@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01770: (2016-06-03 )
MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVLIGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHNPVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYLQFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGSTHPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLKDDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLDYNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKAVISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE
Atome Classification :
(20 SA)
.........10.-...-....20.......-.30......-.-.40.-.......50........60........70........80........90........100.......110.......120.-......130-----......-.140..--.....150.........160......-.---170...---....180.......190.......200.......210.......--220--..----..---..---..230-.......240.......250.......260......-.270.......280.......290.......300.......310.......320.......330..-.-....340.......350.......360.......370..----......-380----.--...--...390----------.....---..400-.-.....---------------..410.......420.......430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGKYFGTDGVRG-VAN-SEL
T
P
E
L
A
F
K
VGR-FG
G
Y
V
L
TKD-K-QRP
K
-
V
L
I
GRDTRIS
G
H
M
L
E
G
A
L
V
A
G
L
L
S
I
G
A
E
V
M
R
LGVISTP
G
V
S
Y
L
T
K
A
MDAEA
G
V
M
I
SASHNPVQDN
G
I
K
F
FGGDGFKLS
D
E
Q
-
E
A
E
I
E
R
L
MD-----EPEDKL-PRPVGA--DL
G
L
V
N
--
D
Y
F
E
G
G
Q
K
Y
L
Q
F
L
K
Q
TAD-E---DF
T
G
I
H
---
V
A
L
DCANG
A
T
S
S
L
A
T
H
L
F
A
DLDA
D
V
S
TMGTSPNGLNINDGVGST--
H
P
---
E
A
----
L
S
---
A
F
---
V
K
EKN-AD
L
G
L
A
FDGDG
D
R
L
I
A
VDEKGNIVDG
D
Q
I
M
Y
I
C
S
K
H
-
L
KSEGRLK
D
D
T
V
V
S
T
V
M
S
NL
G
F
Y
K
A
L
E
K
E
G
I
K
S
V
Q
T
AVG
D
R
Y
V
V
E
A
M
K
KDGYNVGGEQS
G
H
L
I
F
L
D-Y-NTT
G
D
G
L
L
S
A
I
M
L
M
N
T
L
K
ATGK
P
L
S
E
L
A
A
E
M
Q
K
F
P
-
Q
L
L
----
V
N
V
R
VT-
D
K
Y
----K--VEE--
N
E
K
V
K
A
----------
V
I
S
E
V
---
E
K
E
M--N-GD
G
R
I
---------------
L
V
RPSGT
E
P
L
V
R
V
M
A
EA
K
T
K
E
L
C
D
E
Y
V
N
R
I
V
E
V
V
R
S
E
MGLE
1
PsiBlast_PDB
97.95
79%
-88
- C3 -
3PDK
3
GLMM_BACAN
A:
[23-467]
-
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
N
-
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
-
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
-
E
A
E
I
E
A
L
L
D
-----
K
E
V
D
E
L
-
P
R
P
T
G
T
--
N
L
G
Q
V
S
--
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
---
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
S
T
--
H
P
---
E
V
----
L
A
---
E
L
---
V
K
E
K
G
-
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
-
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
K
K
----
L
--
A
L
E
--
N
E
K
I
K
E
----------
I
I
R
V
V
---
E
E
E
M
--
N
-
G
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
--
35
HHSearch
97.85
79%
-89
- C3 -
3PDK
3
GLMM_BACAN
A:
[23-467]
-
G
K
Y
F
G
T
D
G
V
R
G
-
V
A
N
-
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
-
