@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu10350: (2016-06-16 )
MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQVDEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGTMYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQRSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSGIADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVTPDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYEAKRRPDCQYAVAAIGSGGGIGLALLFEVLA
Atome Classification :
(26 SA)
...-----......10-....-.-...20........30....-....---40--.---..----......50--.--....---.---..60--.........70........80........90........100.......110.....---.----.120.---------------.-------------.------------.-----------------.--------..--------.----.130---.-------.......140.......150.......160.......170....--------..------.180-----.-------------.--------..-.....-190...-------------...-----..200--------.....--------..-..210.......220.......230.......240.......250.......260.......270.......280.......290.......300.---.--.....310.......320.......330......-.-340.......350.......360..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
A
-----
V
I
V
DA
K
R
T-IFGN-Q-NGLLKPFL
P
E
D
L
A
A
P
I
I
R
C
-
L
S
R
K
---
L
---
E
---
D
Q
----
V
D
E
V
I
LGN--A--TGRG---G---
N
L
A
---
R
L
S
A
L
QAGLPLSVPG
M
T
I
D
R
QCGS
G
L
E
A
V
R
Y
A
C
S
L
I
QAGA
G
T
M
Y
I
AGGSESSSQSP
F
---
S
----
E
R--A---------------R-------------F------------S-----------------P--------DA--------I----GDP----D-------MGI
A
A
E
Y
T
A
A
R
Y
S
I
S
R
S
M
Q
D
E
Y
A
L
L
S
H
Q
RSRNAHDE
G
F
Y
R
E
E
V
V
--------
A
L------GE-------L-------------E--------T
D
-
E
A
F
L
K-T-R
P
I
E
-------------
A
II-----PRA----------KP
V
F
D--------TS-SG
T
V
T
AANSSGIADG
A
A
A
L
L
V
M
EEEKAAAL
G
L
K
P
V
L
R
F
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G
S
A
V
SGIHPNFPPAA
P
V
V
A
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R
Q
L
L
H
THDVTPDDI
D
L
F
EINE
A
F
A
V
K
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C
V
C
S
Q
ELGI
P
---
F
--
S
K
I
N
VRG
G
A
L
A
LGHPYGAS
G
A
A
L
V
T
R
L
F
Y
E
A
KRR-P-DC
Q
Y
A
V
A
A
IGSGG
G
I
G
L
A
L
L
F
E
V
LA
105
HHSearch
93.43
38%
-93
- C3 -
1WL4
7
THIC_HUMAN
A:
[6-396]
D
P
V
-----
V
I
V
S
A
A
R
T
-
I
I
G
S
-
F
-
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
-
V
L
K
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V
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----
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S
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Q
---
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---
L
----
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RTGV
K
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PLTD--
S
-------------
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LCD---------
G
L----------------
T
--------
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A
--------
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----
H
N
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----
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N
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K
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-------------
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K
T
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--------------
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----------
K
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L
--------
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P
A
N
A
S
G
I
N
D
G
A
A
A
V
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L
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K
K
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A
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K
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L
G
L
N
---
P
--
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K
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G
A
I
A
L
G
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G
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L
L
H
T
L
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M
-
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--
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V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
R
--
7
PsiBlast_PDB
92.79
36%
-94
- C3 -
3SS6
6
?
