@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu11230: (2016-06-17 )
MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPSYKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKWNIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDGNKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGIVLSNGPGDPKAIQPYLGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQNHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIFDDYLKNVIPARREIAHA
Atome Classification :
(20 SA)
-.........10........20.-.-.......30........40........50........60...----------..----------...70........80........90........100.......110.......120...-....130.....-..140..---------......150.......-160.-----------------.-......170..--.......180.......190-.-...-..-.200.......210-----.---....---.-..---220.....-.--.---230.......240.......250...--....260.......--------270-------.-------........280.......290.......300.......310.......320.......330.......340.......350.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-ME
G
Y
L
V
L
EDGTSFSGELDGH-E-N-CTG
E
A
V
F
F
TGMT
G
Y
Q
E
V
LTDPSYK
G
Q
I
I
V
F
T
YPLIGNYGINE----------KD----------FESKKPQ
V
K
A
A
V
V
Y
E
A
C
D
H
F
S
H
Y
E
A
V
Y
S
L
K
E
Y
L
Q
KWNI
P
L
L
THV
D
T
R
A
V
V
K
K
I
RANGTM-
G
A
T
V
T
ASKEG
A
E
-
I
A
L-Q
P
E
---------
N
V
A
E
Q
A
S
A
Q
E
I
S
TFGD-GN-
K
-----------------
H
-
I
A
L
I
DFG--
Y
K
--
K
S
I
A
S
S
L
V
KRG
C
K
V
T
V
V
P
Y
Q
-
Q
-
M
E
A
-VY-NIKPD
G
I
V
L
SNGP------G---D
P
K
A
---
I
-
Q
P
---
Y
L
G
K
I
K
S
I
-
I
--
S
---RFP
T
L
G
I
C
LG
H
Q
L
I
A
L
A
FGG
N
T
F
K
LP--FGHRGANHPVIDRK--------
T
---------
K
-------
R
V
F
M
TSQNH
S
Y
V
VDEQSINEE
E
L
T
I
R
F
H
HVNDTSVEGLAHKKL
P
V
M
S
V
Q
FHPEAHPGPAESE
W
I
F
D
D
Y
L
K
N
V
I
P
A
R
R
E
IAHA
1
PsiBlast_PDB
85.04
36%
-80
- C3 -
1JDB
2
CARA_ECOLI
C:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
RAFPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
TLTGGLPQAKKEDELPF
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E-
T
---
D
I
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
5
PsiBlast_PDB
84.17
36%
-76
- C3 -
1C30
2
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPEAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
7
PsiBlast_PDB
83.95
36%
-84
- C3 -
1M6V
2
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPQAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
----
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
6
PsiBlast_PDB
83.82
36%
-76
- C3 -
1C3O
2
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPEAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
S
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
2
PsiBlast_PDB
83.35
36%
-78
- C3 -
1BXR
2
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPQAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
4
PsiBlast_PDB
83.32
36%
-77
- C3 -
1T36
1
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPEAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
D
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
3
PsiBlast_PDB
83.19