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
-
E
A
E
I
E
A
L
L
D
-----
K
E
V
D
E
L
-
P
R
P
T
G
T
--
N
L
G
Q
V
S
--
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
---
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
S
T
--
H
P
---
E
V
----
L
A
---
E
L
---
V
K
-
E
K
G
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
-
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
K
K
----
L
--
A
L
E
--
N
E
K
I
K
E
----------
I
I
R
V
V
---
E
E
E
M
--
N
-
G
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
--
21
PsiBlast_CBE
97.40
79%
-89
- C3 -
3PDK
5
GLMM_BACAN
B:
[24-467]
--
K
Y
F
G
T
D
G
V
R
G
-
V
A
N
-
K
E
L
T
P
E
L
A
F
K
I
G
R
-
F
G
G
Y
V
L
T
K
D
-
T
-
D
R
P
K
-
V
I
I
G
R
D
T
R
I
S
G
H
M
L
E
G
A
L
V
A
G
L
L
S
T
G
A
E
V
M
R
L
G
V
I
S
T
P
G
V
A
Y
L
T
K
A
L
D
A
Q
A
G
V
M
I
S
A
S
H
N
P
V
Q
D
N
G
I
K
F
F
G
S
D
G
F
K
L
T
D
E
Q
-
E
A
E
I
E
A
L
L
D
-----
K
E
V
D
E
L
-
P
R
P
T
G
T
--
N
L
G
Q
V
S
--
D
Y
F
E
G
G
Q
K
Y
L
Q
Y
I
K
Q
T
V
E
-
E
---
D
F
S
G
L
H
---
I
A
L
D
C
A
H
G
A
T
S
S
L
A
P
Y
L
F
A
D
L
E
A
D
I
S
T
M
G
T
S
P
N
G
M
N
I
N
D
G
V
G
S
T
--
H
P
---
E
V
----
L
A
---
E
L
---
V
K
E
K
G
-
A
D
I
G
L
A
F
D
G
D
G
D
R
L
I
A
V
D
E
K
G
N
I
V
D
G
D
Q
I
M
F
I
C
A
K
Y
-
M
K
E
T
G
Q
L
K
H
N
T
V
V
S
T
V
M
S
N
L
G
F
Y
K
A
L
E
A
N
G
I
T
S
D
K
T
A
V
G
D
R
Y
V
M
E
E
M
K
R
G
G
Y
N
L
G
G
E
Q
S
G
H
I
I
L
L
D
-
Y
-
I
T
T
G
D
G
M
L
S
A
L
Q
L
V
N
I
M
K
M
T
K
K
P
L
S
E
L
A
G
E
M
T
K
F
P
-
Q
L
L
----
V
N
V
R
V
T
-
D
K
K
----
L
--
A
L
E
--
N
E
K
I
K
E
----------
I
I
R
V
V
---
E
E
E
M
--
N
-
G
D
G
R
I
---------------
L
V
R
P
S
G
T
E
P
L
I
R
V
M
A
E
A
P
T
Q
E
V
C
D
A
Y
V
H
R
I
V
E
V
V
K
A
E
V
G
--
2
PsiBlast_PDB
80.22
39%
-75
- C3 -
3I3W
1
GLMM_FRATT
A:
[3-442]
--
K
Y
F
G
T
D
G
I
R
G
E
V
A
N
-
S
T
I
T
V
E
F
T
Q
K
L
G
N
-
A
V
G
S
L
I
N
Q
--
K
-
N
Y
P
K
F
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
-
E
E
E
V
E
D
M
I
D
GDFIY
Q
P
Q
F
K
F
G
S
Y
K
I
L
A
--
N
A
--
I
D
--
E
Y
I
E
--
S
I
Y
S
R
F
A
K
F
V
-------
N
Y
K
G
-
K
---
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
N
I
N
V
G
C
G
A
T
--
C
V
---
S
N
----
I
K
---
K
A
---
V
K
E
Q
K
-
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
Q
Y
-
S
D
I
C
G
--
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
-
G
T
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
K
L
Q
G
E
L
M
Q
-
Q
T
L
----
I
N
V
P
L
T
-
K
K
V
----
A
--
R
E
D
--
L
Q
K
V
A
S
----------
D
V
N
D
V
---
E
K
R
L
--
G
-
N
R
G
R
V
---------------
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
---
37
HHSearch
77.85
38%
-75
- C3 -
3I3W
1
GLMM_FRATT
A:
[3-442]
--
K
Y
F
G
T
D
G
I
R
G
-
E
V
A
N
S
T
I
T
V
E
F
T
Q
K
L
G
N
-
A
V
G
S
L
I
N
Q
K
-
N
-
Y
P
K
F
-
V
I
V
G
Q
D
T
R
S
S
G
G
F
L
K
F
A
L
V
S
G
L
N
A
A
G
I
D
V
L
D
L
G
V
V
P
T
P
V
V
A
F
M
T
V
K
H
R
A
A
A
G
F
V
I
T
A
S
H
N
K
F
T
D
N
G
I
K
L
F
S
S
N
G
F
K
L
D
D
A
L
-
E
E
E
V
E
D
M
I
D
-----
G
D
---
F
-
I
Y
Q
P
Q
F
--
K
F
G
S
Y
K
--
I
L
A
N
A
I
D
E
Y
I
E