A:
[6-394]
-
N
V
-----
V
I
T
A
A
V
R
S
-
P
I
G
T
-
F
-
G
G
A
L
K
N
V
T
P
V
E
L
A
V
P
V
L
Q
E
-
A
V
K
R
GG-
V
---
E
P--
H
E
----
V
D
E
V
I
L
G
H
--
C
--
I
Q
R
T
DE-
A
---
N
T
A
---
R
T
A
A
L
A
A
G
F
P
D
T
V
T
G
Y
T
I
Q
R
Q
C
S
S
G
M
Q
A
I
M
S
A
A
M
Q
I
Q
L
G
V
S
E
V
V
V
A
G
G
V
E
A
M
S
S
S
P
Y
---
A
L---
K
Q
--
H
---------------
R
-------------
W
------------
G
QRLQHGEIR
D
T
V
W
E
V
L-
E
--------
D
P
--------
I
----
H
H
I
----
M
-------
M
G
E
T
A
E
N
L
V
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Y
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R
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E
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D
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V
A
L
R
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H
T
L
A
L
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A
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S
G
Y
F
D
D
Q
I
V
--------
P
I
-------------------------------------------
T
I
K
-
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-
R
R
K
E
-------------
V
V
F
S
KDEH
P
R
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A
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K
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A
GL
K
P
A
F
---------
R
K
-
D
G
S
V
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A
G
N
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S
G
L
N
D
G
S
A
V
L
V
L
M
S
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E
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A
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R
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L
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D
L
D
---
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K
V
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V
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P
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C
T
G
A
R
I
T
V
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L
I
H
E
L
K
R
R
---
G
L
E
K
G
I
A
S
L
C
V
G
G
G
I
G
V
A
L
F
I
E
A
L
-
110
HHSearch
92.17
38%
-89
- C3 -
3GOA
2
FADA_SALTY
A:
[2-386]
E
Q
V
-----
V
I
V
D
A
I
R
T
-
P
M
G
R
S
K
-
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
-
L
L
A
R
N
PS
L
---
T
A--
A
T
----
L
D
D
I
Y
W
G
C
--
V
--
Q
Q
T
L
EQG
F
---
N
I
A
---
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
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I
M
T
G
D
A
Q
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C
L
V
G
G
V
E
H
M
G
H
V
P
M
---
S
----
H
G
--
V
---------------
D
-------------
F
HP----------
G
-----------------
L
S------------------------
G
----
M
-------
M
G
L
T
A
E
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A
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I
I
--------
P
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------
G
G
-------
H
-------------
D
ADG
V
L
K
Q
F
N
Y
-
D
E
V
I
R
P
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T
T
V
E
--------------
A
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-----
S
T
L
----------
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--------
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G
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T
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G
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P
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G
P
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N
G
G
A
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L
G
H
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C
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R
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T
L
I
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L
M
E
R
K
-
D
--
A
Q
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
--
103
HHSearch
90.38
40%
-87
- C3 -
3SS6
6
?
A:
[5-393]
H
N
V
-----
V
I
T
A
A
V
R
S
-
P
I
G
T
-
F
-
G
G
A
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K
N
V
T
P
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L
A
V
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Q
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-
A
V
K
R
GG-
V
---
E
P--
H
E
----
V
D
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V
I
L
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H
--
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I
Q
R
T
DE-
A
---
N
T
A
---
R
T
A
A
L
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F
P
D
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T
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C
S
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M
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A
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Q
L
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V
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G
G
V
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A
M
S
S
S
P
Y
---
A
----
L
K
Q-
H
---------------
R
-------------
W
GQRLQHGE----
I
-----------------
R
--------
D
T
V
W
E
V
LEDP
I
----
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H
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----
M
-------
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G
E
T
A
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L
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Q
Y
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Q
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------
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I
-------
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R
R
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S
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-----
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L
----------
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A
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S
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G
N
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V
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G
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W
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L
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D
A
D
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A
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Q
Y
L
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V
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K
E
L
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L
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R
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V
N
G
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G
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G
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G
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C
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S
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I
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E
L
K
R
R
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G
--
L
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A
S
L
C
V
G
G
G
I
G
V
A
L
F
I
E
A
--
115
HHSearch
90.19
40%
-87
- C3 -
4WYS
-
ATOB_ECOLI
A:
[2-391]
K
N
C
-----
V
I
V
S
A
V
R
T
-
A
I
G
S
-
F
-
N
G
S
L
A
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I
D
L
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A
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K
A
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---
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Q
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----
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D
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I
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G
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--
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--
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Q
A
G
LG-
Q
---
N
P
A
---
R
Q
A
L
L
K
S
G
L
A
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T
V
C
G
F
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N
K
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L
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A
Q
A
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Q
A
G
Q
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A
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G
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E
N
M
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L
A
P
Y
---
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----
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A
RS-------------
G
-------------
Y
R
L
G
D
G
Q
------
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-----------------
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--------
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G
Y
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K
T
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-------------
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--------
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-------------
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-----
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----------
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A
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A
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N
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Y
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K
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---
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V
N
G
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A
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L
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A
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D
--
K
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L
G
L
A
T
L
C
I
G
G
G
Q
G
I
A
M
V
I
E
---
117
HHSearch
89.30
40%
-83
- C3 -
1ULQ
-
?