36%
-76
- C3 -
1CE8
1
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPQAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
C
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
47
PsiBlast_CBE
80.08
33%
-73
- C3 -
5DOT
1
CPSM_HUMAN
B:
[35-486]
---
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
-
S
-
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
TTALDELGLS
K
Y
----------
L
E
S
N
G
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
-
L
G
K
I
E
F
E
G
Q
P
V
D
F
V
D
P
-
N
K
Q
---------
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
-
G
N
P
T
-----------------
K
-
V
V
A
V
D
C
G
--
I
K
--
N
N
V
I
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
-
H
---
D
-
F
T
-
K
M
E
Y
D
G
I
L
I
A
G
G
P
------
G
---
N
P
A
L
---
A
-
E
P
---
L
I
Q
N
V
R
K
I
-
L
--
E
SDR
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
--
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
--------
N
---------
K
-------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
T
L
--
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
-------------
9
PsiBlast_PDB
80.07
33%
-73
- C3 -
5DOT
3
CPSM_HUMAN
A:
[35-486]
---
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
-
S
-
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
TTALDELGLS
K
Y
----------
L
E
S
N
G
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
-
L
G
K
I
E
F
E
G
Q
P
V
D
F
V
D
P
-
N
K
Q
---------
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
-
G
N
P
T
-----------------
K
-
V
V
A
V
D
C
G
--
I
K
--
N
N
V
I
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
-
H
---
D
-
F
T
-
K
M
E
Y
D
G
I
L
I
A
G
G
P
------
G
---
N
P
A
L
---
A
-
E
P
---
L
I
Q
N
V
R
K
I
-
L
--
E
SDR
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
--
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
--------
N
---------
K
-------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
T
L
--
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
-------------
64
HHSearch
79.54
34%
-68
- C3 -
5DOT
3
CPSM_HUMAN
A:
[33-495]
-
Q
T
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
-
P
-
S
S
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
----------
T
T
ALDELGLSKY
L
E
S
N
G
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
-
L
G
K
I
E
F
E
G
Q
P
V
D
-
F
V
D
P
N
K
Q
---------
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
G
N
P
-
T
-----------------
K
-
V
V
A
V
D
C
G
--
I
K
--
N
N
V
I
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
-
H
-
D
F
T
-
K
---
M
E
Y
D
G
I
L
I
A
G
G
P
------
G
---
N
P
A
L
---
A
-
E
P
---
L
I
Q
N
V
R
K
I
L
E
SD
R
---
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
--
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
--------
N
---------
K
-------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
-
T
L
P
A
-
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
S
L
I
K
K
G
K
A
T
----
46
PsiBlast_CBE
79.29
33%
-72
- C3 -
5DOU
1
CPSM_HUMAN
B:
[35-409]
---
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