S
I
Y
S
R
F
A
K
F
---
V
N
Y
K
G
K
---
V
V
V
D
C
A
H
G
A
A
S
H
N
F
E
A
L
L
D
K
F
G
I
N
Y
V
S
I
A
S
N
P
D
G
L
N
I
N
V
G
C
G
A
T
--
C
V
---
S
N
----
I
K
---
K
A
---
V
K
-
E
Q
K
A
D
L
G
I
S
L
D
G
D
A
D
R
I
I
I
V
D
E
N
G
Q
E
I
D
G
D
G
I
L
N
I
L
A
Q
Y
-
S
D
I
C
G
--
G
T
N
G
I
V
G
T
Q
M
T
N
M
S
Y
E
N
H
Y
R
A
N
K
I
P
F
I
R
S
K
V
G
D
R
Y
V
L
E
D
L
V
K
Y
G
Y
K
I
G
G
E
S
S
G
H
V
I
N
L
N
-
F
-
G
T
T
G
D
G
L
F
T
A
I
Q
L
L
A
I
F
S
Q
A
D
K
P
V
S
E
F
K
L
Q
G
E
L
M
Q
---
Q
----
T
L
I
N
V
P
-
L
T
K
----
K
--
V
A
R
E
D
L
Q
K
V
A
S
----------
D
V
N
D
V
---
E
--
K
R
L
G
-
N
R
G
R
V
---------------
L
L
R
P
S
G
T
E
P
V
L
R
V
M
V
E
A
D
D
K
S
L
A
T
N
E
A
E
Y
L
V
E
K
V
K
Q
K
L
---
36
HHSearch
74.93
34%
-65
- C3 -
1WQA
1
?
A:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
N
-
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
-
G
R
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
V
E
E
L
F
F
-----
K
E
D
--
F
-
D
R
A
K
W
Y
--
E
I
G
E
V
R
--
R
E
-
D
I
I
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
E
A
I
K
K
R
K
P
F
---
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
F
P
A
R
N
P
E
P
N
EE
N
L
---
K
E
----
F
M
---
E
I
---
V
K
-
A
L
G
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
-
V
L
K
E
K
--
G
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
-
G
D
R
----
H
A
-
I
V
N
K
V
A
E
M
A
R
E
R
G
Y
T
V
D
----
T
T
D
G
A
---
K
--
I
I
-
F
-
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
---
24
PsiBlast_CBE
73.20
34%
-64
- C3 -
1WQA
1
?
B:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
N
-
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
-
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
V
E
E
L
F
F
-------
K
E
D
F
-
D
R
A
K
W
Y
--
E
I
G
E
V
R
RE
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
I
K
K
R
KPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
A
R
--
N
P
---
E
P
NEEN
L
K
---
E
F
MEI
V
K
A
L
G
-
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
---
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
G
D
R
H
AIVN
K
--
V
A
E
--
M
A
R
E
R
G
----------
Y
T
V
D
T
TDG
A
K
I
I
--
F
-
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
---
23
PsiBlast_CBE
73.12
34%
-63
- C3 -
1WQA
1
?
C:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
N
-
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
-
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
V
E
E
L
F
F
-------
K
E
D
F
-
D
R
A
K
W
Y
--
E
I
G
E
V
R
RE
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
I
K
K
R
KPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
A
R
--
N
P
---
E
P
NEEN
L
K
---
E
F
MEI
V
K
A
L
G
-
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
---
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
G
D
R
H
AIVN
K
--
V
A
E
--
M
A
R
E
R
G
----------
Y
T
V
D
T
TDG
A
K
I
I
--
F
-
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
---
22
PsiBlast_CBE
72.89
34%
-63
- C3 -
1WQA
1
?
D:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
N
-
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
-
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
V
E
E
L
F
F
-------
K
E
D
F
-
D
R
A
K
W
Y
--
E
I
G
E
V
R
RE
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
I
K
K
R
KPF
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
A
R
--
N
P
---
E
P
NEEN
L
K
---
E
F
MEI
V
K
A
L
G
-
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
---
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
G
D
R
H
AIVN
K
--
V
A
E
--
M
A
R
E
R
G
----------
Y
T
V
D
T
TDG
A
K
I
I
--
F
-
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
---
6
PsiBlast_PDB
72.81
28%
-71
- C3 -
1K2Y
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
A
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
3
PsiBlast_PDB
72.70
34%
-63
- C3 -
1WQA
1
?
A:
[1-454]
M
G
K
L
F
G
T
F
G
V
R
G
-
I
A
N
-
E
K
I
T
P
E
F
A
M
K
I
G
M
-
A
F
G
T
L
L
K
R
E
G
R
-
K
K
P
L
-
V
V
V
G
R
D
T
R
V
S
G
E
M
L
K
E
A
L
I
S
G
L
L
S
V
G
C
D
V
I
D
V
G
I
A
P
T
P
A
V
Q
W
A
T
K
H
F
N
A
D
G
G
A
V
I
T
A
S
H
N
P
P
E
Y
N
G
I
K
L
L
E
P
N
G
M
G
L
K
K
E
R
-
E
A
I
V
E
E
L
F
F
-------
K
E
D
F
-
D
R
A
K
W
Y
--
E
I
G
E
V
R
R
E
D
I
I
---
K
P
Y
I
E
A
I
K
S
K
V
D
-
V
---
E
A
I
K
K
R
K
P
F
V
V
V
D
T
S
N
G
A
G
S
L
T
L
P
Y
L
L
R
E
L
G
C
K
V
I
T
V
N
A
Q
P
D
G
Y
-----
F
P
A
R
--
N
P
---
E
P
NEEN
L
K
---
E
F
M
E
I
V
K
A
L
G
-
A
D
F
G
V
A
Q
D
G
D
A
D
R
A
V
F
I
D
E
N
G
R
F
I
Q
G
D
K
T
F
A
L
V
A
D
A
V
L
K
E
K
G
---
G
G
L
L
V
T
T
V
A
T
S
N
L
L
D
D
I
A
K
K
H
G
A
K
V
M
R
T
K
V
G
D
L
I
V
A
R
A
L
Y
E
N
N
G
T
I
G
G
E
E
N
G
G
V
I
F
P
E
-
H
-
V
L
G
R
D
G
A
M
T
V
A
K
V
V
E
I
F
A
K
S
G
K
K
F
S
E
L
I
D
E
L
P
K
Y
Y
-
Q
I
K
----
T
K
R
H
V
E
G
D
R
H
A
I
V
N
K
--
V
A
E
--
M
A
R
E
R
G
----------
Y
T
V
D
T
TD
G
A
K
I
I
--
F
-
E
D
G
W
V
---------------
L
V
R
A
S
G
T
E
P
I
I
R
I
F
S
E
A
K
S
K
E
K
A
Q
E
Y
L
N
L
G
I
E
L
L
E
K
A
L
---
14
PsiBlast_PDB
72.45
28%
-70
- C3 -
2H5A
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
5
PsiBlast_PDB
72.09
28%
-70
- C3 -
4MRQ
13
ALGC_PSEAE
A:
[11-444]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
--------
E
K
N
D
L
-
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
D
L
I
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STP
E
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLD
G
V
R
V
D
Y
PK
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
12
PsiBlast_PDB
72.05
28%
-71
- C3 -
1PCM
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
17
PsiBlast_PDB
71.79
28%
-69
- C3 -
4IL8
3
ALGC_PSEAE
A:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
D
L
I
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
A