A:
[3-399]
-
E
A
-----
W
I
V
E
A
V
R
T
-
P
I
G
K
-
H
-
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
-
L
V
D
R
S
G-
V
---
P
K--
E
E
----
V
E
D
V
Y
A
G
C
--
A
--
N
Q
A
G
EDN
R
---
N
V
A
---
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
---
A
----
V
P
K
-
P
ER-------------
G
-------------
F
P
T
G
N
L
V
M
Y
DTTL
G
-----------------
W
RFVN
P
K
M
Q
A
L
--------
Y
----
G
T
E
----
S
-------
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
--------
P
V
------
P
V
-------
K
-------------
R
GK
E
E
I
L
V
-
E
Q
-
D
E
G
P
R
R
D
-
T
S
L
E
--------------
K
L
-----
A
A
L
----------
R
P
V
F
R
--------
E
--
G
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
ME-
D
--
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
-
K
--
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
G
--
18
PsiBlast_PDB
89.15
35%
-91
- C3 -
2C7Z
-
THIK2_ARATH
A:
[51-437]
-
D
V
-----
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
-
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
-
L
I
E
K
---
T
---
N
LNP
S
E
----
V
G
D
I
V
V
G
T
--
V
--
L
A
P
G
---
S
---
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
---
A
----
W
E
----------------------------------------------------------------------------------
K
----
K
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
--------
P
V
------
K
T
-------
K
-------------
L
--------
V
D
-
P
K
T
G
D
-
E
-
K
P
I
T
V
SVDDGIRPTTTL
A
S
L
-----
G
K
L
----------
K
P
V
F
---------
K
K
-
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
---
101
HHSearch
88.68
37%
-85
- C3 -
2WU9
6
THIK2_ARATH
A:
[31-418]
-
D
V
-----
V
I
V
A
A
H
R
T
-
P
L
C
K
S
K
-
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
-
L
I
E
K
T
N-
L
---
N
P--
S
E
----
V
G
D
I
V
V
G
T
--
V
--
L
A
P
G
S
Q
R
A
---
S
E
C
---
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
---
A
----
W
E
--
G
---------------
S
-------------
V
NPAVKKF-----
A
-----------------
Q
--------
A
Q
--------
N
----
C
L
L
----
P
-------
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
--------
P
V
------
K
T
-------
K
L
V
D
PKTG
D
E
K
P
I
T
V
--------
S
V
-
D
D
G
I
R
-
P
T
T
T
L
A
--------------
S
L
-----
G
K
L
----------
K
P
V
F
K
--------
K
--
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
-
G
K
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
R
--
114
HHSearch
88.47
35%
-85
- C3 -
2VU1
5
THIL_ZOORA
A:
[3-391]
P
S
I
-----
V
I
A
S
A
A
R
T
-
A
V
G
S
-
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
-
V
L
E
R
A
G-
V
---
A
A--
G
E
----
V
N
E
V
I
L
G
Q
--
V
--
L
P
A
G
EG-
Q
---
N
P
A
---