-
S
-
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
TTALDELGLS
K
Y
----------
L
E
S
N
G
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
-
L
G
K
I
E
F
E
G
Q
P
V
D
F
V
D
P
-
N
K
Q
---------
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
-
G
N
P
T
-----------------
K
-
V
V
A
V
D
C
G
--
I
K
--
N
N
V
I
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
-
H
---
D
-
F
T
-
K
M
E
Y
D
G
I
L
I
A
G
G
P
------
G
---
N
P
A
L
---
A
-
E
P
---
L
I
Q
N
V
R
K
I
-
L
--
E
S
DR
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
--
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
--------
N
---------
K
-------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
T
L
--
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
-------------
10
PsiBlast_PDB
79.00
33%
-72
- C3 -
5DOU
2
CPSM_HUMAN
A:
[35-413]
---
A
H
I
V
L
E
D
G
T
K
M
K
G
Y
S
F
G
H
P
S
-
S
-
V
A
G
E
V
V
F
N
T
G
L
G
G
Y
P
E
A
I
T
D
P
A
Y
K
G
Q
I
L
T
M
A
N
P
I
I
G
N
G
G
A
P
D
TTALDELGLS
K
Y
----------
L
E
S
N
G
I
K
V
S
G
L
L
V
L
D
Y
S
K
D
Y
N
H
W
L
A
T
K
S
L
G
Q
W
L
Q
E
E
K
V
P
A
I
Y
G
V
D
T
R
M
L
T
K
I
I
R
D
K
G
T
M
-
L
G
K
I
E
F
E
G
Q
P
V
D
F
V
D
P
-
N
K
Q
---------
N
L
I
A
E
V
S
T
K
D
V
K
V
Y
G
K
-
G
N
P
T
-----------------
K
-
V
V
A
V
D
C
G
--
I
K
--
N
N
V
I
R
L
L
V
K
R
G
A
E
V
H
L
V
P
W
N
-
H
---
D
-
F
T
-
K
M
E
Y
D
G
I
L
I
A
G
G
P
------
G
---
N
P
A
L
---
A
-
E
P
---
L
I
Q
N
V
R
K
I
-
L
--
E
S
DR
K
E
P
L
F
G
I
S
T
G
N
L
I
T
G
L
A
A
G
A
K
T
Y
K
M
S
--
M
A
N
R
G
Q
N
Q
P
V
L
N
I
T
--------
N
---------
K
-------
Q
A
F
I
T
A
Q
N
H
G
Y
A
L
D
N
T
L
--
P
A
G
W
K
P
L
F
V
N
V
N
D
Q
T
N
E
G
I
M
H
E
S
K
P
F
F
A
V
Q
F
H
P
E
V
T
P
G
P
I
D
T
E
Y
L
F
D
S
F
F
-------------
8
PsiBlast_PDB
77.18
36%
-57
- C3 -
1KEE
2
CARA_ECOLI
B:
[7-379]
-----
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
N
G
C
I
I
A
G
D
N
P
D
A
A
-
L
A
L
-
E
K
A
R
A
FPGLNGM
D
L
A
K
E
V
T
T
A
E
A
Y
S
W
T
Q
-
G
S
-
W
T
LTGGLPEAKKEDELP
F
H
-
V
V
A
Y
D
F
G
--
A
K
--
R
N
I
L
R
M
L
V
D
R
G
C
R
L
T
I
V
P
A
Q
T
S
-
A
E
D
-
V
L
-
K
M
N
P
D
G
I
F
L
S
N
G
P
------
G
---
D
P
A
P
---
C
-
D
Y
---
A
I
T
A
I
Q
K
F
-
L
E
-
T
---
D
I
P
V
F
G
I
-
L
G
H
Q
L
L
A
L
A
S
G
A
K
T
V
K
M
K
--
F
G
H
H
G
G
N
H
P
V
K
D
V
E
--------
K
---------
N
-------
V
V
M
I
T
A
Q
N
H
G
F
A
V
D
E
A
T
L
-
P
A
N
L
R
V
T
H
K
S
L
F
D
G
T
L
Q
G
I
H
R
T
D
K
P
A
F
S
F
Q
G
H
P
E
A
S
P
G
P
H
D
A
A
P
L
F
D
H
F
I
E
L
I
E
Q
Y
R
K
-----
72
HHSearch
55.42
29%
-104
- C3 -
1QDL
-
TRPG_SULSO
B:
[2-195]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-----------------
L
-
T
L
I
I
D
N
Y
--
D
S
F
V
Y
N
I
A
Q
I
V
G
E
L
G
S
Y
P
I
V
I
R
N
D
-
E
I
S
I
K
-
G
I
E
R
I
D
P
D
R
L
I
I
S
P
G
P
------
G
---
T
P
E
K
---
R
-
E
D
IGV
S
L
D
V
I
K
Y
L
-
G
--
K
---
R
T
P
I
L
G
V
C
L
G
H
Q
A
I
G
Y
A
F
G
A
K
I
R
R
A
R
--
K
V
F
H
G
K
I
S
N
I
I
L
V
N
--------
N
SPLSLYYGI
A
-------
K
E
F
K
A
T
R
Y
H
S
L
V
V
D
E
--
V
H
R
-
P
L
I
V
D
A
I
S
A
E
D
N
E
I
M
A
I
H
H
E
E
Y
P
I
Y
G
V
Q
F
H
P
E
S
V
G
T
S
-
L
G
Y
K
I
L
Y
N
F
L
N
R
V
----------