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
S
T
P
E
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTL
D
G
V
R
V
D
YP
K
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
11
PsiBlast_PDB
71.79
28%
-70
- C3 -
1PCJ
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
10
PsiBlast_PDB
71.71
28%
-71
- C3 -
1P5G
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
13
PsiBlast_PDB
71.60
28%
-69
- C3 -
2H4L
2
ALGC_PSEAE
X:
[19-452]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
VE
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
DLI
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
STPE
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTLDGVRVDYPKGWG
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
7
PsiBlast_PDB
71.60
28%
-71
- C3 -
2FKF
2
ALGC_PSEAE
A:
[18-451]
---------
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
A
I
G
S
E
S
L
A
R
G
-
E
---
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
I
Q
A
L
R
E
R
I
E
--------
K
N
D
L
-
A
S
G
V
G
S
V
E
Q
V
D
I
L
P
--
R
Y
F
K
Q
I
R
D
D
I
A
M
A
K
P
------------
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
---
E
N
----
L
K
D
L
I
A
K
---
V
K
A
E
N
-
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
P
G
A
D
--
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
R
W
-
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
---
F
S
A
F
P
-
S
D
I
ST
P
E
I
N
I
T
V
T
-
E
D
S
----
K
--
F
---------
A
----------
I
I
E
A
L
---
Q
R
D
A
--
Q
W
G
E
G
N
I
TTL
D
G
V
R
V
D
YPK
G
W
G
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
----
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
---
40
HHSearch
71.45
28%
-65
- C3 -
1P5D
2
ALGC_PSEAE
X:
[10-456]
P
A
S
I
F
R
A
Y
D
I
R
G
-
V
V
G
-
D
T
L
T
A
E
T
A
Y
W
I
G
R
-
A
I
G
S
E
S
L
A
R
---
G
E
P
C
-
V
A
V
G
R
D
G
R
L
S
G
P
E
L
V
K
Q
L
I
Q
G
L
V
D
C
G
C
Q
V
S
D
V
G
M
V
P
T
P
V
L
Y
Y
A
A
N
V
L
E
G
K
S
G
V
M
L
T
G
S
H
N
P
P
D
Y
N
G
F
K
I
V
V
A
-
G
E
T
L
A
N
E
Q
-
I
Q
A
L
R
E
R
I
E
-----
K
N
D
--
L
-----
A
S
--
G
V
G
S
V
E
--
Q
V
-
D
I
L
P
R
Y
F
K
Q
I
R
D
D
I
A
-----
M
A
K
P
M
K
---
V
V
V
D
C
G
N
G
V
A
G
V
I
A
P
Q
L
I
E
A
L
G
C
S
V
I
P
L
Y
C
E
V
D
G
N
F
P
N
H
H
P
D
P
G
--
K
P
ENL
K
D
----
L
I
---
A
K
---
V
K
-
A
E
N
A
D
L
G
L
A
F
D
G
D
G
D
R
V
G
V
V
T
N
T
G
T
I
I
Y
P
D
R
L
L
M
L
F
A
K
D
-
V
V
S
R
N
--
P
G
A
D
I
I
F
D
V
K
C
T
R
R
L
I
A
L
I
S
G
Y
G
G
R
P
V
M
W
K
T
G
H
S
L
I
K
K
K
M
K
E
T
G
A
L
L
A
G
E
M
S
G
H
V
F
F
K
E
-
R
W
F
G
F
D
D
G
I
Y
S
A
A
R
L
L
E
I
L
S
Q
D
Q
R
D
S
E
H
V
F
S
A
F
P
S
D
I
S
T
P
E
----
I
N
I
T
V
T
-
E
D
S
----
K
FA
I
I
E
----
A
L
Q
R
DAQWGEGNIT
T
L
D
G
V
---
R
--
V
D-
Y
-
P
K
G
W
G
---------------
L
V
R
A
S
N
T
T
P
V
L
V
L
R
F
E
A
D
T
E
E
E
L
E
R
I
K
T
V
F
R
N
Q
L
K
A
V
D
---