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
---
C
----
A
H
--
L
RGGV
K
M
G
D
F
KMID--
T
-------------
M
IKDG--------
L
-----------------
T
--------
D
A
--------
F
----
Y
G
Y
----
H
-------
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
--------
P
F
------
I
V
-------
K
-------------
G
R
K
G
D
I
T
V
-
D
A
-
D
E
Y
I
R
H
G
-
A
T
L
D
--------------
S
M
-----
A
K
L
----------
R
P
A
F
D
--------
K
--
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
---
P
--
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
-
G
--
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
--
9
PsiBlast_PDB
88.26
36%
-91
- C3 -
1WL4
7
THIC_HUMAN
A:
[4-395]
---GSDPV
V
I
V
S
A
A
R
T
-
I
I
G
S
-
F
-
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
-
V
L
K
R
---
A
---
T
VAP
E
D
----
V
S
E
V
I
F
G
H
V
L
A
--
A
G
C
G
---
Q
---
N
P
V
---
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
---
L
----
A
Y
--
L
---------------
R
-------------
T
------------
G
V
K
I
G
E
M
PLTDSILCDGL
T
--------
D
A
--------
F
----
H
N
C
----
H
-------
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
TR
K
G
L
------
I
E
-------
V
-------------
K
--------
T
D
-
E
F
P
R
H
-
G
-
S
N
I
E
-------------
A
M
------
S
K
L
----------
K
P
Y
F
L
--------
T
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
---
P
--
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
-
G
-
R
S
R
-
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
---
10
PsiBlast_PDB
87.92
36%
-89
- C3 -
1WL5
5
THIC_HUMAN
A:
[4-395]
---GSDPV
V
I
V
S
A
A
R
T
-
I
I
G
S
-
F
-
N
G
A
L
A
A
V
P
V
Q
D
L
G
S
T
V
I
K
E
-
V
L
K
R
---
A
---
T
VAP
E
D
----
V
S
E
V
I
F
G
H
V
L
A
--
A
G
C
G
---
Q
---
N
P
V
---
R
Q
A
S
V
G
A
G
I
P
Y
S
V
P
A
W
S
C
Q
M
I
C
G
S
G
L
K
A
V
C
L
A
V
Q
S
I
G
I
G
D
S
S
I
V
V
A
G
G
M
E
N
M
S
K
A
P
H
---
L
----
A
Y
--
L
---------------
R
-------------
T
------------
G
V
K
I
G
E
M
PLTDSILCDGL
T
--------
D
A
--------
F
----
H
N
C
----
H
-------
M
G
I
T
A
E
N
V
A
K
K
W
Q
V
S
R
E
D
Q
D
K
V
A
V
L
S
Q
N
R
T
E
N
A
Q
K
A
G
H
F
D
K
E
I
V
P
V
L
V
S
TR
K
G
L
------
I
E
-------
V
-------------
K
--------
T
D
-
E
F
P
R
H
-
G
-
S
N
I
E
-------------
A
M
------
S
K
L
----------
K
P
Y
F
L
--------
T
D
G
T
G
T
V
T
P
A
N
A
S
G
I
N
D
G
A
A
A
V
V
L
M
K
K
S
E
A
D
K
R
G
L
T
P
L
A
R
I
V
S
W
S
Q
V
G
V
E
P
S
I
M
G
I
G
P
I
P
A
I
K
Q
A
V
T
K
A
G
W
S
L
E
D
V
D
I
F
E
I
N
E
A
F
A
A
V
S
A
A
I
V
K
E
L
G
L
N
---
P
--
E
K
V
N
I
E
G
G
A
I
A
L
G
H
P
L
G
A
S
G
C
R
I
L
V
T
L
L
H
T
L
E
R
M
-
G
-
R
S
R
-
G
V
A
A
L
C
I
G
G
G
M
G
I
A
M
C
V
Q
---
76
PsiBlast_CBE
87.56
34%
-92
- C3 -
3SVK
1
?