81
HHSearch
52.12
23%
-135
- C3 -
3TQI
-
GUAA_COXBU
A:
[7-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
H
-----------------
R
-
I
L
I
L
D
F
G
--
S
Q
Y
A
Q
L
I
A
R
R
V
R
E
I
G
V
Y
C
E
L
M
P
C
D
-
I
-
D
E
E
-
T
I
R
D
F
N
P
H
G
I
I
L
S
G
G
P
------
E
--------------------
A
P
A
F
I
F
E
--
I
---
G
C
P
V
L
G
I
C
Y
G
M
Q
T
M
A
Y
Q
L
G
G
K
V
N
-------
E
F
G
H
A
-
Q
L
R
V
L
N
PAFLFDGI
E
---------
D
QVSPQG
E
P
L
L
D
V
W
M
S
H
G
D
I
V
S
E
--
L
P
P
-
G
F
E
A
T
A
C
T
D
-
N
S
P
L
A
A
M
A
D
F
K
R
R
F
F
G
L
Q
F
H
P
E
V
T
H
T
P
-
Q
G
H
R
I
L
A
H
F
V
I
H
I
C
Q
C
I
------
20
PsiBlast_PDB
50.38
29%
-165
- C3 -
1GPM
1
GUAA_ECOLI
A:
[6-122]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
K
-----------------
H
R
I
L
I
L
D
F
G
SQ
Y
T
--
Q
L
V
A
R
R
V
R
E
L
G
V
Y
C
E
L
W
A
W
D
-
V
-
T
E
A
Q
I
R
-
D
F
N
P
S
G
I
I
L
S
G
G
P
ESTTEE
N
---
S
P
R
A
---
P
-
Q
----
Y
V
F
E
--------
A
---
G
V
P
V
F
G
V
C
Y
G
M
Q
T
M
A
M
Q
L
G
G
H
V
--------------------------------------------------------------------------------------------------------------------------------
53
Fugue
50.11
36%
-101
- C3 -
1A9X
-
CARA_ECOLI
B:
[1-149]
I
K
S
A
L
L
V
L
E
D
G
T
Q
F
H
G
R
A
I
G
A
-
T
G
S
-
A
V
G
E
V
V
F
N
T
S
M
T
G
Y
Q
E
I
L
T
D
P
S
Y
S
R
Q
I
V
T
L
T
Y
P
H
I
G
N
V
G
T
N
D
----------
A
D
----------
E
E
S
S
Q
V
H
A
Q
G
L
V
I
R
D
L
P
L
I
A
S
N
F
R
N
T
E
D
L
S
S
Y
L
K
R
H
N
I
V
A
I
A
D
I
D
T
R
K
L
T
R
L
L
R
E
K
G
A
Q
-
N
G
C
I
I
A
G
D
N
P
D
A
-
A
L
A
-
L
E
K
---------
A
R
A
F
P
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
HHSearch
48.43
25%
-85
* C3 *
2A9V
3
GUAAA_THEAC
A:
[13-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
L
-----------------
K
-
I
Y
V
V
D
N
G
--
G
Q
WT
H
R
E
W
R
V
L
R
E
L
G
V
D
T
K
I
V
P
N
D
-
I
-
D
S
S
-
E
L
--
D
G
L
D
G
L
V
L
S
G
G
A
------
P
---
N
I
D
E
---
E
L
D
K
---
L
G
S
V
G
K
Y
I
D
D
--
H
---
N
Y
P
I
L
G
I
C
V
G
A
Q
F
I
A
L
H
F
G
A
S
V
V
K
A
K
--
H
P
E
F
G
K
T
-
K
V
S
V
M
H
--------
S
---------
E
NIFGGLP
S
E
I
T
V
W
E
N
H
N
D
E
I
I
N
--
L
P
D
-
D
F
T
L
A
A
S
S
A
-
T
C
Q
V
Q
G
F
Y
H
K
T
R
P
I
Y
A
T
Q
F
H
P
E
V
E
H
T
Q
-
Y
G
R
D
I
F
R
N
F
I
G
I
C
A
S
Y
R
E
I
----
15
PsiBlast_PDB
47.37
32%
-165
- C3 -
2YWC
-
GUAA_THET8
A:
[2-120]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
V
L
D
F
G
SQ
Y
T
--
R
L
I
A
R
R
L
R
E
L
R
A
F
S
L
I
L
P
G
D
-
A
P
L
E
E
-
V
L
-
K
H
R
P
Q
A
L
I
L
S
G
G
P
------
R
SVF
D
P
D
A
---
P
-
R
P
------
D
P
R
L
F
-
S
--
S
---
G
L
P
L
L
G
I
C
Y
G
M
Q
L
L
A
Q
E
L
G
G
R
V
--------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
47.24
30%
-104
- C3 -
1QDL
-
TRPG_SULSO
B:
[37-178]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-
I
K
G
-
I
E
-
R
I
D
P
D
R
L
I
I
S
P
G
P
------
G
---
T
P
E
K
RED
I
-
G
V
---
S
L
D
V
I
K
Y
L
-
G
--
K
---
R
T
P
I
L
G
V
C
L
G
H
Q
A
I
G
Y
A
F
G
A
K
I
R
R
A
R
K
V
F
H
G
K
I
S
N
I
I
L
V
N
N
S
PLSLYYG-
I
---------
A
-------
K
E
F
K
A
T
R
Y
H
S
L
V
V
D
E
V
---
H
R
P
L
I
V
D
A
I
S
A
E
D
N
E
I
M
A
I
H
H
E
E
Y
P
I
Y
G
V
Q
F
H
P
E
S
----------------------------