
85.25
46%
-83
- C6 -
1B7B
1
ARCC1_ENTFC
A:
[2-308]
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
NDA--
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
-
D
S
-
E
K
-
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
-
T
E
A
-------
E
A
K
E
----------
A
M
Q
A
-
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
-----Q
E
--
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
---
M
S
G
-
D
E
I
V
G
T
V
V
2
PsiBlast_PDB
84.92
48%
-80
- C6 -
1B7B
1
ARCC1_ENTFC
A:
[4-308]
--
K
M
V
V
A
L
G
G
N
A
I
L
S
N
DA---
S
A
H
-----
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
-
A
-
A
D
-
S
E
K
N
P
----
A
M
P
L
D
T
C
V
A
M
T
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
--
T
E
-------
A
E
A
K
----------
E
A
M
Q
A
G
A
---
I
F
K
E
D
A
G
R
G
W
R
K
V
V
P
S
P
K
P
I
D
I
H
E
---
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
---
Q
E
----
L
-
K
G
V
E
A
V
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
N
K
Q
A
I
I
T
S
L
E
-
N
L
G
S
M
S
G
D
E
I
-
V
G
T
V
V
---
38
PsiBlast_CBE
84.73
42%
-92
- C6 -
4JZ7
1
?
C:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
37
PsiBlast_CBE
84.37
42%
-92
- C6 -
4JZ7
1
?
D:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
35
PsiBlast_CBE
84.09
42%
-88
- C6 -
4JZ8
1
?
C:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
33
PsiBlast_CBE
84.03
42%
-82
- C6 -
4JZ9
1
?
B:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
42
PsiBlast_CBE
84.00
42%
-90
- C6 -
3KZF
1
?
B:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
---------------------------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
--
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
32
PsiBlast_CBE
83.88
42%
-89
- C6 -
4JZ9
1
?
C:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
8
PsiBlast_PDB
83.88
42%
-88
- C6 -
4OLC
2
?
A:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
7
PsiBlast_PDB
83.76
42%
-86
- C6 -
4JZ9
1
?
A:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
41
PsiBlast_CBE
83.56
42%
-91
- C6 -
3KZF
1
?
C:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDY
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
--------------------------------------------
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
----
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
28
PsiBlast_CBE
83.55
42%
-90
- C6 -
4OLC
1
?
D:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
40
PsiBlast_CBE
83.45
42%
-90
- C6 -
3KZF
1
?
D:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
---------------------------------
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
-------
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
--
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
30
PsiBlast_CBE
83.20
42%
-86
- C6 -
4OLC
2
?
B:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
31
PsiBlast_CBE
83.09
42%
-85
- C6 -
4JZ9
1
?
D:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
5
PsiBlast_PDB
83.05
42%
-98
- C6 -
4JZ7
1
?
A:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
---------------------------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
29
PsiBlast_CBE
83.04
42%
-89
- C6 -
4OLC
2
?
C:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
-------
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
6
PsiBlast_PDB
83.02
42%
-87
- C6 -
4JZ8
1
?
A:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
36
PsiBlast_CBE
82.98
42%
-88
- C6 -
4JZ8
1
?
B:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
39
PsiBlast_CBE
82.52
42%
-91
- C6 -
4JZ7
1
?
B:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GD
Y
D
T
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
---------------------------------------------------
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
Y
K
K
P
D
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
34
PsiBlast_CBE
82.45
42%
-85
- C6 -
4JZ8
1
?
D:
[8-316]
---
V
V
I
A
L
G
G
N
A
-
M
L
Q
-----
A
K
E
-----
K
GDYDT
Q
R
K
N
V
E
I
A
A
S
E
I
Y
K
I
H
K
A
G
Y
K
V
V
L
T
S
G
N
G
P
Q
V
G
A
I
K
L
Q
N
Q
A
A
-
A
---
G
V
S
P
----
E
M
P
L
H
V
C
G
A
M
S
Q
G
F
I
G
Y
M
M
S
Q
A
M
D
N
V
F
C
A
N
N
E
P
A
N
C
V
T
C
V
T
Q
T
L
V
D
P
K
D
Q
A
F
T
N
P
T
K
P
V
G
R
F
Y
T
E
Q
E
-------
A
K
D
L
----------
M
A
A
N
P
G
K
---
I
L
R
E
D
A
G
R
G
W
R
V
V
V
P
S
P
R
P
L
E
I
V
E
---
Y
G
V
I
K
T
L
I
D
N
N
V
L
V
I
C
T
N
G
G
G
I
P
C
K
-
R
---
E
N
-
K
--
V
I
S
G
V
D
A
V
I
D
K
D
L
A
T
S
L
L
A
K
T
L
N
S
D
Y
L
M
I
L
T
D
V
L
N
--
A
C
I
N
-----
E
R
K
L
E
E
I
K
L
S
E
I
L
A
L
E
K
D
G
H
F
A
A
G
S
M
G
P
K
V
R
A
A
I
E
F
T
Q
A
T
G
K
-
M
S
I
I
T
S
L
S
-
T
A
V
D
-
A
L
N
G
K
-
C
G
T
R
I
I
K
-
54
HHSearch
78.55
43%
-78
- C6 -
2WE5
2
ARCC1_ENTFA
A:
[2-310]
G
K
K
M
V
V
A
L
G
G
N
A
-
I
L
S
-----
N
D
A
S
A
H
--
A
-----
Q
Q
Q
A
L
V
Q
T
S
A
Y
L
V
H
L
I
K
Q
G
H
R
L
I
V
S
H
G
N
G
P
Q
V
G
N
L
L
L
Q
Q
Q
A
A
D
S
E
K
N
P
A
M
P
----
L
D
--
T
C
V
A
M
T
-
Q
G
S
I
G
Y
W
L
S
N
A
L
N
Q
E
L
N
K
A
G
I
K
K
Q
V
A
T
V
L
T
Q
V
V
V
D
P
A
D
E
A
F
K
N
P
T
K
P
I
G
P
F
L
-
T
E
A
E
A
K
E
A
M
Q
A
G
A
I
F
K
--------
E
D
A
G
R
G
W
R
K
V
V
P
S
----------------
P
K
P
I
D
IHE
A
E
T
I
N
T
L
I
K
N
D
I
I
T
I
S
C
G
G
G
G
I
P
V
V
-
G
QEL
K
G
-
V
--
E
-
A
V
----
I
D
K
D
F
A
S
E
K
L
A
E
L
V
D
A
D
A
L
V
I
L
T
G
V
D
Y
--
V
C
I
N
Y
G
K
P
D
E
K
Q
L
T
N
V
T
V
A
E
L
E
E
Y
K
Q
A
G
H
F
A
P
G
S
M
L
P
K
I
E
A
A
I
Q
F
V
E
S
Q
P
-
N
K
Q
A
I
I
T
S
L
E
N
L
G
S
-
M
S
G
D
E
I
V
G
T
V
V
T
K
-