B:
[9-405]
--
A
-----
F
I
Y
E
A
I
R
T
-
P
R
G
K
-
Q
K
N
G
S
L
T
E
V
K
P
L
N
L
V
V
G
L
V
D
E
-
L
R
R
R
---
Y
---
P
---
D
L
DETL
I
S
D
M
I
L
G
V
--
V
-------------
D
I
A
---
R
T
A
V
L
A
A
G
L
P
E
T
T
G
G
V
Q
L
N
----
S
G
L
E
A
V
N
T
A
A
Q
K
V
R
S
G
W
D
D
L
V
L
A
G
G
V
E
S
M
-----------------------------------------------
W
------------
A
-----------------
T
--------
D
P
ETNYR---
I
----
G
F
V
----
P
-------
Q
G
I
G
A
D
L
I
A
T
L
E
G
F
S
R
E
D
V
D
A
Y
A
L
R
S
Q
Q
K
A
A
A
A
W
S
G
G
Y
F
A
K
S
V
V
--------
P
V
------
R
D
QNGLVI-
L
-------------
D
--------
H
D
-
E
H
M
R
P
-
D
-
T
T
M
E
-------------
G
L
------
A
K
L
----------
K
T
A
F
D
LQKYHWVE
K
I
-
N
H
V
H
T
G
G
N
S
S
G
I
V
D
G
A
A
L
V
L
V
G
S
E
K
A
G
K
S
Q
G
L
T
P
R
A
R
I
V
A
T
A
T
S
------
M
L
T
G
P
T
P
A
T
R
K
V
L
D
R
A
G
L
T
I
D
D
I
D
L
F
E
L
N
E
A
F
A
S
V
V
L
K
F
Q
K
D
L
N
I
P
---
D
--
E
K
L
N
V
N
G
G
A
I
A
M
G
H
P
L
G
A
T
G
A
M
I
T
G
T
M
V
D
E
L
E
R
R
---
N
A
R
R
A
L
I
T
L
C
I
G
G
G
M
G
V
A
T
I
I
E
---
17
PsiBlast_PDB
87.42
35%
-90
- C3 -
2C7Y
-
THIK2_ARATH
A:
[51-437]
-
D
V
-----
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
-
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
-
L
I
E
K
---
T
---
N
LNP
S
E
----
V
G
D
I
V
V
G
T
--
V
--
L
A
P
G
---
S
---
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
--------------------------------------------------------------------------------------------------
K
F
A
----
Q
A
Q
N
C
L
L
P
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
--------
P
V
------
K
T
-------
K
-------------
L
--------
V
D
-
P
K
T
G
D
-
E
-
K
P
I
T
V
SVDDGIRPTTT
L
A
S
L
-----
G
K
L
----------
K
P
V
F
---------
K
K
-
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
---
15
PsiBlast_PDB
86.99
35%
-88
- C3 -
2WU9
6
THIK2_ARATH
A:
[31-417]
-
D
V
-----
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
-
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
-
L
I
E
K
---
T
---
N
LNP
S
E
----
V
G
D
I
V
V
G
T
--
V
--
L
A
P
G
---
S
---
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
---
A
----
W
E
--
G
---------------
S
-------------
V
------------
N
-----------------
P
--------
A
V
--------
K
----
K
F
A
----
Q
A
Q
N
C
L
LP
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
--------
P
V
------
K
T
-------
K
-------------
L
--------
V
D
-
P
K
T
G
D
-
E
-
K
P
I
T
V
S
V
DDGIRPTTT
L
A
S
L
-----
G
K
L
----------
K
P
V
F
---------
K
K
-
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
---
13
PsiBlast_PDB
86.66
37%
-81
- C3 -
1ULQ
-
?
A:
[3-398]
-
E
A
-----
W
I
V
E
A
V
R
T
-
P
I
G
K
-
H
-
G
G
A
L
A
S
V
R
P
D
D
L
L
A
H
A
L
S
V
-
L
V
D
R
---
S
GVP
K
---
E
E
----
V
E
D
V
Y
A
G
C
--
A
--
N
Q
A
G
---
E
DNR
N
V
A
---
R
M
A
L
L
L
A
G
F
P
V
E
V
A
G
C
T
V
N
R
L
C
G
S
G
L
E
A
V
A
Q
A
A
R
A
I
W
A
G
E
G
K
V
Y
I
G
S
G
V
E
S
M
S
R
A
P
Y
---
A
V
P
K
P
E
R
--
G
F
P
T
G
N
L
V
M
Y
DTTLGW
R
-------------
F
------------
V
-----------------
N
--------
P
K
--------
M
Q
A
L
Y
G
T
E
----
S
-------
M
G
E
T
A
E
N
L
A
E
M
Y
G
I
R
R
E
E
Q
D
R
F
A
L
L
S
H
Q
K
A
V
R
A
W
E
E
G
R
F
Q
D
E
V
V
--------
P
V
P
V
K
R--
G
K
E
E
I
L
---
V
-------------
E
--------
Q
D
-
E
G
P
R
R
-
D
-
T
S
L
E
-------------
K
L
A
-----
A
-
L
----------
R
P
V
F
---------
R
E
-
G
G
T
V
T
A
G
N
S
S
P
L
N
D
G
A
A
A
V
L
L
V
S
D
D
Y
A
K
A
H
G
L
R
P
L
A
R
V
R
A
I
A
V
A
G
V
P
P
R
I
M
G
I
G
P
V
P
A
T
R
K
A
L
E
R
A
G
L
S
F
S
D
L
G
L
I
E
L
N
E
A
F
A
A
Q
A
L
A
V
L
R
E
W
S
L
S
---
M
ED
Q
R
L
N
P
N
G
G
A
I
A
L
G
H
P
L
G
A
S
G
A
R
I
L
T
T
L
V
H
E
M
R
R
R
---
K
V
Q
F
G
L
A
T
M
C
I
G
V
G
Q
G
I
A
V
V
V
E
---
37
PsiBlast_CBE
86.42
35%
-88
- C3 -
2WU9
3
THIK2_ARATH
B:
[31-417]
-
D
V
-----
V
I
V
A
A
H
R
T
P
L
C
K
S
-
K
-
R
G
N
F
K
D
T
Y
P
D
D
L
L
A
P
V
L
R
A
-
L
I
E
K
---
T
---
N
LNP
S
E
----
V
G
D
I
V
V
G
T
--
V
--
L
A
P
G
---
S
---
Q
R
A
S
E
C
R
M
A
A
F
Y
A
G
F
P
E
T
V
A
V
R
T
V
N
R
Q
C
S
S
G
L
Q
A
V
A
D
V
A
A
A
I
K
A
G
F
Y
D
I
G
I
G
A
G
L
E
S
M
T
T
N
P
M
---
A
----
W
E
--
G
---------------
S
-------------
V
------------
N
-----------------
P
--------
A
V
--------
K
----
K
F
A
----
Q
A
Q
N
C
L
LP
M
G
V
T
S
E
N
V
A
Q
R
F
G
V
S
R
Q
E
Q
D
Q
A
A
V
D
S
H
R
K
A
A
A
A
T
A
A
G
K
F
K
D
E
I
I
--------
P
V
------
K
T
-------
K
-------------
L
--------
V
D
-
P
K
T
G
D
-
E
-
K
P
I
T
V
S
V
DDGIRPTTT
L
A
S
L
-----
G
K
L
----------
K
P
V
F
---------
K
K
-
D
G
T
T
T
A
G
N
S
S
Q
V
S
D
G
A
G
A
V
L
L
M
K
R
S
V
A
M
Q
K
G
L
P
V
L
G
V
F
R
T
F
A
A
V
G
V
D
P
A
I
M
G
I
G
P
A
V
A
I
P
A
A
V
K
A
A
G
L
E
L
D
D
I
D
L
F
E
I
N
E
A
F
A
S
Q
F
V
Y
C
R
N
K
L
G
L
D
---
P
--
E
K
I
N
V
N
G
G
A
M
A
I
G
H
P
L
G
A
T
G
A
R
C
V
A
T
L
L
H
E
M
K
R
R
G
K
-
D
C
R
F
G
V
V
S
M
C
I
G
T
G
M
G
A
A
A
V
F
E
---
120
HHSearch
86.03
40%
-81
* C3 *
4O9A
-
THIL_CUPNH
A:
[3-392]
-
D
V
-----
V
I
V
S
A
A
R
T
-
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
-
A
L
E
R
A
G-
V
---
K
P--
E
Q
----
V
S
E
V
I
M
G
Q
--
V
--
L
T
A
G
SG-
Q
---
N
P
A
---
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
---
V
----
L
P
G-
S
RDGFRM
G
D
A
K
L
V
D
--
T
-------------
M
I
V
D
G
--------
L
-----------------
W
--------
D
V
--------
Y
----
N
Q
Y
----
H
-------
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
--------
P
V
------
L
I
-------
P
Q
RK
G
D
P
V
A
-----
F
--------
K
T
-
D
E
F
V
R
Q
G
-
A
T
L
D
--------------
S
M
-----
S
G
L
----------
K
P
A
F
D
--------
K
--
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
---
T
--
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
-
D
--
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
--
42
PsiBlast_CBE
85.71
33%
-83
- C3 -
1DLV
5
THIL_ZOORA
A:
[3-389]
--------
V
I
A
S
A
A
R
T
-
A
V
G
S
-
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
-
V
L
E
R
---
A
GVA
A
---
G
E
----
V
N
E
V
I
L
G
Q
--
V
LP
A
G
E
G
---
Q
---
N
P
A
---
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
---
C
----
A
H
--
L
---------------
R
GGVKMGDFKMIDT
M
------------
I
-----------------
K
--------
D
G
--------
L
----
T
D
A
FYGY
H
-------
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
--------
P
F
IVKGRK
G
D
-------
I
-------------
T
--------
V
D
A
D
E
Y
I
R
-
H
-
G
A
T
L
-------------
D
S
M
-----
A
K
L
----------
R
P
A
F
D
---------
K
-
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
---
P
--
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
---
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
L
-
48
PsiBlast_CBE
85.59
33%
-82
- C3 -
2VU2
1
THIL_ZOORA
C:
[6-392]
--------
V
I
A
S
A
A
R
T
-
A
V
G
S
-
F
-
N
G
A
F
A
N
T
P
A
H
E
L
G
A
T
V
I
S
A
-
V
L
E
R
---
A
GVA
A
---
G
E
----
V
N
E
V
I
L
G
Q
--
V
LP
A
G
E
G
---
Q
---
N
P
A
---
R
Q
A
A
M
K
A
G
V
P
Q
E
A
T
A
W
G
M
N
Q
L
C
G
S
G
L
R
A
V
A
L
G
M
Q
Q
I
A
T
G
D
A
S
I
I
V
A
G
G
M
E
S
M
S
M
A
P
H
---
C
----
A
H
--
L
---------------
R
GGVKMGDFKMIDT
M
------------
I
-----------------
K
--------
D
G
--------
L
----
T
D
A
FYGY
H
-------
M
G
T
T
A
E
N
V
A
K
Q
W
Q
L
S
R
D
E
Q
D
A
F
A
V
A
S
Q
N
K
A
E
A
A
Q
K
D
G
R
F
K
D
E
I
V
--------
P
F
IVKGRK
G
D
-------
I
-------------
T
--------
V
D
A
D
E
Y
I
R
-
H
-
G
A
T
L
-------------
D
S
M
-----
A
K
L
----------
R
P
A
F
D
---------
K
-
E
G
T
V
T
A
G
N
A
S
G
L
N
D
G
A
A
A
A
L
L
M
S
E
A
E
A
S
R
R
G
I
Q
P
L
G
R
I
V
S
W
A
T
V
G
V
D
P
K
V
M
G
T
G
P
I
P
A
S
R
K
A
L
E
R
A
G
W
K
I
G
D
L
D
L
V
E
A
N
E
A
F
A
A
Q
A
C
A
V
N
K
D
L
G
W
D
---
P
--
S
I
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
A
R
I
L
N
T
L
L
F
E
M
K
R
R
---
G
A
R
K
G
L
A
T
L
C
I
G
G
G
M
G
V
A
M
C
I
E
S
L
-
31
PsiBlast_CBE
85.47
39%
-78
- C3 -
4O99
1
THIL_CUPNH
B:
[2-390]
-
D
V
-----
V
I
V
S
A
A
R
T
-
A
V
G
K
-
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
GV-
K
---
P
---
E
Q
----
V
S
E
V
I
M
G
Q
VL
T
--
A
G
S
G
---
Q
---
N
P
A
---
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
C
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
A
A
P
H
VLP
G
----
S
R
--
D
---------------
G
-------------
F
------------
R
MGDAKLVDTMIVDGL--
W
--------
D
V
--------
Y
----
N
Q
Y
----
H
-------
M
G
I
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
--------
P
V
LIPQRK
G
D
PVA----
F
-------------
K
--------
T
D
-
E
-
F
V
R
-
Q
-
G
A
T
L
-------------
D
S
M
-----
S
G
L
----------
K
P
A
F
D
---------
K
-
A
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
---
T
--
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
---
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
---
27
PsiBlast_CBE
84.68
37%
-81
- C3 -
4XL2
7
THLA_CLOAB
A:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVD
E
M
I
T
D
G
L
W
--------
D
A
--------
F
----
N
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
V
I
K
G
RK
G
E
T
V
-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
---
26
PsiBlast_CBE
84.09
37%
-80
- C3 -
4XL2
7
THLA_CLOAB
B:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVDEMITDGL
W
--------
D
A
--------
F
----
N
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
VIKGRK
G
E
TV-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
---
29
PsiBlast_CBE
83.76
37%
-78
- C3 -
4WYR
3
THLA_CLOAB
B:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVDEMITDGL
W
--------
D
A
--------
F
----
Y
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
VIKGRK
G
E
TV-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
---
5
PsiBlast_PDB
82.82
37%
-77
- C3 -
4WYR
5
THLA_CLOAB
A:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVD
E
M
I
T
D
GL
W
--------
D
A
--------
F
----
Y
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
V
I
K
G
RK
G
E
T
V
-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
---
2
PsiBlast_PDB
82.30
37%
-74
- C3 -
4XL3
4
?
A:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L
--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVDEMITDGL
W
--------
D
A
--------
F
----
N
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
V
I
K
G
RK
G
E
T
V
-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
---
22
PsiBlast_CBE
80.81
37%
-72
- C3 -
4XL3
3
?
B:
[5-390]
--------
V
I
A
S
A
V
R
T
-
A
I
G
S
-
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
-
A
V
K
K
---
A
GIK
P
---
E
D
----
V
N
E
V
I
L
G
N
--
V
LQ
A
G
L
G
---
Q
---
N
P
A
---
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
R
A
P
Y
L--
A
----
N
N
--
A
---------------
R
-------------
W
------------
G
YRMGNAKFVDEMITDGL
W
--------
D
A
--------
F
----
N
D
Y
----
H
-------
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
--------
P
V
VIKGRK
G
E
TV-----
V
-------------
D
--------
T
D
-
E
H
P
R
F
-
G
-
S
T
I
E
-------------
G
L
------
A
K
L
----------
K
P
A
F
---------
K
K
-
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
--
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
---
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
---